Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
The
breakthroughs
experienced
in
the
development
of
cutting-edge,
reliable,
and
multipurpose
(bio)electroanalytical
technologies
their
successful
incursion
into
underexplored
scenarios
have
demonstrated
unique
potential
to
act
as
enablers
ongoing
transformation
from
reactive
predictive,
preventive,
personalized,
participatory
healthcare,
currently
known
"P4"
medicine.
This
transformation,
more
than
a
vision,
is
necessity
achieve
new
generation
efficient,
sustainable,
tailored
individual
needs
healthcare.
promising
outlook
focus
this
Perspective,
which
addition
highlighting
some
most
shocking
related
research
over
last
5
years,
offers
prospective
insightful
view
opportunities
imminent
advances
that
shape
future
these
fascinating
technologies.
ACS Nano,
Год журнала:
2024,
Номер
18(36), С. 24605 - 24616
Опубликована: Авг. 26, 2024
Sweat
analysis
has
advanced
from
diagnosing
cystic
fibrosis
and
testing
for
illicit
drugs
to
noninvasive
monitoring
of
health
biomarkers.
This
article
introduces
the
rapid
development
wearable
flexible
sweat
sensors,
highlighting
key
milestones
various
sensing
strategies
real-time
analytes.
We
discuss
challenges
such
as
developing
high-performance
nanomaterial-based
biosensors,
ensuring
continuous
production
sampling,
achieving
high
sweat/blood
correlation,
biocompatibility.
The
potential
machine
learning
enhance
these
sensors
personalized
healthcare
is
presented,
enabling
tracking
prediction
physiological
changes
disease
onset.
Leveraging
advancements
in
electronics,
nanomaterials,
biosensing,
data
analytics,
biosensors
promise
revolutionize
management,
prevention,
prediction,
promoting
healthier
lifestyles
transforming
medical
practices
globally.
Recently,
flexible
electronics
have
significantly
transformed
information
and
communications
technology
(ICT).
In
particular,
wearable
devices,
via
integration
with
attachable
biosensors,
driven
the
development
of
new
types
biosensors
diagnostic
devices
for
point-of-care
testing
(POCT).
Moreover,
electrochemical
can
be
applied
to
diagnose
diseases
in
real
time
based
on
synergistic
effect
generated
from
incorporation
technique.
Besides,
improve
sensitivity
while
retaining
their
wearability,
novel
nanomaterials
nanotechnologies
been
introduced.
this
review,
recent
studies
nanotechnology-based
accurate
disease
diagnosis
are
discussed.
First,
widely
used
techniques
developing
electrodes,
including
nanolithography-
nano/microneedle-based
patches,
presented.
Next,
latest
such
as
diabetes
dermatitis
discussed
by
categorizing
into
categories.
Finally,
review
explores
research
trends
application
nanotechnology-enabled
nanopatterning
nano/microneedle
technologies
biosensors.
This
suggests
approaches
methods
real-time
under
POCT
applications.
ACS Nano,
Год журнала:
2024,
Номер
18(46), С. 31713 - 31736
Опубликована: Ноя. 7, 2024
Sensitive
and
quantitative
detection
of
chemical
biological
molecules
for
screening,
diagnosis
monitoring
diseases
is
essential
to
treatment
planning
response
monitoring.
Electrochemical
biosensors
are
fast,
sensitive,
easy
miniaturize,
which
has
led
rapid
development
in
clinical
diagnosis.
Benefiting
from
their
excellent
molecular
recognition
ability
high
programmability,
DNA
nanomaterials
could
overcome
the
Debye
length
electrochemical
by
simple
design
well
suited
as
elements
biosensors.
Therefore,
enhance
sensitivity
specificity
biosensors,
significant
progress
been
made
recent
years
optimizing
design.
Here,
establishment
sensing
strategies
based
on
reviewed
detail.
First,
structural
nanomaterial
examined
improving
overcoming
length.
In
addition,
electrical
signal
transduction
amplification
reviewed,
applications
nanomaterial-based
integrated
devices
further
summarized.
Finally,
main
opportunities
challenges
detecting
disease
biomarkers
presented
an
aim
guide
with
specificity.
Abstract
Recent
advancements
in
wearable
electrochemical
biosensors
have
opened
new
avenues
for
on‐body
and
continuous
detection
of
biomarkers,
enabling
personalized,
real‐time,
preventive
healthcare.
While
glucose
monitoring
has
set
a
precedent
biosensors,
the
field
is
rapidly
expanding
to
include
wider
range
analytes
crucial
disease
diagnosis,
treatment,
management.
In
this
review,
recent
key
innovations
are
examined
design
manufacturing
underpinning
these
biosensing
platforms
including
biorecognition
elements,
signal
transduction
methods,
electrode
substrate
materials,
fabrication
techniques.
The
applications
then
highlighted
detecting
variety
biochemical
markers,
such
as
small
molecules,
hormones,
drugs,
macromolecules,
biofluids
interstitial
fluid,
sweat,
wound
exudate,
saliva,
tears.
Additionally,
review
also
covers
advances
platforms,
multi‐sensory
integration,
closed‐loop
control,
power
supply.
Furthermore,
challenges
associated
with
critical
issues
discussed,
biocompatibility,
biofouling,
sensor
degradation,
opportunities
materials
science,
nanotechnology,
artificial
intelligence
overcome
limitations.
