Facile Preparation of Multifunctional Hydrogels with Sustained Resveratrol Release Ability for Bone Tissue Regeneration DOI Creative Commons
Wenhai Zhang, Zheng Li,

Yi Yan

и другие.

Gels, Год журнала: 2024, Номер 10(7), С. 429 - 429

Опубликована: Июнь 28, 2024

Injectable hydrogels show great promise for bone tissue engineering applications due to their high biocompatibility and drug delivery capabilities. The defects in osteoporosis are usually characterized by an oxidative inflammatory microenvironment that impairs the regeneration capability of tissues. To attenuate reactive oxygen species (ROS) promote regeneration, anti-oxidative hydrogel with osteogenic capacity was developed this study. poorly water soluble, natural antioxidant, resveratrol, encapsulated thiolated Pluronic F-127 micelles over 50-times-enhanced solubility. injectable facilely formed because new thioester bond between free thiol group modified arylate hyaluronic acid (HA)–acrylate. resveratrol-loaded showed good viscoelastic properties vitro stability cyto-compatible bone-marrow-derived mesenchymal stem cells (BMSCs). allowed a sustained release resveratrol at least two weeks effectively enhanced differentiation BMSCs up-regulation markers, including ALP, OCN, RUNX-2, COL1. Moreover, exhibited anti-inflammatory abilities through scavenging intracellular ROS RAW264.7 inhibiting gene expression secretion pro-inflammatory cytokines TNF-α IL-1β under LPS exposure. In summary, results suggest our multifunctional loaded bearing osteogenic, anti-oxidative, actions is easily prepared represents promising platform repair osteoporotic defects.

Язык: Английский

3D Printed Multifunctional Biomimetic Bone Scaffold Combined with TP‐Mg Nanoparticles for the Infectious Bone Defects Repair DOI Creative Commons
Xulin Hu, Jiao Chen,

Shuhao Yang

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Май 28, 2024

Abstract Infected bone defects are one of the most challenging problems in treatment due to high antibiotic failure rate and lack ideal grafts. In this paper, inspired by clinical cement filling treatment, α ‐c phosphate ( ‐TCP) with self‐curing properties is composited β ‐tricalcium constructed a bionic cancellous scaffolding system α/β‐tricalcium / low‐temperature 3D printing, gelatin preserved inside scaffolds as an organic phase, later loaded metal–polyphenol network structure tea polyphenol‐magnesium (TP‐Mg) nanoparticles. The mimic components mechanical strength (>100 MPa) based on ‐TCP through printing. Meanwhile, TP‐Mg exhibit significant inhibition Staphylococcus aureus S.aureus ) promote transition macrophages from M1 pro‐inflammatory M2 anti‐inflammatory phenotype. addition, composite scaffold also exhibits excellent bone‐enhancing effects synergistic effect Mg 2+ Ca . study, multifunctional ceramic ‐TCP@TP‐Mg) that integrates anti‐inflammatory, antibacterial, osteoinduction constructed, which promotes late regenerative healing while modulating early microenvironment infected defects, has promising application defects.

Язык: Английский

Процитировано

19
Progress in biomaterials inspired by the extracellular matrix DOI Creative Commons

Zhuolin Chen,

Chengcheng Du, Senrui Liu

и другие.

Giant, Год журнала: 2024, Номер 19, С. 100323 - 100323

Опубликована: Июль 10, 2024

Inspired by the extracellular matrix (ECM), biomaterials have emerged as promising strategies in biomedical research and engineering domain, offering unique characteristics for tissue regeneration, drug delivery, therapeutic interventions, cellular investigations. The ECM, a dynamic network structure secreted various cells, primarily comprises diverse proteins capable of facilitating tissue-ECM signaling regulatory functions through its rich array bioactive substances multi-level structural properties. Drawing inspiration from intricate biochemical composition natural researchers developed to encapsulate these features create biomimetic microenvironments, such electrospinning, hydrogels/hydrogel microspheres, decellularized ECM(dECM), ECM-mimicking peptides. Furthermore, mimicking ECM components, ECM-inspired exhibit varying degrees functionalization, including providing support, cell adhesion, signal transduction, mitigating immune responses, remodeling. In summary, advancements offer significant promise addressing key challenges fields engineering, regenerative medicine, delivery.

Язык: Английский

Процитировано

13
Engineered hydrogel microspheres for spheroids and organoids construction DOI

Tingting Gai,

Yuanwei Zhang, Guangfeng Li

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155131 - 155131

Опубликована: Авг. 24, 2024

Язык: Английский

Процитировано

13
Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO‐1/GPX4 pathway DOI
Lei Huang, Jiayi Wang,

Jieqin Yu

и другие.

