STUDIES IN ENGINEERING AND EXACT SCIENCES,
Год журнала:
2024,
Номер
5(2), С. e11649 - e11649
Опубликована: Дек. 6, 2024
In
this
work
the
study
investigates
intermolecular
interactions
in
Guanosine
(Guo)
into
β-cyclodextrin
(β-CD)
and
their
derivatives,
such
as
hydroxypropyl-βCD
(HPβCD)
inclusion
complexes
using
Density
Functional
Theory
including
dispersion
correction
(DFT-D3)
method
following
functional,
B3LYP/6-31G
basis
set
both
gaz
aqueous
phases.
These
geometries
were
optimized
final
results
examined
contrasted.
The
global
chemical
reactivity
descriptors,
Fukui
function,
HOMO
LUMO
energies
calculated.
TD-DFT
was
used
to
determine
absorption
spectra.To
forecast
reactive
sites
for
electrophilic
nucleophilic
attack,
molecular
electrostatic
potential
computed.
interaction
bonds
investigated
formation
of
conventional
hydrogen
detected
by
AIM
analysis.
nature
further
elucidated
non-covalent
(NCI).
This
showed
that
van
der
Waals
contribute
significantly
complex.
To
gain
more
insight
emission
complex,
gap
energy
(EHOMO-ELUMO)
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(5), С. 2742 - 2761
Опубликована: Апрель 19, 2024
Periodontitis
is
a
common
condition
characterized
by
bacterial
infection
and
the
disruption
of
body's
immune-inflammatory
response,
which
causes
damage
to
teeth
supporting
tissues
eventually
results
in
tooth
loss.
Current
therapy
involves
systemic
local
administration
antibiotics.
However,
existing
treatments
cannot
exert
effective,
sustained
release
maintain
an
effective
therapeutic
concentration
drug
at
lesion
site.
Hydrogels
are
used
treat
periodontitis
due
their
low
cytotoxicity,
exceptional
water
retention
capability,
controlled
profile.
can
imitate
extracellular
matrix
periodontal
cells
while
offering
suitable
sites
load
This
article
reviews
utilization
hydrogels
for
based
on
pathogenesis
clinical
manifestations
disease.
Additionally,
latest
strategies
smart
main
techniques
hydrogel
preparation
have
been
discussed.
The
information
will
aid
designing
preparing
future
treatment.
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
High
levels
of
reactive
oxygen
species
(ROS)
and
hypoxia
in
diabetic
wounds
significantly
hinder
the
healing
process.
In
this
work,
a
kind
catalase-like
nanozyme-hybrid
hydrogel
was
developed
to
explore
potential
harnessing
endogenous
excessive
ROS
as
an
source
synergistically
regulate
oxidative
stress
hypoxia,
thereby
enhancing
wound
healing.
The
hydrogels
exhibited
rapid
degradation
controlled
release
ferrihydrite
nanozymes
response
stress,
which
continuously
catalyzed
decomposition
H2O2
generate
oxygen,
effectively
scavenging
reducing
risk
local
toxicity.
relieved
intracellular
hypoxic
microenvironment
simultaneously
vitro.
dressings
inhibited
damage
at
sites,
promoted
epidermis
formation
collagen
deposition,
accelerated
db/db
mice.
Therefore,
represent
promising
strategy
for
dressings,
addressing
both
improve
outcomes.
