Rheumatoid
arthritis
(RA)
is
a
chronic
inflammatory
autoimmune
disease
accompanied
by
persistent
multiarticular
synovitis
and
cartilage
degradation.
The
present
clinical
treatments
are
limited
to
disease-modifying
anti-rheumatic
drugs
(DMARDs)
aims
relieve
pain
control
the
inflammation
of
RA.
Despite
considerable
advances
in
research
RA,
employment
current
procedure
enormous,
hindered
systemic
side
effect,
frequent
administration,
tolerance
from
long-lasting
high
costs.
Emerging
immunoengineering-based
strategies,
such
as
multiple
immune-active
nanotechnologies
via
mechanism-based
immunology
approaches,
have
been
developed
improve
specific
targeting
reduce
adverse
reactions
for
RA
treatments.
Here,
we
review
recent
studies
immunoengineering
treatment
prospect
future
has
also
discussed.
Triple
negative
breast
cancer
(TNBC)
cells
have
a
high
demand
for
oxygen
and
glucose
to
fuel
their
growth
spread,
shaping
the
tumor
microenvironment
(TME)
that
can
lead
weakened
immune
system
by
hypoxia
increased
risk
of
metastasis.
To
disrupt
this
vicious
circle
improve
therapeutic
efficacy,
strategy
is
proposed
with
synergy
ferroptosis,
immunosuppression
reversal
disulfidptosis.
An
intelligent
nanomedicine
GOx-IA@HMON@IO
successfully
developed
realize
strategy.
The
Fe
release
behaviors
indicate
glutathione
(GSH)-responsive
degradation
HMON.
results
titanium
sulfate
assay,
electron
spin
resonance
(ESR)
spectra,
5,5'-Dithiobis-(2-nitrobenzoic
acid
(DTNB)
assay
T
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(47)
Опубликована: Июль 31, 2024
Abstract
Near‐infrared
photosensitizers
are
valuable
tools
to
improve
treatment
depth
in
photodynamic
therapy
(PDT).
However,
their
low
singlet
oxygen
(
1
O
2
)
generation
ability,
indicated
by
quantum
yield,
presents
a
formidable
challenge
for
PDT.
To
overcome
this
challenge,
the
heptamethine
cyanine
was
decorated
with
biocompatible
S
Scy7
and
Se
Secy7
atom.
We
observe
that
exhibits
redshift
main
absorption
~840
nm
an
ultra‐efficient
capacity.
The
emergence
of
strong
intramolecular
charge
transfer
effect
between
atom
polymethine
chain
considerably
narrows
energy
gap
(0.51
eV),
heavy
strengthens
spin–orbit
coupling
(1.44
cm
−1
),
both
which
greatly
improved
high
triplet
state
yield
(61
%),
determines
.
Therefore,
demonstrated
excellent
capacity,
is
~24.5‐fold
indocyanine
green,
~8.2‐fold
IR780,
~1.3‐fold
methylene
blue
under
low‐power‐density
850
irradiation
(5
mW
−2
).
considerable
phototoxicity
toward
cancer
cells
buried
12
mm
tissue.
Nanoparticles
formed
encapsulating
within
amphiphilic
polymers
lecithin,
promising
antitumor
anti‐pulmonary
metastatic
effects,
exhibiting
remarkable
potential
advancing
PDT
deep
tissues.
Due
to
the
inherent
low
immunogenicity
and
immunosuppressive
tumor
microenvironment
(TME)
of
malignant
cancers,
clinical
efficacy
application
immunotherapy
have
been
limited.
Herein,
a
bimetallic
drug-gene
co-loading
network
(Cu/ZIF-8@U-104@siNFS1-HA)
is
developed
that
increased
intracellular
labile
iron
pool
(LIP)
enhanced
weakly
acidic
TME
by
co-suppressing
dual
enzymatic
activities
carbonic
anhydrase
IX
(CA
IX)
cysteine
desulfurylase
(NFS1),
inducing
safe
efficient
initial
immunogenic
ferroptosis.
