Boronophenylalanine‐Functionalized Platinum Nanozymes Sensitizing Neutron Capture Therapy DOI Open Access
Xiangxia Li, Guiyuan Chen,

Bing Hong

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 29, 2024

Abstract Boron neutron capture therapy (BNCT), which uses high‐energy particles generated by the reaction of 10 B isotope with thermal neutrons to kill tumor cells precisely at microscale, has become a promising treatment approach aggressive and recurrent cancers. The development highly selective boron drugs for devices beams is crucial BNCT. Borophenylalanine (BPA), most widely used containing drug in clinic, problems fast metabolism poor retention. Therefore, improve therapeutic effect BPA, this study reports BPA‐loaded platinum nanoparticles (Pt‐ BPA NPs) conduct BNCT experiments beam an accelerator source. Pt‐ NPs achieve deep penetration retention, thereby significantly inhibiting growth subcutaneous colorectal tumors mice. Furthermore, unlike classic drugs, have superior catalytic properties can sensitize increasing reactive oxygen species (ROS) production. Since observation improvements immune responses induced sensitized BNCT, its further combination checkpoint blockade results significant suppression both primary secondary tumors. In summary, provides new aspect nanomedicines sensitization.

Язык: Английский

Molecular engineering of AIE-active boron clustoluminogens for enhanced boron neutron capture therapy DOI Creative Commons

Wenli Ma,

Yanyang Wang,

Yilin Xue

и другие.

Chemical Science, Год журнала: 2024, Номер 15(11), С. 4019 - 4030

Опубликована: Янв. 1, 2024

This study presents a new type of boron carrier for neutron capture therapy that integrates imaging, lung cancer targeting drug and carborane, showcases an impressive therapeutic efficacy against tumors both in vitro vivo .

Язык: Английский

Процитировано

18
Hexagonal boron nitride nanomaterials for biomedical applications DOI Creative Commons
Congling Wang, Yanyang Long,

Yuxian Deng

и другие.

BMEMat, Год журнала: 2024, Номер 2(2)

Опубликована: Янв. 3, 2024

Abstract Hexagonal boron nitride (h‐BN) nanomaterials are a rising star in the field of biomedicine. This review presents an overview progress h‐BN for biological applications. It begins with general introduction structural characteristics h‐BN, followed by brief its physical and chemical properties, including thermal, band mechanical reactivity, biodegradability biocompatibility, then emphasizes on recent biomedical applications drug delivery, neutron capture therapy (BNCT), bioimaging nanozyme, ends challenges perspectives related to The advantages BN used were analyzed, their problems also discussed, inspiring future rational designs nanomedicines.

Язык: Английский

Процитировано

13
Novel promising boron agents for boron neutron capture therapy: Current status and outlook on the future DOI
Hong Xu,

Ji Liu,

Ruixi Li

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 511, С. 215795 - 215795

Опубликована: Апрель 17, 2024

Язык: Английский

Процитировано

13
A PD‐L1 siRNA‐Loaded Boron Nanoparticle for Targeted Cancer Radiotherapy and Immunotherapy DOI Open Access
Shaohui Deng, Lijun Hu, Guo Chen

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 16, 2025

Although the combination of radiotherapy and immunotherapy is regarded as a promising clinical treatment strategy, numerous trials have failed to demonstrate synergistic effects. One key reasons that conventional radiotherapies inevitably damage intratumoral effector immune cells. Boron Neutron Capture Therapy (BNCT) precise selectively kills tumor cells while sparing adjacent normal cells, by utilizing 10B agents neutron irradiation. Therefore, combinational BNCT-immunotherapy holds promise for achieving more effective Here it develops 10B-containing polymer self-assembled with PD-L1 siRNA form 10B/siPD-L1 nanoparticles BNCT-immunotherapy. Unlike antibodies, can inhibit intracellular upregulated BNCT, activating T-cell immunity also suppressing DNA repair. This enhance BNCT-induced damage, promoting immunogenic cell death (ICD) further amplifying antitumor effect. The results demonstrated BNCT using precisely killed T induced potent response, inhibiting distal metastatic tumors.

