Journal of Controlled Release, Год журнала: 2025, Номер 383, С. 113799 - 113799
Опубликована: Май 3, 2025
Язык: Английский
Advanced Science, Год журнала: 2023, Номер 10(32)
Опубликована: Сен. 25, 2023
Extracellular vesicles (EVs), involved in essential physiological and pathological processes of the organism, have emerged as powerful tools for disease treatment owing to their unique natural biological characteristics artificially acquired advantages. However, limited targeting ability, insufficient production yield, low drug-loading capability simplex EVs greatly hindered development clinical translation. Therefore, establishment multifunctional hybrid membrane nanovesicles (HMNVs) with favorable adaptability flexibility has become key expanding practical application EVs. This timely review summarizes current progress HMNVs biomedical applications. Different preparation strategies including physical, chemical, chimera approaches are first discussed. then individually describes diverse types based on homologous or heterologous cell substances, a fusion liposome, well bacterial membrane. Subsequently, specific emphasis is placed highlight applications toward various diseases representative examples. Finally, ongoing challenges prospects currently developed translational briefly presented. will not only stimulate broad interest among researchers from disciplines but also provide valuable insights promising nanoplatforms precision medicine.
Язык: Английский
Процитировано
46
Biotechnology Advances, Год журнала: 2025, Номер 81, С. 108546 - 108546
Опубликована: Фев. 26, 2025
Язык: Английский
Процитировано
4
Journal of the American Chemical Society, Год журнала: 2023, Номер 145(20), С. 11206 - 11214
Опубликована: Май 11, 2023
The manipulation of the flexibility/rigidity polymeric chains to control their function is commonly observed in natural macromolecules but largely unexplored synthetic systems. Herein, we construct a series protein-mimetic nano-switches consisting gold nanoparticle (GNP) core, polypeptide linker, and an optically functional molecule (OFM), whose biological can be dynamically regulated by flexibility linker. At dormant state, adopts flexible, random-coiled conformation, bringing GNP OFM close proximity that leads "turn-off" OFM. Once treated with alkaline phosphatase (ALP), are activated due increased separation distance between driven coil-to-helix flexible-to-rigid transition therefore enable selective fluorescence imaging or photodynamic therapy response ALP overproduced tumor cells. over polymer represents effective strategy manipulate optical activity nano-switches, which mimics delicate structure-property relationship proteins.
Язык: Английский
Процитировано
28
Advanced Materials, Год журнала: 2023, Номер 36(30)
Опубликована: Окт. 6, 2023
Abstract Acute liver failure (ALF) is a life‐threatening disease associated with the rapid development of inflammatory storms, level elevation reactive oxygen species (ROS), and hepatocyte necrosis, which results in high short‐term mortality. Except for transplantation, no effective strategies are available ALF therapy due to progression narrow window therapeutic time. Therefore, there an urgent demand explore fast modalities treatment. Herein, multifunctional tetrahedral DNA nanoplatform (TDN) constructed by incorporating tumor necrosis factor‐α siRNA (siTNF‐α) through hybridization antioxidant manganese porphyrin (MnP4) via π–π stacking interaction G‐quadruplex (G4) surprisingly significant therapy. TDN‐siTNF‐α/‐G4‐MnP4 silences TNF‐α macrophages siTNF‐α polarizes them anti‐inflammatory M2 phenotype, providing appropriate microenvironments viability. Additionally, scavenges intracellular ROS MnP4, protecting hepatocytes from oxidative‐stress‐associated cell death. Furthermore, TDN itself promotes proliferation modulating cycle. shows almost complete accumulation after intravenous injection exhibits excellent efficacy within 2 h. The nanoformulation provides strategy therapy, expanding its application innovative treatments diseases.
Язык: Английский
Процитировано
25
Small Structures, Год журнала: 2024, Номер 5(5)
Опубликована: Янв. 23, 2024
There is growing interest in developing cell membrane‐coated nanoparticles (CNPs) for unique host mimicry and therapeutic applications. The continuous evolution of this technology has motivated the coating with hybrid membranes originating from diverse types. resulting (hybrid CNPs) exhibit a higher level synergy among multifunctionalities better multitasking capabilities than their monotypic counterparts. This advancement catalyzed initiation numerous research opportunities, marking advent promising frontier review outlines emerging biomedical applications CNPs, focusing on drug targeting, immune modulation, biological neutralization, disease diagnosis. Within each application, underscores how strategic hybridization distinct augments nanoparticle efficacy. Overall, insights presented herein consolidate our understanding current may inspire novel designs new
Язык: Английский
Процитировано
15
Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102241 - 102241
Опубликована: Фев. 21, 2024
Arthritis has become the most common joint disease globally. Current attention shifted towards preventing and exploring pharmaceutical surgical treatments for early-stage arthritis. M2 macrophages are known their anti-inflammatory properties ability to support cartilage repair, offering relief from Whereas, it remains a great challenge promote beneficial secretion of prevent progression Therefore, is warranted investigate new strategies that could use functions enhance its therapeutic effects. This review aims explore macrophage cell membrane-coated biomimetic nanovesicles targeted treatment arthritis such as osteoarthritis (OA), rheumatoid (RA), gouty (GA). Cell membrane-camouflaged nanovesicle attracted increasing attention, which successfully combine advantages both membrane delivered drug. We discuss roles in pathophysiology targets Then, preparation concluded. Moreover, we applications arthritis, OA, RA, GA. Taken together, hold tremendous prospect biomedical
Язык: Английский
Процитировано
13
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 208, С. 115302 - 115302
Опубликована: Апрель 3, 2024
Cardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a significant global health challenge. Consequently, development innovative therapeutic strategies to enhance CVDs treatment is imperative. RNA-based therapies, encompassing non-coding RNAs, mRNA, aptamers, and CRISPR/Cas9 technology, have emerged promising tools for addressing CVDs. However, inherent challenges associated with RNA, such poor cellular uptake, susceptibility RNase degradation, capture by reticuloendothelial system, underscore necessity combining these therapies effective drug delivery systems. Various non-viral systems, including extracellular vesicles, lipid-based carriers, polymeric inorganic nanoparticles, well hydrogels, shown promise in enhancing efficacy RNA therapeutics. In this review, we offer an overview most relevant explored emphasize pivotal role systems augmenting their effectiveness. Additionally, discuss current status that hinder clinical translation.
