Journal of Nanotheranostics,
Год журнала:
2023,
Номер
4(1), С. 55 - 85
Опубликована: Фев. 8, 2023
Currently,
intelligent,
responsive
biomaterials
have
been
widely
explored,
considering
the
fact
that
provide
controlled
and
predictable
results
in
various
biomedical
systems.
Responsive
nanostructures
undergo
reversible
or
irreversible
changes
presence
of
a
stimulus,
stimuli
can
be
temperature,
magnetic
field,
ultrasound,
pH,
humidity,
pressure,
light,
electric
etc.
Different
types
being
used
drug
delivery
shall
explained
here.
Recent
research
progress
design,
development
applications
comprising
is
also
described
More
emphasis
will
given
on
explored
for
smart
at
target
site
such
as
wound
healing,
cancer
therapy,
inflammation,
pain
management
order
to
achieve
improved
efficacy
sustainability
with
lowest
side
effects.
However,
it
still
big
challenge
develop
well-defined
ordered
output;
thus,
challenges
faced
during
design
these
included
this
article.
Clinical
perspectives
applicability
targeted
discussed
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100582 - 100582
Опубликована: Фев. 16, 2023
Hydrogels
are
essential
biomaterials
due
to
their
favorable
biocompatibility,
mechanical
properties
similar
human
soft
tissue
extracellular
matrix,
and
repair
properties.
In
skin
wound
repair,
hydrogels
with
antibacterial
functions
especially
suitable
for
dressing
applications,
so
novel
hydrogel
dressings
have
attracted
widespread
attention,
including
the
design
of
components,
optimization
preparation
methods,
strategies
reduce
bacterial
resistance,
etc.
this
review,
we
discuss
fabrication
challenges
associated
crosslinking
methods
chemistry
materials.
We
investigated
advantages
limitations
(antibacterial
effects
mechanisms)
different
components
in
achieve
good
properties,
response
stimuli
such
as
light,
sound,
electricity
resistance.
Conclusively,
provide
a
systematic
summary
findings
(crosslinking
methods)
an
outlook
on
long-lasting
effects,
broader
spectrum,
diversified
forms,
future
development
prospects
field.
Abstract
Tumor
immunotherapy
exerts
its
anti-tumor
effects
by
stimulating
and
enhancing
immune
responses
of
the
body.
It
has
become
another
important
modality
therapy
with
significant
clinical
efficacy
advantages
compared
to
chemotherapy,
radiotherapy
targeted
therapy.
Although
various
kinds
tumor
immunotherapeutic
drugs
have
emerged,
challenges
faced
in
delivery
these
drugs,
such
as
poor
permeability
low
cell
uptake
rate,
had
prevented
their
widespread
application.
Recently,
nanomaterials
emerged
a
means
for
treatment
different
diseases
due
targeting
properties,
biocompatibility
functionalities.
Moreover,
possess
characteristics
that
overcome
defects
traditional
immunotherapy,
large
drug
loading
capacity,
precise
easy
modification,
thus
leading
wide
application
immunotherapy.
There
are
two
main
classes
novel
nanoparticles
mentioned
this
review:
organic
(polymeric
nanomaterials,
liposomes
lipid
nanoparticles)
inorganic
(non-metallic
metallic
nanomaterials).
Besides,
fabrication
method
nanoparticles,
Nanoemulsions,
was
also
introduced.
In
summary,
review
article
mainly
discussed
research
progress
based
on
past
few
years
offers
theoretical
basis
exploring
strategies
future.
Advanced Functional Materials,
Год журнала:
2022,
Номер
33(3)
Опубликована: Ноя. 9, 2022
Abstract
Architected
hydrogels
are
widely
used
in
biomedicine,
soft
robots,
and
flexible
electronics
while
still
possess
big
challenges
strong
toughness,
shape
modeling.
