Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Abstract
Abnormal
friction
forces,
compact
matrix
structure,
and
dynamic
acidic
microenvironment
in
osteoarthritis
(OA)
make
it
difficult
to
remodel
cartilage
regeneration
by
integrating
prominent
inflammatory
responses
anabolism.
Here,
pH‐responsive
PSBMA‐
b
‐PColBP@KGN
nanoparticles
(PSPK
NPs)
are
developed
a
simple
supramolecular
assembly
process.
PSPK
NPs
found
reduce
the
coefficient
of
(0.028)
under
high
loading
pressure
(10.41
MPa).
The
synergistic
effect
KGN
release
coupling
deep
penetration
promotes
generation
microenvironment.
Further,
vivo
studies
confirm
potential
restoring
homeostasis,
as
evidenced
reduced
osteophyte
volume,
aligned
structures,
abundant
matrix.
This
study
provides
novel
insights
into
effects
release,
penetration,
hydration
lubrication
on
OA
treatment,
offering
strategy
for
design
tissue‐adaptive
promote
tissue
inflammation‐related
diseases.
ACS Nano,
Год журнала:
2024,
Номер
18(15), С. 10625 - 10641
Опубликована: Апрель 2, 2024
Development
of
nanomedicines
that
can
collaboratively
scavenge
reactive
oxygen
species
(ROS)
and
inhibit
inflammatory
cytokines,
along
with
osteogenesis
promotion,
is
essential
for
efficient
osteoarthritis
(OA)
treatment.
Herein,
we
report
the
design
a
ROS-responsive
nanomedicine
formulation
based
on
fibronectin
(FN)-coated
polymer
nanoparticles
(NPs)
loaded
azabisdimethylphoaphonate-terminated
phosphorus
dendrimers
(G4-TBP).
The
constructed
G4-TBP
NPs-FN
size
268
nm
are
stable
under
physiological
conditions,
be
specifically
taken
up
by
macrophages
through
FN-mediated
targeting,
dissociated
in
oxidative
microenvironment.
dendrimer
having
intrinsic
anti-inflammatory
property
FN
both
antioxidative
properties
display
integrated
functions
ROS
scavenging,
hypoxia
attenuation,
macrophage
M2
polarization,
thus
protecting
from
apoptosis
creating
designed
bone
immune
microenvironment
stem
cell
osteogenic
differentiation.
These
characteristics
lead
to
their
effective
treatment
an
OA
model
vivo
reduce
pathological
changes
joints
including
synovitis
inhibition
cartilage
matrix
degradation
simultaneously
promote
differentiation
repair.
developed
combining
advantages
bioactive
treat
may
immunomodulatory
therapy
different
diseases.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(5)
Опубликована: Ноя. 22, 2023
Abstract
Osteoarthritis
(OA)
is
a
prevalent,
chronic
degenerative
disease
that
affects
people
worldwide.
It
characterized
by
the
destruction
of
cartilage
and
inflammatory
reactions.
High
levels
reactive
oxygen
species
(ROS)
cause
oxidative
stress,
which
damages
lipids,
proteins,
DNA,
leading
to
cell
damage
death.
Furthermore,
ROS
also
induces
production
cytokines
chemotaxis,
further
worsening
response
damaging
resulted
in
limited
movement.
Herein,
this
work
reports
dual‐functional
injectable
hydrogel,
can
help
inhibit
inflammation
scavenging
provide
lubrication
reduce
wear
tear
on
joints.
To
create
3‐aminophenylboronic
acid
modified
hyaluronic
synthesized,
then
crosslinked
with
hydroxyl‐containing
polyvinyl
alcohol
(PVA)
construct
dual
dynamic
covalent
hydrogel
oHA‐PBA‐PVA
gel,
Gel
(HPP).
The
mentioned
here
possesses
unique
bond
structure
allows
it
be
injected,
self‐heal,
lubrication.
This
innovative
approach
offers
new
possibility
for
treating
osteoarthritis
combining
anti‐inflammatory
effects.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 14, 2024
In
the
past
11
years,
there
has
been
a
surge
in
studies
exploring
regulatory
effect
of
Traditional
Chinese
Medicine
(TCM)
on
ferroptosis.
However,
significant
gap
persists
comprehensive
scientometric
analysis
and
scientific
mapping
research,
especially
tracking
evolution,
primary
contributors,
emerging
research
focal
points.
This
study
aims
to
comprehensively
update
advancements
targeting
ferroptosis
with
various
TCMs
during
previous
years.
The
data,
covering
period
from
1
January
2012,
30
November
2023,
were
retrieved
Web
Science
database.
For
in-depth
visualized
analyses,
series
advanced
analytical
instruments
employed.
findings
highlight
China’s
predominant
role,
accounting
for
71.99%
total
publications
significantly
shaping
this
domain.
Noteworthy
productivity
was
observed
at
institutions,
including
Guangzhou
University
Medicine,
Chengdu
Zhejiang
University.
Thomas
Efferth
emerged
as
foremost
author
within
field,
while
Frontiers
Pharmacology
boasted
highest
publication
count.
pinpointed
hepatocellular
carcinoma,
chemical
drug-induced
liver
injury,
mitochondrial
diseases,
acute
kidney
failure
most
critical
disorders
addressed
realm.
offers
bibliometric
evaluation,
enhancing
our
understanding
present
status
TCM
therapy
managing
ferroptosis-related
diseases.
