Metal‐Phenolic Network with Pd Nanoparticle Nodes Synergizes Oxidase‐Like and Photothermal Properties to Eradicate Oral Polymicrobial Biofilm‐Associated Infections

Advanced Materials, Год журнала: 2023, Номер 36(7)

Опубликована: Ноя. 10, 2023

Designing an effective treatment strategy to combat oral diseases caused by complex polymicrobial biofilms remains a great challenge. Herein, series of metal-phenolic network with Pd nanoparticle nodes using polyphenols as stabilizers and reducing agents is constructed. Among them, sulfonated lignin-Pd (SLS-Pd) ultrafine size palladium nanoparticles broadband near infrared absorption exhibit excellent oxidase-like activity stable photothermal effect. In vitro experiments demonstrate that the superoxide radical generated SLS-Pd exhibits selective antibacterial effects, while its effect induced hyperthermia potent antifungal properties. This difference further elucidated RNA-sequencing analysis all-atom simulation. Moreover, SLS-Pd-mediated synergistic antimicrobial system remarkable efficacy in combating various biofilms. By establishing root canal model oropharyngeal candidiasis model, feasibility treating biofilm-related infections validated. provides promising therapeutic approach for biofilm-associated cavity.

Язык: Английский

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Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing

Bioactive Materials, Год журнала: 2024, Номер 44, С. 131 - 151

Опубликована: Окт. 15, 2024

Язык: Английский

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Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Chemical Society Reviews, Год журнала: 2024, Номер 53(7), С. 3273 - 3301

Опубликована: Янв. 1, 2024

Oral diseases are prevalent but challenging owing to the highly movable and wet, microbial inflammatory environment. Polymeric materials regarded as one of most promising biomaterials due their good compatibility, facile preparation, flexible design obtain multifunctionality. Therefore, a variety strategies have been employed develop with improved therapeutic efficacy by overcoming physicobiological barriers in oral diseases. In this review, we summarize polymeric for treatment First, present unique environment including environment, which hinders effective Second, series designing towards such highlighted. For example, multifunctional armed wet-adhesive, antimicrobial, anti-inflammatory functions through advanced chemistry nanotechnology effectively treat These achieved wet-adhesive polymers modified hydroxy, amine, quinone, aldehyde groups provide strong wet-adhesion hydrogen covalent bonding, electrostatic hydrophobic interactions, developing antimicrobial cationic polymers, peptides, antibiotic-conjugated synthesizing phenolic hydroxy cysteine that function immunomodulators electron donors reactive oxygen species reduce inflammation. Third, various delivery systems enhanced mucosa biofilm penetration capabilities, nanoparticles, hydrogels, patches, microneedles, constructed antibiotics, immunomodulators, antioxidants achieve efficacy. Finally, insights into challenges future development promise clinical translation.

Язык: Английский

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A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing

Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 740 - 755

Опубликована: Март 19, 2024

Язык: Английский

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An injectable and coagulation-independent Tetra-PEG hydrogel bioadhesive for post-extraction hemostasis and alveolar bone regeneration

Bioactive Materials, Год журнала: 2024, Номер 37, С. 106 - 118

Опубликована: Март 19, 2024

Effective control of post-extraction hemorrhage and alveolar bone resorption is critical for successful extraction socket treatment, which remains an unmet clinical challenge. Herein, injectable Tetra-PEG hydrogel that possesses rapid gelation, firm tissue adhesion, high mechanical strength, suitable degradability, excellent biocompatibility developed as a sutureless coagulation-independent bioadhesive the management sockets. Our results demonstrate robust adhesive sealing by can provide reliable protection underlying wound stabilize blood clots to facilitate healing.

Язык: Английский

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Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing

Biomaterials, Год журнала: 2025, Номер unknown, С. 123134 - 123134

Опубликована: Янв. 1, 2025

Язык: Английский

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Low‐Dose Cu Ions Assisted by Mild Thermal Stimulus Inducing Bacterial Cuproptosis‐Like Death for Antibiosis and Biointegration

Advanced Functional Materials, Год журнала: 2023, Номер 34(1)

Опубликована: Сен. 15, 2023

Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) is threatening human health due to its resistance multiple antibiotics. Excessive copper (Cu) ions target the lipoylated proteins of tricarboxylic acid cycle cancer cells, inducing proteotoxic stress and their cuproptosis death. Whether plays a part in killing MRSA by low‐dose supplement Cu remains be explored. Herein, Cu‐doped hydroxyapatite nanorods (PC) are prepared on polyetheretherketone (PEEK) resist infection improve PEEK performance tissue integration with assistance near‐infrared (NIR) irradiation, mechanism against elucidated. Mild photothermal stimulation increases bacterial membrane permeability, accelerating ions’ intake consequently cuproptosis‐like death MRSA. It confirmed aggregation dihydrolipoamide S‐acetyltrans‐ferase (DLAT), deactivation glutathione peroxides 4 (GPX4), destabilization Fe─S cluster ferredoxin (FDX1) lipoyl synthase (LIAS). Fortunately, fibroblast behaviors upregulated NIR‐irradiated PC. In vivo, PC NIR irradiation exhibits outstanding elimination, reduced inflammation response, improved biointegration. Overall, it demonstrated that can induced at non‐cytotoxic dose when cooperated mild heat stimulus, this strategy has greatly promising application improving clinic.

