Nano Research, Год журнала: 2023, Номер 17(4), С. 2451 - 2461
Опубликована: Сен. 30, 2023
Язык: Английский
Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)
Опубликована: Май 30, 2024
Язык: Английский
Процитировано
79
Advanced Functional Materials, Год журнала: 2023, Номер 33(48)
Опубликована: Июль 21, 2023
Abstract Single‐atom nanozymes (SAzymes) are considered as the most promising candidates for natural enzymes due to their atomically dispersed active sites that closely resemble metal centers of counterparts. However, a significant challenge still exists improving catalytic activities, retarding practical applications. Herein, this article presents through application human self‐driven triboelectric device impose electrical stimulus, multiple enzyme‐like activities single‐atom copper nanozyme (Cu‐NC) remarkably improved, thereby boosting cancer cell oxidative damage and death realizing improved therapy. Under an stimulus with 20 V voltage, peroxidase, catalase, oxidase, glutathione oxidase like Cu‐NC all boost generation free radicals. Through calculation, work analyzes how modulates activity via decreasing adsorption energy H 2 O on Cu sites, increasing d xy orbital near Fermi level, shifting d‐band center Cu, facilitating reactions. This opens new perspectives nanoenzymes
Язык: Английский
Процитировано
52
Analytical Chemistry, Год журнала: 2023, Номер 95(44), С. 16383 - 16391
Опубликована: Окт. 26, 2023
The rational design of efficient nanozymes and the immobilization enzymes are great significance for construction high-performance biosensors based on nano-/bioenzyme catalytic systems. Herein, a novel V-TCPP(Fe) metal-organic framework nanozyme with two-dimensional nanosheet morphology is rationally designed by using V2CTx MXene as metal source iron tetrakis(4-carboxyphenyl)porphine (FeTCPP) ligand an organic linker. It exhibits enhanced peroxidase- catalase-like activities luminol-H2O2 chemiluminescent (CL) behavior. Based experimental theoretical results, these excellent enzyme-like derived from two-site synergistic effect between V nodes FeTCPP ligands in V-TCPP(Fe). Furthermore, confined system developed zeolitic imidazole (ZIF) coencapsulation bioenzyme. Using acetylcholinesterase (AChE) model, our constructed V-TCPP(Fe)/AChE@ZIF was successfully used colorimetric/CL dual-mode visual biosensing organophosphorus pesticides. This work expected to provide new insights into systems, encouraging applications catalysis biosensing.
Язык: Английский
Процитировано
46
Nano-Micro Letters, Год журнала: 2024, Номер 16(1)
Опубликована: Фев. 6, 2024
Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.
Язык: Английский
Процитировано
41
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 172, С. 117573 - 117573
Опубликована: Фев. 9, 2024
Nanozymes, enzyme-mimetic nanomaterials that combine features of nanoscale material with the catalytic properties enzymes, have undergone rapid development in recent years. While enzymes remained integral to biosensor technologies for past few decades, potential nanozymes overcome low stability and high production costs biological is turning them into promising candidates. Over decade, been explored a myriad biosensing applications. However, only small subset these efforts has resulted devices platforms are potentially suitable on-site/point-of-care monitoring. To promote this area, review first provides concise overview different paper-based technologies, their architecture functionality, language conducive nanozyme research community. The review, then, critically discusses progress made integration on-site detection food contaminants, environmental pollutants, disease biomarkers. challenges associated transition solution-based biosensors relevant highlighted, strategies those proposed. We envision could narrow gap impeding translation nanozyme-based from laboratories real-world scenarios by encouraging consolidated cross-disciplinary trans-sectoral efforts.
Язык: Английский
Процитировано
23
Advanced Functional Materials, Год журнала: 2024, Номер 34(24)
Опубликована: Фев. 15, 2024
Abstract Thanks to their properties, stability, and multifunctionality, nanozymes are increasingly impacting several fields, including medicine, diagnostics, environmental science. However, clear information about catalytic properties mechanisms is still lacking. Several critical issues currently under discussions, such as the absence of univocally accepted mechanisms, standardized protocols for directly comparing versus enzymes, a comprehensive characterization performance in different chemical/biological environments. All these strongly limit advancement field. Herein, metrology analysis both methodological procedures attempted, taking platinum case study thanks multifunctional features. The oxidoreductase activities Pt‐nanozymes (i.e., peroxidase‐, oxidase‐, catalase‐like reactions) critically investigated physical/chemical environments, clarifying fundamental aspects providing general guidelines nanozyme characterization. Furthermore, PtNP compared with natural enzymes conditions, behavior evaluated by calculating turnover frequency (TOF) normalization strategies. results highlight that efficient catalysts, exhibiting outstanding activity. This work clarifies key points concerning Pt‐nanozyme metrological issues, workflow can become reference characterizations.
Язык: Английский
Процитировано
22
iScience, Год журнала: 2025, Номер 28(2), С. 111763 - 111763
Опубликована: Янв. 7, 2025
Recent years have witnessed tremendous advances in wearable sensors, which play an essential role personalized healthcare for their ability real-time sensing and detection of human health information. Nanozymes, capable mimicking the functions natural enzymes addressing limitations, possess unique advantages such as structural stability, low cost, ease mass production, making them particularly beneficial constructing recognition units biosensors. In this review, we aim to delineate latest advancements nanozymes development biosensors, focusing on key developments nanozyme immobilization strategies, technologies, biomedical applications. The review also highlights current challenges future perspectives. Ultimately, it aims provide insights research endeavors rapidly evolving area.
Язык: Английский
Процитировано
3
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
The traditional biocatalytic precipitation (BCP) strategy often required the participation of H2O2, but H2O2 had problem self-decomposition, which prevented its application in quantitative analysis. This work first found that a bimetallic single-atom catalyst (Co/Zn–N–C SAC) could effectively activate dissolved O2 to produce reactive oxygen species (ROS) due superior oxidase (OXD)-like activity. Experimental investigations demonstrated Co/Zn–N–C SAC preferred highly active hydroxyl radicals (•OH), oxidized 3-amino-9-ethyl carbazole (AEC) reddish-brown insoluble precipitates. Based on this property, unique oxygen-activated photoelectrochemical (PEC) biosensor was developed for chloramphenicol (CAP) detection. Cesium platinum bromide nanocrystals (Cs2PtBr6 NCs) were new type halide perovskite with lead-free, narrow band gaps, and water-oxygen resistance. Cs2PtBr6 NCs showed excellent cathodal PEC performance without an exogenous coreactant used As "proof-of-concept application", introduced onto surface by using CAP dual-aptamer sandwich strategy. activated ROS, AEC precipitates, quenching signal In summary, overcome restriction enzymatic BCP requiring improved stability accuracy analysis, also broadened range coreactant-free perovskite-type biosensors.
Язык: Английский
Процитировано
3
Nanoscale, Год журнала: 2023, Номер 16(1), С. 44 - 60
Опубликована: Ноя. 30, 2023
With the rapid evolution of sensing technologies, integration nanoscale catalysts, particularly those mimicking enzymatic functions, into electrochemical devices has surfaced as a pivotal advancement.
Язык: Английский
Процитировано
33
The Analyst, Год журнала: 2024, Номер 149(5), С. 1416 - 1435
Опубликована: Янв. 1, 2024
The research progress of MOF-based nanozymes with oxidoreductase-like activity.
Язык: Английский
Процитировано
11