Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

Chemical Society Reviews, Год журнала: 2021, Номер 50(6), С. 4185 - 4219

Опубликована: Янв. 1, 2021

Molecular design directions for overcoming the photodynamic therapy challenges.

Язык: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Год журнала: 2020, Номер 50(2), С. 1111 - 1137

Опубликована: Ноя. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Язык: Английский

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Second Near‐Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy

Advanced Materials, Год журнала: 2020, Номер 33(4)

Опубликована: Дек. 16, 2020

Abstract Immunotherapy has offered new treatment options for cancer; however, the therapeutic benefits are often modest and desired to be improved. A semiconducting polymer nanoadjuvant (SPN II R) with a photothermally triggered cargo release second near‐infrared (NIR‐II) photothermal immunotherapy is reported here. SPN R consists of nanoparticle core as an NIR‐II converter, which doped toll‐like receptor (TLR) agonist adjuvant coated thermally responsive lipid shell. Upon photoirradiation, effectively generates heat not only ablate tumors induce immunogenic cell death (ICD), but also melt layers on‐demand TLR agonist. The combination ICD activation TLR7/TLR8 enhances maturation dendritic cells, amplifies anti‐tumor immune responses. Thus, single R‐mediated inhibits growth both primary distant eliminates lung metastasis in murine mouse model. This study thus provides remote‐controlled smart delivery system synergize photomedicine enhanced cancer treatment.

Язык: Английский

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Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

Advanced Materials, Год журнала: 2020, Номер 33(4)

Опубликована: Дек. 11, 2020

Abstract Tumor immunometabolism contributes substantially to tumor proliferation and immune cell activity, thus plays a crucial role in the efficacy of cancer immunotherapy. Modulation boost immunotherapy is mostly based on small‐molecule inhibitors, which often encounter issues off‐target adverse effects, drug resistance, unsustainable response. In contrast, enzymatic therapeutics can potentially bypass these limitations but has been less exploited. Herein, an organic polymer nanoenzyme (SPNK) with near‐infrared (NIR) photoactivatable immunotherapeutic effects reported for photodynamic immunometabolic therapy. SPNK composed semiconducting core conjugated kynureninase (KYNase) via PEGylated singlet oxygen ( 1 O 2 ) cleavable linker. Upon NIR photoirradiation, generates not only exert effect induce immunogenic death cancer, also unleash KYNase trigger its activity degrade immunosuppressive kynurenine (Kyn). Such combinational mediated by promotes infiltration effector T cells, enhances systemic antitumor immunity, ultimately permits inhibition both primary distant tumors living mice. Therefore, this study provides promising approach toward remotely controlled immunomodulation improved anticancer

Язык: Английский

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Transformable Nanosensitizer with Tumor Microenvironment‐Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(25), С. 14051 - 14059

Опубликована: Апрель 2, 2021

Abstract Despite the promise of sonodynamic processes in cancer therapy, existing sonosensitizers often fail to regulate generation reactive oxygen species (ROS) against tumors, potentially leading off‐target toxicity normal tissues. We report a transformable core‐shell nanosonosensitizer (TiO 2 @CaP) that reinvigorates ROS and dissolves its CaP shell release Ca 2+ an acidic tumor microenvironment (TME) under ultrasound activation. Thus, TiO @CaP acts as smart specifically induces mitochondrial dysfunction via overloading intracellular ions synergize with process TME. substantially enhances immunogenic cell death, resulting enhanced T‐cell recruitment infiltration into cold (4T1). In conjunction checkpoint blockade therapy (anti‐PD 1), @CaP‐mediated elicits systemic antitumor immunity, regression non‐treated distant tumors inhibition lung metastasis. This work paves way development “smart” TME‐activatable temporospatial control over responses.

Язык: Английский

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Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near‐Infrared Construction

Small, Год журнала: 2021, Номер 17(6)

Опубликована: Янв. 15, 2021

Photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention in disease diagnosis treatment. Although many exogenous contrast agents been developed for PA PTT, the design guidelines to amplify their performances remain challenging are highly demanded. Semiconducting polymer nanoparticles (SPNs) composed of polymers with π-electron delocalized backbones can be designed PTT performance, because clear structure-property relation versatility modifying molecular structures tune photophysical properties. This review summarizes recent advances photoacoustic applications semiconducting a focus on signal amplification second near-infrared (NIR-II, 1000-1700 nm) construction. The strategies such as screening, fluorescence quenching, accelerated heat dissipation, size-dependent dissipation first discussed brightness SPNs vivo PA. approaches shifting absorption NIR-II then introduced so improve tissue penetration depth therapy. At last, current challenges perspectives field discussed.

