Current advances in nanozyme-based nanodynamic therapies for cancer
Acta Biomaterialia,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Advanced Materials Research at CUHK: From Biomedicine to Electronics and Beyond
Advanced Materials,
Год журнала:
2025,
Номер
37(2)
Опубликована: Янв. 1, 2025
This
special
issue
spans
a
diverse
array
of
topics,
including
nanomedicine,
tissue
engineering,
regenerative
medicine,
organs-on-chips,
biosensing,
soft
robotics,
smart
devices,
nanofabrication,
energy
saving
and
storage,
catalysis,
spintronics,
electronics,
neuromorphic
computing.
It
showcases
the
breadth
depth
advanced
materials
research
at
Chinese
University
Hong
Kong
(CUHK),
highlighting
innovation,
collaboration,
excellence
CUHK's
scientists.
Язык: Английский
Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Poor
prognosis
and
chemotherapy
response
stem
from
difficulties
in
precise
targeting
the
lack
of
effective
synergistic
treatments.
Nanozymes
show
promising
potential
tumor
chemodynamic
therapy
(CDT)
by
catalyzing
hydrogen
peroxide
(H₂O₂)
decomposition
glutathione
depletion
microenvironment
(TME).
However,
integrating
with
CDT
remains
challenging.
In
this
study,
a
porous
Fe/Cu
bimetallic
nanozyme
carrier
(FeCuNPs)
is
developed
for
co‐loading
humanized
3F8
anti‐GD2
disialoganglioside
antibody
(3F8)
novel
pyridazinone‐based
chemotherapeutic
agent
(IMB),
forming
nanoreactor
(3F8@FeCuNPs@IMB)
targeted
CDT.
The
responds
specifically
to
acidic
TME
as
primary
insurance,
allowing
controlled
release
IMB
at
site.
coating
on
surface
acts
secondary
minimizing
drug
leakage
during
delivery
process
ensuring
chemotherapy.
Furthermore,
FeCuNPs
act
peroxidase‐like
(POD)
oxidase‐like
(GSHOX)
enzymes,
hydroxyl
radical
(•OH)
generation
depleting
excess
GSH,
enhancing
results
vitro
vivo
indicate
that
dual
insurance
designed
3F8@FeCuNPs@IMB
offers
prospect
targeted,
precise,
combination
against
melanoma.
Язык: Английский
Targeting breast cancer: the promise of phage-based nanomedicines
Breast Cancer Research and Treatment,
Год журнала:
2025,
Номер
211(3), С. 561 - 580
Опубликована: Апрель 17, 2025
Язык: Английский
Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities
Bioengineering,
Год журнала:
2025,
Номер
12(5), С. 469 - 469
Опубликована: Апрель 29, 2025
Bacteriophages,
with
their
distinctive
ability
to
selectively
target
host
bacteria,
stand
out
as
a
compelling
tool
in
the
realm
of
drug
and
gene
delivery.
Their
assembly
from
proteins
nucleic
acids,
coupled
modifiable
biologically
unique
properties,
enables
them
serve
efficient
safe
delivery
systems.
Unlike
conventional
nanocarriers,
which
face
limitations
such
non-specific
targeting,
cytotoxicity,
reduced
transfection
efficiency
vivo,
engineered
phages
exhibit
promising
potential
overcome
these
hurdles
improve
outcomes.
This
review
highlights
bacteriophage-based
systems
innovative
for
delivering
therapeutic
agents.
It
explores
strategies
engineering
bacteriophage,
categorizes
principal
types
employed
delivery,
evaluates
applications
disease
therapy.
provides
intriguing
details
use
natural
therapy
diseases
cancer,
bacterial
viral
infections,
veterinary
diseases,
neurological
disorders,
well
phage
display
technology
generating
monoclonal
antibodies
against
various
human
diseases.
Additionally,
CRISPR-Cas9
genetically
is
elucidated.
Furthermore,
it
critical
analysis
challenges
associated
phage-based
systems,
offering
insights
overcoming
obstacles.
By
showcasing
advancements
integration
into
nanotechnology,
this
study
underscores
revolutionize
approaches
inspire
future
innovations
medicine.
Язык: Английский
Nanofiber Drug Delivery Systems: Recent Advances in Nanofabrication and Their Role in Targeted Therapy in Cancer, Neurodegenerative, and Cardiovascular Diseases
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(5)
Опубликована: Май 1, 2025
ABSTRACT
Nanofiber‐based
drug
delivery
systems
show
strong
potential
due
to
their
high
surface
area‐to‐volume
ratio
and
adjustable
structure.
Recent
studies
demonstrated
loading
efficiencies
exceeding
85%,
with
sustained
release
kinetics
up
96
h.
In
cancer
models,
nanofiber‐based
carriers
improved
accumulation
at
tumor
sites
by
3–4
fold
compared
conventional
formulations,
enhancing
therapeutic
efficacy
minimizing
systemic
toxicity.
This
review
outlines
methods
for
precise
nanofiber
shape
function
control
through
electrospinning
solution
blow
spinning
techniques.
advancements
in
technology
have
proven
promising
biomedical
applications
where
they
are
utilized
tissue
engineering,
neurodegenerative
disease
management,
wound
healing,
targeted
therapy.
Nanofibers
as
an
optimal
system
that
improves
cellular
restoration,
together
controlled
deep
penetration
capabilities.
The
recent
development
of
dual‐drug
systems,
stimuli‐responsive
nanofibers,
scaffolds
composed
nanofibers
smart
materials
has
expanded
usage
precision
medicine.
Research
now
demonstrates
facilitate
remodeling
functions
along
angiogenesis
promotion,
inflammatory
response
stability
improvement.
also
focuses
on
the
patents
a
system.
addition,
this
presents
new
approaches
overcome
these
challenges
based
interdisciplinary
cooperation,
AI‐driven
design
such
sophisticated
bioinformatics
tools.
review,
advances
prospects
realizing
revolution
field
improving
healthcare
outcomes
presented
detailed
overview.
Язык: Английский
Surface etching nano-flowers of Fe-Mn bimetallic oxide nano-cubes: determination of L-cysteine by its oxidase activity
Journal of Food Composition and Analysis,
Год журнала:
2025,
Номер
unknown, С. 107734 - 107734
Опубликована: Май 1, 2025
Язык: Английский
Tumor‐Targeted Catalytic Immunotherapy
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Cancer
immunotherapy
holds
significant
promise
for
improving
cancer
treatment
efficacy;
however,
the
low
response
rate
remains
a
considerable
challenge.
To
overcome
this
limitation,
advanced
catalytic
materials
offer
potential
in
augmenting
by
modulating
immunosuppressive
tumor
microenvironment
(TME)
through
precise
biochemical
reactions.
Achieving
optimal
targeting
precision
and
therapeutic
efficacy
necessitates
thorough
understanding
of
properties
underlying
mechanisms
tumor-targeted
materials.
This
review
provides
comprehensive
systematic
overview
recent
advancements
their
critical
role
enhancing
immunotherapy.
It
highlights
types
reactions,
construction
strategies
materials,
fundamental
targeting,
including
passive,
bioactive,
stimuli-responsive,
biomimetic
approaches.
Furthermore,
outlines
various
tumor-specific
strategies,
encompassing
tissue,
cell,
exogenous
TME-responsive,
cellular
TME
strategies.
Finally,
discussion
addresses
challenges
future
perspectives
transitioning
into
clinical
applications,
offering
insights
that
pave
way
next-generation
therapies
provide
substantial
benefits
to
patients
settings.
Язык: Английский