Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162243 - 162243
Опубликована: Апрель 1, 2025
Язык: Английский
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5161 - 5180
Опубликована: Авг. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Язык: Английский
Процитировано
18
Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159239 - 159239
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
7
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 14, 2024
Abstract Antimicrobial photodynamic therapy (aPDT) has emerged as an appealing therapeutic option against biofilm infections. However, effectively penetrating the dense barrier of and anchoring bacteria to achieve elimination wound healing under hypoxic environments remains a challenge for aPDT. Herein, three type I/II Hypocrellin B (HB)‐cationic photosensitizers (HB‐P, HB‐TP, HB‐TTP) are designed based on multi‐cationic long chains molecular engineering strategy. With increasing number introduced cations, reactive oxygen species (ROS) production bacterial‐anchoring abilities HB‐cationic greatly enhanced. Notably, HB‐TTP demonstrates higher aPDT activity broad‐spectrum antibacterial properties. Furthermore, address conundrum biofilm‐infected wounds, ROS‐responsive core‐shell microneedle (HB‐TTP&EGF@MN) is by biphasically integrating growth factor. When penetrates biofilm, shell quickly dissolves releases removal laser irradiation. The core subsequently degraded slowly in presence endogenous ROS within wound, facilitating sustained release factor promote tissue regeneration. This work not only provides effective strategy rational design efficient antimicrobial agents but also proposes innovative ideas development controlled‐release pharmaceutical materials synergize
Язык: Английский
Процитировано
15
Small, Год журнала: 2024, Номер 20(45)
Опубликована: Июль 28, 2024
Several natural Chinese herbal medicines have demonstrated considerable potential in facilitating wound healing, while the primary concern remains centered around optimizing formulation and structure to maximize their efficacy. To address this, a microneedles drug delivery system is proposed that harnesses gelatinized starch key ingredients-aloe vera berberine. After aged well-designed mold, starch-based are fabricated with suitable mechanical strength load components. The resulting hydrogel microneedles, enriched integrated berberine aloe, exhibit antibacterial, anti-inflammatory, fibroblast growth-promoting properties, thereby healing whole process. In vivo experimental results underscore notable achievements of early-stage antibacterial effects subsequent tissue reconstruction, contributing significantly overall These emphasize advantageous combination traditional medicine presenting novel strategy for repair opening new avenues application medicine.
Язык: Английский
Процитировано
11
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101553 - 101553
Опубликована: Фев. 5, 2025
Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140851 - 140851
Опубликована: Фев. 9, 2025
Язык: Английский
Процитировано
1
Carbohydrate Polymers, Год журнала: 2024, Номер 347, С. 122751 - 122751
Опубликована: Сен. 15, 2024
Язык: Английский
Процитировано
8
Small Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 21, 2024
Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug while complemented with noninvasiveness patient compliance. Currently, the topical application of antimicrobials restricts drugs to critical areas wound bed, largely due barriers posed by necrotic tissue, scab formation, bacterial biofilms, which severely diminish bioavailability therapeutics. MNs enabled efficient targeted overcome many chronic challenges. Over past decade, significant progress has been made develop unique properties tailored for vaccines, anticancer, antimicrobials. As ongoing research continues refine MN design, material properties, formulations, potential revolutionizing efficacy, experience, therapeutic outcomes remains at forefront scientific research. In this review, insights are provided into latest progress, current developments, diverse applications delivery. Herein, translational is highlighted perspective on challenges associated clinical translation provided. Furthermore, review aids in identifying gaps empowering contributing future implementation cutting‐edge systems effectively tackle resistance.
Язык: Английский
Процитировано
6
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(27), С. 34743 - 34756
Опубликована: Июнь 27, 2024
Infection and oxidative stress seriously hinder the healing of diabetic wounds, resulting in various serious health clinical problems. Herein, a sustainable biological hydrogen (H
Язык: Английский
Процитировано
5
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155575 - 155575
Опубликована: Сен. 7, 2024
Язык: Английский
Процитировано
5