Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
Lethal
bleeding
from
severe
trauma
or
surgical
injuries
to
vital
organs
threatens
the
lives
of
patients.
Advanced
design
efficient
hemostatic
sealants
endowed
with
both
rapid
curing
and
strong
tissue
adhesion
remains
a
considerable
challenge.
This
study
proposes
novel
strategy
that
implements
covalent
linkages
biological
tissues
during
sealant
curing.
A
rapidly
photocurable
strongly
adhesive
based
on
diazirine‐conjugated
chitosan
(DC)
is
successfully
developed,
demonstrating
gelation
time
8
s
burst
pressure
200
mmHg.
The
DC
accelerates
in
vitro
clotting
by
facilitating
aggregation
erythrocytes
platelets,
as
well
platelet
activation.
In
liver
perforation
model,
substantially
promotes
healing
hepatic
wounds
improves
survival.
not
only
achieves
hemostasis
incision,
femoral
artery
perforation,
cardiac
but
also
recovery
rabbit
model.
phototriggered
opens
up
new
avenue
for
clinical
applications,
particularly
lethal
hemorrhage.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 18, 2024
Abstract
Polymer
gels
stand
out
as
emerging
and
promising
materials
in
adhesives.
However,
flexible
network
network–solvent
mismatch
affect
their
strengths
stabilities.
Regulating
the
architectures
of
polymer
via
molecular
design
is
a
strategy
to
overcome
these
drawbacks.
Herein,
novel
polymeric
rigid
cage
(PRC)
structure
proposed
for
capturing
bulky
vegetable
oils
mechanically
interlocking
supramolecular
interactions
or
steric
hindrance
effect
fabricate
universal
gels‐based
By
rationally
designing
refining
architectures,
prepared
by
4,4′‐diphenylmethane
diisocyanate
(MDI)
N
,
″,
″‐tetra(2‐hydroxypropyl)
ethylenediamine
(EDTP)
possesses
optimal
encapsulation
epoxidized
linseed
oil
(ELO).
The
resulting
RCE‐50
gel
exhibited
robust
mechanical
properties
(≈65
MPa)
excellent
stability
(high
temperatures,
high
pressures,
solvents
immersion).
Owing
strength
polyurethane
network,
adhesion
high‐density
amino
ester
groups,
well
hydrophobic
toughening
effects
ELO,
can
be
used
versatile
adhesive
with
under
different
conditions.
This
study
proposes
new
approach
innovating
gels,
provides
idea
porous
materials,
offers
fresh
insights
developing
bio‐based
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 7, 2025
Abstract
Inspired
by
the
critical
role
of
platelets
in
hemostasis,
hemostatic
agents
aim
to
enable
rapid
blood
clotting,
essential
for
saving
lives
severe
hemorrhages.
Traditional
methods
often
rely
on
slow
binding
limited
cellular
components
and
proteins
rendering
them
inadequate
scenarios.
In
this
study,
macroscopic
supramolecular
materials
capable
moisture‐triggered
release
nanosized
glycan‐based
platelet
substitutes
(PS)
are
developed
facilitate
expedited
hemostasis.
The
inherent
chemistry
these
PS
modified
with
catechol
alkyl
enables
instant
amalgamation
red
cells
albumin,
forming
a
durable
gel
that
exhibits
self‐healing
anti‐adhesion
properties,
effectively
minimizing
rebleeding
postoperative
complications.
Meanwhile,
Pad
instantly
adheres
various
organs
resists
arterial
pressure
constructing
microstructure‐adapting
layer
tissue
surface.
rodent
porcine
trauma
models
liver
femoral
arteries
coagulation
disorders,
PS‐releasing
hemostat
stops
bleeding
within
45
s
is
easily
detached
without
after
use.
integration
fast‐acting
interactions,
biocompatibility,
characteristics
positions
as
promising
candidates
solutions
potential
translational
applications
managing
traumatic
bleeding.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
The
skin
is
fragile,
making
it
very
vulnerable
to
damage
and
injury.
Untreated
wounds
can
pose
a
serious
threat
human
health.
Three-dimensional
polymer
network
hydrogels
have
broad
application
prospects
in
wound
dressings
due
their
unique
properties
structure.
therapeutic
effect
of
traditional
limited,
while
multifunctional
composite
show
greater
potential.
Multifunctional
regulate
moisture
through
formula
adjustment.
Moreover,
be
combined
with
bioactive
ingredients
improve
performance
healing
applications.
Stimulus-responsive
respond
specifically
the
environment
meet
needs
different
stages.
This
review
summarizes
material
types,
structure,
properties,
design
considerations,
formulation
strategies
for
hydrogel
used
healing.
We
discuss
various
types
recently
developed
dressings,
highlights
importance
tailoring
physicochemical
addresses
potential
challenges
preparing
dressings.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Abstract
Hemophilic
arthropathy
(HA),
a
form
of
arthritis
associated
with
joint
bleeding,
presents
extra
challenges
in
treatment
due
to
intermittent
bleeding‐induced
iron‐overloading,
oxidative
stress,
and
inflammation.
Conventional
therapeutic
approaches
have
predominantly
concentrated
on
achieving
hemostasis
reducing
inflammation,
yet
they
fallen
short
effectively
managing
iron
overload
safeguarding
cartilage,
resulting
less‐than‐ideal
outcomes.
To
address
these
issues,
series
injectable
hydrogels
is
facilely
fabricated
via
one‐step
assembly
polyphenols,
chelators,
lipoic
acid.
In
vitro
investigations
demonstrate
that
the
not
only
good
performances
antioxidation
anti‐inflammation,
but
also
exhibit
promising
prospects
removal,
adhesion
resistance,
wear
resistance.
Moreover,
vivo
studies
are
further
carried
out
indicate
diminished
inflammatory
response,
ameliorative
iron‐overload‐related
lesion
indicators,
cartilage
preservation.
This
class
robust
multifunctional
composed
clinically
available
drugs
along
commonly
used
commercial
ingredients
would
offer
new
opportunities
toward
efficient
HA.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Abstract
Well‐integration
of
multiple
bioactive
components
into
a
biological
patch
without
damaging
its
cellular
matrix
structure
is
crucial
for
infectious
abdominal
wall
defect
repair
but
remains
challenging.
Herein,
novel
asymmetric
composite
(bPVA/SIS
+
‐NP)
developed
by
in
situ
introducing
zwitterionic
polyvinyl
alcohol
molecular
brush
(bPVA)
hydrogel
to
cationic
small
intestinal
submucosal
decellularized
(SIS
)
via
self‐induced
phase
separation
based
united
strategy.
Due
high
hydrogen
bonding
crosslinking
and
strong
mechanical
interlocking
with
SIS
‐NP
layer,
bPVA
layer
can
maintain
stable
anti‐contamination
the
corresponding
anti‐adhesion
properties
contaminated
environment.
On
basis
preserving
an
original
extracellular
skeleton,
show
contact
anti‐bacterial
ability
at
acute
stage
together
prolonged
drug
release
during
healing
repair.
Furthermore,
combination
layers
lead
burst
pressure
tolerance.
By
comprehensive
control
bacteria
their
necrotic
products,
bPVA/SIS
achieve
anti‐infection,
anti‐adhesion,
pro‐healing
on
rats.
Therefore,
opens
new
avenue
bio‐friendly
construction
multifunctional
patches
address
stringent
requirements
