ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(8), С. 5037 - 5056
Опубликована: Май 24, 2024
The
oral
and
nasal
cavities
serve
as
critical
gateways
for
infectious
pathogens,
with
microorganisms
primarily
gaining
entry
through
these
routes.
Our
first
line
of
defense
against
invaders
is
the
mucosal
membrane,
a
protective
barrier
that
shields
body's
internal
systems
from
infection
while
also
contributing
to
vital
functions
like
air
nutrient
intake.
One
key
features
this
its
ability
protect
physiological
system
pathogens.
Additionally,
tolerance
plays
crucial
role
in
maintaining
homeostasis
by
regulating
pH
water
balance
within
body.
Recognizing
importance
barrier,
researchers
have
developed
various
formulations
enhance
immune
response.
Mucosal
vaccines,
example,
deliver
antigens
directly
tissues,
triggering
local
stimulation
ultimately
inducing
systemic
immunity.
Studies
shown
lipid-based
such
liposomes
virosomes
can
effectively
elicit
both
responses.
Furthermore,
mucoadhesive
polymeric
particles,
their
prolonged
delivery
target
sites,
demonstrated
an
enhanced
This
Review
delves
into
material
selection
approaches
optimizing
Chemical Engineering Journal,
Год журнала:
2024,
Номер
487, С. 150403 - 150403
Опубликована: Март 16, 2024
Hydrogels
have
emerged
in
various
biomedical
applications,
including
tissue
engineering
and
medical
devices,
due
to
their
ability
imitate
the
natural
extracellular
matrix
(ECM)
of
tissues.
However,
conventional
static
hydrogels
lack
dynamically
respond
changes
surroundings
withstand
robust
biophysical
microenvironment
trigger
on-demand
functionality
such
as
drug
release
mechanical
change.
In
contrast,
multifunctional
dynamic
can
adapt
external
stimuli
drawn
great
attention
recent
studies.
It
is
realized
that
integration
nanomaterials
into
provides
numerous
functionalities
for
a
variety
applications
cannot
be
achieved
by
hydrogels.
This
review
article
comprehensive
overview
advances
designing
fabricating
applications.
We
describe
different
types
based
on
breakable
reversible
covalent
bonds
well
noncovalent
interactions.
These
mechanisms
are
described
detail
useful
reference
crosslinking
strategies
strongly
influence
properties
also
discuss
use
potential
benefits.
further
explores
nanocomposite
hydrogels,
delivery,
engineering,
bioadhesives,
wound
healing,
cancer
treatment,
mechanistic
study,
multiple-scale
Finally,
we
challenges
future
perspectives
field
diverse
technologies.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 8, 2024
Abstract
Dry
eye
disease
(DED)
is
associated
with
ocular
hyperosmolarity
and
inflammation.
The
marketed
topical
drops
for
DED
treatment
often
lack
bioavailability
precorneal
residence
time.
In
this
study,
we
investigated
catechol-functionalized
polyzwitterion
p(MPC-
co
-DMA),
composed
of
2-methacryloyloxyethyl
phosphorylcholine
(MPC)
dopamine
methacrylamide
(DMA)
monomers,
as
potential
nanotherapeutics
DED.
copolymers
were
synthesized
via
random
free-radical
copolymerization,
producing
different
proportions
catecholic
functionalization.
All
as-prepared
polymer
compositions
displayed
good
biocompatibility.
At
a
feeding
ratio
1:1,
p(MPC
1
-
-DMA
)
can
facilitate
robust
mucoadhesion
Michael
addition
and/or
Schiff
base
reaction,
thus
prolonging
time
after
4
days
instillation.
hydration
lubrication
MPC
radical-scavenging
DMA
endow
the
nano-agent
to
ease
tear-film
corneal
A
single
dose
(1
mg/mL)
post-instillation
protect
cornea
against
reactive
oxygen
species,
inhibiting
cell
apoptosis
over-expression
pro-inflammatory
factors
(IL-6
TNF-α).
clinical
assessment,
DED-induced
rabbit
eyes
receiving
could
increase
lacrimal
fluid
secretion
by
5-fold
higher
than
cyclosporine
A.
enhanced
lubricity,
mucoadhesion,
anti-oxidation/anti-inflammation
properties
has
shown
high
promise
bioactive
drop
formulation
treating
Molecules,
Год журнала:
2022,
Номер
27(14), С. 4504 - 4504
Опубликована: Июль 14, 2022
The
first
bioprocess
that
occurs
in
response
to
wounding
is
the
deterrence
of
local
hemorrhage.
This
accomplished
by
platelet
aggregation
and
initiation
hemostasis
cascade.
resulting
blood
clot
immediately
enables
cessation
bleeding
then
functions
as
a
provisional
matrix
for
wound
healing,
which
begins
few
days
after
injury.
Here,
fibrinogen
fibrin
fibers
are
key
players,
because
they
literally
serve
scaffolds
tissue
regeneration
promote
migration
cells,
well
ingrowth
tissues.
Fibrin
also
an
important
modulator
healing
host
defense
system
against
microbes
effectively
maintains
incoming
leukocytes
acts
reservoir
growth
factors.
review
presents
recent
advances
understanding
applications
fibrin-fiber-incorporated
biomedical
materials
applied
subsequent
repair.
It
discusses
how
fibrin-based
function
through
several
stages
including
physical
barrier
formation,
entrapment
bacteria,
drug
cell
delivery,
eventual
degradation.
Pure
not
mechanically
strong
stable
enough
act
singular
repair
material.
To
alleviate
this
problem,
paper
will
demonstrate
modification
with
next-generation
exhibiting
enhanced
stability
medical
efficacy,
along
detailed
look
at
mechanical
properties
fibrin-laden
materials.
Specifically,
nanocomposites
their
role
repair,
sustained
release,
delivery
sites,
skin
reconstruction,
drug-loaded
be
demonstrated
discussed.
