Progress in Biomedical Engineering,
Год журнала:
2022,
Номер
4(3), С. 032003 - 032003
Опубликована: Июль 1, 2022
Abstract
Vision
is
an
extraordinary
sense
through
which
we
can
appreciate
the
beauty
of
world
live
in,
gain
invaluable
knowledge
and
communicate
with
others
using
visual
expression
arts.
On
contrary,
blindness
a
threatening
medical
condition
disrupting
life
affected
people
their
families.
Therefore,
restoring
sight
one
open
challenges
our
society.
Today,
synergistic
convergence
science
technology
holds
potential
to
provide
blind
patients
artificial
vision
prostheses:
type
implantable
device
able
reactivate
neurons
electrical
stimulation.
Although
clinical
trials
showed
that
restoration
still
far
away,
significant
technological
advances
make
prostheses
valuable
solution
for
patients.
This
review
not
only
description
state-of-the-art.
Instead,
it
provides
reader
update
on
recent
developments,
critical
discussion
challenges,
overview
promising
future
directions.
ACS Nano,
Год журнала:
2023,
Номер
17(6), С. 5211 - 5295
Опубликована: Март 9, 2023
Humans
rely
increasingly
on
sensors
to
address
grand
challenges
and
improve
quality
of
life
in
the
era
digitalization
big
data.
For
ubiquitous
sensing,
flexible
are
developed
overcome
limitations
conventional
rigid
counterparts.
Despite
rapid
advancement
bench-side
research
over
last
decade,
market
adoption
remains
limited.
To
ease
expedite
their
deployment,
here,
we
identify
bottlenecks
hindering
maturation
propose
promising
solutions.
We
first
analyze
achieving
satisfactory
sensing
performance
for
real-world
applications
then
summarize
issues
compatible
sensor-biology
interfaces,
followed
by
brief
discussions
powering
connecting
sensor
networks.
Issues
en
route
commercialization
sustainable
growth
sector
also
analyzed,
highlighting
environmental
concerns
emphasizing
nontechnical
such
as
business,
regulatory,
ethical
considerations.
Additionally,
look
at
future
intelligent
sensors.
In
proposing
a
comprehensive
roadmap,
hope
steer
efforts
towards
common
goals
guide
coordinated
development
strategies
from
disparate
communities.
Through
collaborative
efforts,
scientific
breakthroughs
can
be
made
sooner
capitalized
betterment
humanity.
Biosensors,
Год журнала:
2020,
Номер
10(7), С. 79 - 79
Опубликована: Июль 21, 2020
Biosensors
devices
have
attracted
the
attention
of
many
researchers
across
world.
They
capability
to
solve
a
large
number
analytical
problems
and
challenges.
are
future
ubiquitous
for
disease
diagnosis,
monitoring,
treatment
health
management.
This
review
presents
an
overview
biosensors
field,
highlighting
current
research
development
bio-integrated
implanted
biosensors.
These
micro-
nano-fabricated,
according
numerous
techniques
that
adapted
in
order
offer
suitable
mechanical
match
biosensor
surrounding
tissue,
therefore
decrease
body's
biological
response.
For
this,
most
skin-integrated
use
polymer
layer
as
versatile
flexible
structural
support,
combined
with
functional/active
material,
generate,
transmit
process
obtained
signal.
A
few
challenging
issues
implantable
devices,
well
strategies
overcome
them,
also
discussed
this
review,
including
response,
power
supply,
data
communication.
Elastic
stretchability
and
function
density
represent
two
key
figures
of
merits
for
stretchable
inorganic
electronics.
Various
design
strategies
have
been
reported
to
provide
both
high
levels
density,
but
the
densities
are
mostly
below
80%.
While
stacked
device
layout
can
overcome
this
limitation,
soft
elastomers
used
in
previous
studies
could
highly
restrict
deformation
interconnects.
Here,
we
introduce
multilayer
network
materials
as
a
general
platform
incorporate
individual
components
interconnects,
without
posing
any
essential
constraint
their
deformations.
Quantitative
analyses
show
substantial
enhancement
(e.g.,
by
~7.5
times)
elastic
serpentine
interconnects
compared
that
based
on
elastomers.
The
proposed
strategy
allows
demonstration
miniaturized
electronic
system
(11
mm
10
mm),
with
moderate
(~20%)
an
unprecedented
areal
coverage
(~110%),
which
serve
compass
display,
somatosensory
mouse,
physiological-signal
monitor.
Advanced Materials,
Год журнала:
2022,
Номер
34(34)
Опубликована: Март 30, 2022
Bioelectronic
implantable
systems
(BIS)
targeting
biomedical
and
clinical
research
should
combine
long-term
performance
biointegration
in
vivo.
Here,
recent
advances
novel
encapsulations
to
protect
flexible
versions
of
such
from
the
surrounding
biological
environment
are
reviewed,
focusing
on
material
strategies
synthesis
techniques.
Considerable
effort
is
put
thin-film
encapsulation
(TFE),
specifically
organic-inorganic
multilayer
architectures
as
a
conformal
alternative
conventional
rigid
cans.
TFE
direct
contact
with
medium
thus
must
exhibit
not
only
biocompatibility,
inertness,
hermeticity
but
also
mechanical
robustness,
conformability,
compatibility
manufacturing
microfabricated
devices.
Quantitative
characterization
methods
barrier
reviewed
particular
emphasis
water-vapor
transmission
rate
through
electrical,
optical,
or
electrochemical
principles.
The
integrability
functionalization
into
functional
bioelectronic
interfaces
discussed.
represents
must-have
component
for
next-generation
implants
diagnostic
therapeutic
functions
human
healthcare
precision
medicine.
