Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

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Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 10, 2024

Language: Английский

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Zinc Oxide‐Enhanced Copper Sulfide Nanozymes Promote the Healing of Infected Wounds by Activating Immune and Inflammatory Responses

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Bacterial infection and an excessive inflammatory response are two major factors that affect the healing of infected wounds. The zinc oxide/copper sulfide (ZnO-CuS) microspheres (MSs) developed in this work can kill bacteria resist inflammation. ZnO-CuS exhibits different enzyme-like activities depending on pH. In acidic environments, peroxidase-like (POD-like) activity convert hydrogen peroxide (H

Language: Английский

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A twin S-scheme CoFe2O4/VCNDA/BiVO4 nanozyme for photo-auto-enzyme-coupled catalytic degradation of carbamazepine

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153606 - 153606

Published: June 29, 2024

Language: Английский

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Hydrophilic Shape‐Memory Nanozyme Aerogel for the Development of a Reusable and Signal‐Amplified Sensor

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Nanozymes hold great promise for biosensing applications, yet their practical implementation is hampered by limitations in signal enhancement, reusability, and device integration. Herein, the development of a hydrophilic shape‐memory nanozyme aerogel that addresses these challenges reported. The platform constructed embedding chitosan‐protected platinum nanoparticles (Pt‐CS NPs), which exhibit intrinsic peroxidase (POD) activity, within polyacrylic acid (PAA) matrix. This hybrid Pt‐CS/PAA retains effect PAA component as well POD activity Pt‐CS NPs. Importantly, exhibits differential adsorption behaviors toward two distinct oxidation products, oxidized 3,3′,5,5′‐tetramethyl‐benzidine (oxTMB) 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (oxABTS), driven differing electrostatic potentials with aerogel. By integrating effect, catalysis, exceptional probe performance, enables realization signal‐amplified or reusable nanozyme‐based assay, when employing TMB ABTS chromogenic substrates, respectively. Furthermore, architecture allows straightforward deviceization, transforming analysis from conventional test paper formats into practical, sensing devices. work establishes generalizable blueprint engineering smart materials shape memory characteristics, opening up new avenues developing advanced platforms enhanced performance user‐friendly operability.

Language: Английский

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FeMo6 integrated covalent organic frameworks: Peroxidase-mimetic colorimetric biosensors for multivariate sensing hydrogen peroxide and ascorbic acid in serum and beverages

Food Chemistry, Journal Year: 2025, Volume and Issue: 479, P. 143727 - 143727

Published: March 6, 2025

Language: Английский

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A Novel Ce─Mn Heterojunction‐Based Multi‐Enzymatic Nanozyme with Cancer‐Specific Enzymatic Activity and Photothermal Capacity for Efficient Tumor Combination Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Catalytic medicine, using enzymes or nanozymes, is an emerging method for cancer treatment. However, its applicability limited by the low catalytic activity in tumor microenvironment (TME). In this work, a versatile and synthesis‐friendly nanozyme, CeO 2 Mn 1.08 O x nanoclusters, prepared. This novel Ce─Mn heterojunction formed oxidation of nanoparticles through H SO 4 /KMnO . exhibits high multi‐enzymatic activities acts as catalase (CAT), peroxidase (POD), oxidase (OXD) mimics under acidic conditions. It can regulate TME relieving hypoxia consuming endogenous glutathione (GSH). Glucose (GOx) then incorporated into linked with poly(ethylene glycol) (PEG) to obtain cascade enzyme system (Ce─Mn)‐PEI/GOx‐PEG. CAT‐like properties, which sensitize GOx‐based starvation therapy, POD‐ OXD‐like generate highly cytotoxic reactive oxygen species (ROS) cells. The glucose catabolic product, , also used ROS. addition, structure provides near‐infrared (NIR) photothermal capability, making it suitable therapy (PTT). Density functional theory (DFT) calculations provide possible reasons capability When combining mild PTT (Ce─Mn)‐PEI/GOx‐PEG efficiently ablate tumors.

Language: Английский

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Microenvironment‐adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm‐associated diabetic chronic wound healing cascade

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Abstract The presence of bacterial biofilms and the occurrence excessive inflammatory response greatly imped healing process chronic wounds in diabetic patients. However, effective strategies to simultaneously address these issues are still lacking. Here, a microenvironment‐adaptive nanodecoy (GC@Pd) is constructed via coordination situ reduction palladium ions on gallic acid‐modified chitosan (GC) promote wound by synergistic biofilm eradication, inflammation alleviation, immunoregulation. During weakly acidic conditions infection stage, GC@Pd serves as induce aggregation. Subsequently, through its oxidase‐like activity generating reactive oxygen species hyperthermia from photothermal effects, it effectively eliminates biofilm. As local microenvironment transitions an alkaline state, enzyme‐like adapts catalase‐like activity, eliminating at site inflammation. Additionally, could selectively capture pro‐inflammatory cytokines Michael addition reactions. In vivo experiments transcriptomic analysis confirmed that accelerate transition proliferative phase reducing response, thus promoting healing. provides potential therapeutic strategy for treating biofilm‐infected wounds.

Language: Английский

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Tumor‐Homing Phage Nanofibers for Nanozyme‐Enhanced Targeted Breast Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Photodynamic therapy (PDT) eliminates cancer cells by converting endogenous oxygen into reactive species (ROS). However, its efficacy is significantly hindered hypoxia in solid tumors. Hence, to engineer filamentous fd phage, a human‐friendly bacteria‐specific virus proposed, nanozyme‐nucleating photosensitizer‐loaded tumor‐homing nanofiber for enhanced production of ROS hypoxic tumor. Specifically, Pt‐binding and peptides are genetically displayed on the sidewall tip respectively. The induced nucleation orientation Pt nanozymes (PtNEs) phage. resultant PtNE‐coated phage exhibits sustained catalytic conversion hydrogen peroxide tumors O 2 producing needed PDT, compared non‐phage‐templated PtNE. Density functional theory (DFT) calculations verify mechanism phage‐templated After intravenous injection indocyanine green (ICG)‐loaded phages breast tumor‐bearing mice, nanofibers home effectively inhibit tumor growth PtNE‐enhanced PDT. can also serve as imaging probe due fluorescence ICG. This work demonstrates that engineered become tumor‐hypoxia‐relieving nanofibers, act cancer‐targeting with improved performance effective targeted

Language: Английский

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A pH‐Sensitive Glucose Oxidase and Hemin Coordination Micelle for Multi‐Enzyme Cascade and Amplified Cancer Chemodynamic Therapy

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Chemodynamic therapy (CDT) is an emerging therapeutic paradigm for cancer treatment that utilizes reactive oxygen species (ROS) to induce apoptosis of cells but few biomaterials have been developed differentiate the and normal achieve precise targeted CDT. Herein, a simple cascade enzyme system developed, termed hemin–micelles–GOx, based on hemin glucose oxidase (GOx)‐encapsulated Pluronic F127 (F127) micelles with pH‐sensitive enzymatic activities. Histidine‐tagged GOx can be easily chelated hemin‐F127 via coordination histidine ferrous ions in center by admixture aqueous solution. In tumor microenvironment (TME), hemin–micelles–GOx exhibits enhanced peroxidase (POD)‐like activities generate toxic hydroxyl radicals due acidic condition, whereas catalase (CAT)‐like, not POD‐like activity amplified, resulting elimination hydrogen peroxide oxygen. murine melanoma model, significantly suppresses growth, demonstrating its great potential as pH‐mediated switch management

Language: Английский

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