Multifunctional Mesoporous Polydopamine‐Based Systematic Delivery of STING Agonist for Enhanced Synergistic Photothermal‐Immunotherapy

Advanced Functional Materials, Год журнала: 2023, Номер 34(1)

Опубликована: Сен. 15, 2023

Abstract The therapeutic application of STING agonists in various malignancies has been limited by factors such as the inability systemic administration and immunosuppressive tumor microenvironment. Herein, this work reports a mesoporous polydopamine‐based multifunctional nanoplatform loaded with agonist MSA‐2 chelated Mn 2+ for synergistic photothermal activation‐based immunotherapy. effectively delivers to site intelligently releases its contents through acid degradation, facilitated effect. Additionally, thermal ablation tissue can induce immunogenic cell death, which helps alleviate microenvironment, thereby enhancing efficacy MSA‐2. Furthermore, works dual‐acting sensitizer MRI contrast agent not only boosts immune response but also allows real‐time tracking nanoplatform. This strategy is proved highly efficacious both impeding primary/metastatic eliciting robust tumor‐specific response. Collectively, an effective delivery synergized therapy pathway activation‐mediated immunotherapy highlighted here provide new ideas strategies optimizing combination cancer treatment.

Язык: Английский

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Afterglow bio-applications by utilizing triplet excited states of organic materials

Science China Chemistry, Год журнала: 2023, Номер 66(11), С. 2930 - 2940

Опубликована: Окт. 23, 2023

Язык: Английский

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Leveraging Semiconducting Polymer Nanoparticles for Combination Cancer Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 36(1)

Опубликована: Окт. 21, 2023

Abstract Cancer immunotherapy has become a promising method for cancer treatment, bringing hope to advanced patients. However, immune‐related adverse events caused by also bring heavy burden Semiconducting polymer nanoparticles (SPNs) as an emerging nanomaterial with high biocompatibility, can eliminate tumors and induce tumor immunogenic cell death through different therapeutic modalities, including photothermal therapy, photodynamic sonodynamic therapy. In addition, SPNs work functional nanocarrier synergize variety of immunomodulators amplify anti‐tumor immune responses. this review, SPNs‐based combination is comprehensively summarized according the SPNs’ modalities type loaded immunomodulators. The in‐depth understanding existing will hopefully inspire design more novel nanomaterials potent effects, ultimately promote their clinical translation.

Язык: Английский

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Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy

Biomarker Research, Год журнала: 2024, Номер 12(1)

Опубликована: Янв. 7, 2024

Abstract The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing crucial role in improving antitumor immunity through effector responses. Targeting the holds promise for overcoming immunosuppressive tumor microenvironments (TME) and promoting effective elimination. However, systemic administration current STING agonists faces challenges related to low bioavailability potential adverse effects, thus limiting their clinical applicability. Recently, nanotechnology-based strategies have been developed modulate TMEs robust immunotherapeutic encapsulation delivery within nanoparticles (STING-NPs) present an attractive avenue immunotherapy. This review explores range designed encapsulate agonists, highlighting benefits, including favorable biocompatibility, improved penetration, efficient intracellular agonists. also summarizes immunomodulatory impacts STING-NPs on TME, enhanced secretion pro-inflammatory cytokines chemokines, dendritic cell activation, cytotoxic T priming, macrophage re-education, vasculature normalization. Furthermore, offers insights into co-delivered nanoplatforms involving alongside agents such chemotherapeutic compounds, checkpoint inhibitors, antigen peptides, other adjuvants. These platforms demonstrate remarkable versatility inducing immunogenic responses ultimately amplifying

Язык: Английский

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Exosome‐Inhibiting Polymeric Sonosensitizer for Tumor‐Specific Sonodynamic Immunotherapy

Advanced Materials, Год журнала: 2024, Номер 36(25)

Опубликована: Март 6, 2024

Combination cancer immunotherapy based on electromagnetic energy and shows potent anti-cancer efficacy. However, as a factor that mediates tumor metastasis immune suppression, the impact of exosomes therapy under stimulation remains unclear. Herein, findings indicate sonodynamic (SDT) increases serum exosome levels by inducing apoptotic loosening extracellular matrix, promoting lung metastasis. To address this problem, an exosome-inhibiting polymeric sonosensitizer (EIPS) selectively inhibiting generation in response to biomarker is synthesized. EIPS consists semiconducting polymer backbone capable SDT poly(ethylene glycol) layer conjugated with tumor-specific enzyme-responsive inhibitor prodrug. After being cleaved Cathepsin B, releases active inhibitors, preventing exosome-mediated suppression As result, elicits robust antitumor effects through synergistic effect inhibition, completely establishing long-term memory effect. This first example showing combining inhibition can elicit without help typical agonists.

Язык: Английский

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Sono‐Triggered Cascade Lactate Depletion by Semiconducting Polymer Nanoreactors for Cuproptosis‐Immunotherapy of Pancreatic Cancer

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(30)

Опубликована: Май 6, 2024

Abstract The high level of lactate in tumor microenvironment not only promotes development and metastasis, but also induces immune escape, which often leads to failures various therapy strategies. We here report a sono‐triggered cascade depletion strategy by using semiconducting polymer nanoreactors (SPN LCu ) for cancer cuproptosis‐immunotherapy. SPN mainly contain as sonosensitizer, oxidase (LOx) conjugated via reactive oxygen species (ROS)‐cleavable linker chelated Cu 2+ . Upon ultrasound (US) irradiation, the generates singlet ( 1 O 2 cut ROS‐cleavable allow release LOx that catalyzes produce hydrogen peroxide (H ). will be reduced + microenvironment, reacts with produced H obtain hydroxyl radical (⋅OH) further improves destroying linkers. As such, achieves effective depletion, thus relieving immunosuppressive roles lactate. Moreover, toxic cuproptosis cause immunogenic cell death (ICD) activating antitumor immunological effect. are used treat both subcutaneous deep‐tissue orthotopic pancreatic observably enhanced efficacy restricting growths. This study provides precise tactic therapy.

Язык: Английский

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Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.

Язык: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Язык: Английский

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The emergence of cancer sono-immunotherapy

Trends in Immunology, Год журнала: 2024, Номер 45(7), С. 549 - 563

Опубликована: Июнь 23, 2024

Язык: Английский

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Biomimetic Dual‐Driven Heterojunction Nanomotors for Targeted Catalytic Immunotherapy of Glioblastoma

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 9, 2024

Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.

Язык: Английский

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