Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 17, 2024
Abstract
Repairing
osteochondral
(OC)
defect
presents
a
significant
challenge
due
to
the
intricate
structural
requirements
and
unpredictable
differentiation
pathways
of
bone
marrow
mesenchymal
stem
cells
(BMSCs).
To
address
this
challenge,
novel
biomimetic
OC
hydrogel
scaffold
is
developed
that
features
structure
soft
hard
components.
This
incorporates
bilayer
metal–organic
frameworks
(MOFs),
specifically
ZIF‐67
in
upper
layer
ZIF‐8
lower
layer,
achieved
through
an
situ
printing
process.
configuration
enables
spatial
temporal
modulation
BMSC
by
controlling
release
Co
2
⁺
Zn
⁺.
The
results
demonstrate
MOF
hydrogels
significantly
outperform
either
lack
MOFs
or
contain
single
type
enhancing
repair
outcomes
rabbit
models
knee
defects.
improved
regenerative
efficacy
attributed
distinct
chondrogenic
osteogenic
cues
provided
MOFs,
effectively
guiding
BMSCs
toward
enhanced
tissue
regeneration.
customizable
not
only
opens
new
avenues
for
innovative
therapeutic
strategies
but
also
holds
great
promise
widespread
clinical
applications.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Abstract
Friction‐induced
energy
consumption
is
a
significant
global
concern,
driving
researchers
to
explore
advanced
lubrication
materials.
In
nature,
vital
for
the
life
cycle
of
animals,
plants,
and
humans,
playing
key
roles
in
movement,
predation,
decomposition.
After
billions
years
evolution,
natural
exhibits
remarkable
professionalism,
high
efficiency,
durability,
intelligence,
offering
valuable
insights
designing
This
review
focuses
on
mechanisms
organisms
advancements
biomimetic
soft
matter
It
begins
by
summarizing
common
biological
behaviors
their
underlying
mechanisms,
followed
current
design
strategies
The
then
outlines
development
performance
these
materials
based
different
strategies.
Finally,
it
discusses
potential
research
directions
prospects
will
be
resource
advancing
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Excessive
intracellular
iron
accumulation
can
induce
mitochondrial
dysfunction,
leading
to
chondrocyte
ferroptosis,
a
key
contributor
cartilage
damage
in
osteoarthritis
(OA).
Here,
micelle-microfluidic
hydrogel
microspheres,
featuring
keto-enol-thiol
bridged
nano-sized
secondary
structures
that
disintegrate
within
the
peroxidative
environment
reveal
β-diketone
groups
with
metal
chelation
capabilities,
are
utilized
for
situ
removal
of
reactive
iron,
thereby
facilitating
repair
through
restoration
homeostasis.
The
relevant
experiments
demonstrate
microspheres
reduce
influx
by
downregulating
transferrin
receptor
(TfR1)
expression
and
decrease
uptake
upregulating
outer
membrane
iron-sulfur
cluster
protein
(CISD1),
thus
restoring
Furthermore,
antioxidant
properties
ketone-thioether
segments
synergistically
mitigate
phospholipid
peroxidation
via
Nrf2/SLC7A11/GPX4
axis,
inhibiting
ferroptosis
slowing
OA
progression.
In
summary,
this
system
sustainably
chelates
coordination
exhibits
great
potential
minimally
invasive
treatment
other
ferroptosis-mediated
diseases.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Март 28, 2025
The
management
of
bone
defects,
particularly
in
aging
populations,
remains
a
major
clinical
challenge.
immune
microenvironment
plays
an
important
role
the
repair
defects
and
favorable
environment
can
effectively
promote
defects.
However,
is
closely
associated
with
chronic
low-grade
systemic
inflammation,
which
adversely
affects
healing.
Persistent
inflammation
critically
regulates
through
all
stages.
This
review
explores
potential
3D-printed
bioceramic
scaffolds
defect
repair,
focusing
on
their
capacity
to
modulate
counteract
effects
aging.
not
only
provide
structural
support
for
regeneration
but
also
serve
as
effective
carriers
anti-osteoporosis
drugs,
offering
novel
therapeutic
strategy
treating
osteoporotic
By
regulating
improving
response,
may
significantly
enhance
context
age-related
degeneration.
approach
underscores
advanced
biomaterials
addressing
dual
challenges
dysregulation,
promising
avenues
development
treatments
elderly.
We
hope
concepts
discussed
this
could
offer
strategies
suggest
future
optimization
scaffolds.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 28, 2025
Introduction
Osteoarthritis
(OA)
is
a
degenerative
disease
of
the
joints
characterized
by
cartilage
degradation
and
synovial
inflammation.
