Bioactive hydrogel formulations for regeneration of pathological bone defects

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 686 - 714

Опубликована: Фев. 17, 2025

Язык: Английский

---

Recent Advances in Host‐Guest Supramolecular Hydrogels for Biomedical Applications

Chemistry - An Asian Journal, Год журнала: 2022, Номер 17(18)

Опубликована: Июль 22, 2022

The recognition-directed host-guest interaction is recognized as a valuable tool for creating supramolecular polymers. Functional hydrogels constructed through the dynamic and reversible complexation are endowed with great many appealing features, such superior self-healing, injectability, flexibility, stimuli-responsiveness biocompatibility, which crucial biological medicinal applications. With numerous topological structures combinations established previously, recent breakthroughs in this area mostly focus on further improvement fine-tuning of various properties practical utilizations. current contribution provides comprehensive overview latest developments hydrogels, particular emphasis innovative molecular-level design strategies hydrogel formation methodologies targeting at wide range active biomedical domains, including drug delivery, 3D printing, wound healing, tissue engineering, artificial actuators, biosensors, etc. Furthermore, brief conclusion discussion steps forward to bring these smart clinical practice also presented.

Язык: Английский

---

Rapid Synthesis of Graphdiyne Films on Hydrogel at the Superspreading Interface for Antibacteria

ACS Nano, Год журнала: 2022, Номер 16(7), С. 11338 - 11345

Опубликована: Июль 8, 2022

Graphdiyne (GDY), a two-dimensional (2D) carbon material with diacetylenic linkages (-C≡C-C≡C-) structures, has attracted enormous attention in various fields. However, the controlled synthesis of GDY films is still challenging because low alkyne coupling efficiency and out-of-plane growth. Here, we employed highly efficient Cu(II)-N,N,N',N'-tetramethylethylenediamine (Cu(II)-TMEDA) catalyst constructed superspreading liquid/liquid interface on hydrogel for rapid controllable thin films. thickness from 4 to 50 nm large-scale uniform morphology can be prepared within 2 h at room temperature. The mechanism growth was revealed nucleation in-plane extension process. Meanwhile, as-grown showed excellent photothermal conversion efficiency, which induces release Cu(II) ions exhibits high synergistic antibacteria.

Язык: Английский

---

Stem Cell‐Niche Engineering via Multifunctional Hydrogel Potentiates Stem Cell Therapies for Inflammatory Bone Loss

Advanced Functional Materials, Год журнала: 2022, Номер 33(2)

Опубликована: Ноя. 4, 2022

Abstract Effective therapies capable of simultaneously inhibiting inflammation and promoting bone healing remain to be developed for inflammatory disease. Stem cell hold great promise a variety diseases, but their translation is hampered by low survival, rapid clearance, limited functional integration transplanted stem cells in target tissues. Herein, multifunctional hydrogel‐based niche engineering strategy reported the treatment loss. By rationally integrating different modules, an injectable engineered, which possesses temperature‐triggered gelling performance, inflammation/oxidative stress‐resolving activity, stem‐cell binding survival‐enhancing capacity, osteogenesis‐promoting capability. Using ectomesenchymal (EMSCs), effectiveness this functionally advanced synthetic demonstrated rats with periodontitis, representative loss Synergistic effects hydrogel EMSCs are also confirmed, respect normalizing pathological microenvironment improving alveolar regeneration periodontal tissue. Mechanistically, osteogenic differentiation capacities mainly achieved incorporated nanotherapy via GDF15/Atf3/c‐Fos axis MAPK signaling pathway. Besides newly engineered hydrogel‐stem promising other defects.

Язык: Английский

---

Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Small, Год журнала: 2023, Номер 19(23)

Опубликована: Март 11, 2023

Abstract Osteoarthritis (OA) is one of the most prevalent age‐related degenerative diseases. With an increasingly aging global population, greater numbers OA patients are providing clear economic and societal burdens. Surgical pharmacological treatments common conventional therapeutic strategies for OA, but often fall considerably short desired or optimal outcomes. development stimulus‐responsive nanoplatforms has come potential improved OA. Enhanced control, longer retention time, higher loading rates, increased sensitivity among benefits. This review summarizes advanced application drug delivery categorized by either those that depend on endogenous stimulus (reactive oxygen species, pH, enzyme, temperature), exogenous (near‐infrared ray, ultrasound, magnetic fields). The opportunities, restrictions, limitations related to these various systems, their combinations, discussed in areas such as multi‐functionality, image guidance, multi‐stimulus response. remaining constraints solutions represented clinical finally summarized.

