Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 29, 2024
Abstract
Chronic
wounds,
particularly
those
associated
with
diabetes,
pose
a
significant
clinical
challenge
due
to
their
tendency
develop
biofilms
that
resist
conventional
antibiotic
treatments.
To
address
this
issue,
novel
therapeutic
strategy
utilizing
pH‐responsive
nanoparticles
loaded
aggregation‐induced
emission
photosensitizers
and
natural
saturated
fatty
acids
(AIE/LA@HMONs−PyB)
for
effective
biofilm
penetration
disruption
is
proposed.
Under
physiological
conditions,
AIE/LA@HMONs−PyB
are
negatively
charged.
Upon
accumulation
at
infected
sites,
however,
the
pyridine
betaine
group
on
surface
of
enables
rapid
protonation
charge
reversal
in
acidic
microenvironment,
thereby
enhancing
ability
penetrate
biofilm.
light
irradiation,
these
generate
reactive
oxygen
species
effectively
disrupt
structure.
This
process
synergistic
action
ciprofloxacin
lower
concentration,
achieving
an
exceptional
vitro
antibacterial
efficiency
99.99%
against
methicillin‐resistant
Staphylococcus
aureus
(
S.
)
biofilms.
Furthermore,
vivo
diabetic
wound
model,
therapy
accelerates
healing
by
reducing
inflammation,
promoting
angiogenesis,
collagen
regeneration.
The
enhanced
significantly
improves
efficacy
combined
approach,
offering
great
promise
advancing
chronic
patient
outcomes.
Biomaterials Science,
Год журнала:
2024,
Номер
12(4), С. 964 - 977
Опубликована: Янв. 1, 2024
In
this
study,
Janus
nanoparticles,
Ce6–PDA/CaP–GSNO,
were
constructed
to
effectively
eradicate
biofilms
and
combat
methicillin-resistant
Staphylococcus
aureus
(MRSA)
infections
through
nitric
oxide
(NO)
synergistic
photodynamic
therapy.
Biomaterials Science,
Год журнала:
2024,
Номер
12(11), С. 2914 - 2929
Опубликована: Янв. 1, 2024
A
universal
strategy
is
developed
to
remarkably
enhance
the
photothermal
conversion
efficiency
of
materials.
This
advancement
enables
effective
treatment
drug-resistant
bacterial
infections
through
safe
therapy.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(39), С. 26983 - 26993
Опубликована: Сен. 18, 2024
While
polyphenolic
substances
stand
as
excellent
antibacterial
agents,
their
antimicrobial
properties
rely
on
the
auxiliary
support
of
micro-/nanostructures.
Despite
offering
a
novel
avenue
for
enhancing
polymer
performance,
controllable
fabrication
mesoporous
polymeric
nanomaterials
encounters
significant
challenges
due
to
intricate
intermolecular
forces.
In
this
article,
catechin
nanoparticles
have
been
successfully
fabricated
using
balanced
multivariate
interaction
approach.
The
harmonization
water-ethanol
ratio
and
ionic
strength
effectively
balances
forces
hydrogen
bonding
π-π
stacking,
facilitating
controlled
assembly
mesostructures.
exhibit
uniform
spherical
structure
(∼100
nm),
open
mesopores
with
diameter
∼15
nm,
high
surface
area
∼106
m
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 29, 2024
Abstract
Chronic
wounds,
particularly
those
associated
with
diabetes,
pose
a
significant
clinical
challenge
due
to
their
tendency
develop
biofilms
that
resist
conventional
antibiotic
treatments.
To
address
this
issue,
novel
therapeutic
strategy
utilizing
pH‐responsive
nanoparticles
loaded
aggregation‐induced
emission
photosensitizers
and
natural
saturated
fatty
acids
(AIE/LA@HMONs−PyB)
for
effective
biofilm
penetration
disruption
is
proposed.
Under
physiological
conditions,
AIE/LA@HMONs−PyB
are
negatively
charged.
Upon
accumulation
at
infected
sites,
however,
the
pyridine
betaine
group
on
surface
of
enables
rapid
protonation
charge
reversal
in
acidic
microenvironment,
thereby
enhancing
ability
penetrate
biofilm.
light
irradiation,
these
generate
reactive
oxygen
species
effectively
disrupt
structure.
This
process
synergistic
action
ciprofloxacin
lower
concentration,
achieving
an
exceptional
vitro
antibacterial
efficiency
99.99%
against
methicillin‐resistant
Staphylococcus
aureus
(
S.
)
biofilms.
Furthermore,
vivo
diabetic
wound
model,
therapy
accelerates
healing
by
reducing
inflammation,
promoting
angiogenesis,
collagen
regeneration.
The
enhanced
significantly
improves
efficacy
combined
approach,
offering
great
promise
advancing
chronic
patient
outcomes.
