ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 15, 2025
As
a
biodegradable
metal,
zinc
(Zn)
offers
promising
material
option
for
barrier
membranes
in
the
field
of
bone
regeneration
due
to
its
suitable
degradation
rate
and
mechanical
properties.
An
ideal
membrane
not
only
blocks
growth
epithelial
fibers
but
also
promotes
regeneration.
Therefore,
we
prepared
an
asymmetric
Zn
with
micrometer-sized
pores
on
one
side
by
laser
etching,
pore
facilitating
cell
adhesion
proliferation,
smooth
blocking
entry.
And
antimicrobial
peptide
GL13K
(P1)
was
loaded
onto
surface
Zn-specific
binding
(NCS)
resist
postoperative
bacterial
infections,
small
intestinal
submucosal
hydrogel
complex
(SIS-P2),
which
specifically
Substance
P
(SP),
placed
modulate
immunity
promote
osteogenesis.
This
innovative
(Zn-P1-SIS-P2
membrane)
exhibited
excellent
mechanical,
antimicrobial,
biocompatibility
More
importantly,
Zn-P1-SIS-P2
macrophage
polarization
toward
M2
type,
thereby
promoting
osteogenic
differentiation
providing
good
immune
microenvironment
In
addition,
inhibited
RANKL-induced
osteoclast
formation
suppressed
resorption
at
site
defects.
conclusion,
demonstrated
all
desirable
qualities
GBR
therapeutic
membrane.
Abstract
Infected
bone
defects
are
one
of
the
most
challenging
problems
in
treatment
due
to
high
antibiotic
failure
rate
and
lack
ideal
grafts.
In
this
paper,
inspired
by
clinical
cement
filling
treatment,
α
‐c
phosphate
(
‐TCP)
with
self‐curing
properties
is
composited
β
‐tricalcium
constructed
a
bionic
cancellous
scaffolding
system
α/β‐tricalcium
/
low‐temperature
3D
printing,
gelatin
preserved
inside
scaffolds
as
an
organic
phase,
later
loaded
metal–polyphenol
network
structure
tea
polyphenol‐magnesium
(TP‐Mg)
nanoparticles.
The
mimic
components
mechanical
strength
(>100
MPa)
based
on
‐TCP
through
printing.
Meanwhile,
TP‐Mg
exhibit
significant
inhibition
Staphylococcus
aureus
S.aureus
)
promote
transition
macrophages
from
M1
pro‐inflammatory
M2
anti‐inflammatory
phenotype.
addition,
composite
scaffold
also
exhibits
excellent
bone‐enhancing
effects
synergistic
effect
Mg
2+
Ca
.
study,
multifunctional
ceramic
‐TCP@TP‐Mg)
that
integrates
anti‐inflammatory,
antibacterial,
osteoinduction
constructed,
which
promotes
late
regenerative
healing
while
modulating
early
microenvironment
infected
defects,
has
promising
application
defects.
Giant,
Год журнала:
2024,
Номер
19, С. 100323 - 100323
Опубликована: Июль 10, 2024
Inspired
by
the
extracellular
matrix
(ECM),
biomaterials
have
emerged
as
promising
strategies
in
biomedical
research
and
engineering
domain,
offering
unique
characteristics
for
tissue
regeneration,
drug
delivery,
therapeutic
interventions,
cellular
investigations.
The
ECM,
a
dynamic
network
structure
secreted
various
cells,
primarily
comprises
diverse
proteins
capable
of
facilitating
tissue-ECM
signaling
regulatory
functions
through
its
rich
array
bioactive
substances
multi-level
structural
properties.
Drawing
inspiration
from
intricate
biochemical
composition
natural
researchers
developed
to
encapsulate
these
features
create
biomimetic
microenvironments,
such
electrospinning,
hydrogels/hydrogel
microspheres,
decellularized
ECM(dECM),
ECM-mimicking
peptides.
Furthermore,
mimicking
ECM
components,
ECM-inspired
exhibit
varying
degrees
functionalization,
including
providing
support,
cell
adhesion,
signal
transduction,
mitigating
immune
responses,
remodeling.
In
summary,
advancements
offer
significant
promise
addressing
key
challenges
fields
engineering,
regenerative
medicine,
delivery.
Environmental Toxicology,
Год журнала:
2024,
Номер
39(7), С. 4066 - 4085
Опубликована: Май 10, 2024
Abstract
Osteoporosis
(OP)
can
result
in
slower
bone
regeneration
than
the
normal
condition
due
to
abnormal
oxidative
stress
and
high
levels
of
reactive
oxygen
species
(ROS),
a
detrimental
for
formation,
making
OP‐related
healing
significant
clinical
challenge.
As
osteogenic
differentiation
ability
marrow
mesenchymal
stem
cells
(BMSCs)
is
closely
related
regeneration;
currently,
this
study
assessed
effects
Picein
on
BMSCs
vitro
osteoporotic
defect
vivo.
Cell
viability
was
determined
by
CCK‐8
assay.
The
production
malonaldehyde,
superoxide
dismutase
activities,
glutathione
evaluated
using
commercially
available
kits,
flow
cytometry
analysis
adopted
detect
macrophage
polarization.
