Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Апрель 23, 2024
Abstract
Currently,
microbial
infections
have
posed
an
arduous
challenge
to
global
public
health,
whereas
the
rise
of
antibiotic
resistance
is
rendering
traditional
therapies
futile,
prompting
development
new
antimicrobial
technologies.
Photoactive
nanomaterials
thus
garnered
a
thriving
interest
for
disinfection
owing
their
superior
antibacterial
efficaciousness,
favorable
biosafety,
and
rapidness
spatiotemporal
precision
in
excreting
bactericidal
actions.
The
review
summarizes
recent
advances
emerging
trends
design,
nanoengineering,
bioapplications
photoactive
antimicrobials.
It
commences
by
elaborating
fundamental
theories
on
bacterial
resistance,
mechanisms
phototherapy.
Subsequently,
regulation
effectiveness
comprehensively
discussed,
centering
criteria
strategies
tuning
photoabsorption
spectra,
photothermal
conversion,
photocatalytic
efficiency,
alongside
tactics
enabling
synergistic
therapies.
This
followed
comparative
analyses
techniques
modalities
synthesizing
engineering
with
diverse
structures,
forms,
functionalities.
Thereafter,
state‐of‐the‐art
applications
phototherapies
across
various
medical
sectors
are
portrayed,
key
challenges
opportunities
finally
discussed
spur
future
innovations
translation.
envisaged
provide
useful
guidance
devising
developing
nanomaterials‐based
photoresponsive
antimicrobials
application‐specific
materials
properties
biological
functions.
Advanced Materials,
Год журнала:
2024,
Номер
36(33)
Опубликована: Июнь 14, 2024
Infectious
diseases
caused
by
bacterial,
viral,
and
fungal
pathogens
present
significant
global
health
challenges.
The
rapid
emergence
of
antimicrobial
resistance
exacerbates
this
issue,
leading
to
a
scenario
where
effective
antibiotics
are
increasingly
scarce.
Traditional
antibiotic
development
strategies
proving
inadequate
against
the
swift
evolution
microbial
resistance.
Therefore,
there
is
an
urgent
need
develop
novel
with
mechanisms
distinct
from
those
existing
antibiotics.
Nanozybiotics,
which
nanozyme-based
antimicrobials,
mimic
catalytic
action
lysosomal
enzymes
in
innate
immune
cells
kill
infectious
pathogens.
This
review
reinforces
concept
nanozymes
provides
comprehensive
summary
recent
research
advancements
on
potential
candidates.
Initially,
nanozybiotics
categorized
based
their
activities,
mimicking
either
oxidoreductase-like
or
hydrolase-like
functions,
thereby
highlighting
superior
combating
then
discusses
progress
treating
infections,
confirming
as
translational
nanozybiotic-based
products,
including
hydrogels,
nanorobots,
sprays,
bandages,
masks,
protective
clothing,
also
considered.
Finally,
current
challenges
future
prospects
nanozybiotic-related
products
explored,
emphasizing
design
capabilities
for
applications.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
Abstract
Dentin
hypersensitivity
(DH),
marked
by
exposed
dentinal
tubules,
presents
as
a
sharp
toothache
triggered
stimuli
and
subsides
when
the
are
removed.
To
address
limitations
of
current
commercial
desensitizers
in
terms
acid
resistance,
friction
stability,
black
phosphorus
nanosheet‐composited
methacrylate
gelatin
hydrogel
(GelMA/BP)
is
developed
for
DH
treatment,
leveraging
synergistic
effects
photothermal
therapy
biomineralization.
Incorporating
BP
nanosheet
provided
GelMA/BP
with
stable
response
continuous
release
phosphate
anions,
which
blocked
tubules
converting
light
energy
into
heat
initiating
In
vitro
desensitizing
showed
that
tubule
diameter
GelMA/BP50
group
(0−1.13
µm)
significantly
reduced
compared
to
DH‐model
(0−3.14
µm).
The
achieved
an
86%
occlusion
rate,
resistance
80%,
76%,
long‐term
stability
74%.
vivo
studies
further
validated
efficacy
GelMA/BP50,
showing
reduction
(0−0.37
rate
79%,
alleviated
increased
intake
weight.
These
results
demonstrate
this
acts
effective
sealant,
offering
promising
clinical
benefits
topical
treatment
DH.
