Emerging nitric oxide gas‐assisted cancer photothermal treatment

Exploration, Год журнала: 2024, Номер 4(6)

Опубликована: Март 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Язык: Английский

---

3D‐Printed Tissue‐Specific Nanospike‐Based Adhesive Materials for Time‐Regulated Synergistic Tumor Therapy and Tissue Regeneration In Vivo

Advanced Functional Materials, Год журнала: 2024, Номер 34(48)

Опубликована: Июнь 26, 2024

Abstract The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of tumors have highlighted need for multifaceted scaffolds that afford tumor therapy, effective vascularized reconstruction. However, challenging trilemma has emerged in realm balance between achieving appropriate mechanical strength, ensuring biocompatibility, optimizing a degradation rate aligns with bone‐regenerative rate. Considering these challenges, innovative theragenerative platform is developed by utilizing 3D printing‐based nanospikes first time. This comprises tissue‐specific nanospiked hydroxyapatite decorated magnesium (nMg) adhesive DNA (aDNA). incorporation nMg within polylactic acid (PLA) matrix confers photothermal capabilities helps modulate properties improve biocompatibility platform. Simultaneously, immobilized aDNA contributed enhancement healing. These 3D‐printed tissue‐adhesive platforms exhibit superior offer controlled degradability. Moreover, they enable eradication bacteria osteosarcoma through hyperthermia promote angiogenesis osteogenesis, both vitro vivo. groundbreaking approach poised pave way fabrication design novel implantable biomaterials integrate therapeutic regenerative functions.

Язык: Английский

---

A Nanographene‐Porphyrin Hybrid for Near‐Infrared‐Ii Phototheranostics

Advanced Science, Год журнала: 2024, Номер 11(18)

Опубликована: Март 2, 2024

Abstract Photoacoustic imaging (PAI)‐guided photothermal therapy (PTT) in the second near‐infrared (NIR‐II, 1000–1700 nm) window has been attracting attention as a promising cancer theranostic platform. Here, it is reported that π‐extended porphyrins fused with one or two nanographene units (NGP‐1 and NGP‐2) can serve new class of NIR‐responsive organic agents, displaying absorption extending to ≈1000 ≈1400 nm NIR‐I NIR‐II windows, respectively. NGP‐1 NGP‐2 are dispersed water through encapsulation into self‐assembled nanoparticles (NPs), achieving high conversion efficiency 60% 69%, respectively, under 808 1064 laser irradiation. Moreover, NIR‐II‐active NGP‐2‐NPs demonstrated photoacoustic responses, along photostability biocompatibility, enabling PAI efficient PTT vivo.

Язык: Английский

---

Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122

Опубликована: Авг. 6, 2024

Язык: Английский

---

Advances in Electrochemical Nitrite Reduction toward Nitric Oxide Synthesis for Biomedical Applications

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use inhalation therapies. The effectiveness of NO-based treatments relies on precise control NO concentrations tailored to specific therapeutic needs. Electrochemical generation (E-NOgen) via nitrite (NO2 -) reduction offers a scalable efficient route controlled production, while also addressing environmental concerns by reducing NO2 - pollution maintaining nitrogen cycle balance. Recent developments catalysts E-NOgen devices have propelled conversion, enabling on-demand production. This review provides overview pathways, with focus cutting-edge Fe/Cu-based catalysts, explores the development biomedical use. Challenges future directions advancing technologies are discussed.

Язык: Английский

---

Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 31, 2025

Язык: Английский

---

A Smart Visualized Phototherapy Switch: From NIR‐I Imaging‐Guided Photodynamic Therapy to NIR‐II‐Guided Photothermal Therapy for Enhanced Cascade Tumor Photoablation

