Chemical Society Reviews, Год журнала: 2024, Номер 53(17), С. 8847 - 8877
Опубликована: Янв. 1, 2024
Significant advances have been made in materials for biomedical applications, including tissue engineering, bioimaging, cancer treatment,
Язык: Английский
Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown
Опубликована: Авг. 21, 2024
Overcoming tumor apoptosis resistance is a major challenge in enhancing cancer therapy. Pyroptosis, lytic form of programmed cell death (PCD) involving inflammasomes, Gasdermin family proteins, and cysteine proteases, offers potential treatment. While photodynamic therapy (PDT) can induce pyroptosis by generating reactive oxygen species (ROS) through the activation photosensitizers (PSs), many PSs lack specific subcellular targets are limited to first near-infrared window, potentially reducing treatment effectiveness. Therefore, developing effective, deep-penetrating, organelle-targeted pyroptosis-mediated phototherapy essential for strategies. Here, we synthesized four molecules with varying benzene ring numbers thiopyrylium structures preliminarily explore their properties. The near-infrared-II (NIR-II) PS Z1, higher count, exhibited superior ROS generation mitochondria-targeting abilities, large Stokes shift. Through nano-precipitation method, Z1 nanoparticles (NPs) also demonstrated high (especially type-I ROS) upon 808 nm laser irradiation, leading efficient mitochondria dysfunction combined apoptosis. Moreover, they exceptional tumor-targeting ability via NIR-II fluorescence imaging (NIR-II FI) photoacoustic (PAI). Furthermore, NPs-mediated effectively inhibited growth minimal adverse effects. Our findings offer promising strategy therapy, warranting further preclinical investigations PDT.
Язык: Английский
Процитировано
18
Chemical Society Reviews, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The past decades have witnessed great strides in phototherapy as an experimental option or regulation-approved treatment numerous cancer indications.
Язык: Английский
Процитировано
18
Light Science & Applications, Год журнала: 2025, Номер 14(1)
Опубликована: Янв. 2, 2025
Abstract The microenvironment of immunosuppression and low immunogenicity tumor cells has led to unsatisfactory therapeutic effects the currently developed nanoplatforms. Immunogenic cell death, such as pyroptosis ferroptosis, can efficiently boost antitumor immunity. However, exploration nanoplatform for dual function inducers combined immune activators that simultaneously trigger ferroptosis remains limited. Herein, a multifunctional pH-responsive theranostic (M@P) is designed constructed by self-assembly aggregation-induced emission photosensitizer MTCN-3 immunoadjuvant Poly(I: C), which are further encapsulated in amphiphilic polymers. This found have characteristics cancer targeting, pH response, near-infrared fluorescence imaging, lysosome targeting. Therefore, after targeting lysosomes, M@P cause dysfunction through generation reactive oxygen species heat under light irradiation, triggering cells, achieving immunogenic enhancing immunotherapy effect with C). anti-tumor been demonstrated vivo experiment 4T1 tumor-bearing mouse model poor immunogenicity. research would provide an impetus well novel strategy enhanced photoimmunotherapy.
Язык: Английский
Процитировано
7
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated
Язык: Английский
Процитировано
5
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.
Язык: Английский
Процитировано
5
Biomaterials, Год журнала: 2023, Номер 305, С. 122455 - 122455
Опубликована: Дек. 27, 2023
Язык: Английский
Процитировано
37
Advanced Materials, Год журнала: 2023, Номер 36(5)
Опубликована: Ноя. 22, 2023
Phototherapy provides a noninvasive and spatiotemporal controllable paradigm to inhibit the evasion of programmed cell death (PCD) tumors. However, conventional photosensitizers (PSs) often induce single PCD process, resulting in insufficient photodamage severely impeding their application scopes. In this study, molecular engineering is conducted by adjusting electron donors develop an aggregation-induced NIR-II emissive PS (DPITQ) for plasma membrane mitochondria dual-targeted tumor therapy evoking synergetic pyroptosis apoptosis. DPITQ displays boosted type I II reactive oxygen species generation as well high photothermal conversion efficacy (43%) after laser irradiation 635 nm. The excellent biocompatibility appropriate lipophilicity help specifically anchor cancer cells. Furthermore, photosensitized can disrupt intact cause mitochondrial dysfunction, ultimately causing concurrent apoptosis suppress proliferation even under hypoxia. It noteworthy that nanoparticles (NPs) present clear fluorescence imaging capability on venous vessels nude mice. Notably, NPs exert efficient imaging-guided phototherapy both multicellular spheroids vivo, maximum destruction tumors but minimum adverse effects normal tissue.
Язык: Английский
Процитировано
33
Advanced Science, Год журнала: 2023, Номер 11(3)
Опубликована: Ноя. 20, 2023
Abstract Cancer immunotherapy has become a mainstream cancer treatment over traditional therapeutic modes. cells can undergo programmed cell death including ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis which are find to have intrinsic relationships with host antitumor immune response. However, direct use of inducers or regulators may bring about severe side effects that also be rapidly excreted degraded low efficacy. Nanomaterials able carry them for long circulation time, high tumor accumulation controlled release achieve satisfactory effect. Nowadays, large number studies focused on nanomedicines‐based strategies through modulating modalities potentiate immunity. Herein, types their function first summarized, state‐of‐the‐art research progresses in nanomedicines mediated pathways (e.g., cuproptosis) response provocation highlighted. Subsequently, the conclusion outlook potential focus discussed.
Язык: Английский
Процитировано
27
Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 375 - 394
Опубликована: Янв. 9, 2024
Pyroptosis is a specific type of programmed cell death (PCD) characterized by distinct morphological changes, including swelling, membrane blebbing, DNA fragmentation, and eventual lysis. closely associated with human-related diseases, such as inflammation malignancies. Since the initial observation pyroptosis in Shigella flexneri-infected macrophages more than 20 years ago, various pyroptosis-inducing agents, ions, small molecules, biological nanomaterials, have been developed for tumor treatment. Given that can activate body's robust immune response against promote formation long-term memory treatment, its status immunogenic self-evident. Therefore, should be used powerful anti-tumor strategy. However, there still lack comprehensive summary most recent advances pyroptosis-based cancer therapy. it vital to fill this gap inspire future drug design better induce cells undergo achieve advanced effects. In review, we summarize detail triggering adequate clearance based on treatment modalities, highlight material therapeutic advantages. Besides, also provide an outlook prospects emerging field next development.
Язык: Английский
Процитировано
18
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Авг. 3, 2024
Compared with conventional therapies, photoimmunotherapy offers precise targeted cancer treatment minimal damage to healthy tissues and reduced side effects, but its efficacy may be limited by shallow light penetration the potential for tumor resistance. Here, an acceptor-donor-acceptor (A-D-A)-structured nanoaggregate is developed dual phototherapy, including photodynamic therapy (PDT) photothermal (PTT), triggered single near-infrared (NIR) light. Benefiting from strong intramolecular charge transfer (ICT), A-D-A-structured nanoaggregates exhibit broad absorption extending NIR region effectively suppressed fluorescence, which enables deep efficient conversion (η = 67.94%). A suitable HOMO-LUMO distribution facilitates sufficient intersystem crossing (ISC) convert ground-state oxygen (
Язык: Английский
Процитировано
17