3D‐Printed In Situ Growth of Bilayer MOF Hydrogels for Accelerated Osteochondral Defect Repair DOI

Kaiqi Qin,

Xinyue Huang, Shengfeng Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 17, 2024

Abstract Repairing osteochondral (OC) defect presents a significant challenge due to the intricate structural requirements and unpredictable differentiation pathways of bone marrow mesenchymal stem cells (BMSCs). To address this challenge, novel biomimetic OC hydrogel scaffold is developed that features structure soft hard components. This incorporates bilayer metal–organic frameworks (MOFs), specifically ZIF‐67 in upper layer ZIF‐8 lower layer, achieved through an situ printing process. configuration enables spatial temporal modulation BMSC by controlling release Co 2 ⁺ Zn ⁺. The results demonstrate MOF hydrogels significantly outperform either lack MOFs or contain single type enhancing repair outcomes rabbit models knee defects. improved regenerative efficacy attributed distinct chondrogenic osteogenic cues provided MOFs, effectively guiding BMSCs toward enhanced tissue regeneration. customizable not only opens new avenues for innovative therapeutic strategies but also holds great promise widespread clinical applications.

Language: Английский

Tribology in Nature: Inspirations for Advanced Lubrication Materials DOI Open Access
Chenxi Qin, Hao Yang, Yaqiong Lü

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Friction‐induced energy consumption is a significant global concern, driving researchers to explore advanced lubrication materials. In nature, vital for the life cycle of animals, plants, and humans, playing key roles in movement, predation, decomposition. After billions years evolution, natural exhibits remarkable professionalism, high efficiency, durability, intelligence, offering valuable insights designing This review focuses on mechanisms organisms advancements biomimetic soft matter It begins by summarizing common biological behaviors their underlying mechanisms, followed current design strategies The then outlines development performance these materials based different strategies. Finally, it discusses potential research directions prospects will be resource advancing

Language: Английский

Citations

3
Metal-organic frameworks based solid-state electrolytes for lithium metal batteries: Modifications and future prospects DOI Creative Commons
Mingjie Liu, Tengfei Liu,

Junling Xu

et al.

Next Energy, Journal Year: 2024, Volume and Issue: 6, P. 100191 - 100191

Published: Sept. 11, 2024

Language: Английский

Citations

15
β‐Diketone Functionalized Microspheres Chelate Reactive Iron via Metal Coordination for Cartilage Repair DOI Open Access
Yong Xu, Xin Gu,

Xingchen Li

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Excessive intracellular iron accumulation can induce mitochondrial dysfunction, leading to chondrocyte ferroptosis, a key contributor cartilage damage in osteoarthritis (OA). Here, micelle-microfluidic hydrogel microspheres, featuring keto-enol-thiol bridged nano-sized secondary structures that disintegrate within the peroxidative environment reveal β-diketone groups with metal chelation capabilities, are utilized for situ removal of reactive iron, thereby facilitating repair through restoration homeostasis. The relevant experiments demonstrate microspheres reduce influx by downregulating transferrin receptor (TfR1) expression and decrease uptake upregulating outer membrane iron-sulfur cluster protein (CISD1), thus restoring Furthermore, antioxidant properties ketone-thioether segments synergistically mitigate phospholipid peroxidation via Nrf2/SLC7A11/GPX4 axis, inhibiting ferroptosis slowing OA progression. In summary, this system sustainably chelates coordination exhibits great potential minimally invasive treatment other ferroptosis-mediated diseases.

Language: Английский

Citations

2
3D-printed bioceramic scaffolds for bone defect repair: bone aging and immune regulation DOI Creative Commons

Haoran Qi,

Bo Zhang, Lian Feng

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 28, 2025

The management of bone defects, particularly in aging populations, remains a major clinical challenge. immune microenvironment plays an important role the repair defects and favorable environment can effectively promote defects. However, is closely associated with chronic low-grade systemic inflammation, which adversely affects healing. Persistent inflammation critically regulates through all stages. This review explores potential 3D-printed bioceramic scaffolds defect repair, focusing on their capacity to modulate counteract effects aging. not only provide structural support for regeneration but also serve as effective carriers anti-osteoporosis drugs, offering novel therapeutic strategy treating osteoporotic By regulating improving response, may significantly enhance context age-related degeneration. approach underscores advanced biomaterials addressing dual challenges dysregulation, promising avenues development treatments elderly. We hope concepts discussed this could offer strategies suggest future optimization scaffolds.

Language: Английский

Citations

1
Fe-MOF-based catalysts for oxygen evolution reaction: Microenvironment regulated by organic ligands, metals and carbonization synergistically DOI

Chenchen Ding,

Weiwei Zhong,

Yuqi Cao

et al.