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

ABSTRACT Imaging‐guided phototherapy holds promise for precision cancer treatment. However, most photosensitizers have only a singular modality of photodynamic therapy (PDT) or photothermal (PTT), which make their therapeutic efficacy severely limited by the hypoxic and complex tumor microenvironment (TME). In this article, we provide smart platform design (BOD‐D) based on visualized light‐triggered phototherapeutic switch transforming from near‐infrared (NIR)‐I imaging‐guided PDT to activatable NIR‐II‐guided PTT while releasing nitric oxide (NO) gas (GT). BOD‐D releases native NIR one‐region fluorescence signals in tumors, is used direct robust killing. As administered, decreasing oxygen content TME becomes progressively insufficient maintain its excellent cell‐killing effect. Subsequently, light triggers dissociation NO BOD‐D, activating agent BOD‐T that emits NIR‐II fluorescence, subsequent PTT. Notably, not light‐mediated mechanism can be switched NIR‐I‐guided PTT, but also released during process will GT sensitize above Our study contributes intelligent cascade photoablation.

Язык: Английский

---

Gene and Photothermal Combination Therapy: Principle, Materials, and Amplified Anticancer Intervention

Small, Год журнала: 2023, Номер 20(6)

Опубликована: Сен. 29, 2023

Gene therapy (GT) and photothermal (PTT) have emerged as promising alternatives to chemotherapy radiotherapy for cancer treatment, offering noninvasiveness reduced side effects. However, their efficacy standalone treatments is limited. GT exhibits slow response rates, while PTT confined local tumor ablation. The convergence of PTT, known GT-PTT, facilitated by gene nanocarriers, has attracted considerable attention across various disciplines. In this integrated approach, reciprocates sensitizing cellular heat, benefits improving translocation, unpacking, expression. Consequently, integration presents a unique opportunity with rapid improved effectiveness. Extensive efforts over the past few years been dedicated development resulting in notable achievements progress from laboratory potential clinical applications. This comprehensive review outlines recent advances including synergistic mechanisms, material systems, imaging-guided therapy, anticancer It also explores challenges future prospects nascent field. By presenting innovative ideas insights into implementation GT-PTT enhanced aims inspire further area research.

Язык: Английский

---

Photo‐Triggered Cascade Therapy: A NIR‐II AIE Luminogen Collaborating with Nitric Oxide Facilitates Efficient Collagen Depletion for Boosting Pancreatic Cancer Phototheranostics

Advanced Materials, Год журнала: 2023, Номер 36(13)

Опубликована: Дек. 29, 2023

The dense extracellular matrix (ECM) in the pancreatic cancer severely hampers penetration of nanodrugs, which causes inferior therapeutic efficacy. To address this issue, a multifunctional liposome, namely, Lip-DTI/NO, integrating type-I photosensitizer DTITBT with glutathione (GSH) or heat-responsive nitric oxide (NO) donor S-nitroso-N-acetyl-D-penicillamine (SNAP) is constructed to deplete tumor ECM, leading enhanced drug delivery and consequently improved phototherapy. loaded possesses multiple functions including NIR-II fluorescence imaging, efficient superoxide radical (O

Язык: Английский

---

Fused Azulenyl Squaraine Derivatives Improve Phototheranostics in the Second Near‐Infrared Window by Concentrating Excited State Energy on Non‐Radiative Decay Pathways

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(17)

Опубликована: Март 6, 2024

Abstract The second near‐infrared (NIR‐II) theranostics offer new opportunities for precise disease phototheranostic due to the enhanced tissue penetration and higher maximum permissible exposure of NIR‐II light. However, traditional regimens lacking effective absorption uncontrollable excited‐state energy decay pathways often result in insufficient theranostic outcomes. Herein a nano‐agent (PS‐1 NPs) based on azulenyl squaraine derivatives with strong band centered at 1092 nm is reported, allowing almost all absorbed excitation dissipate through non‐radiative pathways, leading high photothermal conversion efficiency (90.98 %) photoacoustic response. Both vitro vivo photoacoustic/photothermal therapy results demonstrate deep cancer performance PS‐1 NPs. Even 5 mm deep‐seated tumor model, NPs demonstrated satisfactory anti‐tumor effect imaging‐guided therapy. Moreover, human extracted tooth root canal infection synergistic outcomes 0.5 % NaClO solution resulted therapeutic efficacy comparable clinical gold standard irrigation agent 5.25 NaClO, opening up possibilities expansion agents oral medicine.

Язык: Английский

---