Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Key intracellular in situ synthesis processes, including the of near-infrared fluorescent dyes, oxidative cross-linking, polymerization, and bioorthogonal reactions, as well their biomedical applications were summarized.
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2024, Номер 516, С. 215986 - 215986
Опубликована: Июнь 2, 2024
Язык: Английский
Процитировано
29
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(22), С. 15251 - 15263
Опубликована: Май 23, 2024
Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II light irradiation, Mn@Bi2Se3@RGE-Exos are capable converting hydrogen peroxide into hydroxyl radicals, oxygen, superoxide providing peroxidase (POD), oxidase (OXD), catalase (CAT)-like nanocatalytic cascade. This consequently leads strong oxidative stresses damage cells. vitro, vivo, proteomic analysis further reveal potential disruption cellular homeostasis, enhancement immunological induction cancer cell ferroptosis, showcasing great promise anticancer efficacy against with favorable biosafety profile. Overall, success this study provides feasible strategy future design clinical stimuli-responsive medicine, especially context challenging brain cancers like GBM.
Язык: Английский
Процитировано
25
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Авг. 3, 2024
Compared with conventional therapies, photoimmunotherapy offers precise targeted cancer treatment minimal damage to healthy tissues and reduced side effects, but its efficacy may be limited by shallow light penetration the potential for tumor resistance. Here, an acceptor-donor-acceptor (A-D-A)-structured nanoaggregate is developed dual phototherapy, including photodynamic therapy (PDT) photothermal (PTT), triggered single near-infrared (NIR) light. Benefiting from strong intramolecular charge transfer (ICT), A-D-A-structured nanoaggregates exhibit broad absorption extending NIR region effectively suppressed fluorescence, which enables deep efficient conversion (η = 67.94%). A suitable HOMO-LUMO distribution facilitates sufficient intersystem crossing (ISC) convert ground-state oxygen (
Язык: Английский
Процитировано
17
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.
Язык: Английский
Процитировано
16
Advanced Materials, Год журнала: 2024, Номер 36(45)
Опубликована: Сен. 5, 2024
Abstract Aminopeptidases are exopeptidases that catalyze the cleavage of amino acid residues from N‐terminal fragment protein or peptide substrates. Owing to their function, they play important roles in maturation, signal transduction, cell‐cycle control, and various disease mechanisms, notably cancer pathology. To gain better insights into molecular imaging assisted by fluorescence bio/chemiluminescence probes has become an indispensable method superiorities, including excellent sensitivity, selectivity, real‐time noninvasive imaging. Numerous efforts made develop activatable can effectively enhance efficiency accuracy as well minimize side effects. This review is classified according type aminopeptidases, summarizing some recent works on design, work mechanism, sensing, imaging, theranostic performance probe. Finally, current challenges outlined developing for aminopeptidases provide possible solutions future advancements.
Язык: Английский
Процитировано
12
Chemical Science, Год журнала: 2024, Номер 15(31), С. 12431 - 12441
Опубликована: Янв. 1, 2024
A zwitterionic chemiluminescence strategy makes a breakthrough in highly selective sensing of 1 O 2 towards FDA-approved phototherapy through suppressing inherent photo-induced side reactions.
Язык: Английский
Процитировано
7
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(41)
Опубликована: Июль 4, 2024
Abstract The clinical application of photodynamic therapy (PDT) is limited by oxygen‐dependence and side effects caused photosensitizer residues. Photoinitiators based on the H‐abstraction reaction can address these challenges because they generate alkyl radical‐killing cells independently oxygen undergo rapid bleaching following H‐abstraction. Nonetheless, development photoinitiators for PDT has been impeded absence effective design strategies. Herein, we have developed aryl‐ketone substituted cyanine (ACy−R), first red‐light triggered hypoxic cancer therapy. These ACy−R molecules inherited near‐infrared absorption dye, modification imparted capability. Experimental quantum calculations revealed that modifying electron‐withdrawing groups aryl (e.g., ACy‐5F) improved contribution O atom to photon excitation process promoting intersystem crossing ability. Particularly, ACy‐5F rapidly penetrated enriched in endoplasmic reticulum. Even under severe hypoxia, initiated induced with intracellular biomolecules, inducing necroptosis ferroptosis. Moreover, was degraded after H‐abstraction, thus avoiding long‐term phototoxicity This study not only provides a crucial molecular tool tumors therapy, but also presents promising strategy multifunctional photosensitizers photoinitiators.
Язык: Английский
Процитировано
7
Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 18, 2024
ABSTRACT Photodynamic therapy (PDT) and photothermal (PTT) have emerged promising applications in both fundamental research clinical trials. However, it remains challenging to develop ideal photosensitizers (PSs) that concurrently integrate high photostability, large near‐infrared absorptivity, efficient therapeutic capabilities. Herein, we reported a sample engineering strategy afford benzene‐fused Cy5 dimer ( Cy‐D‐5 ) for synergistically boosting PDT/PTT applications. Intriguingly, exhibits tendency form J ‐aggregates H phosphate‐buffered saline, which show long‐wavelength absorption band bathochromically shifted 810 nm short‐wavelength hypsochromically 745 nm, respectively, when compared its behavior ethanol (778 nm). Density‐functional theory calculations combined with time‐resolved transient optical spectroscopy analysis reveal the fused low Δ E ST (0.51 eV) non‐radiative transition rates (12.6 times greater than of clinically approved PS‐indocyanine green [PS‐ ICG ]). Furthermore, demonstrates higher photosensitizing ability produce 1 O 2 , stronger conversion efficiency η = 64.4%), photostability . These properties enable achieve complete tumor ablation upon 808 laser irradiation, highlighting potential as powerful dual‐function phototherapeutic agent. This work may offer practical other existing dyes red‐shifted spectral range various phototherapy
Язык: Английский
Процитировано
5
Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Abstract Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment due to its non‐invasive nature and high specificity toward malignant tissues. In recent years, variety of protocols have been proposed improve the PDT efficacy, which organelle‐targeted is supposed be quite promising. Particularly, lipid droplets (LDs)‐localized attracts lot interest inherent advantages such abundant LDs in cells their close relation with ferroptosis. This review provides comprehensive summary advancements LDs‐localized photosensitizers (PSs) according chemical structures functions. Especially, these PSs are featured fluorescence emission, thereby facilitating an imaging‐guided phototherapy. The highlights cytocidal actions PSs, cell death pathway cytotoxicity. Finally, some unresolved issues challenges this domain will discussed.
Язык: Английский
Процитировано
4
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
A NIR light-responsive phenothiazine based phototherapeutic system for synergistic cancer treatment.
Язык: Английский
Процитировано
0