Chemical Engineering Journal, Год журнала: 2024, Номер 494, С. 152882 - 152882
Опубликована: Июнь 5, 2024
Язык: Английский
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(22), С. 15251 - 15263
Опубликована: Май 23, 2024
Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II light irradiation, Mn@Bi2Se3@RGE-Exos are capable converting hydrogen peroxide into hydroxyl radicals, oxygen, superoxide providing peroxidase (POD), oxidase (OXD), catalase (CAT)-like nanocatalytic cascade. This consequently leads strong oxidative stresses damage cells. vitro, vivo, proteomic analysis further reveal potential disruption cellular homeostasis, enhancement immunological induction cancer cell ferroptosis, showcasing great promise anticancer efficacy against with favorable biosafety profile. Overall, success this study provides feasible strategy future design clinical stimuli-responsive medicine, especially context challenging brain cancers like GBM.
Язык: Английский
Процитировано
22
Bioactive Materials, Год журнала: 2024, Номер 44, С. 131 - 151
Опубликована: Окт. 15, 2024
Язык: Английский
Процитировано
16
Medical Oncology, Год журнала: 2025, Номер 42(2)
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
2
Antioxidants, Год журнала: 2025, Номер 14(1), С. 104 - 104
Опубликована: Янв. 17, 2025
Breast cancer is one of the most prevalent cancers worldwide. Recent studies have increasingly emphasized role oxidative stress in initiation and progression breast cancer. This article reviews how imbalance influences occurrence advancement cancer, elucidating intricate mechanisms through which reactive oxygen species (ROS) operate this context their potential therapeutic applications. By highlighting these critical insights, review aims to enhance our understanding as a target for innovative strategies management
Язык: Английский
Процитировано
2
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 9, 2025
Abstract Electrodynamic therapy (EDT), with its unique advantages, has demonstrated promising therapeutic effects in tumor treatment. However, efficiency is often limited by the low concentration of chloride ions (Cl⁻) within cells, and non‐degradability noble metal nanomaterials necessarily used this strategy gives rise to safety concerns. Here, we identify voltage‐gated channels (CLC‐7) as a potential chloride‐regulation target melanoma report an enhanced electro‐driven dynamic utilizing surface‐enhanced PtIr@M nanocatalysts address above challenges. Under alternating electric field (AEF), activation CLC‐7 channel promotes massive influx Cl⁻ from extracellular side enhances catalysis water dissociation on generate toxic hydroxyl radicals (·OH). Moreover, large surface area provides abundant exposed active sites that facilitate self‐dissociation followed release Pt ions, thereby inducing DNA damage. More importantly, electrically controlled degradation also effectively minimizes toxicity associated heavy accumulation. It believed electro‐propelled ·OH generation for synergetic based surface‐plus PtIr nanocatalyst represents characterized high‐efficiency biodegradability.
Язык: Английский
Процитировано
1
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 20, 2025
The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes
Язык: Английский
Процитировано
1
Nanomaterials, Год журнала: 2024, Номер 14(7), С. 648 - 648
Опубликована: Апрель 8, 2024
Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity leveraging the microenvironment (TME) mechanisms that boost immune responses. It also minimizes damage surrounding healthy tissues cytotoxicity cells, showing promise cancer treatment, with significant potential. This review covers research progress five major nanodynamic therapies: photodynamic (PDT), electrodynamic (EDT), sonodynamic (SDT), radiodynamic (RDT), chemodynamic (CDT), emphasizing role advanced nanotechnology development for purposes. The mechanisms, effects, challenges faced these NDTs are discussed, along their respective solutions enhancing efficacy, such as pH response, delivery, combined immunotherapy. Finally, this briefly addresses clinical translation NDT.
Язык: Английский
Процитировано
7
Nano Letters, Год журнала: 2024, Номер 24(20), С. 6165 - 6173
Опубликована: Май 8, 2024
Dynamic therapies, which induce reactive oxygen species (ROS) production in situ through endogenous and exogenous stimulation, are emerging as attractive options for tumor treatment. However, the complexity of substantially limits efficacy individual stimulus-triggered dynamic therapy. Herein, bimetallic copper ruthenium (Cu@Ru) core–shell nanoparticles applied endo–exogenous stimulation-triggered The electronic structure Cu@Ru is regulated ligand effects to improve adsorption level small molecules, such water oxygen. heterojunction interface can rapidly separate electron–hole pairs generated by ultrasound light initiate reactions with adsorbed thus enhancing ROS generation. This synergistically complements treatment together from stimulation. In vitro vivo experiments demonstrate that cell apoptosis ferroptosis ROS. study provides a new paradigm stimulation-based synergistic
Язык: Английский
Процитировано
6
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 17, 2024
Abstract Enhancing therapeutic efficacy while reducing the adverse effects of drugs is crucial in cancer treatments. In this study, nitrogen‐doped carbon nanospheres are synthesized with variable enzymatic activities through pyrolysis a covalent organic framework (COF). These show increased peroxidase (POD) and oxidase (OXD) tumor microenvironment, generating reactive oxygen species (ROS) that help eliminate cells. Under normal conditions, they display catalase (CAT) superoxide dismutase (SOD) activities, promoting antioxidative protection. Their porous structure π–π/hydrophobic interactions allow for loading chemotherapeutic agent doxorubicin (DOX). The then enveloped by cell membranes, stabilizing drug load enabling targeted delivery pH‐sensitive release. This system induces ferroptosis cells activates strong anti‐tumor immune response, leading to enhanced immunotherapy breast reduced metastasis lungs. Importantly, varied nanomedicine mitigate cardiotoxicity DOX chemotherapy, improving treatment minimizing side effects. approach introduces nano‐enzyme distinctive innovative preparation, setting new standard efficient, low‐toxicity therapy.
Язык: Английский
Процитировано
6
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 9, 2024
Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.
Язык: Английский
Процитировано
6