Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Авг. 20, 2022
The
primate
amygdala
is
a
complex
consisting
of
over
dozen
nuclei
that
have
been
implicated
in
host
cognitive
functions,
individual
differences,
and
psychiatric
illnesses.
These
functions
are
implemented
through
distinct
connectivity
profiles,
which
documented
animals
but
remain
largely
unknown
humans.
Here
we
present
results
from
25
neurosurgical
patients
who
had
concurrent
electrical
stimulation
the
with
intracranial
electroencephalography
(electrical
tract-tracing;
es-TT),
or
fMRI
fMRI;
es-fMRI),
methods
providing
strong
inferences
about
effective
subdivisions
rest
brain.
We
quantified
functional
medial
lateral
amygdala,
temporal
order
these
connections
on
timescale
milliseconds,
also
detail
second-order
among
key
nodes.
findings
provide
uniquely
detailed
characterization
human
will
inform
neuroimaging
studies
healthy
clinical
populations.
Advanced Materials,
Год журнала:
2022,
Номер
34(34)
Опубликована: Март 30, 2022
Bioelectronic
implantable
systems
(BIS)
targeting
biomedical
and
clinical
research
should
combine
long-term
performance
biointegration
in
vivo.
Here,
recent
advances
novel
encapsulations
to
protect
flexible
versions
of
such
from
the
surrounding
biological
environment
are
reviewed,
focusing
on
material
strategies
synthesis
techniques.
Considerable
effort
is
put
thin-film
encapsulation
(TFE),
specifically
organic-inorganic
multilayer
architectures
as
a
conformal
alternative
conventional
rigid
cans.
TFE
direct
contact
with
medium
thus
must
exhibit
not
only
biocompatibility,
inertness,
hermeticity
but
also
mechanical
robustness,
conformability,
compatibility
manufacturing
microfabricated
devices.
Quantitative
characterization
methods
barrier
reviewed
particular
emphasis
water-vapor
transmission
rate
through
electrical,
optical,
or
electrochemical
principles.
The
integrability
functionalization
into
functional
bioelectronic
interfaces
discussed.
represents
must-have
component
for
next-generation
implants
diagnostic
therapeutic
functions
human
healthcare
precision
medicine.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(32)
Опубликована: Июнь 8, 2023
Abstract
The
desirable
implantable
neural
interfaces
can
accurately
record
bioelectrical
signals
from
neurons
and
regulate
activities
with
high
spatial/time
resolution,
facilitating
the
understanding
of
neuronal
functions
dynamics.
However,
electrochemical
performance
(impedance,
charge
storage/injection
capacity)
is
limited
miniaturization
integration
electrodes.
“crosstalk”
caused
by
uneven
distribution
elctric
field
leads
to
lower
electrical
stimulation/recording
efficiency.
mismatch
between
stiff
electrodes
soft
tissues
exacerbates
inflammatory
responses,
thus
weakening
transmission
signals.
Though
remarkable
breakthroughs
have
been
made
through
incorporation
optimizing
electrode
design
functionalized
nanomaterials,
chronic
stability,
long‐term
activity
in
vivo
still
need
further
development.
In
this
review,
interface
challenges
mainly
on
electrochemistry
biology
are
discussed,
followed
summarizing
typical
optimization
technologies
exploring
recent
advances
application
based
traditional
metallic
materials,
emerging
2D
conducting
polymer
hydrogels,
etc.,
for
enhancing
interfaces.
strategies
improving
durability
including
enhanced
adhesion
minimized
response,
also
summarized.
promising
directions
finally
presented
provide
enlightenment
high‐performance
future,
which
will
promote
profound
progress
neuroscience
research.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(17), С. 8632 - 8712
Опубликована: Янв. 1, 2024
Bioelectronics
is
a
hot
research
topic,
yet
an
important
tool,
as
it
facilitates
the
creation
of
advanced
medical
devices
that
interact
with
biological
systems
to
effectively
diagnose,
monitor
and
treat
broad
spectrum
health
conditions.
Electrical
stimulation
(ES)
pivotal
technique
in
bioelectronics,
offering
precise,
non-pharmacological
means
modulate
control
processes
across
molecular,
cellular,
tissue,
organ
levels.
This
method
holds
potential
restore
or
enhance
physiological
functions
compromised
by
diseases
injuries
integrating
sophisticated
electrical
signals,
device
interfaces,
designs
tailored
specific
mechanisms.
review
explains
mechanisms
which
ES
influences
cellular
behaviors,
introduces
essential
principles,
discusses
performance
requirements
for
optimal
systems,
highlights
representative
applications.
From
this
review,
we
can
realize
based
bioelectronics
therapy,
regenerative
medicine
rehabilitation
engineering
technologies,
ranging
from
tissue
neurological
modulation
cardiovascular
cognitive
functions.
underscores
versatility
various
biomedical
contexts
emphasizes
need
adapt
complex
clinical
landscapes
addresses.