Here,
inspired
with
the
universal
hydrogen
bonding
interactions
biological
systems,
a
strain‐induced
microphase
separation
path
toward
achieving
printable,
tough
supramolecular
polymer
by
bond
engineering
is
developed.
Specifically,
it
subtly
designs
fabricates
poly
(N‐acryloylsemicarbazide‐co‐acrylic
acid)
high
energy
phase
conversion
induced
reconstruction.
The
resultant
exhibited
unique
behavior,
resulting
excellent
toughness
with,
for
example,
an
ultimate
stress
of
9.1
±
0.3
MPa,
strain
levels
1020
126%,
33.7
6.6
MJ
m
−3
,
fracture
171.1
34.3
kJ
−2
.
More
importantly,
engineered
dynamic
memory
character,
i.e
fixing
at
low
temperature
recovery
after
heating.
As
proof
concept,
tailored
hydrogel
stents
readily
manufactured
3D
printing,
which
showed
good
biocompatibility,
load‐bearing
drug
elution,
being
beneficial
biomedical
applications.
It
believed
that
present
printing
architected
ultrahigh
can
broaden
their
Overexpression
of
classically
activated
macrophages
(M1)
subtypes
and
assessed
reactive
oxygen
species
(ROS)
levels
are
often
observed
in
patients
with
ulcerative
colitis.
At
present,
the
treatment
system
these
two
problems
has
yet
to
be
established.
Here,
chemotherapy
drug
curcumin
(CCM)
is
decorated
Prussian
blue
analogs
a
straightforward
cost-saving
manner.
Modified
CCM
can
released
inflammatory
tissue
(acidic
environment),
eventually
causing
M1
transform
into
M2
inhibiting
pro-inflammatory
factors.
Co(III)
Fe(II)
have
abundant
valence
variations,
lower
REDOX
potential
CCM-CoFe
PBA
enables
ROS
clearance
through
multi-nanomase
activity.
In
addition,
effectively
alleviated
symptoms
UC
mice
induced
by
DSS
inhibited
progression
disease.
Therefore,
present
material
may
used
as
new
therapeutic
agent
for
UC.
Nature Reviews Bioengineering,
Год журнала:
2023,
Номер
1(3), С. 208 - 225
Опубликована: Фев. 2, 2023
Oral
administration
is
a
widespread
and
convenient
drug
delivery
approach.
However,
oral
can
be
affected
by
the
complex
digestive
tract
environment,
including
irregular
tissue
morphology,
presence
of
enzymes,
mucus
mucosal
barriers,
spatiotemporal
variance
in
physiological
parameters.
These
obstacles
prevent
many
therapeutics.
To
overcome
these
challenges,
devices
designed
with
bioinspired
compositions,
structures
or
functions
to
make
more
drugs
available
for
administration.
Various
have
been
developed
harnessing
biological
materials
living
microorganisms,
imitating
functions.
In
this
Review,
we
discuss
design
modification
devices,
examining
engineering
strategies
target
specific
tissues
applications.
We
highlight
how
key
bottlenecks
addressed
through
designs,
concluding
an
outlook
on
remaining
challenges
towards
clinical
translation
devices.
commonly
used
strategy
deliver
harsh
environment
prevents
negatively
affect
efficacy.
This
Review
discusses
microorganisms
into
that
associated
delivery.
Materials Horizons,
Год журнала:
2023,
Номер
11(1), С. 37 - 101
Опубликована: Окт. 27, 2023
The
unique
network
characteristics
and
stimuli
responsiveness
of
supramolecular
hydrogels
have
rendered
them
highly
advantageous
in
the
field
wound
dressings,
showcasing
unprecedented
potential.
However,
there
are
few
reports
on
a
comprehensive
review
hydrogel
dressings
for
repair
hemostasis.
This
first
introduces
major
cross-linking
methods
hydrogels,
which
includes
hydrogen
bonding,
electrostatic
interactions,
hydrophobic
host-guest
metal
ligand
coordination
some
other
interactions.
