Abstract
Commencing
with
the
breakdown
of
diabetic
osteoimmune
microenvironment,
multiple
pathogenic
factors,
including
hyperglycemia,
inflammation,
hypoxia,
and
deleterious
cytokines,
are
conjointly
involved
in
progression
periodontal
bone
regeneration.
Based
on
challenge
regeneration
treatment
absence
real‐time
feedback
blood
oxygen
fluctuation
diabetes
mellitus,
a
novel
self‐adaptive
hyperthermia
supramolecular
cascade
nano‐reactor
ACFDG
is
constructed
via
one‐step
self‐assembly
strategy
to
address
factors
Hyperthermia
possesses
high
photothermal
conversion
efficiency
(32.1%),
it
can
effectively
inhibit
vicious
cycle
ROS‐inflammatory
through
catalytic
reactions,
up‐regulate
expression
heat
shock
proteins
(HSPs)
under
near‐infrared
(NIR)
irradiation,
which
promotes
Remarkably,
provide
non‐invasive
diagnosis
changes
during
photoacoustic
(PA)
imaging,
thus
timely
monitor
hypoxia
status.
In
conclusion,
this
multifunctional
combined
PA
imaging
for
efficacy
monitoring
provides
important
insights
into
biological
mechanisms
potential
clinical
theranostics.
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100827 - 100827
Опубликована: Окт. 2, 2023
Biofilms
are
aggregates
of
organized
microbial
growth
that
function
as
barriers
and
create
a
stable
internal
environment
for
cell
survival.
The
bacteria
in
the
biofilms
exhibit
characteristics
quite
different
from
planktonic
bacteria,
such
strong
resistance
to
antibiotics
other
bactericides,
getting
out
host
immunity,
developing
harsh
environments,
which
all
contribute
persistent
intractable
treatment.
Hence,
there
is
an
urgent
need
develop
novel
materials
strategies
combat
biofilms.
However,
most
reviews
on
anti-biofilms
published
recent
years
based
specific
fields
or
materials.
Microorganisms
ubiquitous,
except
context
medical
health
issues;
however,
exert
detrimental
effects
advancement
progress
various
fields.
Therefore,
this
review
aims
provide
comprehensive
summary
effective
methodologies
applicable
across
industries.
Firstly,
process
formation
was
introduced
enhance
our
comprehension
"enemy".
Secondly,
intervene
important
links
were
discussed,
taking
timely
action
during
early
weak
stages
Thirdly,
treatment
mature
summarized
deal
with
break
through
defense
line.
Finally,
several
substances
antibacterial
properties
presented.
concludes
standpoint
author
about
potential
developments
strategies.
This
may
help
researchers
quickly
understand
research
challenges
field
design
more
efficient
methods
Abstract
Topical
antibiotics
can
be
utilized
to
treat
periodontitis,
while
their
delivery
stratagems
with
controlled
release
and
long‐lasting
bactericidal
inhibition
are
yet
challenging.
Herein,
inspired
by
the
defensive
behavior
of
cuttlefish
expelling
ink,
this
work
develops
innovative
thermal‐responsive
melanin‐integrated
porous
microparticles
(MPs)
through
microfluidic
synthesis
for
periodontitis
treatment.
These
MPs
composed
melanin
nanoparticles
(NPs),
poly(N‐isopropylacrylamide)
(PNIPAM),
agarose.
Benefiting
from
excellent
biocompatibility
large
surface
area
ratio
MPs,
they
deliver
abundant
NPs.
Under
near‐infrared
irradiation,
NPs
convert
photo
energy
into
thermal
energy.
This
leads
agarose
melting
subsequent
shrinkage
microspheres
induced
pNIPAM,
thereby
facilitating
In
addition,
released
serve
as
a
highly
effective
photothermal
agent,
displaying
potent
antibacterial
activity
against
porphyromonas
gingivalis
possessing
natural
anti‐inflammatory
properties.
unique
characteristics
further
demonstrated
in
vivo
experiments,
showing
effects
treatment
infected
wounds
periodontitis.
Therefore,
catfish‐inspired
photo‐responsive
controlled‐release
drug
hold
tremendous
potential
clinical
applications.
Abstract
Commencing
with
the
breakdown
of
diabetic
osteoimmune
microenvironment,
multiple
pathogenic
factors,
including
hyperglycemia,
inflammation,
hypoxia,
and
deleterious
cytokines,
are
conjointly
involved
in
progression
periodontal
bone
regeneration.
Based
on
challenge
regeneration
treatment
absence
real‐time
feedback
blood
oxygen
fluctuation
diabetes
mellitus,
a
novel
self‐adaptive
hyperthermia
supramolecular
cascade
nano‐reactor
ACFDG
is
constructed
via
one‐step
self‐assembly
strategy
to
address
factors
Hyperthermia
possesses
high
photothermal
conversion
efficiency
(32.1%),
it
can
effectively
inhibit
vicious
cycle
ROS‐inflammatory
through
catalytic
reactions,
up‐regulate
expression
heat
shock
proteins
(HSPs)
under
near‐infrared
(NIR)
irradiation,
which
promotes
Remarkably,
provide
non‐invasive
diagnosis
changes
during
photoacoustic
(PA)
imaging,
thus
timely
monitor
hypoxia
status.
In
conclusion,
this
multifunctional
combined
PA
imaging
for
efficacy
monitoring
provides
important
insights
into
biological
mechanisms
potential
clinical
theranostics.
