Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Cuproptosis
that
utilizes
copper
ionophore
to
induce
programmed
cell
death
holds
promise
for
enhancing
the
effectiveness
of
conventional
anticancer
therapies
and
triggering
efficient
adaptive
immune
responses.
However,
non-tumor-specific
release
Cu
ions
can
cuproptosis
cause
irreversible
damage
normal
tissues.
To
maximize
therapeutic
effects
tumor-specific
cuproptosis,
this
work
reports
first
time
regulation
degradation
behaviors
Cu-based
nanomaterials
using
graphene
quantum
dots
(GQDs)
as
a
protection
layer.
The
deposition
GQDs
not
only
avoids
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(21)
Опубликована: Янв. 30, 2024
Abstract
Rescuing
dental
implants
from
plaque‐induced
infection
and
implementing
effective
plaque
control
methods
in
a
limited
oral
environment
pose
challenges
for
modern
dentistry.
To
address
this
issue,
Al
ion
doped
strontium
titanate/titanium
dioxide
nanotubes
(Al‐SrTiO
3
/TiO
2
nanotubes,
Al‐STNT)
are
designed
as
an
ultrasound‐responsive
nanocoating
immobilized
on
the
Ti
implant
surface.
Introducing
3+
ions
into
inorganic
sonosensitive
SrTiO
heterojunction
induces
oxygen
vacancies
disrupts
lattice
of
.
By
overcoming
bandgap
barrier
through
ultrasonic
stimulated
piezoelectric
effect,
Al‐STNT
produces
more
reactive
species
(ROS).
In
sonodynamic
therapy
(SDT)
process,
stimulus
abundant
ROS
efficiently
disrupting
bacteria
biofilm
inhibiting
metabolism.
Moreover,
specific
nanoscale
coating
endows
with
osteogenic
activity,
facilitating
formation
rigid
osseointegration
between
surface
alveolar
bone.
mimicking
human
rats,
demonstrates
optimal
postimplant
while
retaining
its
antibacterial
ability
sonosensitizer.
Thanks
to
portability
ultrasound
instrument
stability
implant‐based
sonosensitizer,
strategy
presents
attractive
option
patients
self‐treat
secure
long‐term
success
their
implants.
Different
from
the
direct
delivery
of
chemodynamic
agents
into
tumor
tissue
for
therapy
(CDT),
this
work
reports
fabrication
heterojunction
sonosensitizers
(CD/TiSe
2
)
in
situ
generation
by
responding
to
microenvironment
(TME),
realizing
CDT‐enhanced
sono‐immunotherapy.
The
redox
TiSe
acidic
TME
leads
formation
TiO
x
Se
2−
containing
(0),
selenate,
and
Ti
3+
/Ti
4+
couple,
which
can
facilitate
CDT
through
a
‐mediated
Fenton‐like
reaction
consume
overexpressed
glutathione
(GSH)
via
GSH
depletion.
Moreover,
ions
generated
process
promote
maturation
dendritic
cells,
consequently
activating
adaptive
immune
responses.
In
another
aspect,
construction
heterojunctions
within
carbon
dots
improves
reactive
oxygen
species
(ROS)
efficiency
cascaded
manner,
enhances
sonodynamic
activity
amplifies
performance.
More
importantly,
ROS
produced
efficiently
triggers
immunogenic
cell
death
synergistic
based
on
elicitation
antitumor
immunity
with
aid
an
checkpoint
blockade.
This
thus
provides
distinct
paradigm
transition
metal
selenide‐originated
agent
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 12, 2024
Improving
reaction
selectivity
is
the
next
target
for
nanozymes
to
mimic
natural
enzymes.
Currently,
majority
of
strategies
in
this
field
are
exclusively
applicable
metal-organic-based
or
organic-based
nanozymes,
while
limited
regulating
metal
oxide-based
semiconductor
nanozymes.
Herein,
taking
Co
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 23, 2024
Low-intensity
ultrasound-mediated
sonodynamic
therapy
(SDT),
which,
by
design,
integrates
sonosensitizers
and
molecular
oxygen
to
generate
therapeutic
substances
(e.g.,
toxic
hydroxyl
radicals,
superoxide
anions,
or
singlet
oxygen)
at
disease
sites,
has
shown
enormous
potential
for
the
effective
treatment
of
a
variety
diseases.
Nanoscale
play
crucial
role
in
SDT
process
because
their
structural,
compositional,
physicochemical,
biological
characteristics
are
key
determinants
efficacy.
In
particular,
advances
materials
science
nanotechnology
have
invigorated
series
optimization
strategies
augmenting
efficacy
nanosonosensitizers.
This
comprehensive
review
systematically
summarizes,
discusses,
highlights
state-of-the-art
studies
on
current
achievements
nanosonosensitizer
enhanced
treatment,
with
an
emphasis
general
design
principles
nanosonosensitizers
strategies,
mainly
including
organic
inorganic
Additionally,
recent
advancements
optimized
applications
aimed
treating
various
diseases,
such
as
cancer,
bacterial
infections,
atherosclerosis,
autoimmune
clarified
detail.
Furthermore,
effects
improved
versatile
thoroughly
discussed.
The
concludes
highlighting
challenges
future
opportunities
this
rapidly
evolving
research
field
expedite
its
practical
clinical
translation
application.
ACS Nano,
Год журнала:
2024,
Номер
18(34), С. 23579 - 23598
Опубликована: Авг. 16, 2024
Considering
the
profound
impact
of
structure
on
heterojunction
catalysts,
rational
design
emerging
catalysts
with
optimized
energy
band
structures
is
required
for
antitumor
efficiency.
