ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Osteosarcoma,
a
predominant
malignant
tumor
among
adolescents,
exhibits
high
mortality
and
suboptimal
immunotherapy
efficacy
due
to
collagen-dense
extracellular
matrix
(ECM)
that
hinders
cytotoxic
T
lymphocyte
(CTL)
infiltration.
Herein,
we
developed
mesoporous
polydopamine
(MPDA)
nanoparticles
encapsulating
bromelain
the
immune
adjuvant
R848
(M@B/R),
aimed
at
enhancing
photothermal
immunotherapy.
These
efficiently
accumulate
site
following
injection.
Upon
near-infrared
(NIR)
light
irradiation,
therapy
(PTT)
induces
immunogenic
cell
death
in
cells
and,
with
aid
of
R848,
promotes
dendritic
maturation,
activating
antitumor
immunity
leading
CTL
infiltration
into
tumor.
Concurrently,
NIR-induced
heating
activates
bromelain,
resulting
ECM
degradation
improved
penetration
Our
vivo
evaluations
demonstrate
potent
effects
osteosarcoma-bearing
mice.
This
integrated
approach
offers
promising
strategy
for
overcoming
physical
barriers
ECM-rich
tumors,
marking
significant
advancement
treatment
osteosarcoma.
Abstract
Photothermal
therapy
(PTT)
has
garnered
significant
attention
in
recent
years,
but
the
standalone
application
of
PTT
still
faces
limitations
that
hinder
its
ability
to
achieve
optimal
therapeutic
outcomes.
Nitric
oxide
(NO),
being
one
most
extensively
studied
gaseous
molecules,
presents
itself
as
a
promising
complementary
candidate
for
PTT.
In
response,
various
nanosystems
have
been
developed
enable
simultaneous
utilization
and
NO‐mediated
gas
(GT),
with
integration
photothermal
agents
(PTAs)
thermally‐sensitive
NO
donors
prevailing
approach.
This
combination
seeks
leverage
synergistic
effects
GT
while
mitigating
potential
risks
associated
toxicity
through
use
single
laser
irradiation.
Furthermore,
additional
internal
or
external
stimuli
employed
trigger
release
when
combined
different
types
PTAs,
thereby
further
enhancing
efficacy.
comprehensive
review
aims
summarize
advancements
gas‐assisted
cancer
treatment.
It
commences
by
providing
an
overview
precursors,
including
those
sensitive
photothermal,
light,
ultrasound,
reactive
oxygen
species,
glutathione.
These
precursors
are
discussed
context
dual‐modal
PTT/GT.
Subsequently,
incorporation
other
treatment
modalities
such
chemotherapy
(CHT),
photodynamic
(PDT),
alkyl
radical
therapy,
radiation
immunotherapy
(IT)
creation
triple‐modal
nanoplatforms
is
presented.
The
explores
tetra‐modal
therapies,
PTT/GT/CHT/PDT,
PTT/GT/CHT/chemodynamic
(CDT),
PTT/GT/PDT/IT,
PTT/GT/starvation
(ST)/IT,
PTT/GT/Ca
2+
overload/IT,
PTT/GT/ferroptosis
(FT)/IT,
PTT/GT/CDT/IT.
Finally,
challenges
future
perspectives
concerning
these
novel
paradigms
discussed.
anticipated
serve
valuable
resource
studies
focused
on
development
innovative
photothermal/NO‐based
nanotheranostics.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(48)
Опубликована: Июнь 26, 2024
Abstract
The
growing
concerns
regarding
cancer
recurrence,
unpredictable
bone
deficiencies,
and
postoperative
bacterial
infections
subsequent
to
the
surgical
removal
of
tumors
have
highlighted
need
for
multifaceted
scaffolds
that
afford
tumor
therapy,
effective
vascularized
reconstruction.
However,
challenging
trilemma
has
emerged
in
realm
balance
between
achieving
appropriate
mechanical
strength,
ensuring
biocompatibility,
optimizing
a
degradation
rate
aligns
with
bone‐regenerative
rate.
Considering
these
challenges,
innovative
theragenerative
platform
is
developed
by
utilizing
3D
printing‐based
nanospikes
first
time.
This
comprises
tissue‐specific
nanospiked
hydroxyapatite
decorated
magnesium
(nMg)
adhesive
DNA
(aDNA).
incorporation
nMg
within
polylactic
acid
(PLA)
matrix
confers
photothermal
capabilities
helps
modulate
properties
improve
biocompatibility
platform.
Simultaneously,
immobilized
aDNA
contributed
enhancement
healing.
These
3D‐printed
tissue‐adhesive
platforms
exhibit
superior
offer
controlled
degradability.
Moreover,
they
enable
eradication
bacteria
osteosarcoma
through
hyperthermia
promote
angiogenesis
osteogenesis,
both
vitro
vivo.
groundbreaking
approach
poised
pave
way
fabrication
design
novel
implantable
biomaterials
integrate
therapeutic
regenerative
functions.
Abstract
Photoacoustic
imaging
(PAI)‐guided
photothermal
therapy
(PTT)
in
the
second
near‐infrared
(NIR‐II,
1000–1700
nm)
window
has
been
attracting
attention
as
a
promising
cancer
theranostic
platform.
