Multifunctional PtCuTe Nanosheets with Strong ROS Scavenging and ROS‐Independent Antibacterial Properties Promote Diabetic Wound Healing

Advanced Materials, Год журнала: 2023, Номер 36(8)

Опубликована: Сен. 19, 2023

Abstract Nanozymes, as one of the most efficient reactive oxygen species (ROS)‐scavenging biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite recent attempts at improving catalytic efficiency Pt‐based nanozymes (e.g., PtCu, best systems), they still display quite limited ROS scavenging capacity and ROS‐dependent antibacterial effects on bacteria or immunocytes, which leads to uncontrolled poor Hence, a new class multifunctional PtCuTe nanosheets with excellent catalytic, ROS‐independent antibacterial, proangiogenic, anti‐inflammatory, immuno‐modulatory properties for boosting healing, is reported. The show stronger better than PtCu. It also revealed that can enhance vascular tube formation, stimulate macrophage polarization toward M2 phenotype improve fibroblast mobility, outperforming conventional Moreover, promotes crosstalk between different cell types form positive feedback loop. Consequently, stimulates proregenerative environment relevant populations ensure normal tissue repair. Utilizing mouse model, it demonstrated significantly facilitated regeneration highly vascularized skin, percentage closure being over 90% 8th day, among reported comparable biomaterials.

Язык: Английский

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Chlorella‐Loaded Antibacterial Microneedles for Microacupuncture Oxygen Therapy of Diabetic Bacterial Infected Wounds

Advanced Materials, Год журнала: 2024, Номер 36(15)

Опубликована: Фев. 2, 2024

Abstract Hypoxia and infection are urgent clinical problems in chronic diabetic wounds. Herein, living Chlorella ‐loaded poly(ionic liquid)‐based microneedles (PILMN‐Chl) constructed for microacupuncture oxygen antibacterial therapy against methicillin‐resistant Staphylococcus aureus (MRSA)‐infected The PILMN‐Chl can stably continuously produce more than 30 h due to the photosynthesis of loaded self‐supported . By combining barrier penetration capabilities microneedles, continuous sufficient supply , sterilization activities PIL, accelerate wounds vivo by topical targeted hypoxia relief deep parts Thus, self‐oxygen produced modality may provide a promising facile therapeutic strategy treating chronic, hypoxic, infected

Язык: Английский

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An in situ dressing material containing a multi‐armed antibiotic for healing irregular wounds

Aggregate, Год журнала: 2024, Номер 5(3)

Опубликована: Янв. 4, 2024

Abstract Acute and infected wounds resulting from accidents, battlefield trauma, or surgical interventions have become a global healthcare burden due to the complex bacterial infection environment. However, conventional gauze dressings present insufficient contact with irregular lack antibacterial activity against multi‐drug‐resistant bacteria. In this study, we develop in situ nanofibrous tailored fit of various shapes sizes while providing nanoscale comfort excellent properties. Our approach involves fabrication these using handheld electrospinning device that allows for direct deposition nanofiber onto specific wound sites, perfect conformal closure without any mismatch 2 min. The are loaded multi‐armed antibiotics exhibit outstanding Staphylococcus aureus ( S. ) methicillin‐resistant . Compared vancomycin, dressing shows great performance up 98% vitro vivo experiments demonstrate ability prevent infection, greatly alleviate inflammation, promote healing. findings highlight potential personalized clinical applications, including emergency, accident, treatment.

Язык: Английский

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Gold nanoclusters encapsulated microneedle patches with antibacterial and self‐monitoring capacities for wound management

Aggregate, Год журнала: 2024, Номер 5(3)

Опубликована: Янв. 25, 2024

Abstract The management of infected wounds is always great significance and urgency in clinical biomedical fields. Recent efforts this area are focusing on the development functional wound patches with effective antibacterial, drug delivery, sensor properties. Here, we present novel hyaluronic acid (HA) microneedle these features by encapsulating aminobenzeneboronic acid‐modified gold nanoclusters (A‐GNCs) for management. A‐GNCs loaded were derived from negative‐mold replication showed high mechanical strength to penetrate skin. release was realized degradation HA, self‐monitor released actives based dynamic bright orange fluorescence emitted under ultraviolet radiation. As could destroy bacteria membranes, excellent vitro antibiosis ability. Based features, have demonstrated inhibition, residual self‐monitoring, healing promotion abilities Escherichia coli‐ or Staphylococcus aureus ‐infected These results indicated potential such applications.

