Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417

Опубликована: Янв. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Язык: Английский

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Nanozymes for nanohealthcare

Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)

Опубликована: Май 30, 2024

Язык: Английский

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Advanced nanozymes possess peroxidase-like catalytic activities in biomedical and antibacterial fields: review and progress

Nanoscale, Год журнала: 2024, Номер 16(7), С. 3324 - 3346

Опубликована: Янв. 1, 2024

POD nanozymes for bactericidal treatment.

Язык: Английский

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Aggregation-Induced Emission-Armored Living Bacteriophage-DNA Nanobioconjugates for Targeting, Imaging, and Efficient Elimination of Intracellular Bacterial Infection

ACS Nano, Год журнала: 2024, Номер 18(4), С. 3199 - 3213

Опубликована: Янв. 16, 2024

Intracellular bacterial infections bring a considerable risk to human life and health due their capability elude immune defenses exhibit significant drug resistance. As result, confronting managing these present substantial challenges. In this study, we developed multifunctional living phage nanoconjugate by integrating aggregation-induced emission luminogen (AIEgen) photosensitizers nucleic acids onto bacteriophage framework (forming MS2-DNA-AIEgen bioconjugates). These nanoconjugates can rapidly penetrate mammalian cells specifically identify intracellular bacteria while concurrently producing detectable fluorescent signal. By harnessing the photodynamic property of AIEgen photosensitizer bacteriophage's inherent targeting lysis capability, be effectively eliminated activity infected restored. Moreover, our engineered were able expedite healing process in bacterially wounds observed diabetic mice models simultaneously enhancing within

Язык: Английский

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Reactive Microneedle Patches with Antibacterial and Dead Bacteria‐Trapping Abilities for Skin Infection Treatment

Advanced Science, Год журнала: 2024, Номер 11(23)

Опубликована: Апрель 6, 2024

Abstract Bacterial skin infections are highly prevalent and pose a significant public health threat. Current strategies primarily focused on the inhibition of bacterial activation while disregarding excessive inflammation induced by dead bacteria remaining in body effect acidic microenvironment during therapy. In this study, novel dual‐functional MgB 2 microparticles integrated microneedle (MgB MN) patch is presented to kill eliminate for infection management. The not only can produce local alkaline promote proliferation migration fibroblasts keratinocytes, but also achieve >5 log inactivation. Besides, effectively mitigate bacteria‐induced through interaction with lipopolysaccharide (LPS). With incorporation these microparticles, resultant MN patches capture bacteria, thereby mitigating inflammation. Therefore, show good therapeutic efficacy managing animal infections, including abscesses wounds. These results indicate that reactive metal borides‐integrated hold great promise treatment clinical infections.

Язык: Английский

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Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms

Advanced Materials, Год журнала: 2024, Номер 36(33)

Опубликована: Июнь 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Язык: Английский

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Photoelectrons Sequentially Regulate Antibacterial Activity and Osseointegration of Titanium Implants

Advanced Materials, Год журнала: 2023, Номер 36(2)

Опубликована: Ноя. 17, 2023

Abstract Titanium implants are widely used ; however, implantation occasionally fails due to infections during the surgery or poor osseointegration after surgery. To solve problem, an intelligent functional surface on titanium implant that can sequentially eradicate bacteria biofilm at initial period and promote late of post‐surgery time is designed. Such surfaces be excited by near infrared light (NIR), with rare earth nanoparticles upconvert NIR visible range adsorb Au nanoparticles, supported oxide porous film implants. Under irradiation, converts energy phonon hot electrons lattice vibrations, while former flows directly contact substance partially reacts surrounding generate reactive oxygen species, latter leads local temperature increase. The microbes eradicated treatment in vitro vivo. Additionally, exhibits superior biocompatibility for cell survival, adhesion, proliferation, osteogenic differentiation, which provides foundation osseointegration. In vivo experiments demonstrate also promoted. This work thus demonstrates NIR‐generated biofilms regulate process, providing new solutions fabricate efficient surfaces.

Язык: Английский

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Copper incorporated biomaterial-based technologies for multifunctional wound repair

Theranostics, Год журнала: 2023, Номер 14(2), С. 547 - 570

Опубликована: Дек. 5, 2023

The treatment of wounds is a worldwide challenge, and wound infection can affect the effectiveness further increase disease burden. Copper an essential trace element that has been shown to have broad-spectrum antibacterial effects be involved in inflammation, proliferation, remodeling stages healing. Compared treatments such as bioactive factors skin grafts, copper advantage being low-cost easily available, received lot attention Recently, biomaterials made by incorporating into glasses, polymeric scaffolds hydrogels used promote healing release ions. In addition, copper-incorporated with catalytic, photothermal, photosensitive properties also accelerate through microenvironment regulation. This review summarizes mechanisms copper- incorporated their roles healing, discusses current challenges. A comprehensive understanding role will help facilitate new preclinical clinical studies, thus leading development novel therapeutic tools.

Язык: Английский

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Gold nanoclusters encapsulated microneedle patches with antibacterial and self‐monitoring capacities for wound management

Aggregate, Год журнала: 2024, Номер 5(3)

Опубликована: Янв. 25, 2024

Abstract The management of infected wounds is always great significance and urgency in clinical biomedical fields. Recent efforts this area are focusing on the development functional wound patches with effective antibacterial, drug delivery, sensor properties. Here, we present novel hyaluronic acid (HA) microneedle these features by encapsulating aminobenzeneboronic acid‐modified gold nanoclusters (A‐GNCs) for management. A‐GNCs loaded were derived from negative‐mold replication showed high mechanical strength to penetrate skin. release was realized degradation HA, self‐monitor released actives based dynamic bright orange fluorescence emitted under ultraviolet radiation. As could destroy bacteria membranes, excellent vitro antibiosis ability. Based features, have demonstrated inhibition, residual self‐monitoring, healing promotion abilities Escherichia coli‐ or Staphylococcus aureus ‐infected These results indicated potential such applications.

Язык: Английский

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Phage-based delivery systems: engineering, applications, and challenges in nanomedicines

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 25, 2024

Abstract Bacteriophages (phages) represent a unique category of viruses with remarkable ability to selectively infect host bacteria, characterized by their assembly from proteins and nucleic acids. Leveraging exceptional biological properties modifiable characteristics, phages emerge as innovative, safe, efficient delivery vectors. The potential drawbacks associated conventional nanocarriers in the realms drug gene include lack cell-specific targeting, cytotoxicity, diminished vivo transfection efficiency. In contrast, engineered phages, when employed cargo vectors, hold promise surmount these limitations attain enhanced efficacy. This review comprehensively outlines current strategies for engineering delineates principal types utilized delivery, explores application phage-based systems disease therapy. Additionally, an incisive analysis is provided, critically examining challenges confronted within domain nanotechnology. primary objective this article furnish theoretical reference that contributes reasoned design development potent systems. Graphical abstract

Язык: Английский

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