Current advances in nanozyme-based nanodynamic therapies for cancer
Acta Biomaterialia,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Advanced Materials Research at CUHK: From Biomedicine to Electronics and Beyond
Advanced Materials,
Год журнала:
2025,
Номер
37(2)
Опубликована: Янв. 1, 2025
This
special
issue
spans
a
diverse
array
of
topics,
including
nanomedicine,
tissue
engineering,
regenerative
medicine,
organs-on-chips,
biosensing,
soft
robotics,
smart
devices,
nanofabrication,
energy
saving
and
storage,
catalysis,
spintronics,
electronics,
neuromorphic
computing.
It
showcases
the
breadth
depth
advanced
materials
research
at
Chinese
University
Hong
Kong
(CUHK),
highlighting
innovation,
collaboration,
excellence
CUHK's
scientists.
Язык: Английский
Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Poor
prognosis
and
chemotherapy
response
stem
from
difficulties
in
precise
targeting
the
lack
of
effective
synergistic
treatments.
Nanozymes
show
promising
potential
tumor
chemodynamic
therapy
(CDT)
by
catalyzing
hydrogen
peroxide
(H₂O₂)
decomposition
glutathione
depletion
microenvironment
(TME).
However,
integrating
with
CDT
remains
challenging.
In
this
study,
a
porous
Fe/Cu
bimetallic
nanozyme
carrier
(FeCuNPs)
is
developed
for
co‐loading
humanized
3F8
anti‐GD2
disialoganglioside
antibody
(3F8)
novel
pyridazinone‐based
chemotherapeutic
agent
(IMB),
forming
nanoreactor
(3F8@FeCuNPs@IMB)
targeted
CDT.
The
responds
specifically
to
acidic
TME
as
primary
insurance,
allowing
controlled
release
IMB
at
site.
coating
on
surface
acts
secondary
minimizing
drug
leakage
during
delivery
process
ensuring
chemotherapy.
Furthermore,
FeCuNPs
act
peroxidase‐like
(POD)
oxidase‐like
(GSHOX)
enzymes,
hydroxyl
radical
(•OH)
generation
depleting
excess
GSH,
enhancing
results
vitro
vivo
indicate
that
dual
insurance
designed
3F8@FeCuNPs@IMB
offers
prospect
targeted,
precise,
combination
against
melanoma.
Язык: Английский
Targeting breast cancer: the promise of phage-based nanomedicines
Breast Cancer Research and Treatment,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
Язык: Английский
Tumor‐Targeted Catalytic Immunotherapy
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Cancer
immunotherapy
holds
significant
promise
for
improving
cancer
treatment
efficacy;
however,
the
low
response
rate
remains
a
considerable
challenge.
To
overcome
this
limitation,
advanced
catalytic
materials
offer
potential
in
augmenting
by
modulating
immunosuppressive
tumor
microenvironment
(TME)
through
precise
biochemical
reactions.
Achieving
optimal
targeting
precision
and
therapeutic
efficacy
necessitates
thorough
understanding
of
properties
underlying
mechanisms
tumor-targeted
materials.
This
review
provides
comprehensive
systematic
overview
recent
advancements
their
critical
role
enhancing
immunotherapy.
It
highlights
types
reactions,
construction
strategies
materials,
fundamental
targeting,
including
passive,
bioactive,
stimuli-responsive,
biomimetic
approaches.
Furthermore,
outlines
various
tumor-specific
strategies,
encompassing
tissue,
cell,
exogenous
TME-responsive,
cellular
TME
strategies.
Finally,
discussion
addresses
challenges
future
perspectives
transitioning
into
clinical
applications,
offering
insights
that
pave
way
next-generation
therapies
provide
substantial
benefits
to
patients
settings.
Язык: Английский