Abstract
Wounds
and
the
subsequent
formation
of
scars
constitute
a
unified
complex
phased
process.
Effective
treatment
is
crucial;
however,
diverse
therapeutic
approaches
for
different
wounds
scars,
as
well
varying
needs
at
stages,
present
significant
challenges
in
selecting
appropriate
interventions.
Microneedle
patch
(MNP),
novel
minimally
invasive
transdermal
drug
delivery
system,
has
potential
integrated
programmed
various
diseases
shown
promising
applications
types
scars.
In
this
comprehensive
review,
latest
biotechnological
innovations
MNPs
these
fields
are
thoroughly
explored,
summarizing
their
powerful
abilities
to
accelerate
healing,
inhibit
scar
formation,
manage
related
symptoms.
Moreover,
scenarios
discussed.
Additionally,
side
effects,
manufacturing
processes,
material
selection
explore
clinical
translational
investigated.
This
groundwork
can
provide
theoretical
basis
serve
catalyst
future
pursuit
favorable
options
skin
tissue
regeneration.
Advanced Materials,
Год журнала:
2023,
Номер
36(8)
Опубликована: Сен. 19, 2023
Abstract
Nanozymes,
as
one
of
the
most
efficient
reactive
oxygen
species
(ROS)‐scavenging
biomaterials,
are
receiving
wide
attention
in
promoting
diabetic
wound
healing.
Despite
recent
attempts
at
improving
catalytic
efficiency
Pt‐based
nanozymes
(e.g.,
PtCu,
best
systems),
they
still
display
quite
limited
ROS
scavenging
capacity
and
ROS‐dependent
antibacterial
effects
on
bacteria
or
immunocytes,
which
leads
to
uncontrolled
poor
Hence,
a
new
class
multifunctional
PtCuTe
nanosheets
with
excellent
catalytic,
ROS‐independent
antibacterial,
proangiogenic,
anti‐inflammatory,
immuno‐modulatory
properties
for
boosting
healing,
is
reported.
The
show
stronger
better
than
PtCu.
It
also
revealed
that
can
enhance
vascular
tube
formation,
stimulate
macrophage
polarization
toward
M2
phenotype
improve
fibroblast
mobility,
outperforming
conventional
Moreover,
promotes
crosstalk
between
different
cell
types
form
positive
feedback
loop.
Consequently,
stimulates
proregenerative
environment
relevant
populations
ensure
normal
tissue
repair.
Utilizing
mouse
model,
it
demonstrated
significantly
facilitated
regeneration
highly
vascularized
skin,
percentage
closure
being
over
90%
8th
day,
among
reported
comparable
biomaterials.
Advanced Materials,
Год журнала:
2024,
Номер
36(15)
Опубликована: Фев. 2, 2024
Abstract
Hypoxia
and
infection
are
urgent
clinical
problems
in
chronic
diabetic
wounds.
Herein,
living
Chlorella
‐loaded
poly(ionic
liquid)‐based
microneedles
(PILMN‐Chl)
constructed
for
microacupuncture
oxygen
antibacterial
therapy
against
methicillin‐resistant
Staphylococcus
aureus
(MRSA)‐infected
The
PILMN‐Chl
can
stably
continuously
produce
more
than
30
h
due
to
the
photosynthesis
of
loaded
self‐supported
.
By
combining
barrier
penetration
capabilities
microneedles,
continuous
sufficient
supply
,
sterilization
activities
PIL,
accelerate
wounds
vivo
by
topical
targeted
hypoxia
relief
deep
parts
Thus,
self‐oxygen
produced
modality
may
provide
a
promising
facile
therapeutic
strategy
treating
chronic,
hypoxic,
infected
Abstract
Acute
and
infected
wounds
resulting
from
accidents,
battlefield
trauma,
or
surgical
interventions
have
become
a
global
healthcare
burden
due
to
the
complex
bacterial
infection
environment.
However,
conventional
gauze
dressings
present
insufficient
contact
with
irregular
lack
antibacterial
activity
against
multi‐drug‐resistant
bacteria.
In
this
study,
we
develop
in
situ
nanofibrous
tailored
fit
of
various
shapes
sizes
while
providing
nanoscale
comfort
excellent
properties.
Our
approach
involves
fabrication
these
using
handheld
electrospinning
device
that
allows
for
direct
deposition
nanofiber
onto
specific
wound
sites,
perfect
conformal
closure
without
any
mismatch
2
min.
The
are
loaded
multi‐armed
antibiotics
exhibit
outstanding
Staphylococcus
aureus
(
S.
)
methicillin‐resistant
.
Compared
vancomycin,
dressing
shows
great
performance
up
98%
vitro
vivo
experiments
demonstrate
ability
prevent
infection,
greatly
alleviate
inflammation,
promote
healing.
findings
highlight
potential
personalized
clinical
applications,
including
emergency,
accident,
treatment.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Abstract
Injectable
shape‐memory
materials
represent
a
promising
solution
for
managing
severe
bleeding
from
deep,
inaccessible
wounds.
However,
many
existing
expandable
hemostats
consist
of
randomly
porous
networks
and
often
exhibit
inadequate
liquid
absorption,
non‐degradability,
potential
cytotoxicity,
which
limits
their
effectiveness
in
hemostasis
wound
repair.
To
overcome
these
challenges,
this
study
introduces
an
anisotropic
hemostatic
cryogel,
SALC,
featuring
oriented
macroporous
channels
made
biocompatible
polymers
(poly(ethylene
glycol),
gelatin,
lignin)
through
simple
one‐step
cryo‐structuration
process.
This
structural
alignment
provides
the
cryogel
with
low
water
flow
resistance,
efficient
fluid
transport,
rapid
shape
recovery.
