Bioactive Materials, Год журнала: 2024, Номер 46, С. 213 - 228
Опубликована: Дек. 16, 2024
Язык: Английский
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5161 - 5180
Опубликована: Авг. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Язык: Английский
Процитировано
18
ACS Nano, Год журнала: 2024, Номер 18(39), С. 26733 - 26750
Опубликована: Сен. 6, 2024
Rescuing or compensating mitochondrial function represents a promising therapeutic avenue for radiation-induced chronic wounds. Adult stem cell efficacies are primarily dependent on the paracrine secretion of mitochondria-containing extracellular vesicles (EVs). However, effective strategies addressing quantity mitochondria and mitochondria-delivery system lacking. Thus, in this study, we aimed to design an hydrogel microneedle patch (MNP) loaded with cell-derived mitochondria-rich EVs gradually release deliver into wound tissues boost healing. We, first, used metformin enhance biogenesis thereby increasing (termed "Met-EVs") adipose-derived cells. To verify effects Met-EVs, established
Язык: Английский
Процитировано
8
Bioactive Materials, Год журнала: 2024, Номер 42, С. 449 - 477
Опубликована: Сен. 11, 2024
Язык: Английский
Процитировано
6
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 26, 2024
Abstract Diabetic foot ulcer typically undergoes a delayed wound‐healing process owing to the disordered microenvironment, including persistent inflammation, long‐term hypoxia, and excessive fibrosis, eventually leading severe disabilities other poor outcomes. However, current strategies cannot meet dynamic demands during process. Herein, reactive oxygen species (ROS)–responsive oxygen‐generating microneedle platform, consisting of sericin‐based glucose‐responsive hydrogel loaded with verteporfin, for effective diabetic wound healing is proposed. Under highly oxidative functionalized sericin protein depletes overproduced ROS generate oxygen, which can not only alleviate hypoxic microenvironment promote angiogenesis by activating extracellular signal‐regulated kinase Heme Oxygenase‐1 pathways but also decrease expression proinflammatory cytokines. Moreover, hyperglycaemic condition triggers gradual dissociation this platform promotes release verteporfin enhance scarless re‐epithelization via inhibiting yes‐associated signal. This versatile system integrates advantageous features inflammation alleviation, promotion, scar inhibition capabilities, accelerates repair in vivo, offers novel approach self‐supply remodeling.
Язык: Английский
Процитировано
6
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 4771 - 4790
Опубликована: Июль 10, 2024
Microneedles are a novel drug delivery system that offers advantages such as safety, painlessness, minimally invasive administration, simplicity of use, and controllable delivery. As type polymer microneedle with three-dimensional network structure, hydrogel microneedles (HMNs) possess excellent biocompatibility biodegradability encapsulate various therapeutic drugs while maintaining activity, thus attracting significant attention. Recently, they have been widely employed to promote wound healing demonstrated favorable effects. Although there reviews about HMNs, few them focus on management. Herein, we present comprehensive overview the design preparation methods particular emphasis their application status in healing, including acute infected diabetic scarless healing. Finally, examine limitations HMNs management provide suggestions for future research directions.
Язык: Английский
Процитировано
4
International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 124995 - 124995
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
4
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain customizable designs, making them suitable personalized medicine. Understanding the key design parameters challenges during contact biofluids is crucial to optimizing their use across applications. This review summarizes current fabrication techniques considerations tailored meet distinct requirements biosensing We further underscore state of theranostic that integrate propose future directions advancing toward clinical use.
Язык: Английский
Процитировано
0
Science China Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
0
Nano Letters, Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
Diabetic wounds are highly susceptible to bacterial infection, which can lead the formation of biofilms, making diabetic wound healing a major challenge. In this study, composited microneedle that incorporated drug-loaded conjugated polymer nanoparticles and basic fibroblast growth factor was prepared eliminate biofilms promote vascular regeneration. This released minocycline under near-infrared (NIR) light, effectively penetrating biofilms. The photothermal properties polymers, combined with antibacterial action minocycline, contribute eradication elimination drug-resistant bacteria. Moreover, it regulated microenvironment by reducing level oxidative stress, as well production inflammatory factors at site. Meanwhile, boosted cell migration promoted angiogenesis accelerate healing. for biofilm represents promising approach promoting
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 317 - 333
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0