Язык: Английский

Процитировано

1
Targeting the organelle for radiosensitization in cancer radiotherapy DOI Creative Commons

Xiaoyan Sun,

Lin-Jie Wu, Lina Du

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(2), С. 100903 - 100903

Опубликована: Март 11, 2024

Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low energy deposition, severe damage surrounding normal cells, and high tumor resistance radiation. Among various radiotherapy methods, boron neutron capture (BNCT) emerged as principal approach improve the therapeutic ratio of malignancies reduce lethality tissue, but it remains deficient in terms insufficient accumulation well short retention time, which limits curative effect. Recently, series radiosensitizers that can selectively accumulate specific organelles cells have been developed precisely target radiotherapy, thereby reducing side effects tissue damage, overcoming radioresistance, improving radiosensitivity. In review, we mainly focus on field nanomedicine-based discuss organelle-targeted radiosensitizers, specifically nucleus, mitochondria, endoplasmic reticulum lysosomes. Furthermore, carriers used BNCT are particularly presented. Through demonstrating recent developments radiosensitization, hope provide insight into design clinical treatment.

Язык: Английский

Процитировано

6
The Dawn of a New Era: Tumor-Targeting Boron Agents for Neutron Capture Therapy DOI
Ting Luo,

Wenzhi Huang,

Feiyi Chu

и другие.

Molecular Pharmaceutics, Год журнала: 2023, Номер 20(10), С. 4942 - 4970

Опубликована: Сен. 20, 2023

Cancer is widely recognized as one of the most devastating diseases, necessitating development intelligent diagnostic techniques, targeted treatments, and early prognosis evaluation to ensure effective personalized therapy. Conventional unfortunately, suffer from limitations an increased risk severe complications. In light these challenges, boron neutron capture therapy (BNCT) has emerged a promising approach for cancer treatment with unprecedented precision selectively eliminate tumor cells. The distinctive characteristics BNCT hold potential revolutionize field oncology. However, clinical application advancement technology face significant hindrance due inherent flaws limited availability current drugs, which pose substantial obstacles practical implementation continued progress BNCT. Consequently, there urgent need develop efficient agents higher content specific tumor-targeting properties. Researchers aim address this by integrating strategies BNCT, ultimate goal establishing effective, readily available, cutting-edge modality cancer. This review delves into recent advancements in focusing on made developing specifically designed By exploring state emphasizing prospects agents, provides comprehensive overview highlights its transformative option

Язык: Английский

Процитировано

15
Boron Nanocomposites for Boron Neutron Capture Therapy and in Biomedicine: Evolvement and Challenges DOI Creative Commons
Farooq Ahmad

Biomaterials Research, Год журнала: 2025, Номер 29

Опубликована: Янв. 1, 2025

Cancer remains a major concern for human health worldwide. To fight the curse of cancer, boron neutron capture therapy is an incredibly advantageous modality in treatment cancer as compared to other radiotherapies. Due tortuous vasculature and around tumor regions, ( 10 B) compounds preferentially house into cells, creating large dose gradient between highly mingled cells normal cells. Epithermal or thermal bombardment leads tumor-cell-selective killing due generation heavy particles yielded from situ fission reaction. However, challenges nanocomposites’ development have been synthesis part well requirement selective targeting delivery therapeutic concentrations with nominal healthy tissue accumulation retention. circumvent above challenges, this review discusses boride nanocomposite design, safety, biocompatibility biomedical applications general public use. This sparks interest using nanocomposites agents repurposing them comorbidity treatments, future scientific opportunities, hope accelerate stimulus developing possible composite nanomedicine research

Язык: Английский

Процитировано

0
Boron nitride nanosheets, quantum dots, and dots: Synthesis, properties, and biomedical applications DOI Creative Commons
Raksha Dubey,

Matthew Cowles,

Zohreh Salimi

и другие.

