Bioactive Materials, Год журнала: 2025, Номер 50, С. 215 - 231
Опубликована: Апрель 11, 2025
Язык: Английский
Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 37 - 53
Опубликована: Ноя. 17, 2024
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9100 - 9100
Опубликована: Авг. 22, 2024
The impressive adhesive capacity of marine mussels has inspired various fascinating designs in biomedical fields. Mussel-inspired injectable hydrogels, as a type promising mussel-inspired material, have attracted much attention due to their minimally invasive property and desirable functions provided by components. In recent decades, hydrogels been designed widely applied numerous rational incorporation catechol groups endows the with potential exhibit many properties, including tissue adhesiveness self-healing, antimicrobial, antioxidant capabilities, broadening applications this review, we first give brief introduction adhesion mechanism characteristics hydrogels. Further, typical design strategies are summarized. methodologies for integrating into polymers crosslinking methods discussed section. addition, systematically overview applications, focus on how unique properties these benefit challenges perspectives last This review may provide new inspiration novel bioinspired facilitate application
Язык: Английский
Процитировано
5
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 3, 2024
Abstract Hydrogen‐bonded organic frameworks (HOFs) are emerging as multifunctional materials with exceptional biocompatibility, abundant active sites, and tunable porosity, which highly beneficial for advanced wound care. However, a significant challenge involves transforming pristine HOFs powders into lightweight, ultrathin, freestanding membranes compatible soft biological systems. Herein, the study successfully develops shape‐adaptive HOF‐based matrix (HMMs) using polymer‐assisted liquid‐air interface technique. The HMMs conform seamlessly to tissues of different sizes shapes, effectively stopping bleeding, provide high water‐vapor permeability. Notably, both in vitro vivo studies mice models demonstrated that these tissue‐conformable significantly accelerate healing by modulating inflammatory environment injured tissue promoting rapid re‐epithelialization. Furthermore, RNA‐seq analysis mechanistic revealed reduce inflammation facilitate transition from proliferative stage remodeling skin development. This work not only opens up new avenues care but also establishes foundation hybridizing polymers wide range potential applications.
Язык: Английский
Процитировано
5
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 18, 2024
Abstract Polymer gels stand out as emerging and promising materials in adhesives. However, flexible network network–solvent mismatch affect their strengths stabilities. Regulating the architectures of polymer via molecular design is a strategy to overcome these drawbacks. Herein, novel polymeric rigid cage (PRC) structure proposed for capturing bulky vegetable oils mechanically interlocking supramolecular interactions or steric hindrance effect fabricate universal gels‐based By rationally designing refining architectures, prepared by 4,4′‐diphenylmethane diisocyanate (MDI) N , ″, ″‐tetra(2‐hydroxypropyl) ethylenediamine (EDTP) possesses optimal encapsulation epoxidized linseed oil (ELO). The resulting RCE‐50 gel exhibited robust mechanical properties (≈65 MPa) excellent stability (high temperatures, high pressures, solvents immersion). Owing strength polyurethane network, adhesion high‐density amino ester groups, well hydrophobic toughening effects ELO, can be used versatile adhesive with under different conditions. This study proposes new approach innovating gels, provides idea porous materials, offers fresh insights developing bio‐based
Язык: Английский
Процитировано
4
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 107075 - 107075
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Biomacromolecules, Год журнала: 2024, Номер 25(11), С. 7529 - 7542
Опубликована: Окт. 28, 2024
Moisture loss, infection, and severe inflammatory reactions are the primary factors affecting burn wound healing leading to scar formation. Herein, we developed a quercetin-loaded polysaccharide-based injectable hydrogel (named PECE). The PECE consists of oxidized sodium alginate (OAlg) coupled with chitosan (CS) via Schiff bases electrostatic interactions, while Que is incorporated hydrogen bonding. Benefiting from hydroxyl carboxyl groups, features distinguished moisturizing ability. Additionally, sustained release imparts remarkable antibacterial activity against
Язык: Английский
Процитировано
3
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 7, 2025
Abstract Inspired by the critical role of platelets in hemostasis, hemostatic agents aim to enable rapid blood clotting, essential for saving lives severe hemorrhages. Traditional methods often rely on slow binding limited cellular components and proteins rendering them inadequate scenarios. In this study, macroscopic supramolecular materials capable moisture‐triggered release nanosized glycan‐based platelet substitutes (PS) are developed facilitate expedited hemostasis. The inherent chemistry these PS modified with catechol alkyl enables instant amalgamation red cells albumin, forming a durable gel that exhibits self‐healing anti‐adhesion properties, effectively minimizing rebleeding postoperative complications. Meanwhile, Pad instantly adheres various organs resists arterial pressure constructing microstructure‐adapting layer tissue surface. rodent porcine trauma models liver femoral arteries coagulation disorders, PS‐releasing hemostat stops bleeding within 45 s is easily detached without after use. integration fast‐acting interactions, biocompatibility, characteristics positions as promising candidates solutions potential translational applications managing traumatic bleeding.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140814 - 140814
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
The skin is fragile, making it very vulnerable to damage and injury. Untreated wounds can pose a serious threat human health. Three-dimensional polymer network hydrogels have broad application prospects in wound dressings due their unique properties structure. therapeutic effect of traditional limited, while multifunctional composite show greater potential. Multifunctional regulate moisture through formula adjustment. Moreover, be combined with bioactive ingredients improve performance healing applications. Stimulus-responsive respond specifically the environment meet needs different stages. This review summarizes material types, structure, properties, design considerations, formulation strategies for hydrogel used healing. We discuss various types recently developed dressings, highlights importance tailoring physicochemical addresses potential challenges preparing dressings.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Abstract Hemophilic arthropathy (HA), a form of arthritis associated with joint bleeding, presents extra challenges in treatment due to intermittent bleeding‐induced iron‐overloading, oxidative stress, and inflammation. Conventional therapeutic approaches have predominantly concentrated on achieving hemostasis reducing inflammation, yet they fallen short effectively managing iron overload safeguarding cartilage, resulting less‐than‐ideal outcomes. To address these issues, series injectable hydrogels is facilely fabricated via one‐step assembly polyphenols, chelators, lipoic acid. In vitro investigations demonstrate that the not only good performances antioxidation anti‐inflammation, but also exhibit promising prospects removal, adhesion resistance, wear resistance. Moreover, vivo studies are further carried out indicate diminished inflammatory response, ameliorative iron‐overload‐related lesion indicators, cartilage preservation. This class robust multifunctional composed clinically available drugs along commonly used commercial ingredients would offer new opportunities toward efficient HA.
Язык: Английский
Процитировано
0