Язык: Английский

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A Polymer Multicellular Nanoengager for Synergistic NIR‐II Photothermal Immunotherapy

Advanced Materials, Год журнала: 2021, Номер 33(14)

Опубликована: Фев. 26, 2021

Abstract Cell‐membrane‐coated nanoparticles (CCNPs) that integrate the biophysiological advantages of cell membranes with multifunctionalities synthetic materials hold great promise in cancer immunotherapy. However, strategies have yet to be revealed further improve their immunotherapeutic efficacy. Herein, a polymer multicellular nanoengager (SPNE) for synergistic second‐near‐infrared‐window (NIR‐II) photothermal immunotherapy is reported. The consists an NIR‐II absorbing as core, which camouflaged fused derived from immunologically engineered tumor cells and dendritic (DCs) vaccine shell. In association high accumulation lymph nodes tumors, engagement ability SPNE enables effective cross‐interactions among cells, DCs, T leading augmented activation relative bare or tumor‐cell‐coated nanoparticles. Upon deep‐tissue penetrating photoirradiation, eradicates induces immunogenic death, eliciting anti‐tumor immunity. Such effect eventually inhibits growth, prevents metastasis procures immunological memory. Thus, this study presents general cell‐membrane‐coating approach develop photo‐immunotherapeutic agents therapy.

Язык: Английский

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The concept and examples of type-III photosensitizers for cancer photodynamic therapy

Chem, Год журнала: 2021, Номер 8(1), С. 197 - 209

Опубликована: Ноя. 4, 2021

Язык: Английский

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Good Steel Used in the Blade: Well‐Tailored Type‐I Photosensitizers with Aggregation‐Induced Emission Characteristics for Precise Nuclear Targeting Photodynamic Therapy

Advanced Science, Год журнала: 2021, Номер 8(14)

Опубликована: Май 21, 2021

Photodynamic therapy (PDT) has long been recognized to be a promising approach for cancer treatment. However, the high oxygen dependency of conventional PDT dramatically impairs its overall therapeutic efficacy, especially in hypoxic solid tumors. Exploration distinctive strategy involving both high-performance less-oxygen-dependent photosensitizers (PSs) and prominent drug delivery system is an appealing yet significantly challenging task. Herein, precise nuclear targeting protocol based on type-I PSs with aggregation-induced emission (AIE) characteristics fabricated first time. Of two synthesized AIE PSs, TTFMN demonstrated exhibit superior property stronger reactive species (ROS) generation efficiency owing introduction tetraphenylethylene smaller singlet-triplet energy gap, respectively. With aid lysosomal acid-activated TAT-peptide-modified amphiphilic polymer poly(lactic acid)12k-poly(ethylene glycol)5k-succinic anhydride-modified TAT, corresponding TTFMN-loaded nanoparticles accompanied acid-triggered peculiarity can quickly accumulate tumor site, effectively generate ROS region suppress growth under white light irradiation minimized systematic toxicity. This delicate "Good Steel Used Blade" tactic maximizes efficacy offers conceptual while practical paradigm optimized treatment further translational medicine.

Язык: Английский

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Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy

Advanced Materials, Год журнала: 2021, Номер 33(21)

Опубликована: Апрель 19, 2021

Abstract Pancreatic cancer, one of the most lethal malignancies, compromises performance traditional therapeutic regimens in clinic because stromal resistance to systemic drug delivery and poor prognosis caused by tumor metastasis. Therefore, a biocompatible paradigm that can effectively inhibit pancreatic growth while simultaneously eliminating metastasis is urgently needed. Herein, supramolecular nanofibrils are fabricated through coassembly clinically approved immunomodulatory thymopentin near‐infrared indocyanine green for localized photothermal immunotherapy tumors. The resulting long‐range ordered fibrous nanodrugs show improved photophysical capabilities fluorescence imaging conversion significantly promote proliferation differentiation antitumor immune cells. Hence, integration rapid therapy moderate immunomodulation inhibiting promising. utilization molecules construct administered via injection amplifies complementary immunotherapeutic effects components, creating opportunities clinical translation as treatment cancer.

Язык: Английский

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