Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 16, 2024
Bovine
mastitis
is
an
infectious
disease
that
causes
substantial
economic
losses
to
the
dairy
industry
worldwide.
Current
antibiotic
therapy
faces
issues
of
misuse
and
antimicrobial
resistance,
which
has
aroused
concerns
for
both
veterinary
human
medicine.
Thus,
this
study
explored
potential
Colo
EVs
(bovine
colostrum-derived
extracellular
vesicles)
address
mastitis.
Using
LPS-induced
murine
mammary
epithelial
cells
(HC11),
mouse
monocyte
macrophages
(RAW
264.7),
a
model
with
BALB/C
mice,
we
evaluated
safety
efficacy
EVs,
in
vivo
vitro.
had
favorable
biosafety
profiles,
promoting
cell
proliferation
migration
without
inducing
pathological
changes
after
injection
into
glands.
In
mastitis,
significantly
reduced
inflammation,
improved
inflammatory
scores,
preserved
tight
junction
proteins
while
protecting
milk
production.
Additionally,
vitro
experiments
demonstrated
downregulated
cytokine
expression,
markers,
attenuated
NF-κB
pathway
activation.
summary,
inferred
have
promise
as
therapeutic
approach
treatment,
owing
their
anti-inflammatory
properties,
potentially
mediated
through
signaling
modulation.
Neonatal
disorders,
particularly
those
resulting
from
prematurity,
pose
a
major
challenge
to
health
care
and
have
significant
impact
on
infant
mortality
long-term
child
health.
The
limitations
of
current
therapeutic
strategies
emphasize
the
need
for
innovative
treatments.
New
cell-free
technologies
utilizing
extracellular
vesicles
(EVs)
offer
compelling
opportunity
neonatal
therapy
by
harnessing
inherent
regenerative
capabilities
EVs.
These
nanoscale
particles,
secreted
variety
organisms
including
animals,
bacteria,
fungi
plants,
contain
repertoire
bioactive
molecules
with
potential.
This
review
aims
provide
comprehensive
assessment
effects
mechanistic
insights
EVs
stem
cells,
biological
fluids
non-animal
sources,
focus
common
conditions
such
as
hypoxic-ischemic
encephalopathy,
respiratory
distress
syndrome,
bronchopulmonary
dysplasia
necrotizing
enterocolitis.
summarizes
evidence
potential
EVs,
analyzes
their
mechanisms
action,
discusses
challenges
associated
implementation
EV-based
therapies
in
clinical
practice.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(10), С. 4526 - 4543
Опубликована: Июнь 28, 2024
Mesenchymal
stem
cell
(MSC)-based
therapies
have
emerged
as
promising
methods
for
regenerative
medicine;
however,
how
to
precisely
enhance
their
tissue
repair
effects
is
still
a
major
question
in
the
field.
Circulating
extracellular
vesicles
(EVs)
from
diseased
states
carry
diverse
pathological
information
and
affect
functions
of
recipient
cells.
Based
on
this
unique
property,
we
report
that
disease-derived
circulating
EV
(disease-EV)
preconditioning
potent
strategy
enhancing
potency
MSCs
disease
models.
Briefly,
plasma
EVs
lung
or
kidney
injuries
were
shown
contain
distinctly
enriched
molecules
induce
injury-specific
gene
expression
responses
cultured
MSCs.
Disease-EV
improved
performance
(including
proliferation,
migration,
growth
factor
production)
through
metabolic
reprogramming
(such
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 10479 - 10496
Опубликована: Окт. 1, 2024
The
skin
regulates
body
processes.
When
damaged,
it
is
prone
to
breeding
bacteria,
causing
inflammation
and
impeding
wound
healing.
There
an
urgent
need
for
new
dressings
that
can
combat
bacteria
aid
in
infectious
repair.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 16, 2024
Bovine
mastitis
is
an
infectious
disease
that
causes
substantial
economic
losses
to
the
dairy
industry
worldwide.
Current
antibiotic
therapy
faces
issues
of
misuse
and
antimicrobial
resistance,
which
has
aroused
concerns
for
both
veterinary
human
medicine.
Thus,
this
study
explored
potential
Colo
EVs
(bovine
colostrum-derived
extracellular
vesicles)
address
mastitis.
Using
LPS-induced
murine
mammary
epithelial
cells
(HC11),
mouse
monocyte
macrophages
(RAW
264.7),
a
model
with
BALB/C
mice,
we
evaluated
safety
efficacy
EVs,
in
vivo
vitro.
had
favorable
biosafety
profiles,
promoting
cell
proliferation
migration
without
inducing
pathological
changes
after
injection
into
glands.
In
mastitis,
significantly
reduced
inflammation,
improved
inflammatory
scores,
preserved
tight
junction
proteins
while
protecting
milk
production.
Additionally,
vitro
experiments
demonstrated
downregulated
cytokine
expression,
markers,
attenuated
NF-κB
pathway
activation.
summary,
inferred
have
promise
as
therapeutic
approach
treatment,
owing
their
anti-inflammatory
properties,
potentially
mediated
through
signaling
modulation.
