Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

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Nanozymes for nanohealthcare

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: May 30, 2024

Language: Английский

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Advanced nanozymes possess peroxidase-like catalytic activities in biomedical and antibacterial fields: review and progress

Nanoscale, Journal Year: 2024, Volume and Issue: 16(7), P. 3324 - 3346

Published: Jan. 1, 2024

POD nanozymes for bactericidal treatment.

Language: Английский

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Reactive Microneedle Patches with Antibacterial and Dead Bacteria‐Trapping Abilities for Skin Infection Treatment

Advanced Science, Journal Year: 2024, Volume and Issue: 11(23)

Published: April 6, 2024

Abstract Bacterial skin infections are highly prevalent and pose a significant public health threat. Current strategies primarily focused on the inhibition of bacterial activation while disregarding excessive inflammation induced by dead bacteria remaining in body effect acidic microenvironment during therapy. In this study, novel dual‐functional MgB 2 microparticles integrated microneedle (MgB MN) patch is presented to kill eliminate for infection management. The not only can produce local alkaline promote proliferation migration fibroblasts keratinocytes, but also achieve >5 log inactivation. Besides, effectively mitigate bacteria‐induced through interaction with lipopolysaccharide (LPS). With incorporation these microparticles, resultant MN patches capture bacteria, thereby mitigating inflammation. Therefore, show good therapeutic efficacy managing animal infections, including abscesses wounds. These results indicate that reactive metal borides‐integrated hold great promise treatment clinical infections.

Language: Английский

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Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Language: Английский

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Aggregation-Induced Emission-Armored Living Bacteriophage-DNA Nanobioconjugates for Targeting, Imaging, and Efficient Elimination of Intracellular Bacterial Infection

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3199 - 3213

Published: Jan. 16, 2024

Intracellular bacterial infections bring a considerable risk to human life and health due their capability elude immune defenses exhibit significant drug resistance. As result, confronting managing these present substantial challenges. In this study, we developed multifunctional living phage nanoconjugate by integrating aggregation-induced emission luminogen (AIEgen) photosensitizers nucleic acids onto bacteriophage framework (forming MS2-DNA-AIEgen bioconjugates). These nanoconjugates can rapidly penetrate mammalian cells specifically identify intracellular bacteria while concurrently producing detectable fluorescent signal. By harnessing the photodynamic property of AIEgen photosensitizer bacteriophage's inherent targeting lysis capability, be effectively eliminated activity infected restored. Moreover, our engineered were able expedite healing process in bacterially wounds observed diabetic mice models simultaneously enhancing within

Language: Английский

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A Fused Membrane‐Camouflaged Biomimetic Nanosystem for Dual‐Targeted Therapy of Septic Arthritis

Small, Journal Year: 2025, Volume and Issue: 21(9)

Published: Jan. 19, 2025

Abstract Due to the inherent aseptic and enclosed characteristics of joint cavity, septic arthritis (SA) almost inevitably leads intractable infections rapidly progressing complex pathological environments. Presently, SA faces not only deficient effectiveness gold‐standard systemic antibiotic therapy but also scarcity effective localized targeted approaches standardized animal models. Herein, an ingenious multifunctional nanosystem is designed, which involves methylation hyaluronic acid (HA), copolymerization with DEGDA, loading vancomycin (VAN), then coating fused macrophage‐platelet membrane (denoted as FM@HA@VAN). Upon intra‐articular administration, FM@HA@VAN nanoparticles exhibit sustained retention selectively targeting infected sites, leveraging macrophage‐mediated inflammation homing platelet‐directed bacteria targeting. The acidic microenvironment triggers responsive release vancomycin, leading potent bactericidal effects. Subsequently, exposed HA@VAN are efficiently internalized by activated macrophages, releasing HA alleviate oxidative stress achieve chondroprotection inhibiting pro‐inflammatory cytokines, neutralizing ROS upregulating macrophage M2 polarization. In vivo model experiments confirm efficacy this dual‐targeting antibacterial approach, demonstrating its precision in eradicating bacterial alleviating associated processes, including synovial hyperplasia cartilage erosion. therapeutic nanosystem, coordinated fused‐membranes, holds promise for enhancing treatment SA.

