Abstract
Albeit
nanozymes‐based
tumor
catalytic
therapy
(NCT)
relies
on
endogenous
chemical
reactions
that
could
achieve
microenvironment
(TME)‐specialized
reactive
oxygen
species
(ROS)
production,
the
unsatisfactory
activity
of
nanozymes
accompanied
by
complex
TME
poses
a
barrier
to
therapeutic
effect
NCT.
Herein,
one‐step
in
situ
synthesis
strategy
is
reported
construct
ternary
Ru/TiO
2−
x
@TiCN
heterojunctions
through
oxidative
conversion
TiCN
nanosheets
(NSs)
TiO
NSs
and
reductive
deposition
Ru
3+
nanoparticles.
The
narrow
bandgap
existence
enhance
ultrasound‐activated
ROS
generation
because
accelerated
electron
transfer
inhibits
electron–hole
pair
recombination.
augmented
production
efficiency
achieved
with
triple
enzyme‐like
activities,
which
amplifies
levels
cascade
manner
decomposition
H
2
O
relieve
hypoxia
heterojunction‐mediated
NCT,
as
well
depletion
overexpressed
glutathione.
satisfactory
effects
are
synergetic
sonodynamic
complete
elimination
tumors
without
recurrence.
This
highlights
potential
semiconductor
enhanced
sonosensitizers
for
efficient
therapy.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Despite
the
promise
of
sonodynamic
therapy
(SDT)-mediated
immunotherapy,
anticancer
efficacy
current
sonosensitizers
is
greatly
limited
by
immunosuppressive
tumor
microenvironment
(TME)
and
their
inability
to
selectively
respond
it.
Herein,
oxygen
vacancy-rich
MnO2@hydroxyapatite
(Ca10(PO4)6(OH)2)
core-shell
nanospheres
(denoted
as
Ov-MO@CPO)
an
advanced
TME-responsive
sonosensitizer
for
immunotherapy
demonstrated.
The
Ov-MO@CPO
maintains
its
structural
integrity
under
neutral
conditions
but
dissolves
pH-sensitive
hydroxyapatite
shell
acidic
TME
release
active
MnO2
core,
which
reinvigorates
H2O2
consumption
hypoxia
alleviation
due
catalase-like
activity.
Furthermore,
introduced
vacancies
optimize
electronic
structure
Ov-MO@CPO,
with
states
near
Fermi
level
higher
d-band
center.
It
results
in
accelerated
electron-hole
pair
separation
lower
catalytic
energy
barriers
boost
ultrasound
(US)-initiated
ROS
production.
These
multimodal
synergistic
effects
effectively
reverse
microenvironment,
inhibiting
growth
metastasis
4T1
tumor-bearing
mice.
No
evident
toxic
are
observed
normal
mouse
tissues.
Additionally,
when
combined
immune
checkpoint
inhibitor,
Ov-MO@CPO-mediated
SDT
further
improves
effectiveness
immunotherapy.
This
work
affords
a
new
avenue
developing
TME-dependent
SDT-mediated
Advanced Materials,
Год журнала:
2023,
Номер
36(9)
Опубликована: Ноя. 7, 2023
Sono-photodynamic
therapy
is
hindered
by
the
limited
tissue
penetration
depth
of
external
light
source
and
quick
recombination
electron-hole
owing
to
random
movement
charge
carriers.
In
this
study,
orthorhombic
ZnSnO
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(52)
Опубликована: Сен. 15, 2023
Abstract
Drugs
treatment
including
antibiotics
or
herbal
medicines
cannot
cure
osteomyelitis
effectively
accompanied
by
drug‐resistance
bacteria
and
even
amputation
after
long‐term
debridement.
Herein,
a
materioherbological
strategy
is
utilized
to
construct
smart
nanovector
of
cationic
starch
(CS)
modified
curcumin
nanoparticles
(CS@Cur
NPs)
for
treating
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
induced
osteomyelitis.
On
the
one
hand,
CS
modification
can
reduce
π–π
accumulation
endow
nanocomposite
with
excellent
water
solubility.
other
hydroxyl
group
in
hydrogen‐bonded
carbonyl
monomer
(methyl
methacrylate,
MMA)
CS,
resulting
decrease
both
bandgap
(between
highest
lowest
occupied
molecular
orbitals,
labeled
as
Δ
E
)
S
1
–T
energy
gap
(Δ
S‐T
while
spin–orbital
coupling
(SOC)
values
increase,
which
benefits
formation
triplet‐state
molecules
under
ultrasonic
irradiation,
significantly
improving
yields
reactive
oxygen
species
(ROS)
capacity.
The
CS@Cur
NPs
constructed
this
paper
produced
large
number
ROS
synergic
targeting
effects
continuous
15
min
clearance
rate
MRSA
infection
rats
be
high
99.93%.
This
study
provides
new
therapeutic
pathogenic
bacteria.
Abstract
Albeit
nanozymes‐based
tumor
catalytic
therapy
(NCT)
relies
on
endogenous
chemical
reactions
that
could
achieve
microenvironment
(TME)‐specialized
reactive
oxygen
species
(ROS)
production,
the
unsatisfactory
activity
of
nanozymes
accompanied
by
complex
TME
poses
a
barrier
to
therapeutic
effect
NCT.
Herein,
one‐step
in
situ
synthesis
strategy
is
reported
construct
ternary
Ru/TiO
2−
x
@TiCN
heterojunctions
through
oxidative
conversion
TiCN
nanosheets
(NSs)
TiO
NSs
and
reductive
deposition
Ru
3+
nanoparticles.
The
narrow
bandgap
existence
enhance
ultrasound‐activated
ROS
generation
because
accelerated
electron
transfer
inhibits
electron–hole
pair
recombination.
augmented
production
efficiency
achieved
with
triple
enzyme‐like
activities,
which
amplifies
levels
cascade
manner
decomposition
H
2
O
relieve
hypoxia
heterojunction‐mediated
NCT,
as
well
depletion
overexpressed
glutathione.
satisfactory
effects
are
synergetic
sonodynamic
complete
elimination
tumors
without
recurrence.
This
highlights
potential
semiconductor
enhanced
sonosensitizers
for
efficient
therapy.
