Emerging biomaterials and bio-nano interfaces in pulmonary hypertension therapy: transformative strategies for personalized treatment DOI Creative Commons
Xiaofa Chen, Lina Xu, Haiyan Shi

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 9, 2025

Pulmonary hypertension (PH) is still an aggressive and progressive illness with vascular remodeling right heart failure despite the therapeutic advances made in recent past. Biomaterials offer attractive route to break current paradigms by inducing repair, facilitating drug targeting, allowing dynamic regeneration of tissue. This review taking integrated approach investigates revolutionary role played novel biomaterials bio–nano interfaces PH treatment. We classify evaluate several classes biomaterial platforms including natural polymers, scaffolds based on synthetic extracellular vesicles (EVs), stimulus-responsive systems emphasis both underlying mechanisms clinical relevance. further address progress artificial intelligence (AI)-based integrating multi-omics tools provide patient-tailored therapy. finally touch ongoing limitations enumerate future directions required take forward biomaterial-based therapies towards reality.

Language: Английский

Advanced zwitterionic polymeric membranes for diverse applications beyond antifouling DOI

Guojiang Gu,

Xiaobin Yang, Yangxue Li

et al.

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: unknown, P. 129848 - 129848

Published: Sept. 1, 2024

Language: Английский

Citations

19
Engineered MXene Biomaterials for Regenerative Medicine DOI

Shengmin Zhang,

Liang Wang, Zhichao Feng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing

Language: Английский

Citations

6
Photothermal Conjugated Polymer Microneedle with Biofilm Elimination and Angiogenesis for Diabetic Wound Healing DOI
Zijuan Wang, Boying Li, Chenyao Nie

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Diabetic wounds are highly susceptible to bacterial infection, which can lead the formation of biofilms, making diabetic wound healing a major challenge. In this study, composited microneedle that incorporated drug-loaded conjugated polymer nanoparticles and basic fibroblast growth factor was prepared eliminate biofilms promote vascular regeneration. This released minocycline under near-infrared (NIR) light, effectively penetrating biofilms. The photothermal properties polymers, combined with antibacterial action minocycline, contribute eradication elimination drug-resistant bacteria. Moreover, it regulated microenvironment by reducing level oxidative stress, as well production inflammatory factors at site. Meanwhile, boosted cell migration promoted angiogenesis accelerate healing. for biofilm represents promising approach promoting

Language: Английский

Citations

4
Hydrogel-based pressure sensors for electronic skin systems DOI

Yidan Chen,

Chenghui Lv,

X.S. Ye

et al.

Matter, Journal Year: 2025, Volume and Issue: 8(3), P. 101992 - 101992

Published: March 1, 2025

Citations

3
Hyperthermia-enhanced immunoregulation hydrogel for oxygenation and ROS neutralization in diabetic foot ulcers DOI
Xiaoliang Qi, Ying Li,

Yajing Xiang

et al.

Published: March 1, 2025

Language: Английский

Citations

3
Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing DOI Open Access

Yongsen Zhao,

Shiqi Zhao, Yu Du

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

The precise spatiotemporal control of reactive oxygen species (ROS) generation and scavenging remains pivotal for infected wound healing. However, conventional nanozymes fail to adaptively regulate ROS dynamics across inflammatory proliferative phases. A near-infrared (NIR)-activated inverse oxide/alloy-structured nanozyme (Co7Fe3/ZnO@C) is developed, featuring enzymatic cascade activities tune homeostasis through synergistic chemodynamic (CDT), photodynamic (PDT), photothermal (PTT) therapies. orchestrates a self-regulated cascade: peroxidase (POD)-like activity initially generates bactericidal hydroxyl radicals in acidic wounds, while subsequent NIR triggers hot electron transfer from Co7Fe3 ZnO, facilitating synchronized superoxide dismutase (SOD)-like, catalase (CAT)-like radical antioxidant capacity (HORAC) scavenge residual ROS. This cascaded network dynamically balances production (POD) (NIR-driven SOD/CAT/HORAC), eradicating bacteria resolving inflammation. In vitro/vivo studies have shown that the proposed method maintaining can markedly enhance rate healing by regulation environment within injured tissue facilitation rapid re-epithelialization. work provides an intelligent platform simulates function natural enzymes constructs reaction strategy balance antibacterial anti-inflammatory demands microenvironment.

