Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Янв. 7, 2024
Abstract
The
incidence
of
large
bone
and
articular
cartilage
defects
caused
by
traumatic
injury
is
increasing
worldwide;
the
tissue
regeneration
process
for
these
injuries
lengthy
due
to
limited
self‐healing
ability.
Endogenous
bioelectrical
phenomenon
has
been
well
recognized
play
an
important
role
in
homeostasis
regeneration.
Studies
have
reported
that
electrical
stimulation
(ES)
can
effectively
regulate
various
biological
processes
holds
promise
as
external
intervention
enhance
synthesis
extracellular
matrix,
thereby
accelerating
Hence,
electroactive
biomaterials
considered
a
biomimetic
approach
ensure
functional
recovery
integrating
physiological
signals,
including
electrical,
biochemical,
mechanical
signals.
This
review
will
discuss
endogenous
bioelectricity
tissue,
effects
ES
on
cellular
behaviors.
Then,
recent
advances
materials
their
applications
are
systematically
overviewed,
with
focus
advantages
disadvantages
repair
performances
modulation
cell
fate.
Finally,
significance
mimicking
electrophysiological
microenvironment
target
emphasized
future
development
challenges
strategies
proposed.
Abstract
Sonodynamic
therapy
(SDT)
as
a
promising
non‐invasive
anti‐tumor
means
features
the
preferable
penetration
depth,
which
nevertheless,
usually
can't
work
without
sonosensitizers.
Sonosensitizers
produce
reactive
oxygen
species
(ROS)
in
presence
of
ultrasound
to
directly
kill
tumor
cells,
and
concurrently
activate
immunity
especially
after
integration
with
microenvironment
(TME)‐engineered
nanobiotechnologies
combined
therapy.
Current
sonosensitizers
are
classified
into
organic
inorganic
ones,
current
most
reviews
only
cover
highlighted
their
applications.
However,
there
have
few
specific
that
focus
on
including
design
principles,
regulation,
etc.
In
this
review,
first
according
rationales
rather
than
composition,
action
underlying
chemistry
highlighted.
Afterward,
what
how
TME
is
regulated
based
sonosensitizers‐based
SDT
nanoplatform
an
emphasis
targets‐engineered
elucidated.
Additionally,
applications
non‐cancer
diseases
also
outlined.
Finally,
setbacks
challenges,
proposed
potential
solutions
future
directions
pointed
out.
This
review
provides
comprehensive
detailed
horizon
sonosensitizers,
will
arouse
more
attentions
SDT.
Carbon,
Год журнала:
2024,
Номер
223, С. 118970 - 118970
Опубликована: Фев. 26, 2024
Hydrogel-integrated
graphene
superstructures
(GSSs)
represent
a
promising
platform
for
applications
in
tissue
engineering
and
regenerative
medicine.
Graphene,
two-dimensional
carbon-based
material,
possesses
remarkable
mechanical,
thermal,
electrical
characteristics,
making
it
strong
candidate
application
biomedicine.
Researchers
have
pursued
the
integration
of
with
hydrogels,
known
their
biocompatibility
ability
to
provide
conducive
environment
cellular
growth,
craft
sophisticated
scaffolds
tailored
needs.
The
hydrogels
enables
construction
3D
frameworks
that
closely
mimic
natural
extracellular
matrix
(ECM)
found
biological
tissues.
Hydrogels
furnish
biocompatible,
well-hydrated
environment,
while
component
bolsters
scaffold's
mechanical
integrity
conductivity.
This
amalgamation
enhances
adhesion,
differentiation,
proliferation,
thereby
facilitating
regeneration.
A
notable
advantage
hydrogel-integrated
GSSs
lies
capacity
support
growth
differentiation
variety
cell
types
such
as
PC12,
MG-63,
U-87,
MC3T3-E1
lines.
Overall,
exhibit
great
potential
advancing
biomimetic
combination
unique
properties
development
advanced
scaffold
systems
Further
research
this
domain
will
play
crucial
role
medicine
treatment
various
diseases
injuries.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(28)
Опубликована: Фев. 6, 2024
Abstract
Diabetic
wound
healing
is
a
serious,
complex,
and
chronic
process;
one
current
promising
focusing
technology
in
this
area
stem
cell
treatment.
Here,
novel
porous
microneedle
(MN)
arrays
fabricated,
which
can
highly
mimetic
niches,
through
template
filling,
particle
etching
method.
The
human
adipose‐derived
cells
(ADSCs)
are
encapsulated
Matrigel
then
loaded
into
the
MN
by
post‐perfusion.
Because
of
extracellular
matrix‐mimicking,
biocompatible
offers
bionic
microenvironment
nest
suitable
for
growth.
Benefiting
from
numerous
pore
structures
MNs,
ADSCs
have
enough
space
to
fully
absorb
nutrients,
proliferate
greatly
exhibit
prompted
function.
In
addition,
cell‐loaded
mechanical
strength
penetrate
skin,
allowing
get
deep
areas.
Based
on
these
features,
performance
resultant
promoting
tissue
regeneration
demonstrated,
collagen
deposition
angiogenesis
diabetes
wounds
rat
models.
Thus,
it
believe
that
bioinspired
MNs
act
as
excellent
scaffolds
will
find
many
practical
values
clinic
healing.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Янв. 7, 2024
Abstract
The
incidence
of
large
bone
and
articular
cartilage
defects
caused
by
traumatic
injury
is
increasing
worldwide;
the
tissue
regeneration
process
for
these
injuries
lengthy
due
to
limited
self‐healing
ability.
Endogenous
bioelectrical
phenomenon
has
been
well
recognized
play
an
important
role
in
homeostasis
regeneration.
Studies
have
reported
that
electrical
stimulation
(ES)
can
effectively
regulate
various
biological
processes
holds
promise
as
external
intervention
enhance
synthesis
extracellular
matrix,
thereby
accelerating
Hence,
electroactive
biomaterials
considered
a
biomimetic
approach
ensure
functional
recovery
integrating
physiological
signals,
including
electrical,
biochemical,
mechanical
signals.
This
review
will
discuss
endogenous
bioelectricity
tissue,
effects
ES
on
cellular
behaviors.
Then,
recent
advances
materials
their
applications
are
systematically
overviewed,
with
focus
advantages
disadvantages
repair
performances
modulation
cell
fate.
Finally,
significance
mimicking
electrophysiological
microenvironment
target
emphasized
future
development
challenges
strategies
proposed.