Consequently,
it
aids
both
seasoned
researchers
newcomers
by
accelerating
access
vital
information
fostering
innovative
concept
extraction
specialized
field.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7099 - 7121
Опубликована: Июль 1, 2024
Abstract:
Introduction
of
exogenous
genes
into
target
cells
to
overcome
various
tumor
diseases
caused
by
genetic
defects
or
abnormalities
and
gene
therapy,
a
new
treatment
method,
provides
promising
strategy
for
treatment.
Over
the
past
decade,
therapy
has
made
exciting
progress;
however,
it
still
faces
challenge
low
nucleic
acid
delivery
release
efficiencies.
The
emergence
nonviral
vectors,
primarily
nanodelivery
systems
(NDRS),
resulted
in
historic
breakthrough
application
therapy.
NDRS,
especially
stimulus-responsive
NDRS
that
can
respond
timely
manner
changes
internal
external
microenvironment
(eg,
pH,
high
concentration
glutathione/reactive
oxygen
species,
overexpressed
enzymes,
temperature,
light,
ultrasound,
magnetic
field),
shown
excellent
loading
advantages
precision
efficiency
been
widely
applied.
only
disadvantage
is
poor
transfection
limits
in-depth
clinical
practice,
owing
presence
biological
barriers
body.
Therefore,
this
review
first
introduces
development
history
current
obstacles
faced
delivery,
strategies
these
obstacles,
conventional
then
focuses
on
latest
research
progress
improving
efficiency.
Finally,
future
challenges
prospects
may
face
transformation
are
discussed
provide
references
enhancing
Keywords:
treatment,
efficiency,
microenvironment,
physiological
barrier,
efficacy
improvement
Military Medical Research,
Год журнала:
2024,
Номер
11(1)
Опубликована: Дек. 5, 2024
Abstract
Bioactive
peptides
and
proteins
(BAPPs)
are
promising
therapeutic
agents
for
tissue
repair
with
considerable
advantages,
including
multifunctionality,
specificity,
biocompatibility,
biodegradability.
However,
the
high
complexity
of
microenvironments
their
inherent
deficiencies
such
as
short
half-live
susceptibility
to
enzymatic
degradation,
adversely
affect
efficacy
clinical
applications.
Investigating
fundamental
mechanisms
by
which
BAPPs
modulate
microenvironment
developing
rational
delivery
strategies
essential
optimizing
administration
in
distinct
repairs
facilitating
translation.
This
review
initially
focuses
on
through
influence
via
reactive
oxygen
species,
blood
lymphatic
vessels,
immune
cells,
cells.
Then,
a
variety
platforms,
scaffolds
hydrogels,
electrospun
fibers,
surface
coatings,
assisted
particles,
nanotubes,
two-dimensional
nanomaterials,
nanoparticles
engineered
summarized
incorporate
effective
repair,
modification
aimed
at
enhancing
loading
efficiencies
release
kinetics
also
reviewed.
Additionally,
can
be
precisely
regulated
endogenous
stimuli
(glucose,
enzymes,
pH)
or
exogenous
(ultrasound,
heat,
light,
magnetic
field,
electric
field)
achieve
on-demand
tailored
specific
needs.
Furthermore,
this
potential
across
various
types,
bone,
cartilage,
intervertebral
discs,
muscle,
tendons,
periodontal
tissues,
skin,
myocardium,
nervous
system
(encompassing
brain,
spinal
cord,
peripheral
nerve),
endometrium,
well
ear
ocular
tissue.
Finally,
current
challenges
prospects
discussed.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(10)
Опубликована: Ноя. 27, 2023
Abstract
Precision
medicine
requires
precise
regulation
of
drugs
in
terms
time,
space,
and
dosage.
Exogenous
control
systems,
such
as
electrical
responsiveness,
have
made
great
progress.
However,
wearable
or
implantable
controlled
drug
release
devices
still
face
major
challenges
due
to
limitations
including
limited
battery
life,
large
size,
fixed
power
supply.
To
overcome
these
limitations,
the
fabrication
autonomous
is
available
endure
extended
periods
without
reliance
on
external
sources.
As
a
promising
strategy,
nanogenerators
(NGs)
turn
body
mechanical
energy
into
electricity,
powering
long‐term
release.
In
this
review,
current
status
delivery
systems
(DDS)
briefly
outlined
importance
self‐driven
emphasized.
The
main
types
operational
mechanisms
various
are
introduced.
This
review
also
focuses
summarizing
latest
progress
self‐powered
based
(NG‐based
CDRs).
Additionally,
their
applications
field
introduced
detail.
Finally,
existing
future
trends
NG‐based
CDRs
discussed
from
perspectives
clinical
needs
practical
translation.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июль 1, 2024
Osteoarthritis
(OA)
is
a
degenerative
disease
linked
to
aging
and
obesity.
The
global
population
has
led
an
increasing
number
of
OA
patients,
imposing
significant
economic
burden
on
society.
Traditional
drugs
treatment
methods
often
fail
achieve
satisfactory
outcomes.
With
the
rapid
advancement
nanomaterial
delivery
systems,
numerous
studies
have
focused
utilizing
nanomaterials
as
carriers
efficient
by
effectively
loading
delivering
bioactive
ingredients
(e.g.,
drugs,
nucleic
acids)
tailored
unique
pathological
conditions,
such
weakly
acidic
microenvironment
synovial
fluid
in
patients.
This
review
highlights
latest
advancements
use
pH-responsive
nanoparticles
for
treatment,
emphasizing
principle
targeted
drug
leveraging
inflamed
joints.
It
further
discusses
composition,
synthesis,
response
mechanism,
target
selection,
application,
recent
research
findings
nanoparticles,
while
also
addressing
challenges
future
directions
this
promising
field.
