Phospholipid-derived lysophospholipids in (patho)physiology
Atherosclerosis,
Год журнала:
2024,
Номер
398, С. 118569 - 118569
Опубликована: Авг. 23, 2024
Phospholipids
(PL)
are
major
components
of
cellular
membranes
and
changes
in
PL
metabolism
have
been
associated
with
the
pathogenesis
numerous
diseases.
Lysophosphatidylcholine
(LPC)
particular,
is
a
comparably
abundant
component
oxidatively
damaged
tissues.
LPC
originates
from
cleavage
phosphatidylcholine
(PC)
by
phospholipase
A
Язык: Английский
Molecules in the Serotonin-Melatonin Synthesis Pathway Have Distinct Interactions with Lipid Membranes
The Journal of Physical Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
The
neurotransmitter
serotonin
is
involved
in
physiological
processes
such
as
appetite,
sleep,
and
mood
diseases
anxiety
depression.
Traditionally,
the
effects
of
were
thought
to
be
initiated
by
binding
its
target
transmembrane
receptors.
It
also
known
that
can
bind
directly
membrane
with
high
affinity
modulate
lipid
dynamics,
lateral
segregation
lipids,
vesicular
association,
protein
activity.
We
investigated
if
other
small
molecules
metabolic
pathway,
some
which
are
signaling
while
others
not,
have
similar
modulating
effects.
Therefore,
we
examined
several
metabolites:
5-hydroxytryptophan
(5-HTP),
serotonin,
N-acetylserotonin
(NAS),
melatonin
model
membranes
mimicking
synaptic
membranes.
Using
2H
NMR
spectroscopy
deuterated
1-palmitoyl-2-oleoyl-glycero-3-phosphocholine
(POPC),
observed
all
metabolites
disorder
membrane-mimicking
largest
disordering
effect
was
for
NAS
smallest
tryptophan.
fluorescence
correlation
spectroscopy,
it
found
only
promotes
association
did
not.
Furthermore,
differed
their
distribution
employing
solid
state
1H
magic
angle
spinning
nuclear
Overhauser
enhancement
(NOESY)
experiments
simple
POPC
Similar
results
obtained
mimics
using
molecular
dynamics
simulations.
In
conclusion,
causal
between
modulation
remains
elusive,
this
study
suggests
small-molecule
drugs
drastic
biological
mediated
through
membrane.
finding
changes
structure
lead
very
different
distributions
possibility
developing
future.
Язык: Английский
Photoswitchable phospholipids for the optical control of membrane processes, protein function, and drug delivery
Communications Materials,
Год журнала:
2025,
Номер
6(1)
Опубликована: Апрель 1, 2025
Recent
insights
into
the
function
and
composition
of
cell
membranes
have
transformed
our
understanding
from
primarily
viewing
these
structures
as
passive
barriers
to
recognizing
them
dynamic
entities
actively
involved
in
many
cellular
functions.
This
review
highlights
advances
photopharmacology
phospholipids,
emphasizing
particular
role
diacylglycerophospholipids
impact
their
polymorphic
nature
on
synthetic
membrane
properties
metabolic
processes.
We
explore
photoswitchable
diacylglycerophospholipids,
termed
'photolipids',
which
permit
precise,
reversible
modifications
via
light-induced
isomerization.
The
ability
optically
switch
phospholipid
has
potential
applications
controlling
dynamics,
protein
function,
signaling
pathways,
offers
promising
strategies
for
drug
delivery
treatment
diseases.
Developments
azobenzene
hemithioindigo
based
photolipids
are
discussed,
underscoring
utility
biomedical
biomaterial
science
due
unique
photophysical
properties.
Cell
that
Review
recent
exploring
how
they
used
applications.
Язык: Английский
Precise control of transmembrane current via regulating bionic lipid membrane composition
Science Advances,
Год журнала:
2024,
Номер
10(35)
Опубликована: Авг. 30, 2024
The
transport
of
ions
through
biological
ion
channels
is
regulated
not
only
by
their
structural
characteristics
but
also
the
composition
phospholipid
membrane,
which
serves
as
a
carrier
for
nanochannels.