Environmental Toxicology, Год журнала: 2024, Номер 39(7), С. 4066 - 4085

Опубликована: Май 10, 2024

Abstract Osteoporosis (OP) can result in slower bone regeneration than the normal condition due to abnormal oxidative stress and high levels of reactive oxygen species (ROS), a detrimental for formation, making OP‐related healing significant clinical challenge. As osteogenic differentiation ability marrow mesenchymal stem cells (BMSCs) is closely related regeneration; currently, this study assessed effects Picein on BMSCs vitro osteoporotic defect vivo. Cell viability was determined by CCK‐8 assay. The production malonaldehyde, superoxide dismutase activities, glutathione evaluated using commercially available kits, flow cytometry analysis adopted detect macrophage polarization. Osteogenic capacity alkaline phosphatase (ALP) activity, ALP staining, Alizarin red S staining. expression osteogenic‐related proteins (OPN, Runx‐2, OCN) genes (ALP, BMP‐4, COL‐1, Osterix) were Western blotting real‐time PCR (RT‐PCR). In addition, proliferation, migration ability, angiogenic human umbilical vein endothelial (HUVECs) EdU scratch test, transwell assay, tube formation respectively. Angiogenic‐related (VEGF, vWF, CD31) also RT‐PCR. Results showed that alleviated erastin‐induced stress, enhanced BMSCs, angiogenesis HUVECs, protects against ferroptosis through Nrf2/HO‐1/GPX4 axis. Moreover, regulate immune microenvironment promoting polarization M2 macrophages vitro. reduce inflammation promotes OP rat models Altogether, these results suggested promote alleviate via pathway, offering as novel antioxidant agent treating defect.

Язык: Английский

Процитировано

12
Spatiotemporal controlled released hydrogels for multi-system regulated bone regeneration DOI
Jingxia Chen, Jiaxin Luo, Jian Feng

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 846 - 861

Опубликована: Июль 6, 2024

Язык: Английский

Процитировано

9
Autophagy inhibition mediated via an injectable and NO-releasing hydrogel for amplifying the antitumor efficacy of mild magnetic hyperthermia DOI Creative Commons

Yaoben Wang,

Xiaobin Chen, Zhiyong Chen

и другие.

Bioactive Materials, Год журнала: 2024, Номер 39, С. 336 - 353

Опубликована: Май 25, 2024

While mild hyperthermia holds great potential in the treatment of solid tumors, thermal stress-triggered self-repairing autophagy significantly compromises its efficacy. To circumvent this obstacle, an injectable hydrogel (NO-Gel) composed thermosensitive poly(ethylene glycol)-polypeptide copolymers modified with abundant NO donors on their side chains is developed. Meanwhile, ferrimagnetic Zn

Язык: Английский

Процитировано

8
Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential DOI Creative Commons
P. L. Wang,

Zhenhong Li,

Yixuan Song

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 13, 2025

Resveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties. Recent studies suggest that these effects are partly mediated through the regulation of macrophage polarization, wherein macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Our review highlights how resveratrol modulates polarization various signaling pathways to achieve therapeutic effects. For example, can activate senescence-associated secretory phenotype (SASP) pathway inhibit signal transducer activator transcription (STAT3) sphingosine-1-phosphate (S1P)-YAP axes, promoting suppressing thereby inhibiting tumor growth. Conversely, it promote suppress by NF-κB activating PI3K/Akt AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. Notably, effect on is concentration-dependent; moderate concentrations tend while higher may favor polarization. This concentration dependence offers new perspectives clinical treatment but also underscores necessity precise dosage control when using resveratrol. In summary, exhibits significant potential in regulating treating related diseases.

Язык: Английский

Процитировано

1
Smart glucose-responsive hydrogel with ROS scavenging and homeostasis regulating properties for diabetic bone regeneration DOI
Ziyang Liu, Jing Mao,

Weiqi Li

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154433 - 154433

Опубликована: Июль 31, 2024

Язык: Английский

Процитировано

6
Anti‐Wound Dehiscence and Antibacterial Dressing with Highly Efficient Self‐Healing Feature for Guided Bone Regeneration Wound Closure DOI Creative Commons
Shenghao Xue, Ning Tang, Cheng Zhou

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Фев. 27, 2024

Guided bone regeneration (GBR) is a well-established technique for preserving and enhancing alveolar ridge structures. Success in GBR relies on fulfilling the Primary wound closure, Angiogenesis, Space maintenance, Stability (PASS) principles. Conventional methods, involving titanium meshes sutures, have drawbacks, including need secondary removal customization challenges. To address these issues, an innovative multifunctional dressing (MGD) based self-healing elastomer (PUIDS) introduced. MGD provides sutureless prevents food particle accumulation, maintains stable environment growth. It offers biocompatibility, bactericidal properties, effectiveness oral model. In summary, reliable, osteogenic GBR, aligning with PASS principles promoting superior post-surgery regeneration.

Язык: Английский

Процитировано

5
Application of Antioxidant Compounds in Bone Defect Repair DOI Creative Commons
Jiajia Wang, Yubing Zhang, Qingming Tang

и другие.

Antioxidants, Год журнала: 2024, Номер 13(7), С. 789 - 789

Опубликована: Июнь 28, 2024

Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair function of cells involved bone formation, posing a serious challenge for repair. Due to potent ROS scavenging ability, as well potential anti-inflammatory immunomodulatory activities, antioxidants play an indispensable role maintenance protection health have gained increasing attention recent years. This narrative review aims give overview main research directions on application antioxidant compounds repair over past decade. In addition, positive effects various their biomaterial delivery systems summarized provide new insights exploring antioxidant-based strategies

Язык: Английский

Процитировано

4