Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Май 9, 2025
Pulmonary
hypertension
(PH)
is
still
an
aggressive
and
progressive
illness
with
vascular
remodeling
right
heart
failure
despite
the
therapeutic
advances
made
in
recent
past.
Biomaterials
offer
attractive
route
to
break
current
paradigms
by
inducing
repair,
facilitating
drug
targeting,
allowing
dynamic
regeneration
of
tissue.
This
review
taking
integrated
approach
investigates
revolutionary
role
played
novel
biomaterials
bio–nano
interfaces
PH
treatment.
We
classify
evaluate
several
classes
biomaterial
platforms
including
natural
polymers,
scaffolds
based
on
synthetic
extracellular
vesicles
(EVs),
stimulus-responsive
systems
emphasis
both
underlying
mechanisms
clinical
relevance.
further
address
progress
artificial
intelligence
(AI)-based
integrating
multi-omics
tools
provide
patient-tailored
therapy.
finally
touch
ongoing
limitations
enumerate
future
directions
required
take
forward
biomaterial-based
therapies
towards
reality.
MXene-based
materials
have
attracted
significant
interest
due
to
their
distinct
physical
and
chemical
properties,
which
are
relevant
fields
such
as
energy
storage,
environmental
science,
biomedicine.
MXene
has
shown
potential
in
the
area
of
tissue
regenerative
medicine.
However,
research
on
its
applications
regeneration
is
still
early
stages,
with
a
notable
absence
comprehensive
reviews.
This
review
begins
detailed
description
intrinsic
properties
MXene,
followed
by
discussion
various
nanostructures
that
can
form,
spanning
from
0
3
dimensions.
The
focus
then
shifts
biomaterials
engineering,
particularly
immunomodulation,
wound
healing,
bone
regeneration,
nerve
regeneration.
MXene's
physicochemical
including
conductivity,
photothermal
characteristics,
antibacterial
facilitate
interactions
different
cell
types,
influencing
biological
processes.
These
highlight
modulating
cellular
functions
essential
for
Although
developing,
versatile
structural
attributes
suggest
role
advancing
Diabetic
wounds
are
highly
susceptible
to
bacterial
infection,
which
can
lead
the
formation
of
biofilms,
making
diabetic
wound
healing
a
major
challenge.
In
this
study,
composited
microneedle
that
incorporated
drug-loaded
conjugated
polymer
nanoparticles
and
basic
fibroblast
growth
factor
was
prepared
eliminate
biofilms
promote
vascular
regeneration.
This
released
minocycline
under
near-infrared
(NIR)
light,
effectively
penetrating
biofilms.
The
photothermal
properties
polymers,
combined
with
antibacterial
action
minocycline,
contribute
eradication
elimination
drug-resistant
bacteria.
Moreover,
it
regulated
microenvironment
by
reducing
level
oxidative
stress,
as
well
production
inflammatory
factors
at
site.
Meanwhile,
boosted
cell
migration
promoted
angiogenesis
accelerate
healing.
for
biofilm
represents
promising
approach
promoting
Transactions of Tianjin University,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Abstract
Flexible
strain
sensors
have
received
tremendous
attention
because
of
their
potential
applications
as
wearable
sensing
devices.
However,
the
integration
key
functions
into
a
single
sensor,
such
high
stretchability,
low
hysteresis,
self-adhesion,
and
excellent
antifreezing
performance,
remains
an
unmet
challenge.
In
this
respect,
zwitterionic
hydrogels
emerged
ideal
material
candidates
for
breaking
through
above
dilemma.
The
mechanical
properties
most
reported
hydrogels,
however,
are
relatively
poor,
significantly
restricting
use
under
load-bearing
conditions.
Traditional
improvement
approaches
often
involve
complex
preparation
processes,
making
large-scale
production
challenging.
Additionally,
prepared
with
chemical
crosslinkers
typically
fragile
prone
to
irreversible
deformation
large
strains,
resulting
in
slow
recovery
structure
function.
To
fundamentally
enhance
pure
effective
approach
is
regulation
monomers
targeted
design
strategy.
This
study
employed
novel
monomer
carboxybetaine
urethane
acrylate
(CBUTA),
which
contained
one
group
on
its
side
chain.
Through
direct
polymerization
ultrahigh
concentration
solutions
without
adding
any
crosslinker,
we
successfully
developed
supramolecular
enhanced
properties,
self-adhesive
behavior,
performance.
Most
importantly,
resultant
exhibited
tensile
strength
toughness
displayed
ultralow
hysteresis
conditions
up
1100%.
outstanding
performance
was
attributed
unique
liquid–liquid
phase
separation
phenomenon
induced
by
CBUTA
aqueous
solution,
well
polymer
chain
entanglement
strong
hydrogen
bonds
between
groups
chains.
application
high-performance
triboelectric
nanogenerators
further
explored.
Overall,
work
provides
promising
strategy
developing
flexible
self-powered
electronic
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
The
precise
spatiotemporal
control
of
reactive
oxygen
species
(ROS)
generation
and
scavenging
remains
pivotal
for
infected
wound
healing.
However,
conventional
nanozymes
fail
to
adaptively
regulate
ROS
dynamics
across
inflammatory
proliferative
phases.
