Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(28)
Опубликована: Июль 27, 2024
Abstract
Excessive
use
of
antibiotics
and
the
formation
bacterial
biofilms
can
lead
to
persistent
infections
caused
by
drug‐resistant
bacteria,
rendering
ineffective
immune
responses
even
life‐threatening.
There
is
an
urgent
need
explore
synergistic
antibacterial
therapies
across
all
stages
infection.
Drawing
inspiration
from
properties
neutrophil
extracellular
traps
(NETs)
integrating
biofilm
dispersal
mechanism
involving
boronic
acid–catechol
interaction,
multifunctional
bismuth‐based
polypeptide
nanonets
(PLBA‐Bi‐Fe‐TA)
are
developed.
These
designed
capture
bacteria
through
a
coordination
complex
cationic
polypeptides
(PLBA)
with
acid‐functionalized
side
chains,
alongside
metal
ions
(bismuth
(Bi)
iron
(Fe)),
tannic
acid
(TA).
Leveraging
nanoconfinement‐enhanced
high‐contact
network‐driven
multiple
efficiency,
PLBA‐Bi‐Fe‐TA
demonstrates
excellent
ability
swiftly
their
polysaccharides.
This
interaction
culminates
in
highly
hydrophilic
complex,
effectively
enabling
rapid
inhibition
dispersion
antibiotic‐resistant
biofilms,
while
Fe‐TA
shows
mild
photothermal
further
assist
fluffy
mature
biofilm.
In
addition,
Bi
beneficial
regulate
polarization
macrophages
pro‐inflammatory
phenotype
kill
escaping
bacteria.
summary,
this
novel
approach
offers
promising
bionic
optimization
strategy
for
treating
bacterial‐associated
at
synergetic
treatment.
Advanced Materials,
Год журнала:
2024,
Номер
36(32)
Опубликована: Июнь 5, 2024
Antibiotic-resistant
pathogens
have
become
a
global
public
health
crisis,
especially
biofilm-induced
refractory
infections.
Efficient,
safe,
and
biofilm
microenvironment
(BME)-adaptive
therapeutic
strategies
are
urgently
demanded
to
combat
antibiotic-resistant
biofilms.
Here,
inspired
by
the
fascinating
biological
structures
functions
of
phages,
de
novo
design
spiky
Ir@Co
Abstract
The
emergence
of
multidrug‐resistant
bacteria
poses
a
significant
challenge
in
the
treatment
osteomyelitis,
rendering
traditional
antibiotic
strategies
inadequate
terms
achieving
complete
cure.
In
recent
years,
triggerable
biomaterial‐based,
antibiotic‐free
osteomyelitis
have
rapidly
evolved,
demonstrating
excellent
bactericidal
effects.
Triggerable
biomaterials‐based
theranostics
encompass
physical
signal
response
and
host
immune
modulation
approaches.
These
can
be
effective
against
drug‐resistant
bacteria,
circumventing
gradual
acquisition
resistance
that
often
accompanies
treatment.
Additionally,
inherent
properties
biomaterials
facilitate
precise
imaging
osteomyelitis.
There
is
no
doubt
biomaterial‐mediated,
therapies
are
emerging
as
trend,
which
critically
important
combating
bacteria‐induced
this
review,
we
summarize
latest
advances
from
both
pathogen‐directed
host‐directed
perspectives.
design
regimens
specific
action
mechanisms
biomaterial‐based
nanoplatforms
also
clarified.
Finally,
outline
challenges
faced
by
various
provide
an
outlook
on
prospects
for
synergistic
interactions.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 19, 2024
Abstract
The
eradication
of
recalcitrant
bacterial
biofilm
infections
necessitates
the
development
speedy
diagnostics
and
prompt
therapeutics.
However,
constructing
a
portable
versatile
platform
that
enables
in
situ
monitoring
accompanied
by
potent
antibiofilm
activity
remains
challenging.
To
address
this
conundrum,
microneedle
theranostic
patch
(Mn:
C/G@MN)
is
devised
incorporating
an
innovative
biophotonic
probe
(manganese‐doped
carbon
dots,
Mn:
CDs)
into
methacrylated
gelatin
for
visual
infection
on‐demand
photo‐therapy.
C/G@MN
penetrates
physical
barrier
biofilms
to
track
their
acidic
microenvironment,
exhibiting
visualized
fluorescence
color
change
(from
yellow
turquoise)
enable
naked‐eye
infection.
Furthermore,
can
drastically
eradicate
through
synergy
local
hyperthermia
hydroxyl
radical
(•OH)
storm
under
808
nm
near‐infrared
light
illumination,
enabling
damaging
extracellular
polymeric
substances
(EPS)
matrix
disperse
subsequently
kill
detached
bacteria.
Both
vitro
vivo
findings
authenticate
monitoring‐and‐treating
be
achieved.
Moreover,
conducive
suppressing
inflammatory
responses,
expediting
collagen
deposition,
stimulating
angiogenesis,
accelerating
biofilm‐infected
wound
healing.
As
envisaged,
work
highlights
potential
such
application
integrated
theranostics
Advances in chemical and materials engineering book series,
Год журнала:
2024,
Номер
unknown, С. 243 - 263
Опубликована: Янв. 29, 2024
Plasma-supported
biochemical
reactions
have
emerged
as
a
promising
and
environmentally
friendly
approach
for
synthesizing
microalgae-based
biofuels.
Microalgae,
single-celled
organisms,
possess
the
unique
capability
of
efficiently
converting
sunlight
into
organic
matter
through
photosynthesis,
positioning
them
potential
green
energy
sources
biofuel
biomass
production.
However,
traditional
microalgae
cultivation
methods
encounter
challenges
concerning
environmental
economic
sustainability,
primarily
due
to
their
high
water
fertilizer
consumption.
In
this
context,
plasma
technology
has
powerful
tool
supporting
optimizing
processes,
offering
greener
more
sustainable
alternative
This
chapter
explores
transformative
plasma-supported
in
microalgal
synthesis.
It
aims
provide
insights
intricate
mechanisms
underlying
innovative
its
implications
renewable
landscape.
