Macrophage-mediated fracture healing: Unraveling molecular mechanisms and therapeutic implications using hydrogel-based interventions

Biomaterials, Год журнала: 2024, Номер 305, С. 122461 - 122461

Опубликована: Янв. 1, 2024

Язык: Английский

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Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3849 - 3849

Опубликована: Март 29, 2024

This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on treatment skin wounds. Regenerative hydrogels, composed mainly water-absorbing polymers, have garnered attention in wound healing, particularly for Their unique properties make them well suited tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist environment optimal facilitating cell migration, proliferation. Biocompatibility is key feature, minimizing adverse reactions promoting natural healing process. Acting as supportive scaffold growth, mimic extracellular matrix, aiding attachment proliferation cells like fibroblasts keratinocytes. Engineered controlled drug release, enhance by angiogenesis, reducing inflammation, preventing infection. The demonstrated acceleration process, beneficial chronic or impaired wounds, adds to appeal. Easy application conformity various shapes practical, including irregular challenging areas. Scar minimization through regeneration crucial, especially cosmetic functional regions. Hydrogels contribute pain management protective barrier, friction, fostering soothing environment. Some with inherent antimicrobial properties, aid infection prevention, which crucial aspect successful healing. flexibility ability conform contours ensure contact, enhancing overall effectiveness. In summary, present promising approach improving outcomes across diverse clinical scenarios. provides comprehensive analysis benefits, mechanisms, challenges associated use this review, authors likely delve into rational design principles efficacy performance Through an exploration methodologies approaches, paper poised highlight how these been instrumental refining potentially revolutionizing therapeutic potential addressing By synthesizing current knowledge highlighting avenues future research, aims advancement medicine ultimately improve patients

Язык: Английский

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Multifunctional Hydrogel Based on Silk Fibroin Promotes Tissue Repair and Regeneration

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Abstract The creation of functional hydrogels with robust load‐bearing capacity adaptable to complex tissue regeneration remains challenging. Silk fibroin (SF) is a natural biomaterial excellent mechanical strength and cell adhesion capacity, possessing tremendous potential solve the aforementioned dilemma. biodegradability biocompatibility molecular structure multiple modifiable moieties provide opportunities for injectability multifunctionality hydrogels. Furthermore, incorporation other polymers or active ingredients can improve basic properties, confer biological activities pharmacological effects, prerequisites fulfill specific requirements. Therefore, SF‐based are widely applied in repair regeneration, especially bone, skin, nerve, liver, myocardium, cornea, which have effectively addressed challenges scaffolds' lack sites, excessive degradation, as well efficient, long‐lasting antimicrobial properties. This review outlines properties SF, discusses types materials commonly used preparation their characteristics, describes current construction methods SF Simultaneously, recent advancements applying multifunctional within tissues explored, focus on role repair, highlighting mechanism based bone skin.

Язык: Английский

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Metal Ion-Containing Hydrogels: Synthesis, Properties, and Applications in Bone Tissue Engineering

Biomacromolecules, Год журнала: 2024, Номер 25(6), С. 3217 - 3248

Опубликована: Янв. 18, 2024

Hydrogel, as a unique scaffold material, features three-dimensional network system that provides conducive conditions for the growth of cells and tissues in bone tissue engineering (BTE). In recent years, it has been discovered metal ion-containing hybridized hydrogels, synthesized with particles foundation, exhibit excellent physicochemical properties, osteoinductivity, osteogenic potential. They offer wide range research prospects field BTE. This review an overview current state advancements concerning hydrogels Within materials science, covers topics such binding mechanisms ions within hydrogel networks, types fabrication methods various influence on properties hydrogels. context BTE, delves into ions, applications relevant experimental studies vitro vivo. Furthermore, future improvements repair can be anticipated through bionics, exploring interactions between development wider types.