Then,
we
advanced
materials
reported
recent
years
then
summarize
basic
principles
each
method.
Next,
classify
structures
before
outlining
their
forming
process
propose
potential
future
directions.
Furthermore,
also
discuss
raw
materials,
structural
design
principles,
material
used
to
achieve
functions
such
as
antibacterial
function,
tissue
adhesion,
substance
delivery,
anti-inflammatory
antioxidant
functions,
cell
behavior
regulation,
angiogenesis
promotion,
hemostasis
innovative
years.
Finally,
existing
problems
well
development
directions
strategy,
design,
discussed.
is
proposed
stimulate
further
exploration
by
researchers
future.
Abstract
Deregulated
inflammations
induced
by
various
factors
are
one
of
the
most
common
diseases
in
people's
daily
life,
while
severe
inflammation
can
even
lead
to
death.
Thus,
efficient
treatment
has
always
been
hot
topic
research
medicine.
In
past
decades,
as
a
potential
biomaterial,
stimuli‐responsive
hydrogels
have
focus
attention
for
due
their
excellent
biocompatibility
and
design
flexibility.
Recently,
thanks
rapid
development
nanotechnology
material
science,
more
efforts
made
develop
safer,
personal
effective
therapy
some
frequent
but
tough
such
sepsis,
rheumatoid
arthritis,
osteoarthritis,
periodontitis,
ulcerative
colitis.
Herein,
from
recent
studies
articles,
conventional
emerging
delivery
anti‐inflammatory
drugs
summarized.
And
prospects
clinical
translation
future
also
discussed
further
detail.
Nature Materials,
Год журнала:
2024,
Номер
23(9), С. 1292 - 1299
Опубликована: Фев. 27, 2024
Pills
are
a
cornerstone
of
medicine
but
can
be
challenging
to
swallow.
While
liquid
formulations
easier
ingest,
they
lack
the
capacity
localize
therapeutics
with
excipients
nor
act
as
controlled
release
devices.
Here
we
describe
drug
based
on
in
situ-forming
tough
(LIFT)
hydrogels
that
bridge
advantages
solid
and
dosage
forms.
LIFT
form
directly
stomach
through
sequential
ingestion
crosslinker
solution
calcium
dithiol
crosslinkers,
followed
by
drug-containing
polymer
alginate
four-arm
poly(ethylene
glycol)-maleimide.
We
show
robustly
stomachs
live
rats
pigs,
mechanically
tough,
biocompatible
safely
cleared
after
24
h.
deliver
total
dose
comparable
unencapsulated
manner,
protect
encapsulated
therapeutic
enzymes
bacteria
from
gastric
acid-mediated
deactivation.
Overall,
may
expand
access
advanced
for
patients
difficulty
swallowing.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(22)
Опубликована: Май 9, 2024
Hydrogels
have
emerged
as
promising
candidates
for
biomedical
applications,
especially
in
the
field
of
antibacterial
therapeutics,
due
to
their
unique
structural
properties,
highly
tunable
physicochemical
and
excellent
biocompatibility.
The
integration
stimuli-responsive
functions
into
hydrogels
holds
potential
enhance
properties
therapeutic
efficacy,
dynamically
responding
different
external
or
internal
stimuli,
such
pH,
temperature,
enzymes,
light.
Therefore,
this
review
describes
applications
hydrogel
dressings
responsive
stimuli
therapy.
collaborative
interaction
between
materials
is
discussed.
This
synergistic
approach,
contrast
conventional
materials,
not
only
amplifies
effect
but
also
alleviates
adverse
side
effects
diminishes
incidence
multiple
infections
drug
resistance.
provides
a
comprehensive
overview
current
challenges
outlines
future
research
directions
hydrogels.
It
underscores
imperative
ongoing
interdisciplinary
aimed
at
unraveling
mechanisms
wound
healing.
understanding
crucial
optimizing
design
implementation
Ultimately,
aims
offer
scientific
guidance
development
practical
clinical
application
dressings.