SALC
demonstrates
superior
adsorption
retention,
vitro
tamponade
sealing,
pro‐coagulant
properties
compared
to
commercial
gelatin
sponges
XSTAT,
along
favorable
biocompatibility
biodegradability.
The
efficacy
surpasses
clinically
used
counterparts
rat
models
liver
perforation
femoral
artery
transection.
Remarkably,
achieves
effective
porcine
hepatic,
artery,
cardiac
injuries.
Additionally,
supports
tissue
regeneration
by
promoting
cell
migration
angiogenesis
while
mitigating
inflammatory
responses.
is
also
lightweight
easy
carry
implement.
Overall,
shows
clinical
applications
treating
hemorrhages
improving
healing.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 116035 - 116035
Опубликована: Дек. 19, 2023
Diabetic
wounds
(DW)
constitute
a
substantial
burden
on
global
healthcare
owing
to
their
widespread
occurrence
as
complication
of
diabetes.
Angiogenesis,
crucial
process,
plays
pivotal
role
in
tissue
recovery
by
supplying
essential
oxygen
and
nutrients
the
injury
site.
Unfortunately,
diabetes
mellitus,
various
factors
disrupt
angiogenesis,
hindering
wound
healing.
While
biomaterials
designed
enhance
angiogenesis
hold
promise
for
treatment
DWs,
there
is
an
urgent
need
more
in-depth
investigations
fully
unlock
potential
clinical
management.
In
this
review,
we
explore
intricate
mechanisms
that
are
DW
recovery.
We
introduce
rational
design
angiogenesis-enhancing
drug
delivery
systems
(DDS)
provide
comprehensive
summary
discussion
diverse
facilitating
Lastly,
address
emerging
challenges
prospects
DDS
healing,
aiming
offer
understanding
critical
issue
solutions.
Abstract
The
management
of
infected
wounds
is
always
great
significance
and
urgency
in
clinical
biomedical
fields.
Recent
efforts
this
area
are
focusing
on
the
development
functional
wound
patches
with
effective
antibacterial,
drug
delivery,
sensor
properties.
Here,
we
present
novel
hyaluronic
acid
(HA)
microneedle
these
features
by
encapsulating
aminobenzeneboronic
acid‐modified
gold
nanoclusters
(A‐GNCs)
for
management.
A‐GNCs
loaded
were
derived
from
negative‐mold
replication
showed
high
mechanical
strength
to
penetrate
skin.
release
was
realized
degradation
HA,
self‐monitor
released
actives
based
dynamic
bright
orange
fluorescence
emitted
under
ultraviolet
radiation.
As
could
destroy
bacteria
membranes,
excellent
vitro
antibiosis
ability.
Based
features,
have
demonstrated
inhibition,
residual
self‐monitoring,
healing
promotion
abilities
Escherichia
coli‐
or
Staphylococcus
aureus
‐infected
These
results
indicated
potential
such
applications.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(26), С. 33205 - 33222
Опубликована: Июнь 25, 2024
In
diabetic
patients
with
skin
injuries,
bacterial
proliferation,
accumulation
of
reactive
oxygen
species
(ROS)
in
the
tissues,
and
impaired
angiogenesis
make
wound
healing
difficult.
Therefore,
eliminating
bacteria,
removing
ROS,
promoting
are
necessary
for
treating
acute
wounds.
this
study,
benefiting
from
ability
polyphenols
to
form
a
metal-phenolic
network
(MPN)
metal
ions,
TA-Eu
MPN
nanoparticles
(TM
NPs)
were
synthesized.
The
prepared
photothermal
agent
CuS
NPs
TM
then
loaded
onto
supporting
base
needle
tips
PVA/HA
(PH)
microneedles,
respectively,
obtain
PH/CuS/TM
microneedles.
Antibacterial
experiments
showed
that
microneedles
could
remove
bacteria
by
effect.
vitro
effectively
scavenge
inhibit
macrophage
polarization
M1
type,
induce
M2
type
as
well
have
promote
vascular
endothelial
cell
migration
angiogenesis.
Furthermore,
vivo
accelerated
inhibiting
pro-inflammatory
cytokines
rat
model.
efficient
antibacterial,
ROS
scavenging,
anti-inflammatory,
immunomodulatory,
angiogenic
abilities
hold
promise
dressings
Nano Letters,
Год журнала:
2024,
Номер
24(31), С. 9494 - 9504
Опубликована: Июль 26, 2024
Chronic
diabetic
wound
patients
usually
show
high
glucose
levels
and
systemic
immune
disorder,
resulting
in
reactive
oxygen
species
(ROS)
cell
dysfunction,
prolonged
inflammation,
delayed
healing.
Herein,
we
prepared
an
antioxidant
immunomodulatory
polymer
vesicle
for
treatment.
This
is
self-assembled
from
poly(ε-caprolactone)36-block-poly[lysine4-stat-(lysine-mannose)22-stat-tyrosine)16]
([PCL36-b-P[Lys4-stat-(Lys-Man)22-stat-Tyr16]).
Polytyrosine
polypeptide
that
can
scavenge
ROS.
d-Mannose
was
introduced
to
afford
functions
by
promoting
macrophage
transformation
Treg
activation
through
inhibitory
cytokines.
The
mice
treated
with
vesicles
showed
23.7%
higher
a
91.3%
M2/M1
ratio
than
those
PBS.
Animal
tests
confirmed
this
accelerated
healing
achieved
complete
of
S.
aureus-infected
wounds
within
8
days.
Overall,
the
first
scavenging
ROS
regulating
homeostasis,
opening
new
avenues
effective