During
this
process,
Cu
Advanced Materials,
Год журнала:
2024,
Номер
36(52)
Опубликована: Ноя. 16, 2024
Radiofrequency
ablation
(RFA),
a
critical
therapy
for
hepatocellular
carcinoma
(HCC),
carries
significant
risk
of
recurrence
and
metastasis,
particularly
owing
to
mechanisms
involving
immune
evasion
antigen
downregulation
via
epigenetic
modifications.
This
study
introduces
"nano-epidrug"
named
MFMP.
MFMP,
which
is
composed
hollow
mesoporous
manganese
dioxide
(MnO2)
nanoparticles,
FIDAS-5
as
an
MAT2A
inhibitor,
macrophage
membrane,
anti-PD-L1
(aPD-L1),
targets
HCC
cells.
By
selectively
binding
these
cells,
MFMP
initially
reverses
suppression
PD-L1
inhibition.
After
endocytosis,
disassembles
in
the
tumor
microenvironment,
releasing
Mn2+.
prevents
cGAS
methylation,
whereas
Mn2+
aids
STING
pathway
restoration.
In
addition,
reduces
m6A
RNA
modification,
suppressing
EGFR
expression.
These
changes
enhance
antigenicity
promote
cytotoxic
T
cell
recognition
killing.
Furthermore,
mediates
immunogenic
death
by
synergizing
with
RFA
through
DNA
demethylation,
mRNA
TBK1
protein
phosphorylation,
thereby
inhibiting
metastasis
enhancing
memory.
Thus,
potential
adjunctive
requiring
clinical
validation.
Abstract
Cancer
immunotherapy
has
attracted
considerable
attention
due
to
its
advantages
of
persistence,
targeting,
and
ability
kill
tumor
cells.
However,
the
efficacy
in
practical
applications
is
limited
by
heterogeneity
complex
immunosuppressive
microenvironments
which
abundant
M2
macrophages
immune
checkpoints
(ICs)
are
present.
Herein,
two
type‐I
aggregation‐induced
emission
(AIE)‐active
photosensitizers
with
various
reactive
oxygen
species
(ROS)‐generating
efficiencies
designed
synthesized.
Engineered
extracellular
vesicles
(EVs)
that
express
ICs
Siglec‐10
first
obtained
from
4T1
The
engineered
EVs
then
fused
AIE
photosensitizer‐loaded
lipidic
nanosystem
form
SEx@Fc‐NPs.
ROS
generated
inner
photosensitizer
SEx@Fc‐NPs
through
photodynamic
therapy
(PDT)
can
convert
into
M1
improve
microenvironment.
outer
EV‐antigens
carry
tumor‐associated
antigens
directly
stimulate
dendritic
cells
maturation
activate
different
types
tumor‐specific
T
overcoming
heterogeneity.
In
addition,
blocking
reversed
macrophage
exhaustion
for
enhanced
antitumor
ability.
This
study
presents
a
combination
PDT,
checkpoints,
greatly
efficiency
expected
serve
as
an
emerging
strategy
microenvironment
overcome
escape.
Materials & Design,
Год журнала:
2024,
Номер
241, С. 112975 - 112975
Опубликована: Апрель 21, 2024
Periodontitis,
a
common
chronic
inflammatory
disease,
is
characterized
by
T
cell
responses
leading
to
gradual
alveolar
bone
loss
and
eventual
tooth
mobility
or
loss.
Herein,
polylysine-derived
carbon
quantum
dots
(PLL-CQDs)
are
synthesized
via
the
pyrolysis
method
facilitate
recovery
of
periodontal
induced
periodontitis
modulating
phenotype.
The
PLL-CQDs,
small
particle
size
(2.31
±
0.70
nm)
fluorescence
properties,
preserved
positive
charge
PLL,
affirming
successful
preparation.
In
vitro
studies
revealed
that
PLL-CQDs
significantly
increased
proliferation
in
concentration-dependent
manner,
while
effectively
suppressing
differentiation
into
CD4+
Furthermore,
they
promoted
alkaline
phosphatase
expression
calcium
nodule
formation
MC3T3-E1
cells,
indicating
potential
for
regeneration.
vivo
experiments
demonstrated
mitigated
resorption
modulated
tissue
inflammation.
Overall,
exhibited
ability
regulate
expedite
healing,
offering
promising
implications
treatment
suggesting
novel
strategies
addressing
immune-associated
diseases
using
CQDs.