Язык: Английский

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Hemostasis Strategies and Recent Advances in Hydrogels for Managing Uncontrolled Hemorrhage

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Hemorrhage continues to pose a significant challenge in various medical contexts, underscoring the need for advanced hemostatic materials. Hemostatic hydrogels have gained recognition as innovative tools addressing uncontrollable bleeding, attributed their distinctive features including biological compatibility, tunable mechanical properties, and exceptional performance. This review provides comprehensive overview of that offer rapid effective bleeding control. Particularly, this focuses on hydrogel design associated mechanisms. Additionally, recent advancements application these materials are discussed detail, especially clinical trials. Finally, challenges potential analyzed assessed. seeks emphasize role biomedical applications hemorrhage control provide perspectives innovation clinically applicable

Язык: Английский

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2D MOFs nanosheets derived from 2D LDHs as a multifunctional sensitizer for sono-photodynamic therapy-mediated tumor treatment

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159771 - 159771

Опубликована: Янв. 1, 2025

Язык: Английский

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Bioactive hydrogel formulations for regeneration of pathological bone defects

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 686 - 714

Опубликована: Фев. 17, 2025

Язык: Английский

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Metal−Organic Frameworks Nucleated by Silk Fibroin and Modified with Tumor‐Targeting Peptides for Targeted Multimodal Cancer Therapy

Advanced Science, Год журнала: 2023, Номер 10(28)

Опубликована: Авг. 23, 2023

Abstract Multimodal therapy requires effective drug carriers that can deliver multiple drugs to specific locations in a controlled manner. Here, the study presents novel nanoplatform constructed using zeolitic imidazolate framework‐8 ( Z IF‐8), nanoscale metal‐organic framework nucleated under mediation of silk fibroin S F). The is modified with newly discovered MCF‐7 breast tumor‐targeting peptide, AREYGTRFSLIGGYR AR peptide). Indocyanine green I CG) and doxorubicin D OX) are loaded onto high encapsulation efficiency (>95%). ICG enables resultant nanoparticles (NPs), called AR‐ZS/ID‐P, release reactive oxygen species for photodynamic P DT) heat photothermal TT) near‐infrared (NIR) irradiation, promoting NIR fluorescence thermal imaging guide DOX‐induced chemotherapy. Additionally, both DOX at acidic tumor conditions due dissolution ZIF‐8 provides drug‐targeting mechanism addition peptide. When intravenously injected, AR‐ZS/ID‐P NPs specifically target tumors exhibit higher anticancer efficacy than other groups through ICG‐enabled PDT PTT DOX‐derived chemotherapy, without inducing side effects. results demonstrate promising multimodal theranostic maximal therapeutic minimal effects targeted controllable delivery.

Язык: Английский

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An Injectable Thermosensitive Hydrogel Containing Resveratrol and Dexamethasone‐Loaded Carbonated Hydroxyapatite Microspheres for the Regeneration of Osteoporotic Bone Defects

Small Methods, Год журнала: 2023, Номер 8(1)

Опубликована: Окт. 6, 2023

Abstract Bone defects in osteoporosis usually present excessive reactive oxygen species (ROS), abnormal inflammation levels, irregular shapes and impaired bone regeneration ability; therefore, osteoporotic are difficult to repair. In this study, an injectable thermosensitive hydrogel poly (D, L‐lactide)‐poly (ethylene glycol)‐ L‐lactide) (PLEL) system containing resveratrol (Res) dexamethasone (DEX) is designed create a microenvironment conducive osteogenesis defects. This PLEL injected filled defect areas achieving rapid sol‐gel transition situ. Res has strong anti‐inflammatory effects that can effectively remove excess free radicals at the damaged site, guide macrophage polarization M2 phenotype, regulate immune responses. Additionally, DEX promote osteogenic differentiation. vitro experiments showed promoted differentiation of mesenchymal stem cells, removed intracellular ROS, regulated reduce inflammatory vivo modulated Overall, study confirmed treat by synergistically modulating damage microenvironment, alleviating responses, promoting osteogenesis; thus, it represents promising drug delivery strategy repair

Язык: Английский

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Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Advanced Science, Год журнала: 2023, Номер 10(24)

Опубликована: Июнь 17, 2023

Bone diseases including bone defects, infections, osteoarthritis, and tumors seriously affect life quality of the patient bring serious economic burdens to social health management, for which current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial-based strategies have been widely applied in treatment orthopedic but are still plagued by deficient bioreactivity. With development nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, excellent drug loading delivery capabilities arise widespread attention achieved considerable achievements disease last decade. However, authors' best knowledge, no review has comprehensively summarized advances LDHs treating so far. Herein, advantages disorders outlined corresponding state-of-the-art first time. The potential LDHs-based nanocomposites extended therapeutics is highlighted perspectives scaffold design proposed facilitated translation.

Язык: Английский

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