Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Atherosclerosis
(AS)
is
a
major
cause
of
cardiovascular
disease
and
characterized
by
high
levels
reactive
oxygen
species
(ROS)
lipid
deposition.
This
study
utilized
ROS-responsive
oxalate
bonds
to
conjugate
simvastatin
(SV)
tertiary
amine-oxide
zwitterionic
polymer
(OPDH),
resulting
in
the
design
nano-prodrug
(OPDH-SV).
In
vitro
experiments
have
proved
that
OPDH-SV
has
excellent
stability
low
toxicity,
can
effectively
reduce
intracellular
ROS
levels,
inhibit
foam
cells
formation.
addition,
able
achieve
cell-to-cell
transmission
through
cell's
"endocytosis-efflux"
mechanism
target
mitochondria.
vivo
further
confirmed
long-term
circulation,
targeted
enrichment,
reduction
vivo.
summary,
good
biosafety
therapeutic
effect,
expected
become
new
type
anti-atherosclerotic
nano-prodrug.
ACS Sensors,
Год журнала:
2024,
Номер
9(9), С. 4898 - 4905
Опубликована: Сен. 5, 2024
Copper
ions,
implicated
in
processes
such
as
oxidative
stress
and
inflammation,
are
believed
to
play
a
crucial
role
cardiovascular
disease,
prevalent
deadly
disease.
Despite
this,
current
diagnostic
methods
fail
detect
early
stage
disease
or
track
copper
ion
accumulation,
limiting
our
understanding
of
the
disease's
progression.
Therefore,
development
noninvasive
techniques
image
ions
is
urgently
needed
enhance
precision
therapeutic
strategies.
In
this
study,
we
report
successful
synthesis
application
ion-activated
photoacoustic
probe,
Antioxidants,
Год журнала:
2023,
Номер
12(12), С. 2022 - 2022
Опубликована: Ноя. 21, 2023
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
progressive
fatal
lung
disease
with
limited
therapeutic
strategy.
Mitochondrial
oxidative
stress
in
macrophages
directly
linked
to
IPF.
Elamipretide(SS-31)
mitochondrion-targeted
peptide
that
has
been
shown
be
safe
and
beneficial
for
multiple
diseases.
However,
whether
SS-31
alleviates
IPF
unclear.
In
the
present
study,
we
used
bleomycin
(BLM)-induced
mouse
model
followed
by
injection
every
other
day
investigate
its
role
explore
possible
mechanism.
Our
results
showed
treatment
significantly
suppressed
BLM-induced
inflammation,
improved
histological
change,
decreased
extracellular
matrix
deposition
inflammatory
cytokines
release.
Impressively,
expression
percentage
of
IL-1β
IL-18
was
downregulated
lower
than
half
treatment.
Mechanistically,
inhibited
IL-33-
or
lipopolysaccharide(LPS)/IL-4-induced
production
suppressing
NOD-like
receptor
thermal
protein
domain
associated
3(NLRP3)
inflammasome
activation.
Nuclear
factor
erythroid
2-related
2(Nrf2)
dramatically
upregulated
along
mitochondrial
function
after
activated
mice.
Conversely,
there
no
significant
change
Nrf2-/-
mice
macrophages.
These
findings
indicated
protected
against
inflammation
inhibiting
Nrf2-mediated
NLRP3
data
provide
initial
evidence
efficacy
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Atherosclerosis
(AS)
is
a
major
cause
of
cardiovascular
disease
and
characterized
by
high
levels
reactive
oxygen
species
(ROS)
lipid
deposition.
This
study
utilized
ROS-responsive
oxalate
bonds
to
conjugate
simvastatin
(SV)
tertiary
amine-oxide
zwitterionic
polymer
(OPDH),
resulting
in
the
design
nano-prodrug
(OPDH-SV).
In
vitro
experiments
have
proved
that
OPDH-SV
has
excellent
stability
low
toxicity,
can
effectively
reduce
intracellular
ROS
levels,
inhibit
foam
cells
formation.
addition,
able
achieve
cell-to-cell
transmission
through
cell's
"endocytosis-efflux"
mechanism
target
mitochondria.
vivo
further
confirmed
long-term
circulation,
targeted
enrichment,
reduction
vivo.
summary,
good
biosafety
therapeutic
effect,
expected
become
new
type
anti-atherosclerotic
nano-prodrug.