Osteogenic
capacity
alkaline
phosphatase
(ALP)
activity,
ALP
staining,
Alizarin
red
S
staining.
expression
osteogenic‐related
proteins
(OPN,
Runx‐2,
OCN)
genes
(ALP,
BMP‐4,
COL‐1,
Osterix)
were
Western
blotting
real‐time
PCR
(RT‐PCR).
In
addition,
proliferation,
migration
ability,
angiogenic
human
umbilical
vein
endothelial
(HUVECs)
EdU
scratch
test,
transwell
assay,
tube
formation
respectively.
Angiogenic‐related
(VEGF,
vWF,
CD31)
also
RT‐PCR.
Results
showed
that
alleviated
erastin‐induced
stress,
enhanced
BMSCs,
angiogenesis
HUVECs,
protects
against
ferroptosis
through
Nrf2/HO‐1/GPX4
axis.
Moreover,
regulate
immune
microenvironment
promoting
polarization
M2
macrophages
vitro.
reduce
inflammation
promotes
OP
rat
models
Altogether,
these
results
suggested
promote
alleviate
via
pathway,
offering
as
novel
antioxidant
agent
treating
defect.
Nano-Micro Letters,
Год журнала:
2024,
Номер
17(1)
Опубликована: Ноя. 27, 2024
Abstract
Bioactive
molecules
have
shown
great
promise
for
effectively
regulating
various
bone
formation
processes,
rendering
them
attractive
therapeutics
regeneration.
However,
the
widespread
application
of
bioactive
is
limited
by
their
low
accumulation
and
short
half-lives
in
vivo.
Hydrogels
emerged
as
ideal
carriers
to
address
these
challenges,
offering
potential
prolong
retention
times
at
lesion
sites,
extend
vivo
mitigate
side
effects,
avoid
burst
release,
promote
adsorption
under
physiological
conditions.
This
review
systematically
summarizes
recent
advances
development
molecule-loaded
hydrogels
regeneration,
encompassing
applications
cranial
defect
repair,
femoral
periodontal
regeneration
with
underlying
diseases.
Additionally,
this
discusses
current
strategies
aimed
improving
release
profiles
through
stimuli-responsive
delivery,
carrier-assisted
sequential
delivery.
Finally,
elucidates
existing
challenges
future
directions
hydrogel
encapsulated
field
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 13, 2025
Resveratrol,
a
polyphenolic
compound
known
for
its
diverse
biological
activities,
has
demonstrated
multiple
pharmacological
effects,
including
anti-inflammatory,
anti-aging,
anti-diabetic,
anti-cancer,
and
cardiovascular
protective
properties.
Recent
studies
suggest
that
these
effects
are
partly
mediated
through
the
regulation
of
macrophage
polarization,
wherein
macrophages
differentiate
into
pro-inflammatory
M1
or
anti-inflammatory
M2
phenotypes.
Our
review
highlights
how
resveratrol
modulates
polarization
various
signaling
pathways
to
achieve
therapeutic
effects.
For
example,
can
activate
senescence-associated
secretory
phenotype
(SASP)
pathway
inhibit
signal
transducer
activator
transcription
(STAT3)
sphingosine-1-phosphate
(S1P)-YAP
axes,
promoting
suppressing
thereby
inhibiting
tumor
growth.
Conversely,
it
promote
suppress
by
NF-κB
activating
PI3K/Akt
AMP-activated
protein
kinase
(AMPK)
pathways,
thus
alleviating
inflammatory
responses.
Notably,
effect
on
is
concentration-dependent;
moderate
concentrations
tend
while
higher
may
favor
polarization.
This
concentration
dependence
offers
new
perspectives
clinical
treatment
but
also
underscores
necessity
precise
dosage
control
when
using
resveratrol.
In
summary,
exhibits
significant
potential
in
regulating
treating
related
diseases.
Bioactive Materials,
Год журнала:
2024,
Номер
39, С. 336 - 353
Опубликована: Май 25, 2024
While
mild
hyperthermia
holds
great
potential
in
the
treatment
of
solid
tumors,
thermal
stress-triggered
self-repairing
autophagy
significantly
compromises
its
efficacy.
To
circumvent
this
obstacle,
an
injectable
hydrogel
(NO-Gel)
composed
thermosensitive
poly(ethylene
glycol)-polypeptide
copolymers
modified
with
abundant
NO
donors
on
their
side
chains
is
developed.
Meanwhile,
ferrimagnetic
Zn
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 789 - 789
Опубликована: Июнь 28, 2024
Bone
defects
caused
by
trauma,
tumor
resection,
and
infections
are
significant
clinical
challenges.
Excessive
reactive
oxygen
species
(ROS)
usually
accumulate
in
the
defect
area,
which
may
impair
function
of
cells
involved
bone
formation,
posing
a
serious
challenge
for
repair.
Due
to
potent
ROS
scavenging
ability,
as
well
potential
anti-inflammatory
immunomodulatory
activities,
antioxidants
play
an
indispensable
role
maintenance
protection
health
have
gained
increasing
attention
recent
years.
This
narrative
review
aims
give
overview
main
research
directions
on
application
antioxidant
compounds
repair
over
past
decade.
In
addition,
positive
effects
various
their
biomaterial
delivery
systems
summarized
provide
new
insights
exploring
antioxidant-based
strategies
