Biomaterials, Год журнала: 2025, Номер 320, С. 123235 - 123235
Опубликована: Март 4, 2025
Язык: Английский
Exploration, Год журнала: 2024, Номер 4(6)
Опубликована: Март 24, 2024
Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.
Язык: Английский
Процитировано
38
Advanced Science, Год журнала: 2024, Номер 11(18)
Опубликована: Март 2, 2024
Abstract Photoacoustic imaging (PAI)‐guided photothermal therapy (PTT) in the second near‐infrared (NIR‐II, 1000–1700 nm) window has been attracting attention as a promising cancer theranostic platform. Here, it is reported that π‐extended porphyrins fused with one or two nanographene units (NGP‐1 and NGP‐2) can serve new class of NIR‐responsive organic agents, displaying absorption extending to ≈1000 ≈1400 nm NIR‐I NIR‐II windows, respectively. NGP‐1 NGP‐2 are dispersed water through encapsulation into self‐assembled nanoparticles (NPs), achieving high conversion efficiency 60% 69%, respectively, under 808 1064 laser irradiation. Moreover, NIR‐II‐active NGP‐2‐NPs demonstrated photoacoustic responses, along photostability biocompatibility, enabling PAI efficient PTT vivo.
Язык: Английский
Процитировано
23
Advanced Functional Materials, Год журнала: 2024, Номер 34(48)
Опубликована: Июнь 26, 2024
Abstract The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of tumors have highlighted need for multifaceted scaffolds that afford tumor therapy, effective vascularized reconstruction. However, challenging trilemma has emerged in realm balance between achieving appropriate mechanical strength, ensuring biocompatibility, optimizing a degradation rate aligns with bone‐regenerative rate. Considering these challenges, innovative theragenerative platform is developed by utilizing 3D printing‐based nanospikes first time. This comprises tissue‐specific nanospiked hydroxyapatite decorated magnesium (nMg) adhesive DNA (aDNA). incorporation nMg within polylactic acid (PLA) matrix confers photothermal capabilities helps modulate properties improve biocompatibility platform. Simultaneously, immobilized aDNA contributed enhancement healing. These 3D‐printed tissue‐adhesive platforms exhibit superior offer controlled degradability. Moreover, they enable eradication bacteria osteosarcoma through hyperthermia promote angiogenesis osteogenesis, both vitro vivo. groundbreaking approach poised pave way fabrication design novel implantable biomaterials integrate therapeutic regenerative functions.
Язык: Английский
Процитировано
22
Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122
Опубликована: Авг. 6, 2024
Язык: Английский
Процитировано
19
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 26, 2025
Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use inhalation therapies. The effectiveness of NO-based treatments relies on precise control NO concentrations tailored to specific therapeutic needs. Electrochemical generation (E-NOgen) via nitrite (NO2 -) reduction offers a scalable efficient route controlled production, while also addressing environmental concerns by reducing NO2 - pollution maintaining nitrogen cycle balance. Recent developments catalysts E-NOgen devices have propelled conversion, enabling on-demand production. This review provides overview pathways, with focus cutting-edge Fe/Cu-based catalysts, explores the development biomedical use. Challenges future directions advancing technologies are discussed.
Язык: Английский
Процитировано
2
Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
2
Small, Год журнала: 2023, Номер 20(6)
Опубликована: Сен. 29, 2023
Gene therapy (GT) and photothermal (PTT) have emerged as promising alternatives to chemotherapy radiotherapy for cancer treatment, offering noninvasiveness reduced side effects. However, their efficacy standalone treatments is limited. GT exhibits slow response rates, while PTT confined local tumor ablation. The convergence of PTT, known GT-PTT, facilitated by gene nanocarriers, has attracted considerable attention across various disciplines. In this integrated approach, reciprocates sensitizing cellular heat, benefits improving translocation, unpacking, expression. Consequently, integration presents a unique opportunity with rapid improved effectiveness. Extensive efforts over the past few years been dedicated development resulting in notable achievements progress from laboratory potential clinical applications. This comprehensive review outlines recent advances including synergistic mechanisms, material systems, imaging-guided therapy, anticancer It also explores challenges future prospects nascent field. By presenting innovative ideas insights into implementation GT-PTT enhanced aims inspire further area research.
Язык: Английский
Процитировано
34
Advanced Materials, Год журнала: 2023, Номер 36(13)
Опубликована: Дек. 29, 2023
The dense extracellular matrix (ECM) in the pancreatic cancer severely hampers penetration of nanodrugs, which causes inferior therapeutic efficacy. To address this issue, a multifunctional liposome, namely, Lip-DTI/NO, integrating type-I photosensitizer DTITBT with glutathione (GSH) or heat-responsive nitric oxide (NO) donor S-nitroso-N-acetyl-D-penicillamine (SNAP) is constructed to deplete tumor ECM, leading enhanced drug delivery and consequently improved phototherapy. loaded possesses multiple functions including NIR-II fluorescence imaging, efficient superoxide radical (O
Язык: Английский
Процитировано
30
Chemical Engineering Journal, Год журнала: 2024, Номер 482, С. 148711 - 148711
Опубликована: Янв. 12, 2024
Язык: Английский
Процитировано
12
Advanced Science, Год журнала: 2024, Номер 11(14)
Опубликована: Фев. 2, 2024
Abstract Hepatocellular carcinoma (HCC) is a form of malignancy with limited curative options available. To improve therapeutic outcomes, it imperative to develop novel, potent modalities. Ketoconazole (KET) has shown excellent efficacy against HCC by eliciting apoptosis. However, its water solubility hampers application in clinical treatment. Herein, mitochondria‐targeted chemo‐photodynamic nanoplatform, CS@KET/P780 NPs, designed using nanoprecipitation strategy integrating newly synthesized photosensitizer (P780) and chemotherapeutic agent KET coated chondroitin sulfate (CS) amplify therapy. In this CS confers tumor‐targeted subsequently pH‐responsive drug delivery behavior binding glycoprotein CD44, leading the release P780 KET. Mechanistically, following laser irradiation, targets destroys mitochondrial integrity, thus inducing apoptosis through enhancement reactive oxygen species (ROS) buildup. Meanwhile, KET‐induced synergistically enhances anticancer effect P780. addition, tumor cells undergoing can trigger immunogenic cell death (ICD) longer‐term antitumor response releasing tumor‐associated antigens (TAAs) damage‐associated molecular patterns (DAMPs), which together contribute improved outcomes HCC. Taken together, NPs bioavailability exhibit exerting chemophototherapy immunity.
Язык: Английский
Процитировано
12