Язык: Английский

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A Versatile Hydrogel with Antibacterial and Sequential Drug-Releasing Capability for the Programmable Healing of Infectious Keratitis

ACS Nano, Год журнала: 2023, Номер 17(23), С. 24055 - 24069

Опубликована: Дек. 4, 2023

Hydrogels have attracted tremendous attention as favorable corneal substitutes for treating severe infectious keratitis (IK). However, current hydrogel-based were majorly designed to promote the single stage of regeneration, which falls short in meeting clinical management needs IK including multiple phases wound healing. Herein, we introduce a versatile hybrid hydrogel (SQPV) composed silk fibroin and chitosan, exhibits spatiotemporal properties drug release. The SQPV is fabricated by incorporating verteporfin-loaded poly(lactic-co-glycolic)-polyethylene glycol-o-nitrobenzene micelles into network, formed from methacrylate glycidyl functionalized quaternized chitosan containing polydeoxyribonucleotide. This double network approach results material with exceptional anti-inflammatory, antibacterial, proliferative stimulation tissue remodeling regulation capabilities. Furthermore, showcases mechanical strength transparency akin those native cornea. Extensive vitro vivo studies validate SQPV's ability effectively eliminate residual bacteria, mitigate inflammation, foster regeneration epithelium stroma, prevent scarring, ultimately expedite In summary, SF/CS-based may represent promising substitute comprehensive repair IK.

Язык: Английский

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Strategies and materials for the prevention and treatment of biofilms

Materials Today Bio, Год журнала: 2023, Номер 23, С. 100827 - 100827

Опубликована: Окт. 2, 2023

Biofilms are aggregates of organized microbial growth that function as barriers and create a stable internal environment for cell survival. The bacteria in the biofilms exhibit characteristics quite different from planktonic bacteria, such strong resistance to antibiotics other bactericides, getting out host immunity, developing harsh environments, which all contribute persistent intractable treatment. Hence, there is an urgent need develop novel materials strategies combat biofilms. However, most reviews on anti-biofilms published recent years based specific fields or materials. Microorganisms ubiquitous, except context medical health issues; however, exert detrimental effects advancement progress various fields. Therefore, this review aims provide comprehensive summary effective methodologies applicable across industries. Firstly, process formation was introduced enhance our comprehension "enemy". Secondly, intervene important links were discussed, taking timely action during early weak stages Thirdly, treatment mature summarized deal with break through defense line. Finally, several substances antibacterial properties presented. concludes standpoint author about potential developments strategies. This may help researchers quickly understand research challenges field design more efficient methods

Язык: Английский

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ROS‐Responsive Core‐Shell Microneedles Based on Simultaneous Efficient Type I/II Photosensitizers for Photodynamic Against Bacterial Biofilm Infections

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Abstract Antimicrobial photodynamic therapy (aPDT) has emerged as an appealing therapeutic option against biofilm infections. However, effectively penetrating the dense barrier of and anchoring bacteria to achieve elimination wound healing under hypoxic environments remains a challenge for aPDT. Herein, three type I/II Hypocrellin B (HB)‐cationic photosensitizers (HB‐P, HB‐TP, HB‐TTP) are designed based on multi‐cationic long chains molecular engineering strategy. With increasing number introduced cations, reactive oxygen species (ROS) production bacterial‐anchoring abilities HB‐cationic greatly enhanced. Notably, HB‐TTP demonstrates higher aPDT activity broad‐spectrum antibacterial properties. Furthermore, address conundrum biofilm‐infected wounds, ROS‐responsive core‐shell microneedle (HB‐TTP&EGF@MN) is by biphasically integrating growth factor. When penetrates biofilm, shell quickly dissolves releases removal laser irradiation. The core subsequently degraded slowly in presence endogenous ROS within wound, facilitating sustained release factor promote tissue regeneration. This work not only provides effective strategy rational design efficient antimicrobial agents but also proposes innovative ideas development controlled‐release pharmaceutical materials synergize

Язык: Английский

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