Язык: Английский

---

Competition-Based Two-Dimensional Photonic Crystal Dually Cross-Linked Supramolecular Hydrogel for Colorimetric and Fluorescent Dual-Mode Sensing of Bisphenol A

Analytical Chemistry, Год журнала: 2023, Номер 95(8), С. 4220 - 4226

Опубликована: Фев. 14, 2023

Bisphenol A (BPA), one of the most abundantly produced endocrine disrupting chemicals, is widely used in everyday plastic products and thus must be monitored. Multimode sensing platforms are able to combine advantages different strategies while solving issues inaccurate test results single signal sensing. However, exploration this field limited due compromise conditions inevitable mutual interferences systems. Herein, we constructed a two-dimensional photonic crystal dually cross-linked supramolecular hydrogel (2DPCDCSH) by utilizing host-guest pair β-cyclodextrin (β-CD) tert-butyl (t-Bu) as second cross-linking for colorimetric fluorescent dual-mode BPA. Based on fact that BPA can act competitive guest break interaction between β-CD t-Bu, density decreased an expansion-induced structural color change occurred. Sensitive selective detection easily achieved measuring Debye diffraction ring diameter or observing 2DPC with limit 1 μg mL-1. Moreover, formation β-CD/BPA complex gave significant enhancement intrinsic fluorescence BPA, obtaining 0.001 The two systems share same reaction condition yield wider dynamic response range than strategy. Overall, proposed method presented efficient, rapid, cost-effective, regenerative analysis shed new insights design diversified platforms.

Язык: Английский

---

Progress in Pluronic F127 Derivatives for Application in Wound Healing and Repair

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 4485 - 4505

Опубликована: Авг. 1, 2023

Abstract: Pluronic F127 hydrogel biomaterial has garnered considerable attention in wound healing and repair due to its remarkable properties including temperature sensitivity, injectability, biodegradability, maintain a moist environment. This comprehensive review provides an in-depth exploration of the recent advancements F127-derived hydrogels, such as F127-CHO, F127-NH 2 , F127-DA, focusing on their applications treatment various types wounds, ranging from burns acute wounds infected diabetic cutaneous tumor uterine scars. Furthermore, meticulously examines intricate interaction mechanisms employed by these hydrogels within microenvironment. By elucidating underlying mechanisms, discussing strengths weaknesses F127, analyzing current state development, expanding trend targeting mitochondria cells with nanomaterial. The enhances our understanding therapeutic effects aims foster development effective safe wound-healing modalities. valuable insights provided this have potential inspire novel ideas for clinical facilitate advancement innovative management approaches. Keywords:

Язык: Английский

---

Cu²⁺‐Anchored Carbon Nano‐Photocatalysts for Visible Water Splitting to Boost Hydrogen Cuproptosis

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(44)

Опубликована: Сен. 16, 2023

Both hydrogen (H2 ) and copper ions (Cu+ can be used as anti-cancer treatments. However, the continuous generation of H2 molecules Cu+ in specific sites tumors is challenging. Here we anchored Cu2+ on carbon photocatalyst (Cu@CDCN) to allow peroxide O2 using two-electron process visible water splitting. The photocatalytic also generated redox-active Cu-carbon centers. Meanwhile, residues reacted with (the obstacle process) accelerate splitting cuprous ion generation, which residue promoted a pro-oxidant effect glutathione through metal-reducing actions. induced mitochondrial dysfunction intracellular redox homeostasis destruction, enabled therapy cuproptosis inhibit cancer cell growth suppress tumor growth. Our research first attempt integrate metal-enhanced solar nanomedicine, may provide safe effective treatment.

Язык: Английский

---

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(26)

Опубликована: Авг. 4, 2023

Abstract The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, have found significant role improving drug delivery inhibiting the growth metastasis tumor cells. Moreover, recent studies highlighted potential modulating microenvironment (TME) enhancing activity immune cells improve therapy efficacy. Various types are currently utilized carriers, immunosuppressants, activators, immunoassay reagents, more for immunotherapy. Necessarily, used immunotherapy can be grouped into two categories: organic inorganic nanomaterials. Though both shown ability achieve purpose immunotherapy, composition properties result differences mechanisms modes action. Organic further divided polymers, cell membranes, nanoemulsion‐modified, hydrogel forms. At same time, broadly classified nonmetallic metallic current work aims explore action these different prospects promoting

Язык: Английский

---

Quercetin‐Loaded Bioglass Injectable Hydrogel Promotes m6A Alteration of Per1 to Alleviate Oxidative Stress for Periodontal Bone Defects

Advanced Science, Год журнала: 2024, Номер 11(29)

Опубликована: Май 15, 2024

Abstract Periodontal disease ranks third among noncommunicable illnesses, behind cancer and cardiovascular disease, is closely related to the occurrence progression of various systemic diseases. However, elucidating processes periodontal promoting bone regeneration remains a challenge. Here, quercetin demonstrated reduce oxidative stress state orofacial mesenchymal stem cells (OMSCs) in vitro affect osteogenic growth OMSCs through molecular mechanisms that mediate m6A change Per1. Nevertheless, limited therapeutic efficacy medication limitations local resulting from small, moist, highly dynamic environment make it challenging treat tissues with medication. Herein, biosafe injectable hydrogel drug‐controlled delivery system constructed as bone‐enhancing factory loaded injury tissues. This drug‐carrying made up nanoscale bioglass microspheres light‐cured hydrogel, allows effective drug particle loading cementation moist environment. Furthermore, demonstrates ability stimulate differentiation Per1‐dependent manner, which ultimately promotes repair, suggesting this has potential for clinical therapy.

Язык: Английский

---