Here,
it
is
reported
that
π‐extended
porphyrins
fused
with
one
or
two
nanographene
units
(NGP‐1
and
NGP‐2)
can
serve
new
class
of
NIR‐responsive
organic
agents,
displaying
absorption
extending
to
≈1000
≈1400
nm
NIR‐I
NIR‐II
windows,
respectively.
NGP‐1
NGP‐2
are
dispersed
water
through
encapsulation
into
self‐assembled
nanoparticles
(NPs),
achieving
high
conversion
efficiency
60%
69%,
respectively,
under
808
1064
laser
irradiation.
Moreover,
NIR‐II‐active
NGP‐2‐NPs
demonstrated
photoacoustic
responses,
along
photostability
biocompatibility,
enabling
PAI
efficient
PTT
vivo.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
Nitric
oxide
(NO)
is
an
essential
molecule
in
biomedicine,
recognized
for
its
antibacterial
properties,
neuronal
modulation,
and
use
inhalation
therapies.
The
effectiveness
of
NO-based
treatments
relies
on
precise
control
NO
concentrations
tailored
to
specific
therapeutic
needs.
Electrochemical
generation
(E-NOgen)
via
nitrite
(NO2
-)
reduction
offers
a
scalable
efficient
route
controlled
production,
while
also
addressing
environmental
concerns
by
reducing
NO2
-
pollution
maintaining
nitrogen
cycle
balance.
Recent
developments
catalysts
E-NOgen
devices
have
propelled
conversion,
enabling
on-demand
production.
This
review
provides
overview
pathways,
with
focus
cutting-edge
Fe/Cu-based
catalysts,
explores
the
development
biomedical
use.
Challenges
future
directions
advancing
technologies
are
discussed.
Gene
therapy
(GT)
and
photothermal
(PTT)
have
emerged
as
promising
alternatives
to
chemotherapy
radiotherapy
for
cancer
treatment,
offering
noninvasiveness
reduced
side
effects.
However,
their
efficacy
standalone
treatments
is
limited.
GT
exhibits
slow
response
rates,
while
PTT
confined
local
tumor
ablation.
The
convergence
of
PTT,
known
GT-PTT,
facilitated
by
gene
nanocarriers,
has
attracted
considerable
attention
across
various
disciplines.
In
this
integrated
approach,
reciprocates
sensitizing
cellular
heat,
benefits
improving
translocation,
unpacking,
expression.
Consequently,
integration
presents
a
unique
opportunity
with
rapid
improved
effectiveness.
Extensive
efforts
over
the
past
few
years
been
dedicated
development
resulting
in
notable
achievements
progress
from
laboratory
potential
clinical
applications.
This
comprehensive
review
outlines
recent
advances
including
synergistic
mechanisms,
material
systems,
imaging-guided
therapy,
anticancer
It
also
explores
challenges
future
prospects
nascent
field.
By
presenting
innovative
ideas
insights
into
implementation
GT-PTT
enhanced
aims
inspire
further
area
research.
Advanced Materials,
Год журнала:
2023,
Номер
36(13)
Опубликована: Дек. 29, 2023
The
dense
extracellular
matrix
(ECM)
in
the
pancreatic
cancer
severely
hampers
penetration
of
nanodrugs,
which
causes
inferior
therapeutic
efficacy.
To
address
this
issue,
a
multifunctional
liposome,
namely,
Lip-DTI/NO,
integrating
type-I
photosensitizer
DTITBT
with
glutathione
(GSH)
or
heat-responsive
nitric
oxide
(NO)
donor
S-nitroso-N-acetyl-D-penicillamine
(SNAP)
is
constructed
to
deplete
tumor
ECM,
leading
enhanced
drug
delivery
and
consequently
improved
phototherapy.
loaded
possesses
multiple
functions
including
NIR-II
fluorescence
imaging,
efficient
superoxide
radical
(O
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(17)
Опубликована: Март 6, 2024
Abstract
The
second
near‐infrared
(NIR‐II)
theranostics
offer
new
opportunities
for
precise
disease
phototheranostic
due
to
the
enhanced
tissue
penetration
and
higher
maximum
permissible
exposure
of
NIR‐II
light.
However,
traditional
regimens
lacking
effective
absorption
uncontrollable
excited‐state
energy
decay
pathways
often
result
in
insufficient
theranostic
outcomes.
Herein
a
nano‐agent
(PS‐1
NPs)
based
on
azulenyl
squaraine
derivatives
with
strong
band
centered
at
1092
nm
is
reported,
allowing
almost
all
absorbed
excitation
dissipate
through
non‐radiative
pathways,
leading
high
photothermal
conversion
efficiency
(90.98
%)
photoacoustic
response.
Both
vitro
vivo
photoacoustic/photothermal
therapy
results
demonstrate
deep
cancer
performance
PS‐1
NPs.
Even
5
mm
deep‐seated
tumor
model,
NPs
demonstrated
satisfactory
anti‐tumor
effect
imaging‐guided
therapy.
Moreover,
human
extracted
tooth
root
canal
infection
synergistic
outcomes
0.5
%
NaClO
solution
resulted
therapeutic
efficacy
comparable
clinical
gold
standard
irrigation
agent
5.25
NaClO,
opening
up
possibilities
expansion
agents
oral
medicine.