Chemical Engineering Science, Journal Year: 2024, Volume and Issue: unknown, P. 120888 - 120888

Published: Oct. 1, 2024

Language: Английский

Citations

4
Beyond Drug Delivery: Metal–Organic Framework-Derived Nanosystems for Bone Regeneration under Complicated Pathological Microenvironments DOI
Yüe Zhao, Yuan Xiong,

Yanli Zhao

et al.

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 22, 2024

Language: Английский

Citations

3
Metal-organic frameworks integrated into carbohydrate polymers as promising platforms for tissue engineering DOI
Moein Safarkhani,

Fahimeh Taghavimandi,

Nazila Biglari

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156847 - 156847

Published: Oct. 1, 2024

Language: Английский

Citations

3
Metal ion-crosslinking multifunctional hydrogel microspheres with inflammatory immune regulation for cartilage regeneration DOI Creative Commons
Zhuoming Xu, Jun Ma,

Hanyin Hu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 28, 2025

Introduction Osteoarthritis (OA) is a degenerative disease of the joints characterized by cartilage degradation and synovial inflammation. Due to complex pathogenesis OA, multifaceted therapies that modulate inflammatory immune microenvironmental disturbances while promoting regeneration are key control progression OA. Methods Herein, multifunctional nanoparticle (DIC/Mg-PDA NPs) was constructed successfully metal chelation effect between Mg 2+ catecholamine bond from dopamine, followed amidation with diclofenac (DIC), which then prepared into an injectable hydrogel microsphere (DIC/Mg-PDA@HM) immune-regulating cartilage-repairing abilities through microfluidic technology for treatment osteoarthritis. Results discussion The sustained release composite microspheres achieved regulation converting macrophages M1 M2 promoted differentiation BMSCs. Moreover, enhanced DIC polydopamine (PDA) effectively downregulated factors, finally OA therapy. In addition, in vivo MRI tissue section staining model proved significant efficacy on conclusion, these novel demonstrated promising prospect multidisciplinary repairing

Language: Английский

Citations

0
Bioengineered Versatile Heterojunctions as Stress Busters Targeting Matrix Degradation and Ferroptosis for Osteoarthritis Therapy DOI Open Access
Zhao Zhang,

Debin Cheng,

Dong Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of articular cartilage, with the underlying mechanism being inability chondrocytes to maintain homeostasis in response changing stress. The stress triggered excess ROS from various factors critical regulating chondrocyte survival and fate. In this study, 2D Mo 4/3 B 2‐ X MBene cerium‐gallic acid metal‐polyphenol network (MPN) together cartilage‐targeted shell hyaluronic WYRGRL (HW) are utilized development bio‐heterojunction MBene@MPN‐HW (MBM‐HW) through self‐assembly. MBM‐HW not only demonstrates superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) enzyme mimicking capabilities effectively scavenge ROS, but also exhibits dual‐responsive release cartilage‐targeting properties. Importantly, both vivo vitro experiments indicate that could alleviate oxidative stress, protect mitochondrial function, suppress cartilage matrix ferroptosis, thereby slowing progression OA. Mechanistically, it demonstrated attenuate Perk/eIF2α cascade mediated integrated restrain maintaining homeostasis. Overall, work underscores robust stress‐relieving capacity MBM‐HW, providing novel approach for treatment

Language: Английский

Citations

0
Microenvironment-Responsive Hydrogels Comprising Engineering Zeolitic Imidazolate Framework-8-Anchored Parathyroid Hormone-Related Peptide-1 for Osteoarthritis Therapy DOI
Guang Shi, Zijian Wu,

Zhuowen Hao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Intra-articular drug injections are effective for osteoarthritis (OA), but challenges such as the complex microenvironment and rapid diffusion require frequent injections. Herein, we propose a biofunctional hydrogel-based strategy prolonged delivery remodeling. We to functionalize zeolitic imidazolate framework-8 with tannic acid (TA-ZIF), anchor PTH-related peptide-1 (PTHrP-1) within this framework (TA-ZIF@P1) incorporate phenylboronic acid-modified gelatin-based hydrogel (GP hydrogel) system (GP@TA-ZIF@P1, GPTP responsive release properties that respond pathological microenvironments of OA. The facilitated controlled, sustained PTHrP-1 via dynamic boronic esters, in vitro vivo studies showing continuous over 28 days. It not only promotes chondrocyte proliferation also exhibits significant cytoprotective effects under hyperactive ROS IL-1β-induced conditions. Notably, transcriptome sequencing confirms facilitates both chondrogenesis inflammatory conditions by deactivating Wnt/β-Catenin signaling pathways enhancing PI3K/AKT pathway. Additionally, delays catabolic metabolism cartilage explants from mice environments. In surgical model mouse OA, show intra-articular injection hydrogels reduced periarticular bone remodeling promoted production glycosaminoglycans while offering chondroprotection against degeneration. To sum up, pioneering research on treatment combined system, offers valuable insights paradigm controlled PTHrP-1, representing advancement OA strategies.

Language: Английский

Citations

0