APL Materials, Год журнала: 2025, Номер 13(4)

Опубликована: Апрель 1, 2025

This review examines three aspects of hexagonal boron nitride (h-BN) nanomaterials: properties, synthesis methods, and biomedical applications. We focus the scope on types h-BN nanostructures: nanosheets (BNNSs, few-layered h-BN, larger than ∼100 nm in lateral dimensions), quantum dots (BN QDs, smaller ∼10 all dimensions, with inherent excitation-dependent fluorescence), dots, wide bandgap without noise fluorescence). The methods BNNSs, BN are summarized top-down bottom-up approaches. Future research should scalability quality products, which essential for reproducible Regarding applications, BNNSs were used as nanocarriers drug delivery, mechanical reinforcements (bone tissue engineering), antibacterial QDs still limited non-specific bioimaging small dimension to construct high-brightness probes (HBPs) gene sequence detections inside cells. To differentiate from other two-dimensional materials, future applications using unique properties nanostructures, such piezoelectricity, neutron capture therapy (BNCT), their electrically insulating optically transparent nature. Examples would be combining BNCT chemo delivery form HBPs enhanced fluorescence by preventing quenching dots.

Язык: Английский

Процитировано

0
Acid-Activated TAT Peptide-Modified Biomimetic Boron Nitride Nanoparticles for Enhanced Targeted Codelivery of Doxorubicin and Indocyanine Green: A Synergistic Cancer Photothermal and Chemotherapeutic Approach DOI
Hui Li, Yuan Fan,

Yizhe Shen

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(19), С. 25101 - 25112

Опубликована: Май 1, 2024

The evolution of nano-drug delivery systems addresses the limitations conventional cancer treatments with stimulus-responsive nanomaterial-based presenting temporal and spatial advantages. Among various nanomaterials, boron nitride nanoparticles (BNNs) demonstrate significant potential in drug treatment, providing a high loading capacity, multifunctionality, low toxicity. However, challenge lies augmenting nanomaterial accumulation exclusively within tumors while preserving healthy tissues. To address this, we introduce novel approach involving cell membrane-functionalized BNNs (CM-BIDdT) for codelivery doxorubicin (Dox) indocyanine green to treat homologous tumor. membrane biomimetic CM-BIDdT possess highly efficient targeting capabilities toward tumor cells. surface modification acylated TAT peptides (dTAT) further enhances nanoparticle intracellular accumulation. Consequently, nanoparticles, responsive acidic microenvironment, hydrolyze amide bonds, activate transmembrane penetrating function, achieve precise substantial at site. Additionally, photothermal effect under laser irradiation not only kills cells through thermal ablation but also destroys on facilitating Dox release. Therefore, fabricated orchestrate chemo-photothermal combination therapy effectively inhibit growth minimal adverse effects, holding promise as new modality synergistic treatment.

Язык: Английский

Процитировано

3
Recent progress of nano-drugs in neutron capture therapy DOI Creative Commons
Yitong Zhou, Kai Cheng, Bo Liu

и другие.

Theranostics, Год журнала: 2024, Номер 14(8), С. 3193 - 3212

Опубликована: Янв. 1, 2024

As a developing radiation treatment for tumors, neutron capture therapy (NCT) has less side effects and higher efficacy than conventional therapy.Drugs with specific isotopes are indispensable counterparts of NCT, as they the indespensable part reaction.Since creation first second generations boron-containing reagents, NCT significantly advanced.Notwithstanding, extant medications, predominantly comprised small molecule boron medicines, have encountered challenges such monofunctionality, inadequate targeting hypermetabolism.There is an urgent need to promote research development new types drugs.Bio-nanomaterials can be introduced into realm nanotechnology give medications richer functionality significant adaptability.This complement advantages each other expected develop more drugs toxicity, low effects, better tumor targeting, high biocompatibility.In this review, we summarized progress nano-drugs in based on different sources used, attempts efforts made by relevant researchers combining nanomaterials hoping provide pivotal references promoting field radiotherapy.

Язык: Английский

Процитировано

3