Current advances in nanozyme-based nanodynamic therapies for cancer

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Advanced Materials Research at CUHK: From Biomedicine to Electronics and Beyond

Advanced Materials, Journal Year: 2025, Volume and Issue: 37(2)

Published: Jan. 1, 2025

This special issue spans a diverse array of topics, including nanomedicine, tissue engineering, regenerative medicine, organs-on-chips, biosensing, soft robotics, smart devices, nanofabrication, energy saving and storage, catalysis, spintronics, electronics, neuromorphic computing. It showcases the breadth depth advanced materials research at Chinese University Hong Kong (CUHK), highlighting innovation, collaboration, excellence CUHK's scientists.

Language: Английский

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Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 469 - 469

Published: April 29, 2025

Bacteriophages, with their distinctive ability to selectively target host bacteria, stand out as a compelling tool in the realm of drug and gene delivery. Their assembly from proteins nucleic acids, coupled modifiable biologically unique properties, enables them serve efficient safe delivery systems. Unlike conventional nanocarriers, which face limitations such non-specific targeting, cytotoxicity, reduced transfection efficiency vivo, engineered phages exhibit promising potential overcome these hurdles improve outcomes. This review highlights bacteriophage-based systems innovative for delivering therapeutic agents. It explores strategies engineering bacteriophage, categorizes principal types employed delivery, evaluates applications disease therapy. provides intriguing details use natural therapy diseases cancer, bacterial viral infections, veterinary diseases, neurological disorders, well phage display technology generating monoclonal antibodies against various human diseases. Additionally, CRISPR-Cas9 genetically is elucidated. Furthermore, it critical analysis challenges associated phage-based systems, offering insights overcoming obstacles. By showcasing advancements integration into nanotechnology, this study underscores revolutionize approaches inspire future innovations medicine.

Language: Английский

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Nanofiber Drug Delivery Systems: Recent Advances in Nanofabrication and Their Role in Targeted Therapy in Cancer, Neurodegenerative, and Cardiovascular Diseases

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(5)

Published: May 1, 2025

ABSTRACT Nanofiber‐based drug delivery systems show strong potential due to their high surface area‐to‐volume ratio and adjustable structure. Recent studies demonstrated loading efficiencies exceeding 85%, with sustained release kinetics up 96 h. In cancer models, nanofiber‐based carriers improved accumulation at tumor sites by 3–4 fold compared conventional formulations, enhancing therapeutic efficacy minimizing systemic toxicity. This review outlines methods for precise nanofiber shape function control through electrospinning solution blow spinning techniques. advancements in technology have proven promising biomedical applications where they are utilized tissue engineering, neurodegenerative disease management, wound healing, targeted therapy. Nanofibers as an optimal system that improves cellular restoration, together controlled deep penetration capabilities. The recent development of dual‐drug systems, stimuli‐responsive nanofibers, scaffolds composed nanofibers smart materials has expanded usage precision medicine. Research now demonstrates facilitate remodeling functions along angiogenesis promotion, inflammatory response stability improvement. also focuses on the patents a system. addition, this presents new approaches overcome these challenges based interdisciplinary cooperation, AI‐driven design such sophisticated bioinformatics tools. review, advances prospects realizing revolution field improving healthcare outcomes presented detailed overview.

Language: Английский

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Surface etching nano-flowers of Fe-Mn bimetallic oxide nano-cubes: determination of L-cysteine by its oxidase activity

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107734 - 107734

Published: May 1, 2025

Language: Английский

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Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Poor prognosis and chemotherapy response stem from difficulties in precise targeting the lack of effective synergistic treatments. Nanozymes show promising potential tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H₂O₂) decomposition glutathione depletion microenvironment (TME). However, integrating with CDT remains challenging. In this study, a porous Fe/Cu bimetallic nanozyme carrier (FeCuNPs) is developed for co‐loading humanized 3F8 anti‐GD2 disialoganglioside antibody (3F8) novel pyridazinone‐based chemotherapeutic agent (IMB), forming nanoreactor (3F8@FeCuNPs@IMB) targeted CDT. The responds specifically to acidic TME as primary insurance, allowing controlled release IMB at site. coating on surface acts secondary minimizing drug leakage during delivery process ensuring chemotherapy. Furthermore, FeCuNPs act peroxidase‐like (POD) oxidase‐like (GSHOX) enzymes, hydroxyl radical (•OH) generation depleting excess GSH, enhancing results vitro vivo indicate that dual insurance designed 3F8@FeCuNPs@IMB offers prospect targeted, precise, combination against melanoma.

Language: Английский

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Targeting breast cancer: the promise of phage-based nanomedicines

Breast Cancer Research and Treatment, Journal Year: 2025, Volume and Issue: 211(3), P. 561 - 580

Published: April 17, 2025

Language: Английский

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Tumor‐Targeted Catalytic Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting by modulating immunosuppressive tumor microenvironment (TME) through precise biochemical reactions. Achieving optimal targeting precision and therapeutic efficacy necessitates thorough understanding of properties underlying mechanisms tumor-targeted materials. This review provides comprehensive systematic overview recent advancements their critical role enhancing immunotherapy. It highlights types reactions, construction strategies materials, fundamental targeting, including passive, bioactive, stimuli-responsive, biomimetic approaches. Furthermore, outlines various tumor-specific strategies, encompassing tissue, cell, exogenous TME-responsive, cellular TME strategies. Finally, discussion addresses challenges future perspectives transitioning into clinical applications, offering insights that pave way next-generation therapies provide substantial benefits to patients settings.

Language: Английский

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