Tumor‐Targeted Catalytic Immunotherapy DOI Open Access

En‐Li Yang,

Wuyin Wang, Yingqi Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting by modulating immunosuppressive tumor microenvironment (TME) through precise biochemical reactions. Achieving optimal targeting precision and therapeutic efficacy necessitates thorough understanding of properties underlying mechanisms tumor-targeted materials. This review provides comprehensive systematic overview recent advancements their critical role enhancing immunotherapy. It highlights types reactions, construction strategies materials, fundamental targeting, including passive, bioactive, stimuli-responsive, biomimetic approaches. Furthermore, outlines various tumor-specific strategies, encompassing tissue, cell, exogenous TME-responsive, cellular TME strategies. Finally, discussion addresses challenges future perspectives transitioning into clinical applications, offering insights that pave way next-generation therapies provide substantial benefits to patients settings.

Language: Английский

Current advances in nanozyme-based nanodynamic therapies for cancer DOI
Xiangyang Zhou,

Shuaipeng Feng,

Qingqing Xu

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

4
Advanced Materials Research at CUHK: From Biomedicine to Electronics and Beyond DOI
Chuanbin Mao

Advanced Materials, Journal Year: 2025, Volume and Issue: 37(2)

Published: Jan. 1, 2025

This special issue spans a diverse array of topics, including nanomedicine, tissue engineering, regenerative medicine, organs-on-chips, biosensing, soft robotics, smart devices, nanofabrication, energy saving and storage, catalysis, spintronics, electronics, neuromorphic computing. It showcases the breadth depth advanced materials research at Chinese University Hong Kong (CUHK), highlighting innovation, collaboration, excellence CUHK's scientists.

Language: Английский

Citations

0
Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy DOI
Xianyu Zhu,

Lingli Gao,

Yanbo Zheng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Poor prognosis and chemotherapy response stem from difficulties in precise targeting the lack of effective synergistic treatments. Nanozymes show promising potential tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H₂O₂) decomposition glutathione depletion microenvironment (TME). However, integrating with CDT remains challenging. In this study, a porous Fe/Cu bimetallic nanozyme carrier (FeCuNPs) is developed for co‐loading humanized 3F8 anti‐GD2 disialoganglioside antibody (3F8) novel pyridazinone‐based chemotherapeutic agent (IMB), forming nanoreactor (3F8@FeCuNPs@IMB) targeted CDT. The responds specifically to acidic TME as primary insurance, allowing controlled release IMB at site. coating on surface acts secondary minimizing drug leakage during delivery process ensuring chemotherapy. Furthermore, FeCuNPs act peroxidase‐like (POD) oxidase‐like (GSHOX) enzymes, hydroxyl radical (•OH) generation depleting excess GSH, enhancing results vitro vivo indicate that dual insurance designed 3F8@FeCuNPs@IMB offers prospect targeted, precise, combination against melanoma.

Language: Английский

Citations

0
Targeting breast cancer: the promise of phage-based nanomedicines DOI

Sarah Gholami,

Hossein Saffarfar,

Mohammad Reza Mehraban

et al.

Breast Cancer Research and Treatment, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Tumor‐Targeted Catalytic Immunotherapy DOI Open Access

En‐Li Yang,

Wuyin Wang, Yingqi Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting by modulating immunosuppressive tumor microenvironment (TME) through precise biochemical reactions. Achieving optimal targeting precision and therapeutic efficacy necessitates thorough understanding of properties underlying mechanisms tumor-targeted materials. This review provides comprehensive systematic overview recent advancements their critical role enhancing immunotherapy. It highlights types reactions, construction strategies materials, fundamental targeting, including passive, bioactive, stimuli-responsive, biomimetic approaches. Furthermore, outlines various tumor-specific strategies, encompassing tissue, cell, exogenous TME-responsive, cellular TME strategies. Finally, discussion addresses challenges future perspectives transitioning into clinical applications, offering insights that pave way next-generation therapies provide substantial benefits to patients settings.

Language: Английский

Citations

1