Language: Английский

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Photoelectrons Sequentially Regulate Antibacterial Activity and Osseointegration of Titanium Implants

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Nov. 17, 2023

Abstract Titanium implants are widely used ; however, implantation occasionally fails due to infections during the surgery or poor osseointegration after surgery. To solve problem, an intelligent functional surface on titanium implant that can sequentially eradicate bacteria biofilm at initial period and promote late of post‐surgery time is designed. Such surfaces be excited by near infrared light (NIR), with rare earth nanoparticles upconvert NIR visible range adsorb Au nanoparticles, supported oxide porous film implants. Under irradiation, converts energy phonon hot electrons lattice vibrations, while former flows directly contact substance partially reacts surrounding generate reactive oxygen species, latter leads local temperature increase. The microbes eradicated treatment in vitro vivo. Additionally, exhibits superior biocompatibility for cell survival, adhesion, proliferation, osteogenic differentiation, which provides foundation osseointegration. In vivo experiments demonstrate also promoted. This work thus demonstrates NIR‐generated biofilms regulate process, providing new solutions fabricate efficient surfaces.

Language: Английский

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Gold nanoclusters encapsulated microneedle patches with antibacterial and self‐monitoring capacities for wound management

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 25, 2024

Abstract The management of infected wounds is always great significance and urgency in clinical biomedical fields. Recent efforts this area are focusing on the development functional wound patches with effective antibacterial, drug delivery, sensor properties. Here, we present novel hyaluronic acid (HA) microneedle these features by encapsulating aminobenzeneboronic acid‐modified gold nanoclusters (A‐GNCs) for management. A‐GNCs loaded were derived from negative‐mold replication showed high mechanical strength to penetrate skin. release was realized degradation HA, self‐monitor released actives based dynamic bright orange fluorescence emitted under ultraviolet radiation. As could destroy bacteria membranes, excellent vitro antibiosis ability. Based features, have demonstrated inhibition, residual self‐monitoring, healing promotion abilities Escherichia coli‐ or Staphylococcus aureus ‐infected These results indicated potential such applications.

Language: Английский

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Fe-Capsaicin Nanozymes Attenuate Sepsis-Induced Acute Lung Injury via NF-κB Signaling

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 73 - 90

Published: Jan. 1, 2024

Background: In sepsis, the lungs are one of most severely affected organs, usually resulting in acute lung injury (ALI). Capsaicin (CAP) is a natural compound found chili peppers that has pain-relieving and anti-inflammatory properties. Here, we report nanoparticles containing capsaicin iron (Fe-CAP NPs) exhibited effects treatment ALI. Methods: The morphological characteristics nanozymes were detected. RAW 264.7 cells divided into four groups: control, lipopolysaccharide (LPS), CAP+LPS Fe-CAP+LPS groups. expression inducible nitric oxide synthase (iNOS), transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α) was assessed by immunofluorescence, Western blot, enzyme-linked immunosorbent assay (ELISA). Nuclear factor kappa-B (NF-κB) determined blot. C57 mice LPS, Interleukin-6 (IL-6) iNOS detected Blot. IL-6 TNF-α serum ELISA. Extravasated Evans blue, histopathological evaluation wet-to-dry (W/D) weight ratio used to assess pulmonary capillary permeability. blood major organs (heart, liver, spleen, kidney) tested for toxicity Fe-CAP NPs. Results: LPS group, TNF-α, iNOS, p-NF-κB p-IKBα increased. However, their significantly decreased group. TGF-β showed opposite trend. vivo, notably increased group but with pretreatment. ameliorated EB leakage, improved histopathology tissue reduced W/D ratio. non-cytotoxicity, when studying these biological activities. Conclusion: NPs could alleviated inflammation inhibiting pro-inflammatory factors macrophages, increasing factors, alleviating damage. Keywords: capsaicin, macrophage, nanoparticles,

Language: Английский

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