Journal of Materials Chemistry A,
Год журнала:
2024,
Номер
12(32), С. 20606 - 20637
Опубликована: Янв. 1, 2024
This
paper
reviews
the
progress
of
flexible
electrodes
in
recent
years,
including
substrates,
active
materials,
manufacturing
methods,
and
their
latest
applications
sensors,
energy
storage,
medical
healthcare.
Stimulating
large
volumes
of
neural
networks
using
macroelectrodes
can
modulate
disorder-associated
brain
circuits
effectively.
However,
conventional
solid-metal
electrodes
often
cause
unwanted
damage
due
to
their
high
mechanical
stiffness.
In
contrast,
low-modulus
liquid
metals
provide
tissue-like
stiffness
while
maintaining
macroscale
electrode
dimensions.
Here,
we
present
implantable
soft
made
from
biocompatible
for
stimulation.
These
probes
be
easily
fabricated
by
simply
filling
polymeric
tubes
with
a
metal,
offering
straightforward
method
creating
stimulation
devices.
They
customized
in
various
lengths
and
diameters
also
serve
as
recording
microelectrodes.
The
tips
are
enhanced
platinum
nanoclusters,
resulting
low
impedance
effective
charge
injection
preventing
metal
leakage
into
tissue.
vivo
experiments
neuropathic
pain
rat
models
demonstrate
the
stability
effectiveness
these
simultaneous
recording,
demonstrating
potential
alleviation
behavioral
control.
Advanced Materials,
Год журнала:
2022,
Номер
34(45)
Опубликована: Авг. 4, 2022
Abstract
Requirements
and
recent
advances
in
research
on
organic
neuroelectronics
are
outlined
herein.
Neuroelectronics
such
as
neural
interfaces
neuroprosthetics
provide
a
promising
approach
to
diagnose
treat
neurological
diseases.
However,
the
current
rigid
not
biocompatible,
so
they
induce
an
immune
response
deterioration
of
signal
transmission.
Organic
materials
candidates
for
interfaces,
due
their
mechanical
softness,
excellent
electrochemical
properties,
biocompatibility.
Also,
nervetronics,
which
mimics
functional
properties
biological
nerve
system,
is
being
developed
overcome
limitations
complex
energy‐consuming
conventional
that
limit
long‐term
implantation
daily‐life
usage.
Examples
recordings
reviewed,
nervetronics
use
artificial
synapses
highlighted,
then
further
requirements
discussed.
Finally,
future
challenges
must
be
achieve
ideal
next‐generation
Microsystems & Nanoengineering,
Год журнала:
2023,
Номер
9(1)
Опубликована: Янв. 30, 2023
Abstract
A
bidirectional
in
vitro
brain–computer
interface
(BCI)
directly
connects
isolated
brain
cells
with
the
surrounding
environment,
reads
neural
signals
and
inputs
modulatory
instructions.
As
a
noninvasive
BCI,
it
has
clear
advantages
understanding
exploiting
advanced
function
due
to
simplified
structure
high
controllability
of
ex
vivo
networks.
However,
core
BCIs,
microelectrode
arrays
(MEAs),
urgently
need
improvements
strength
signal
detection,
precision
modulation
biocompatibility.
Notably,
nanomaterial-based
MEAs
cater
all
requirements
by
converging
multilevel
simultaneously
applying
stimuli
at
an
excellent
spatiotemporal
resolution,
as
well
supporting
long-term
cultivation
neurons.
This
is
enabled
advantageous
electrochemical
characteristics
nanomaterials,
such
their
active
atomic
reactivity
outstanding
charge
conduction
efficiency,
improving
performance
MEAs.
Here,
we
review
fabrication
applied
BCIs
from
interdisciplinary
perspective.
We
also
consider
decoding
coding
activity
through
highlight
various
usages
coupled
dissociated
cultures
benefit
future
developments
BCIs.
Abstract
Electrical
stimulation
as
a
therapeutic
approach
is
widely
applicable
in
terms
of
target
tissues
or
effects.
This
method
can
be
an
alternative
to
conventional
therapies
for
patients
who
are
resistant
drugs
ineligible
surgical
operations.
In
addition,
researchers
have
actively
studied
how
adjust
the
parameters
electrical
order
improve
effectiveness,
many
already
received
treatments
with
stimulation.
With
respect
devices
stimulation,
recent
studies
focused
on
developing
reliability
safe
and
long‐term
From
point
view
engineers,
comprehensive
understanding
modulates
biological
system
essential
develop
advanced
strategies
that
provide
effective
results.
Herein,
fundamental
mechanisms
delivering
reviewed
along
requirements
need
qualified
by
electrodes.
Furthermore,
latest
advances
discussed
followed
introduction
representative
applications