Herein,
we
select
titanium
nitride
(TiN)
and
Pt
to
develop
a
multifunctional
Schottky
named
Pt/H-TiN&SRF
(PHTS)
nanoparticles
(NPs)
narrowed
bandgap
accomplish
"four
birds
one
stone"
involving
enzyo/sono/photo
three
modals
additional
ferroptosis.
The
The
generally
undesirable
bandgap
and
electron-hole
complexation
of
inorganic
sonosensitizers
limit
the
efficiency
reactive
oxygen
species
(ROS)
generation,
affecting
effectiveness
sonodynamic
therapy
(SDT).
Comparatively,
novel
polyvinylpyrrolidone-modified
copper
bismuthate
(PCBO)
are
manufactured
for
a
"three-step"
SDT
promotion.
In
brief,
first,
strong
hybridization
between
Bi
6s
O
2p
orbitals
in
PCBO
narrows
(1.83
eV),
facilitating
rapid
transfer
charge
carriers.
Additionally,
nonequivalent
[CuO
Abstract
Albeit
nanozymes‐based
tumor
catalytic
therapy
(NCT)
relies
on
endogenous
chemical
reactions
that
could
achieve
microenvironment
(TME)‐specialized
reactive
oxygen
species
(ROS)
production,
the
unsatisfactory
activity
of
nanozymes
accompanied
by
complex
TME
poses
a
barrier
to
therapeutic
effect
NCT.
Herein,
one‐step
in
situ
synthesis
strategy
is
reported
construct
ternary
Ru/TiO
2−
x
@TiCN
heterojunctions
through
oxidative
conversion
TiCN
nanosheets
(NSs)
TiO
NSs
and
reductive
deposition
Ru
3+
nanoparticles.
The
narrow
bandgap
existence
enhance
ultrasound‐activated
ROS
generation
because
accelerated
electron
transfer
inhibits
electron–hole
pair
recombination.
augmented
production
efficiency
achieved
with
triple
enzyme‐like
activities,
which
amplifies
levels
cascade
manner
decomposition
H
2
O
relieve
hypoxia
heterojunction‐mediated
NCT,
as
well
depletion
overexpressed
glutathione.
satisfactory
effects
are
synergetic
sonodynamic
complete
elimination
tumors
without
recurrence.
This
highlights
potential
semiconductor
enhanced
sonosensitizers
for
efficient
therapy.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
An
uncomplicated
template
method
was
employed
to
produce
sulfur
vacancies
(V
S
)-doped
hollow
Co
9
8
nanocages
(Co
8−
x
)
endow
a
single-component
nanomaterial
with
simultaneous
catalytic
activity
and
NIR-II
photothermal
property.
ACS Nano,
Год журнала:
2024,
Номер
18(43), С. 29522 - 29534
Опубликована: Окт. 18, 2024
Nanozymes
have
demonstrated
significant
potential
as
promising
alternatives
to
natural
enzymes
in
biomedical
applications.
However,
their
lower
catalytic
activity
compared
that
of
has
limited
practical
utility.
Addressing
this
challenge
necessitates
the
development
innovative
enzymatic
systems
capable
achieving
specific
levels
enzymes.
In
study,
we
focus
on
enhancing
performance
nanozymes
by
introducing
Ru
atoms
into
single-atom-thick
A
layer
V2SnC
MAX
phase,
resulting
formation
V2(Sn0.8Ru0.2)C
with
single-atom
sites.
The
phase
an
exceptional
peroxidase-like
up
1792.6
U
mg-1,
surpassing
a
previously
reported
horseradish
peroxidase
(HRP).
Through
X-ray
photoelectron
spectroscopy
(XPS)
and
density
functional
theory
(DFT)
investigations,
it
been
revealed
both
V2C
atom
layers
Sn
readily
accept
negative
charge
from
Ru,
leading
reduction
energy
barrier
for
H2O2
adsorption.
This
discovery
enabled
successful
application
lateral
flow
immunoassay
heart
failure
biomarkers,
detection
sensitivity
4
pg
mL-1.
Additionally,
broad-spectrum
antibacterial
efficacy.
study
lays
groundwork
precise
design
phase-based
high
activity,
offering
viable
alternative
various
Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Авг. 1, 2024
Bacterial-derived
micro-/nanomedicine
has
garnered
considerable
attention
in
anticancer
therapy,
owing
to
the
unique
natural
features
of
bacteria,
including
specific
targeting
ability,
immunogenic
benefits,
physicochemical
modifiability,
and
biotechnological
editability.
Besides,
bacterial
components
have
also
been
explored
as
promising
drug
delivery
vehicles.
Harnessing
these
features,
cutting-edge
biotechnologies
applied
attenuated
tumor-targeting
bacteria
with
properties
or
functions
for
potent
effective
cancer
treatment,
strategies
gene-editing
genetic
circuits.
Further,
advent
bacteria-inspired
micro-/nanorobots
mimicking
artificial
systems
furnished
fresh
perspectives
formulating
developing
highly
efficient
systems.
Focusing
on
advantages
this
review
delves
into
advances
bacteria-derived
treatment
recent
years,
which
experienced
a
process
from
living
entities
Meanwhile,
summary
relative
clinical
trials
is
provided
primary
challenges
impeding
their
application
are
discussed.
Furthermore,
future
directions
suggested
combat
cancer.