A
near-infrared
(NIR)-activated
inverse
oxide/alloy-structured
nanozyme
(Co7Fe3/ZnO@C)
is
developed,
featuring
enzymatic
cascade
activities
tune
homeostasis
through
synergistic
chemodynamic
(CDT),
photodynamic
(PDT),
photothermal
(PTT)
therapies.
orchestrates
a
self-regulated
cascade:
peroxidase
(POD)-like
activity
initially
generates
bactericidal
hydroxyl
radicals
in
acidic
wounds,
while
subsequent
NIR
triggers
hot
electron
transfer
from
Co7Fe3
ZnO,
facilitating
synchronized
superoxide
dismutase
(SOD)-like,
catalase
(CAT)-like
radical
antioxidant
capacity
(HORAC)
scavenge
residual
ROS.
This
cascaded
network
dynamically
balances
production
(POD)
(NIR-driven
SOD/CAT/HORAC),
eradicating
bacteria
resolving
inflammation.
In
vitro/vivo
studies
have
shown
that
the
proposed
method
maintaining
can
markedly
enhance
rate
healing
by
regulation
environment
within
injured
tissue
facilitation
rapid
re-epithelialization.
work
provides
an
intelligent
platform
simulates
function
natural
enzymes
constructs
reaction
strategy
balance
antibacterial
anti-inflammatory
demands
microenvironment.
Journal of Applied Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
ABSTRACT
Self‐healing
hydrogels
have
become
a
hot
research
topic
in
the
field
of
wound
care
due
to
their
ability
prevent
secondary
damage
dressing
and
reduce
risk
infection.
The
aim
this
study
was
develop
hydrogel
network
system
with
excellent
self‐healing
antimicrobial
properties,
which
is
particularly
suitable
for
applications.
stability
enhanced
by
forming
long
chains
through
lipoic
acid
(LA)
disulfide
bonding
inhibiting
chain
depolymerization
via
polygallic
(PGA)‐mediated
SAr
bonding.
In
addition,
poly(lysine)
(PL)
doped
into
electrostatic
interactions
further
enhance
structural
strength
properties
hydrogels.
This
noncovalent
gel
endowed
softness
fluidity,
enabling
them
adapt
various
shapes.
Through
experimental
results,
it
shown
that
not
only
possessed
mechanical
remarkable
ability,
but
also
exhibited
good
cytocompatibility.
Antimicrobial
tests
more
than
99.9%
effective
against
Escherichia
coli
Staphylococcus
aureus
.
Thus,
PLA/PGA/PL
self‐healing,
antimicrobial,
biocompatibility
shows
great
potential
application
as
dressings
becomes
strong
candidate
dressings.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Abstract
Zwitterionic
hydrogels
have
attracted
intensive
attentions
for
their
exceptional
hydration
and
anti‐fouling
properties,
while
the
exploration
rational
structural
designs
to
achieve
multi‐function
superior
anti‐freezing
capability
remains
an
ongoing
mission.
Herein,
a
new
multi‐functional
zwitterionic
monomer
(ACHPES)
is
designed
developed
from
which
novel
are
fabricated.
The
pyridinium‐sulfonate
motif
endows
hydrogel
with
discoloration
in
both
visible
light
fluorescence
response
pH
stimulus,
enabling
unique
multi‐channel
information
encryption
highly
sensitive
Cu
2+
detection
threshold
of
0.64
ppm.
design
carbamate
group
fulfils
high
bonding
capacity
water,
leading
capability.
As
such,
exhibit
extremely
low
water
freezing
point
−47.3
°C
breaking
elongation
≈500%
at
−20
°C.
outstanding
enables
sensors
electrolytes
excellent
operational
performance
temperatures.
This
innovative
strategy
offers
avenue
functionalization
application
icy
temperature.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Abstract
Although
numerous
enzyme‐mimicking
nanomaterials
have
been
developed
to
regulate
the
highly
reactive
oxygen
species
(ROS)‐rich
microenvironment
of
diabetic
wounds
for
improving
its
healing,
poor
broad‐spectrum
ROS‐scavenging
capacity
and
biological
toxicity
resulting
from
side
reactions
still
require
improvement.
To
tackle
these
challenges,
a
polyphenol‐mediated
copper‐bismuth
bimetallic
artificial
metalloproteinases,
CuBi‐TA@BSA,
based
on
protein‐scaffold
design
strategy,
is
conceptually
engineered.
The
Bi
polyphenols
can
cooperatively
enhance
loading
Cu
ions
their
coordination
within
BSA
scaffold.
CuBi‐TA@BSA
exhibits
remarkable
scavenging
activity
against
various
ROS
via
effectively
donating
electrons,
as
well
reaction
pathway
specificity
catalytic
H
2
O
decomposition
without
POD‐like
activity.
Moreover,
in
vitro
vivo
studies
further
confirm
that
protect
cells
oxidative
damage,
inhibit
onset
progression
inflammation,
promote
wound
healing.
This
work
presents
simple
strategy
biocatalysts
scavenge
accelerate
wound‐healing
process,
also
provides
designing
metalloproteinases
antioxidative
therapy.
