Abstract
Commencing
with
the
breakdown
of
diabetic
osteoimmune
microenvironment,
multiple
pathogenic
factors,
including
hyperglycemia,
inflammation,
hypoxia,
and
deleterious
cytokines,
are
conjointly
involved
in
progression
periodontal
bone
regeneration.
Based
on
challenge
regeneration
treatment
absence
real‐time
feedback
blood
oxygen
fluctuation
diabetes
mellitus,
a
novel
self‐adaptive
hyperthermia
supramolecular
cascade
nano‐reactor
ACFDG
is
constructed
via
one‐step
self‐assembly
strategy
to
address
factors
Hyperthermia
possesses
high
photothermal
conversion
efficiency
(32.1%),
it
can
effectively
inhibit
vicious
cycle
ROS‐inflammatory
through
catalytic
reactions,
up‐regulate
expression
heat
shock
proteins
(HSPs)
under
near‐infrared
(NIR)
irradiation,
which
promotes
Remarkably,
provide
non‐invasive
diagnosis
changes
during
photoacoustic
(PA)
imaging,
thus
timely
monitor
hypoxia
status.
In
conclusion,
this
multifunctional
combined
PA
imaging
for
efficacy
monitoring
provides
important
insights
into
biological
mechanisms
potential
clinical
theranostics.
Advanced Materials,
Год журнала:
2023,
Номер
36(7)
Опубликована: Ноя. 10, 2023
Designing
an
effective
treatment
strategy
to
combat
oral
diseases
caused
by
complex
polymicrobial
biofilms
remains
a
great
challenge.
Herein,
series
of
metal-phenolic
network
with
Pd
nanoparticle
nodes
using
polyphenols
as
stabilizers
and
reducing
agents
is
constructed.
Among
them,
sulfonated
lignin-Pd
(SLS-Pd)
ultrafine
size
palladium
nanoparticles
broadband
near
infrared
absorption
exhibit
excellent
oxidase-like
activity
stable
photothermal
effect.
In
vitro
experiments
demonstrate
that
the
superoxide
radical
generated
SLS-Pd
exhibits
selective
antibacterial
effects,
while
its
effect
induced
hyperthermia
potent
antifungal
properties.
This
difference
further
elucidated
RNA-sequencing
analysis
all-atom
simulation.
Moreover,
SLS-Pd-mediated
synergistic
antimicrobial
system
remarkable
efficacy
in
combating
various
biofilms.
By
establishing
root
canal
model
oropharyngeal
candidiasis
model,
feasibility
treating
biofilm-related
infections
validated.
provides
promising
therapeutic
approach
for
biofilm-associated
cavity.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(7), С. 3273 - 3301
Опубликована: Янв. 1, 2024
Oral
diseases
are
prevalent
but
challenging
owing
to
the
highly
movable
and
wet,
microbial
inflammatory
environment.
Polymeric
materials
regarded
as
one
of
most
promising
biomaterials
due
their
good
compatibility,
facile
preparation,
flexible
design
obtain
multifunctionality.
Therefore,
a
variety
strategies
have
been
employed
develop
with
improved
therapeutic
efficacy
by
overcoming
physicobiological
barriers
in
oral
diseases.
In
this
review,
we
summarize
polymeric
for
treatment
First,
present
unique
environment
including
environment,
which
hinders
effective
Second,
series
designing
towards
such
highlighted.
For
example,
multifunctional
armed
wet-adhesive,
antimicrobial,
anti-inflammatory
functions
through
advanced
chemistry
nanotechnology
effectively
treat
These
achieved
wet-adhesive
polymers
modified
hydroxy,
amine,
quinone,
aldehyde
groups
provide
strong
wet-adhesion
hydrogen
covalent
bonding,
electrostatic
hydrophobic
interactions,
developing
antimicrobial
cationic
polymers,
peptides,
antibiotic-conjugated
synthesizing
phenolic
hydroxy
cysteine
that
function
immunomodulators
electron
donors
reactive
oxygen
species
reduce
inflammation.
Third,
various
delivery
systems
enhanced
mucosa
biofilm
penetration
capabilities,
nanoparticles,
hydrogels,
patches,
microneedles,
constructed
antibiotics,
immunomodulators,
antioxidants
achieve
efficacy.
Finally,
insights
into
challenges
future
development
promise
clinical
translation.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(1)
Опубликована: Сен. 15, 2023
Abstract
Methicillin‐resistant
Staphylococcus
aureus
(MRSA)
is
threatening
human
health
due
to
its
resistance
multiple
antibiotics.
Excessive
copper
(Cu)
ions
target
the
lipoylated
proteins
of
tricarboxylic
acid
cycle
cancer
cells,
inducing
proteotoxic
stress
and
their
cuproptosis
death.
Whether
plays
a
part
in
killing
MRSA
by
low‐dose
supplement
Cu
remains
be
explored.
Herein,
Cu‐doped
hydroxyapatite
nanorods
(PC)
are
prepared
on
polyetheretherketone
(PEEK)
resist
infection
improve
PEEK
performance
tissue
integration
with
assistance
near‐infrared
(NIR)
irradiation,
mechanism
against
elucidated.
Mild
photothermal
stimulation
increases
bacterial
membrane
permeability,
accelerating
ions’
intake
consequently
cuproptosis‐like
death
MRSA.
It
confirmed
aggregation
dihydrolipoamide
S‐acetyltrans‐ferase
(DLAT),
deactivation
glutathione
peroxides
4
(GPX4),
destabilization
Fe─S
cluster
ferredoxin
(FDX1)
lipoyl
synthase
(LIAS).