Язык: Английский
Процитировано
13
Nanomaterials, Год журнала: 2024, Номер 14(5), С. 413 - 413
Опубликована: Фев. 23, 2024
Recent strides in nanomaterials science have paved the way for creation of reliable, effective, highly accurate, and user-friendly biomedical systems. Pioneering integration natural cell membranes into sophisticated nanocarrier architectures, membrane camouflage has emerged as a transformative approach regulated drug delivery, offering benefits minimal immunogenicity coupled with active targeting capabilities. Nevertheless, utility such is curtailed by challenges like suboptimal precision lackluster therapeutic efficacy. Tailored engineering stands at forefront biomedicine, equipping nanoplatforms capacity to conduct more complex operations. This review commences an examination prevailing methodologies engineering, spotlighting strategies direct chemical modification, lipid insertion, hybridization, metabolic glycan labeling, genetic engineering. Following this, evaluation unique attributes various presented, delivering in-depth scrutiny substantial advancements applications driven cutting-edge engineered camouflage. The discourse culminates recapitulating salient influence within nanomaterial prognosticates its seminal role healthcare technologies. It envisaged that insights offered herein will catalyze novel avenues innovation refinement camouflaged nanotechnologies.
Язык: Английский
Процитировано
11
BMEMat, Год журнала: 2024, Номер unknown
Опубликована: Июль 17, 2024
Abstract Immunotherapy has recently emerged as a promising therapeutic modality for the treatment of various diseases such cancer, inflammation, autoimmune diseases, and infectious diseases. Despite its potential, immunotherapy faces challenges related to delivery efficiency off‐target toxicity immunotherapeutic drugs. Nano drug systems offer improvements in biodistribution release kinetics but still suffer from shortcomings high immunogenicity, poor penetration across biological barriers, insufficient tissue permeability. Targeted drugs using living cells become an emerging strategy that can take advantage inherent characteristics deal with defects nano systems. Furthermore, themselves be genetically engineered into cellular enhanced immunotherapy. This review provides in‐depth exploration cell‐derived carriers, detailing their properties, functions, commonly used loading strategies. In addition, role modified synergistic effects are also introduced. By summarizing main advancements limitations field, this offers insights potential cell‐based address existing The introduction recent developments evaluation ongoing research will pave way optimization widespread adoption nano/genetically
Язык: Английский
Процитировано
11
Small, Год журнала: 2025, Номер 21(9)
Опубликована: Янв. 19, 2025
Abstract Due to the inherent aseptic and enclosed characteristics of joint cavity, septic arthritis (SA) almost inevitably leads intractable infections rapidly progressing complex pathological environments. Presently, SA faces not only deficient effectiveness gold‐standard systemic antibiotic therapy but also scarcity effective localized targeted approaches standardized animal models. Herein, an ingenious multifunctional nanosystem is designed, which involves methylation hyaluronic acid (HA), copolymerization with DEGDA, loading vancomycin (VAN), then coating fused macrophage‐platelet membrane (denoted as FM@HA@VAN). Upon intra‐articular administration, FM@HA@VAN nanoparticles exhibit sustained retention selectively targeting infected sites, leveraging macrophage‐mediated inflammation homing platelet‐directed bacteria targeting. The acidic microenvironment triggers responsive release vancomycin, leading potent bactericidal effects. Subsequently, exposed HA@VAN are efficiently internalized by activated macrophages, releasing HA alleviate oxidative stress achieve chondroprotection inhibiting pro‐inflammatory cytokines, neutralizing ROS upregulating macrophage M2 polarization. In vivo model experiments confirm efficacy this dual‐targeting antibacterial approach, demonstrating its precision in eradicating bacterial alleviating associated processes, including synovial hyperplasia cartilage erosion. therapeutic nanosystem, coordinated fused‐membranes, holds promise for enhancing treatment SA.
Язык: Английский
Процитировано
2