Inspired
modulation
currents
lipid
membrane
composition,
exemplified
activation
K
Язык: Английский
Brief Comparison of the Efficacy of Cationic and Anionic Liposomes as Nonviral Delivery Systems
ACS Omega,
Год журнала:
2024,
Номер
9(47), С. 46664 - 46678
Опубликована: Ноя. 13, 2024
In
recent
decades,
the
development
and
application
of
nonviral
vectors,
such
as
liposomes
lipidic
nanoparticles,
for
gene
therapy
drug
delivery
have
seen
substantial
progress.
The
interest
in
physicochemical
properties
structures
complexes
liposome/DNA
liposome/RNA
is
due
to
their
potential
substitute
viruses
carriers
drugs
or
genetic
material
into
cells
with
minimal
cytotoxicity,
which
could
lead
use
therapy.
Initially,
cationic
were
utilized
DNA
vectors;
subsequently,
different
molecules,
polymers,
incorporated
enhance
transfection
efficiency.
Additionally,
liposome/protein
been
developed
vectors
treatment
diseases.
most
relevant
internalization
pathways
these
few
results
obtained
using
targeted
nontargeted
are
discussed
below.
high
cytotoxicity
represents
a
significant
challenge
delivery.
Anionic
offer
promising
alternative
address
limitations
conventional
liposomes,
including
immune
response,
short
circulation
time,
low
toxicity.
This
review
will
discuss
advantages
novel
anionic
liposome-based
systems
that
emerged
result.
advent
designs
manufacturing
techniques
has
facilitated
innovative
systems,
designated
lipid
nanoparticles
(LNPs),
serve
highly
efficacious
regulators
system.
Язык: Английский
Manipulation of encapsulated artificial phospholipid membranes using sub-micellar lysolipid concentrations
Communications Chemistry,
Год журнала:
2024,
Номер
7(1)
Опубликована: Июнь 1, 2024
Abstract
Droplet
Interface
Bilayers
(DIBs)
constitute
a
commonly
used
model
of
artificial
membranes
for
synthetic
biology
research
applications.
However,
their
practical
use
is
often
limited
by
requirement
to
be
surrounded
oil.
Here
we
demonstrate
in-situ
bilayer
manipulation
submillimeter,
hydrogel-encapsulated
droplet
interface
bilayers
(eDIBs).
Monolithic,
Cyclic
Olefin
Copolymer/Nylon
3D-printed
microfluidic
devices
facilitated
the
eDIB
formation
through
high-order
emulsification.
By
exposing
capsules
varying
lysophosphatidylcholine
(LPC)
concentrations,
investigated
interaction
lysolipids
with
three-dimensional
DIB
networks.
Micellar
LPC
concentrations
triggered
bursting
encapsulated
networks,
while
at
lower
network
endured
structural
changes,
precisely
affecting
membrane
dimensions.
This
chemically-mediated
enclosed,
3D-orchestrated
mimics,
facilitates
exploration
readily
accessible
compartmentalized
cellular
machinery.
Collectively,
droplet-based
construct
can
pose
as
chemically
responsive
soft
material
studying
mechanics,
and
drug
delivery,
controlling
cargo
release
from
cell
chassis.
Язык: Английский
Extreme Makeover: The Incredible Cell Membrane Adaptations of Extremophiles to Harsh Environments
Chemical Communications,
Год журнала:
2024,
Номер
60(75), С. 10280 - 10294
Опубликована: Янв. 1, 2024
The
existence
of
life
beyond
Earth
has
long
captivated
humanity,
and
the
study
extremophiles-organisms
surviving
thriving
in
extreme
environments-provides
crucial
insights
into
this
possibility.
Extremophiles
overcome
severe
challenges
such
as
enzyme
inactivity,
protein
denaturation,
damage
cell
membrane
by
adopting
several
strategies.