ACS Nano,
Год журнала:
2023,
Номер
17(2), С. 885 - 895
Опубликована: Янв. 11, 2023
A
robust
neural
interface
with
intimate
electrical
coupling
between
electrodes
and
tissues
is
critical
for
stable
chronic
neuromodulation.
The
development
of
bioadhesive
hydrogel
a
potential
approach
tightly
fixing
the
on
epineurium
surface
to
construct
interface.
Herein,
we
photopatternable,
antifouling,
conductive
(∼6
S
cm–1),
(interfacial
toughness
∼100
J
m–2),
soft,
elastic
(∼290%
strain,
Young's
modulus
7.25
kPa)
establish
bioelectronics.
UV-sensitive
zwitterionic
monomer
can
facilitate
formation
an
electrostatic-assembled
polymer
PEDOT:PSS
network,
it
be
further
photo-cross-linked
into
network.
Such
semi-interpenetrating
network
endows
good
conductivity.
Especially,
photopatternable
feature
enables
facile
microfabrication
processes
multifunctional
(MH)
characteristic
size
50
μm.
MH
electrodes,
which
show
improved
performance
impedance,
charge
storage
capacity,
injection
capability,
produce
effective
stimulation
high
current
density
(1
mA
cm–2)
at
ultralow
voltages
(±25
mV).
could
realize
high-efficient
communication
recording
sciatic
nerve
in
rat
model.
Abstract
A
critical
challenge
lies
in
the
development
of
next‐generation
neural
interface,
mechanically
tissue‐compatible
fashion,
that
offer
accurate,
transient
recording
electrophysiological
(EP)
information
and
autonomous
degradation
after
stable
operation.
Here,
an
ultrathin,
lightweight,
soft
multichannel
interface
is
presented
based
on
organic‐electrochemical‐transistor‐(OECT)‐based
network,
with
capabilities
continuous
high‐fidelity
mapping
signals
biosafety
active
degrading
performing
functions.
Such
platform
yields
a
high
spatiotemporal
resolution
1.42
ms
20
µm,
signal‐to‐noise
ratio
up
to
≈37
dB.
The
implantable
OECT
arrays
can
well
establish
functional
interfaces,
designed
as
fully
biodegradable
electronic
platforms
vivo.
Demonstrated
applications
such
implants
include
real‐time
monitoring
electrical
activities
from
cortical
surface
rats
under
various
conditions
(e.g.,
narcosis,
epileptic
seizure,
electric
stimuli)
electrocorticography
100
channels.
This
technology
offers
general
applicability
great
potential
utility
treatment/diagnosis
neurological
disorders.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(15), С. 7960 - 7982
Опубликована: Янв. 1, 2024
This
review
discusses
the
advancements,
sensor
design,
and
challenges
in
creating
wearable
implantable
nucleic
acid-based
sensors
for
personalized
healthcare
through
real-time
biomarker
analysis
biofluids.
Cyborg and Bionic Systems,
Год журнала:
2025,
Номер
6
Опубликована: Янв. 1, 2025
Materials
that
establish
functional,
stable
interfaces
to
targeted
tissues
for
long-term
monitoring/stimulation
equipped
with
diagnostic/therapeutic
capabilities
represent
breakthroughs
in
biomedical
research
and
clinical
medicine.
A
fundamental
challenge
is
the
mechanical
chemical
mismatch
between
implants
ultimately
results
device
failure
corrosion
by
biofluids
associated
foreign
body
response.
Of
particular
interest
development
of
bioactive
materials
at
level
chemistry
mechanics
high-performance,
minimally
invasive
function,
simultaneously
tissue-like
compliance
vivo
biocompatibility.
This
review
summarizes
most
recent
progress
these
purposes,
an
emphasis
on
material
properties
such
as
response,
integration
schemes
biological
tissues,
their
use
bioelectronic
platforms.
The
article
begins
overview
emerging
classes
platforms
bio-integration
proven
utility
live
animal
models,
high
performance
different
form
factors.
Subsequent
sections
various
flexible,
soft
materials,
ranging
from
self-healing
hydrogel/elastomer
bio-adhesive
composites
materials.
Additional
discussions
highlight
examples
active
systems
support
electrophysiological
mapping,
stimulation,
drug
delivery
treatments
related
diseases,
spatiotemporal
resolutions
span
cellular
organ-scale
dimension.
Envisioned
applications
involve
advanced
brain,
cardiac,
other
organ
systems,
offer
stability
human
subjects
models.
Results
will
inspire
continuing
advancements
functions
benign
thus
yielding
therapy
diagnostics
healthcare.
Advanced Materials,
Год журнала:
2021,
Номер
34(10)
Опубликована: Ноя. 9, 2021
Designing
bioelectronic
devices
that
seamlessly
integrate
with
the
human
body
is
a
technological
pursuit
of
great
importance.
Bioelectronic
medical
reliably
and
chronically
interface
can
advance
neuroscience,
health
monitoring,
diagnostics,
therapeutics.
Recent
major
efforts
focus
on
investigating
strategies
to
fabricate
flexible,
stretchable,
soft
electronic
devices,
advances
in
materials
chemistry
have
emerged
as
fundamental
creation
next
generation
bioelectronics.
This
review
summarizes
contemporary
forthcoming
technical
challenges
related
three
principal
components
devices:
i)
substrates
structural
materials,
ii)
barrier
encapsulation
iii)
conductive
materials.
Through
notable
illustrations
from
literature,
integration
device
fabrication
associated
for
each
material
class
are
highlighted.
