Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration DOI
Li Chen,

Jianye Yang,

Zhengwei Cai

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Янв. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Язык: Английский

A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains DOI
Wen Qin, Qiaoling Yang, Chunyan Zhu

и другие.

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Язык: Английский

Процитировано

34

Hydrogel-integrated graphene superstructures for tissue engineering: From periodontal to neural regeneration DOI Creative Commons
Iman Zare,

Mojdeh Mirshafiei,

Bahareh Kheilnezhad

и другие.

Carbon, Год журнала: 2024, Номер 223, С. 118970 - 118970

Опубликована: Фев. 26, 2024

Hydrogel-integrated graphene superstructures (GSSs) represent a promising platform for applications in tissue engineering and regenerative medicine. Graphene, two-dimensional carbon-based material, possesses remarkable mechanical, thermal, electrical characteristics, making it strong candidate application biomedicine. Researchers have pursued the integration of with hydrogels, known their biocompatibility ability to provide conducive environment cellular growth, craft sophisticated scaffolds tailored needs. The hydrogels enables construction 3D frameworks that closely mimic natural extracellular matrix (ECM) found biological tissues. Hydrogels furnish biocompatible, well-hydrated environment, while component bolsters scaffold's mechanical integrity conductivity. This amalgamation enhances adhesion, differentiation, proliferation, thereby facilitating regeneration. A notable advantage hydrogel-integrated GSSs lies capacity support growth differentiation variety cell types such as PC12, MG-63, U-87, MC3T3-E1 lines. Overall, exhibit great potential advancing biomimetic combination unique properties development advanced scaffold systems Further research this domain will play crucial role medicine treatment various diseases injuries.

Язык: Английский

Процитировано

33

Piezocatalytically-induced controllable mineralization scaffold with bone-like microenvironment to achieve endogenous bone regeneration DOI
Xi Cui,

Lingling Xu,

Yizhu Shan

и другие.

Science Bulletin, Год журнала: 2024, Номер 69(12), С. 1895 - 1908

Опубликована: Апрель 2, 2024

Язык: Английский

Процитировано

32

Bio‐Inspired Porous Microneedles Dwelled Stem Cells for Diabetic Wound Treatment DOI
Lu Fan, Xiaoxuan Zhang, Li Wang

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(28)

Опубликована: Фев. 6, 2024

Abstract Diabetic wound healing is a serious, complex, and chronic process; one current promising focusing technology in this area stem cell treatment. Here, novel porous microneedle (MN) arrays fabricated, which can highly mimetic niches, through template filling, particle etching method. The human adipose‐derived cells (ADSCs) are encapsulated Matrigel then loaded into the MN by post‐perfusion. Because of extracellular matrix‐mimicking, biocompatible offers bionic microenvironment nest suitable for growth. Benefiting from numerous pore structures MNs, ADSCs have enough space to fully absorb nutrients, proliferate greatly exhibit prompted function. In addition, cell‐loaded mechanical strength penetrate skin, allowing get deep areas. Based on these features, performance resultant promoting tissue regeneration demonstrated, collagen deposition angiogenesis diabetes wounds rat models. Thus, it believe that bioinspired MNs act as excellent scaffolds will find many practical values clinic healing.

Язык: Английский

Процитировано

31

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration DOI
Li Chen,

Jianye Yang,

Zhengwei Cai

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Янв. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Язык: Английский

Процитировано

28