Язык: Английский

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Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 296, С. 139685 - 139685

Опубликована: Янв. 10, 2025

Язык: Английский

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Anisotropic Shape‐Memory Cryogel with Oriented Macroporous Channel for Hemorrhage Control and Tissue Generation

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Abstract Injectable shape‐memory materials represent a promising solution for managing severe bleeding from deep, inaccessible wounds. However, many existing expandable hemostats consist of randomly porous networks and often exhibit inadequate liquid absorption, non‐degradability, potential cytotoxicity, which limits their effectiveness in hemostasis wound repair. To overcome these challenges, this study introduces an anisotropic hemostatic cryogel, SALC, featuring oriented macroporous channels made biocompatible polymers (poly(ethylene glycol), gelatin, lignin) through simple one‐step cryo‐structuration process. This structural alignment provides the cryogel with low water flow resistance, efficient fluid transport, rapid shape recovery. SALC demonstrates superior adsorption retention, vitro tamponade sealing, pro‐coagulant properties compared to commercial gelatin sponges XSTAT, along favorable biocompatibility biodegradability. The efficacy surpasses clinically used counterparts rat models liver perforation femoral artery transection. Remarkably, achieves effective porcine hepatic, artery, cardiac injuries. Additionally, supports tissue regeneration by promoting cell migration angiogenesis while mitigating inflammatory responses. is also lightweight easy carry implement. Overall, shows clinical applications treating hemorrhages improving healing.

Язык: Английский

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Enhancing angiogenesis: Innovative drug delivery systems to facilitate diabetic wound healing

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 170, С. 116035 - 116035

Опубликована: Дек. 19, 2023

Diabetic wounds (DW) constitute a substantial burden on global healthcare owing to their widespread occurrence as complication of diabetes. Angiogenesis, crucial process, plays pivotal role in tissue recovery by supplying essential oxygen and nutrients the injury site. Unfortunately, diabetes mellitus, various factors disrupt angiogenesis, hindering wound healing. While biomaterials designed enhance angiogenesis hold promise for treatment DWs, there is an urgent need more in-depth investigations fully unlock potential clinical management. In this review, we explore intricate mechanisms that are DW recovery. We introduce rational design angiogenesis-enhancing drug delivery systems (DDS) provide comprehensive summary discussion diverse facilitating Lastly, address emerging challenges prospects DDS healing, aiming offer understanding critical issue solutions.

Язык: Английский

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Multifunctional Microneedle Patch Based on Metal-Phenolic Network with Photothermal Antimicrobial, ROS Scavenging, Immunomodulatory, and Angiogenesis for Programmed Treatment of Diabetic Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(26), С. 33205 - 33222

Опубликована: Июнь 25, 2024

In diabetic patients with skin injuries, bacterial proliferation, accumulation of reactive oxygen species (ROS) in the tissues, and impaired angiogenesis make wound healing difficult. Therefore, eliminating bacteria, removing ROS, promoting are necessary for treating acute wounds. this study, benefiting from ability polyphenols to form a metal-phenolic network (MPN) metal ions, TA-Eu MPN nanoparticles (TM NPs) were synthesized. The prepared photothermal agent CuS NPs TM then loaded onto supporting base needle tips PVA/HA (PH) microneedles, respectively, obtain PH/CuS/TM microneedles. Antibacterial experiments showed that microneedles could remove bacteria by effect. vitro effectively scavenge inhibit macrophage polarization M1 type, induce M2 type as well have promote vascular endothelial cell migration angiogenesis. Furthermore, vivo accelerated inhibiting pro-inflammatory cytokines rat model. efficient antibacterial, ROS scavenging, anti-inflammatory, immunomodulatory, angiogenic abilities hold promise dressings

Язык: Английский

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Antioxidant and Immunomodulatory Polymer Vesicles for Effective Diabetic Wound Treatment through ROS Scavenging and Immune Modulating

Nano Letters, Год журнала: 2024, Номер 24(31), С. 9494 - 9504

Опубликована: Июль 26, 2024

Chronic diabetic wound patients usually show high glucose levels and systemic immune disorder, resulting in reactive oxygen species (ROS) cell dysfunction, prolonged inflammation, delayed healing. Herein, we prepared an antioxidant immunomodulatory polymer vesicle for treatment. This is self-assembled from poly(ε-caprolactone)36-block-poly[lysine4-stat-(lysine-mannose)22-stat-tyrosine)16] ([PCL36-b-P[Lys4-stat-(Lys-Man)22-stat-Tyr16]). Polytyrosine polypeptide that can scavenge ROS. d-Mannose was introduced to afford functions by promoting macrophage transformation Treg activation through inhibitory cytokines. The mice treated with vesicles showed 23.7% higher a 91.3% M2/M1 ratio than those PBS. Animal tests confirmed this accelerated healing achieved complete of S. aureus-infected wounds within 8 days. Overall, the first scavenging ROS regulating homeostasis, opening new avenues effective

Язык: Английский

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Functional biomacromolecules-based microneedle patch for the treatment of diabetic wound

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131650 - 131650

Опубликована: Апрель 16, 2024

Язык: Английский

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