Due
to
complex
pathogenesis
OA,
multifaceted
therapies
that
modulate
inflammatory
immune
microenvironmental
disturbances
while
promoting
regeneration
are
key
control
progression
OA.
Methods
Herein,
multifunctional
nanoparticle
(DIC/Mg-PDA
NPs)
was
constructed
successfully
metal
chelation
effect
between
Mg
2+
catecholamine
bond
from
dopamine,
followed
amidation
with
diclofenac
(DIC),
which
then
prepared
into
an
injectable
hydrogel
microsphere
(DIC/Mg-PDA@HM)
immune-regulating
cartilage-repairing
abilities
through
microfluidic
technology
for
treatment
osteoarthritis.
Results
discussion
The
sustained
release
composite
microspheres
achieved
regulation
converting
macrophages
M1
M2
promoted
differentiation
BMSCs.
Moreover,
enhanced
DIC
polydopamine
(PDA)
effectively
downregulated
factors,
finally
OA
therapy.
In
addition,
in
vivo
MRI
tissue
section
staining
model
proved
significant
efficacy
on
conclusion,
these
novel
demonstrated
promising
prospect
multidisciplinary
repairing
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Abstract
Osteoarthritis
(OA)
is
a
chronic
joint
disease
characterized
by
degeneration
of
articular
cartilage,
with
the
underlying
mechanism
being
inability
chondrocytes
to
maintain
homeostasis
in
response
changing
stress.
The
stress
triggered
excess
ROS
from
various
factors
critical
regulating
chondrocyte
survival
and
fate.
In
this
study,
2D
Mo
4/3
B
2‐
X
MBene
cerium‐gallic
acid
metal‐polyphenol
network
(MPN)
together
cartilage‐targeted
shell
hyaluronic
WYRGRL
(HW)
are
utilized
development
bio‐heterojunction
MBene@MPN‐HW
(MBM‐HW)
through
self‐assembly.
MBM‐HW
not
only
demonstrates
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPx)
enzyme
mimicking
capabilities
effectively
scavenge
ROS,
but
also
exhibits
dual‐responsive
release
cartilage‐targeting
properties.
Importantly,
both
vivo
vitro
experiments
indicate
that
could
alleviate
oxidative
stress,
protect
mitochondrial
function,
suppress
cartilage
matrix
ferroptosis,
thereby
slowing
progression
OA.
Mechanistically,
it
demonstrated
attenuate
Perk/eIF2α
cascade
mediated
integrated
restrain
maintaining
homeostasis.
Overall,
work
underscores
robust
stress‐relieving
capacity
MBM‐HW,
providing
novel
approach
for
treatment
Intra-articular
drug
injections
are
effective
for
osteoarthritis
(OA),
but
challenges
such
as
the
complex
microenvironment
and
rapid
diffusion
require
frequent
injections.
Herein,
we
propose
a
biofunctional
hydrogel-based
strategy
prolonged
delivery
remodeling.
We
to
functionalize
zeolitic
imidazolate
framework-8
with
tannic
acid
(TA-ZIF),
anchor
PTH-related
peptide-1
(PTHrP-1)
within
this
framework
(TA-ZIF@P1)
incorporate
phenylboronic
acid-modified
gelatin-based
hydrogel
(GP
hydrogel)
system
(GP@TA-ZIF@P1,
GPTP
responsive
release
properties
that
respond
pathological
microenvironments
of
OA.
The
facilitated
controlled,
sustained
PTHrP-1
via
dynamic
boronic
esters,
in
vitro
vivo
studies
showing
continuous
over
28
days.
It
not
only
promotes
chondrocyte
proliferation
also
exhibits
significant
cytoprotective
effects
under
hyperactive
ROS
IL-1β-induced
conditions.
Notably,
transcriptome
sequencing
confirms
facilitates
both
chondrogenesis
inflammatory
conditions
by
deactivating
Wnt/β-Catenin
signaling
pathways
enhancing
PI3K/AKT
pathway.
Additionally,
delays
catabolic
metabolism
cartilage
explants
from
mice
environments.
In
surgical
model
mouse
OA,
show
intra-articular
injection
hydrogels
reduced
periarticular
bone
remodeling
promoted
production
glycosaminoglycans
while
offering
chondroprotection
against
degeneration.
To
sum
up,
pioneering
research
on
treatment
combined
system,
offers
valuable
insights
paradigm
controlled
PTHrP-1,
representing
advancement
OA
strategies.