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Infectious
diseases
pose
considerable
challenges
to
public
health,
particularly
with
the
rise
of
multidrug‐resistant
pathogens
that
globally
cause
high
mortality
rates.
These
can
persist
on
surfaces
and
spread
in
healthcare
settings.
Advances
have
been
made
developing
antimicrobial
materials
reduce
transmission
pathogens,
including
composed
naturally
sourced
polyphenols
their
derivatives,
which
exhibit
potency,
broad‐spectrum
activity,
a
lower
likelihood
promoting
resistance.
This
review
provides
an
overview
recent
advances
fabrication
phenolic
biomaterials,
where
natural
compounds
act
as
active
agents
or
encapsulate
other
(e.g.,
metal
ions,
peptides,
biopolymers).
Various
forms
biomaterials
synthesized
through
these
two
strategies,
particles,
capsules,
hydrogels,
coatings,
are
summarized,
focus
application
wound
healing,
bone
repair
regeneration,
oral
coatings
for
medical
devices.
The
potential
advanced
promising
therapeutic
approach
combating
antimicrobial‐resistant
infections
reducing
microbial
transmission.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 14, 2024
Abstract
Antimicrobial
photodynamic
therapy
(aPDT)
has
emerged
as
an
appealing
therapeutic
option
against
biofilm
infections.
However,
effectively
penetrating
the
dense
barrier
of
and
anchoring
bacteria
to
achieve
elimination
wound
healing
under
hypoxic
environments
remains
a
challenge
for
aPDT.
Herein,
three
type
I/II
Hypocrellin
B
(HB)‐cationic
photosensitizers
(HB‐P,
HB‐TP,
HB‐TTP)
are
designed
based
on
multi‐cationic
long
chains
molecular
engineering
strategy.
With
increasing
number
introduced
cations,
reactive
oxygen
species
(ROS)
production
bacterial‐anchoring
abilities
HB‐cationic
greatly
enhanced.
Notably,
HB‐TTP
demonstrates
higher
aPDT
activity
broad‐spectrum
antibacterial
properties.
Furthermore,
address
conundrum
biofilm‐infected
wounds,
ROS‐responsive
core‐shell
microneedle
(HB‐TTP&EGF@MN)
is
by
biphasically
integrating
growth
factor.
When
penetrates
biofilm,
shell
quickly
dissolves
releases
removal
laser
irradiation.
The
core
subsequently
degraded
slowly
in
presence
endogenous
ROS
within
wound,
facilitating
sustained
release
factor
promote
tissue
regeneration.
This
work
not
only
provides
effective
strategy
rational
design
efficient
antimicrobial
agents
but
also
proposes
innovative
ideas
development
controlled‐release
pharmaceutical
materials
synergize
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(22), С. 10800 - 10826
Опубликована: Янв. 1, 2024
This
review
provides
a
guideline
for
the
rational
design
of
metal–phenolic
network
(MPN)
composites—which
are
fabricated
from
MPN
and
one
or
more
functional
components
(
e.g.
,
drugs,
proteins)—for
various
applications
across
diverse
disciplines.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(44)
Опубликована: Май 27, 2024
Abstract
Biofilm‐associated
infections
pose
complex
challenges
that
require
addressing
the
multifaceted
requirements
of
biofilm
disruption,
bacterial
killing,
and
immunomodulation.
In
this
study,
microenvironment‐adaptive
metallo‐polymeric
nanodecoys
(MPNs)
are
synthesized
through
one‐pot
subcomponent
coordination
in
aqueous
solution,
effectively
eradicating
biofilms
modulating
immune
response.
Within
acidic
microenvironment
biofilms,
positively
charged
MPNs
demonstrated
ability
to
interact
with
eliminate
bacteria
while
facilitating
a
Fenton‐like
reaction
for
efficient
eradication
biofilms.
As
local
shifted
from
neutral
basic
state
during
subsequent
tissue
healing
processes,
adaptively
harness
multiple
properties
bind
pathogen‐associated
molecular
patterns,
scavenge
reactive
oxygen
species,
thereby
response,
alleviating
inflammation,
promoting
healing.
This
study
presents
an
strategy
preparing
enzyme‐mimicking
materials
closely
resemble
natural
metalloenzymes,
offer
alternative
current
antibiotic
treatments
biofilm‐associated
infections.