This
feature
article
focuses
on
molecular
strategies
extremophiles
use
to
maintain
membrane's
structure
fluidity
under
external
stress.
Key
include
homeoviscous
adaptation
(HVA),
involving
regulation
lipid
composition,
osmolyte-mediated
(OMA),
where
small
organic
molecules
protect
Proteins
also
have
direct
indirect
roles
protecting
membrane.
Examining
survival
provides
scientists
with
how
can
adapt
persist
harsh
conditions,
shedding
light
origins
life.
examines
HVA
OMA
their
mechanisms
maintaining
stability,
emphasizing
our
contributions
field.
It
a
brief
overview
proteins
concludes
recommendations
for
future
research
directions.
Язык: Английский
Regulation of Transmembrane Current through Modulation of Biomimetic Lipid Membrane Composition
Faraday Discussions,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 23, 2024
Ion
transport
through
biological
channels
is
influenced
not
only
by
the
structural
properties
of
themselves
but
also
composition
phospholipid
membrane,
which
acts
as
a
scaffold
for
these
nanochannels.
Drawing
inspiration
from
how
lipid
membrane
modulates
ion
currents,
seen
in
activation
K
Язык: Английский
Effects of a Serotonergic Psychedelic on the Lipid Bilayer
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(21), С. 4066 - 4074
Опубликована: Окт. 21, 2024
Serotonergic
psychedelics,
known
for
their
hallucinogenic
effects,
have
attracted
interest
due
to
ability
enhance
neuronal
plasticity
and
potential
therapeutic
benefits.
Although
psychedelic-enhanced
neuroplasticity
is
believed
require
activation
of
5-hydroxytryptamine
(serotonin)
2A
receptors
(5-HT2ARs),
serotonin
itself
less
effective
in
promoting
such
plasticity.
Also,
the
psychoplastogenic
effects
these
molecules
correlate
with
lipophilicity,
leading
suggestions
that
they
act
by
influencing
intracellular
receptors.
However,
lipophilicity
also
implies
a
significant
quantity
lipids
accumulated
lipid
bilayer,
potentially
altering
physical
properties
membrane.
Here,
we
probe
whether
serotonergic
psychedelic
2,5-dimethoxy-4-iodoamphetamine
(DOI)
can
affect
artificial
bilayers
if
processes
as
membrane
fusion.
Solid-state
NMR
spectroscopy
shows
DOI
strongly
induces
disorder
acyl
chains.
Atomic
force
microscopy
it
shrink
ordered
domains
biphasic
bilayer
reduce
needed
form
nanopores
Fluorescence
correlation
promote
vesicle
association,
total
internal
fluorescence
enhances
fusion
supported
bilayer.
While
has
recently
been
shown
cause
similar
more
than
two
orders
magnitude
potent
evoking
these.
Our
results
suggest
receptor-independent
psychedelics
on
membranes
may
contribute
biological
actions,
especially
those
remodeling,
Язык: Английский
Evaluating the Impact of the Membrane Thickness on the Function of the Intramembrane Protease GlpG
Biophysical Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Cellular
membranes
exhibit
a
huge
diversity
of
lipids
and
membrane
proteins
that
differ
in
their
properties
chemical
structure.
Cells
organize
these
molecules
into
distinct
compartments
characterized
by
specific
lipid
profiles
hydrophobic
thicknesses
the
respective
domains.
If
mismatch
occurs
between
protein
surrounding
lipids,
there
can
be
functional
consequences
such
as
reduced
activity.
This
phenomenon
has
been
extensively
studied
for
single-pass
transmembrane
proteins,
rhodopsin,
small
polypeptides
gramicidin.
Here,
we
investigate
E.
coli
rhomboid
intramembrane
protease
GlpG
model
to
systematically
explore
impact
thickness
on
We
used
fully
saturated
1,2-dilauroyl-sn-glycero-3-phosphocholine
(DLPC)
1,2-dimyristoyl-sn-glycero-3-phosphocholine(DMPC)
altered
varying
cholesterol
content.
Physical
parameters
were
determined
Язык: Английский