Fortunately,
fibroblast
behaviors
upregulated
NIR‐irradiated
PC.
In
vivo,
PC
NIR
irradiation
exhibits
outstanding
elimination,
reduced
inflammation
response,
improved
biointegration.
Overall,
it
demonstrated
that
can
induced
at
non‐cytotoxic
dose
when
cooperated
mild
heat
stimulus,
this
strategy
has
greatly
promising
application
improving
clinic.
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 24055 - 24069
Опубликована: Дек. 4, 2023
Hydrogels
have
attracted
tremendous
attention
as
favorable
corneal
substitutes
for
treating
severe
infectious
keratitis
(IK).
However,
current
hydrogel-based
were
majorly
designed
to
promote
the
single
stage
of
regeneration,
which
falls
short
in
meeting
clinical
management
needs
IK
including
multiple
phases
wound
healing.
Herein,
we
introduce
a
versatile
hybrid
hydrogel
(SQPV)
composed
silk
fibroin
and
chitosan,
exhibits
spatiotemporal
properties
drug
release.
The
SQPV
is
fabricated
by
incorporating
verteporfin-loaded
poly(lactic-co-glycolic)-polyethylene
glycol-o-nitrobenzene
micelles
into
network,
formed
from
methacrylate
glycidyl
functionalized
quaternized
chitosan
containing
polydeoxyribonucleotide.
This
double
network
approach
results
material
with
exceptional
anti-inflammatory,
antibacterial,
proliferative
stimulation
tissue
remodeling
regulation
capabilities.
Furthermore,
showcases
mechanical
strength
transparency
akin
those
native
cornea.
Extensive
vitro
vivo
studies
validate
SQPV's
ability
effectively
eliminate
residual
bacteria,
mitigate
inflammation,
foster
regeneration
epithelium
stroma,
prevent
scarring,
ultimately
expedite
In
summary,
SF/CS-based
may
represent
promising
substitute
comprehensive
repair
IK.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(18)
Опубликована: Янв. 23, 2024
Abstract
Antimicrobial
therapy
remains
one
of
the
major
global
challenges,
particularly
in
absence
effective
treatment
strategies
for
drug‐resistant
bacteria.
In
this
study,
a
comprehensive
approach
is
proposed
bacterial
wound
infections
based
on
development
thermal‐cascade
multifunctional
therapeutic
systems
(MTSs),
spanning
from
design
functional
nanoscale
materials
to
macroscopic
smart
hydrogel.
Within
MTSs,
antibiotic‐loaded
hybrid
nanoclusters
enable
targeted
delivery
and
synergistic
mild
hyperthermia‐antibiotic
treatment,
strongly
suppressing
bacteria
while
demonstrating
excellent
biocompatibility
with
normal
cells
tissues.
Furthermore,
near‐infrared
irradiation
can
trigger
photothermal
effects
induce
gelation
thermal‐sensitive
hydrogel,
forming
MTSs
serve
as
highly
adaptable,
drug‐enriched
protective
dressings
infected
wounds.
Both
vitro
vivo
results
substantiate
that
enhance
bioavailability
agents
(including
internalization
tissue
penetration),
exert
completely
eradicate
bacteria,
promoted
healing
revascularization,
demonstrate
biocompatibility.
This
work
offers
an
innovative
demonstration
address
through
advancement
sophisticated
material
systems.
Bioactive Materials,
Год журнала:
2024,
Номер
37, С. 106 - 118
Опубликована: Март 19, 2024
Effective
control
of
post-extraction
hemorrhage
and
alveolar
bone
resorption
is
critical
for
successful
extraction
socket
treatment,
which
remains
an
unmet
clinical
challenge.
Herein,
injectable
Tetra-PEG
hydrogel
that
possesses
rapid
gelation,
firm
tissue
adhesion,
high
mechanical
strength,
suitable
degradability,
excellent
biocompatibility
developed
as
a
sutureless
coagulation-independent
bioadhesive
the
management
sockets.
Our
results
demonstrate
robust
adhesive
sealing
by
can
provide
reliable
protection
underlying
wound
stabilize
blood
clots
to
facilitate
healing.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 14, 2024
Abstract
Antimicrobial
photodynamic
therapy
(aPDT)
has
emerged
as
an
appealing
therapeutic
option
against
biofilm
infections.
However,
effectively
penetrating
the
dense
barrier
of
and
anchoring
bacteria
to
achieve
elimination
wound
healing
under
hypoxic
environments
remains
a
challenge
for
aPDT.
Herein,
three
type
I/II
Hypocrellin
B
(HB)‐cationic
photosensitizers
(HB‐P,
HB‐TP,
HB‐TTP)
are
designed
based
on
multi‐cationic
long
chains
molecular
engineering
strategy.
With
increasing
number
introduced
cations,
reactive
oxygen
species
(ROS)
production
bacterial‐anchoring
abilities
HB‐cationic
greatly
enhanced.
Notably,
HB‐TTP
demonstrates
higher
aPDT
activity
broad‐spectrum
antibacterial
properties.
Furthermore,
address
conundrum
biofilm‐infected
wounds,
ROS‐responsive
core‐shell
microneedle
(HB‐TTP&EGF@MN)
is
by
biphasically
integrating
growth
factor.
When
penetrates
biofilm,
shell
quickly
dissolves
releases
removal
laser
irradiation.
The
core
subsequently
degraded
slowly
in
presence
endogenous
ROS
within
wound,
facilitating
sustained
release
factor
promote
tissue
regeneration.
This
work
not
only
provides
effective
strategy
rational
design
efficient
antimicrobial
agents
but
also
proposes
innovative
ideas
development
controlled‐release
pharmaceutical
materials
synergize