Language: Английский

Citations

2
Engineering Supramolecular Hydrogels via Reversible Photoswitching of Cucurbit[8]uril‐Spiropyran Complexation Stoichiometry DOI
Mengqi Du, Chuang Li

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Abstract The integration of photoswitchable supramolecular units into hydrogels allows for spatiotemporal control over their nanoscale topological network and macroscale properties using light. Nevertheless, the current availability interactions development such materials remains limited. Here, molecular design a novel cucurbit[8]uril‐spiropyran host–guest complex exhibiting fast reversible switching binding ratios between 1:2 1:1 is reported. Photoswitchable complexation stoichiometries are rationally exploited as (de)crosslinking in multiple polymers displaying highly dynamic switchable features that spatiotemporally controlled by exhibit rapid mechanical softening‐hardening upon alternating irradiation with blue UV light, which used to significantly accelerate improve efficiency self‐healing shape‐remolding hydrogels. Furthermore, spiropyran endows unique photochromic reproducible patterning/erasing information storage. Using dual‐light‐assisted extrusion process, meter‐scale hydrogel fibers enhanced structural integrity ionic conductivity constructed woven various slidable knots fluorescent shapes. This work represents an innovative strategy advancing engineered light opens avenues prospective applications adaptive systems.

Language: Английский

Citations

9
Hydrogen-Bonding-Crosslinked Polyzwitterionic Hydrogels with Extreme Stretchability, Ultralow Hysteresis, Self-adhesion, and Antifreezing Performance as Flexible Self-powered Electronic Devices DOI Creative Commons
Siyu Bao, Hongying Wang,

Baocheng Liu

et al.

Transactions of Tianjin University, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Flexible strain sensors have received tremendous attention because of their potential applications as wearable sensing devices. However, the integration key functions into a single sensor, such high stretchability, low hysteresis, self-adhesion, and excellent antifreezing performance, remains an unmet challenge. In this respect, zwitterionic hydrogels emerged ideal material candidates for breaking through above dilemma. The mechanical properties most reported hydrogels, however, are relatively poor, significantly restricting use under load-bearing conditions. Traditional improvement approaches often involve complex preparation processes, making large-scale production challenging. Additionally, prepared with chemical crosslinkers typically fragile prone to irreversible deformation large strains, resulting in slow recovery structure function. To fundamentally enhance pure effective approach is regulation monomers targeted design strategy. This study employed novel monomer carboxybetaine urethane acrylate (CBUTA), which contained one group on its side chain. Through direct polymerization ultrahigh concentration solutions without adding any crosslinker, we successfully developed supramolecular enhanced properties, self-adhesive behavior, performance. Most importantly, resultant exhibited tensile strength toughness displayed ultralow hysteresis conditions up 1100%. outstanding performance was attributed unique liquid–liquid phase separation phenomenon induced by CBUTA aqueous solution, well polymer chain entanglement strong hydrogen bonds between groups chains. application high-performance triboelectric nanogenerators further explored. Overall, work provides promising strategy developing flexible self-powered electronic

Language: Английский

Citations

1
Poly (Lipoic Acid) Hydrogel Dressings With Adhesion, Self‐Healing, and Self‐Adaptive Properties via Dynamic Bonding DOI Open Access
Zhiyuan Zhang, Yan Wang, Chen Wang

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT Self‐healing hydrogels have become a hot research topic in the field of wound care due to their ability prevent secondary damage dressing and reduce risk infection. The aim this study was develop hydrogel network system with excellent self‐healing antimicrobial properties, which is particularly suitable for applications. stability enhanced by forming long chains through lipoic acid (LA) disulfide bonding inhibiting chain depolymerization via polygallic (PGA)‐mediated SAr bonding. In addition, poly(lysine) (PL) doped into electrostatic interactions further enhance structural strength properties hydrogels. This noncovalent gel endowed softness fluidity, enabling them adapt various shapes. Through experimental results, it shown that not only possessed mechanical remarkable ability, but also exhibited good cytocompatibility. Antimicrobial tests more than 99.9% effective against Escherichia coli Staphylococcus aureus . Thus, PLA/PGA/PL self‐healing, antimicrobial, biocompatibility shows great potential application as dressings becomes strong candidate dressings.

Language: Английский

Citations

1
Supramolecular Zwitterionic Hydrogels for Information Encryption, Soft Electronics and Energy Storage at Icy Temperature DOI Creative Commons

G. Wang,

Haochen Ni,

Yifan Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Zwitterionic hydrogels have attracted intensive attentions for their exceptional hydration and anti‐fouling properties, while the exploration rational structural designs to achieve multi‐function superior anti‐freezing capability remains an ongoing mission. Herein, a new multi‐functional zwitterionic monomer (ACHPES) is designed developed from which novel are fabricated. The pyridinium‐sulfonate motif endows hydrogel with discoloration in both visible light fluorescence response pH stimulus, enabling unique multi‐channel information encryption highly sensitive Cu 2+ detection threshold of 0.64 ppm. design carbamate group fulfils high bonding capacity water, leading capability. As such, exhibit extremely low water freezing point −47.3 °C breaking elongation ≈500% at −20 °C. outstanding enables sensors electrolytes excellent operational performance temperatures. This innovative strategy offers avenue functionalization application icy temperature.

Language: Английский

Citations

1