International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138428 - 138428
Опубликована: Дек. 1, 2024
Язык: Английский
ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 884 - 890
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
2
Surfaces and Interfaces, Год журнала: 2024, Номер 51, С. 104676 - 104676
Опубликована: Авг. 1, 2024
Язык: Английский
Процитировано
4
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
Abstract Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye disease, presenting challenge for targeted treatment. Traditional topical ocular drug delivery methods often fail to effectively reach the meibomian glands (MGs). To address this, study has developed soluble microneedles (MN) patch comprising poly(vinyl alcohol), cyclodextrin modified polyacrylic acid, and new indocyanine green. This innovative MN facilitates transdermal release peroxisome proliferator‐activated receptor gamma (PPAR‐γ) agonists, such as rosiglitazone in response near‐infrared ray induced temperature changes. By safely optimizing temperature, liquefied meibum lips, thereby alleviating duct obstruction while releasing drug. patches exhibit sufficient mechanical strength effective skin penetration, its biosafety eyelid application been rigorously assessed vitro vivo. The therapeutic efficiency loaded (ROSI‐MN) treatment MGD evaluated high‐fat mice. After three months treatments, ROSI‐MN administration significantly alleviated clinical manifestations, including surface damage, lipid deposits, glandular hypertrophy, inflammatory infiltration, ultimately improving microstructure biofunction MGs. In conclusion, hold promise an strategy treating diseases beyond MGD.
Язык: Английский
Процитировано
0
Expert Opinion on Drug Safety, Год журнала: 2025, Номер unknown, С. 1 - 9
Опубликована: Фев. 8, 2025
Background Approved by the FDA in 2021, varenicline solution is first nasal spray specifically designed to enhance basal tear film production for treating dry eye disease (DED). However, there a lack of data comprehensively comparing its safety profile conventional DED therapies. Herein, we assess whether ocular adverse events (AEs) are disproportionately reported with real-world use solution.
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125355 - 125355
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Journal of Medical Microbiology, Год журнала: 2025, Номер 74(3)
Опубликована: Март 12, 2025
Introduction. Eye diseases are widespread all over the world and, if left untreated, can lead to blindness. Hypothesis. The use of 0.05% cyclosporine A (CsA) solution for treatment dry eye causes a decrease in discomfort and pain improves objective measures such as tear film breakdown time, Schirmer test results Oxford scale scores due its anti-inflammatory immunomodulatory properties that contribute improved stability production. Aim. This study aimed investigate impact CsA on progression ocular surface diseases. Methodology. An experiment was conducted basis FOCUS ophthalmology centre, Kazakhstan. group 100 individuals diagnosed with mild severe illness were administered drops part protocol. Results. positive effect is explained by effects CsA. showed disease led pain, well an improvement measures, including scores. visual analogue significant reduction symptoms, from 6.8 points at baseline 3.7 day 60. In total, 20% patients reported moderate side effects, during instillation redness surface. Conclusion. It concluded these reduced patient condition enhanced indicators scale, breakup corneal conjunctival staining. differs previous ones it focuses efficacy also examines spectrum frequency which not sufficiently covered studies.
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101276 - 101276
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Langmuir, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Ocular lubrication is a critical component of the biological system. Factors such as tear film instability and corneal epithelial damage can lead to increased friction on ocular surface during blinking, which negatively impacts quality life results in economic burden. Eye drops are commonly used therapeutic purposes. Due frequent movement (blinking, secretion, nasolacrimal drainage), their bioavailability low, requiring applications. In this study, methacylated gellan gum (GGMA) hydrogels were synthesized using methacrylic anhydride low-acyl raw materials. The elastic modulus GGMA hydrogel nearly threefold after introduction alkali metal ions. Macroscopic superlubricity was achieved experiments simulating environment. At contact pressure close 10 kPa, COF reduced 0.004. Detailed sophisticated simulations revealed underlying mechanism, showing that attributed hydration properties ions adsorbed onto surface. exhibits excellent lubricating properties, offering promising potential for enhancing supporting eye health.
Язык: Английский
Процитировано
0
Macromolecular Bioscience, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Abstract As one of the 3D printing technologies, digital light processing (DLP) technology has been widely applied in biomedical engineering. The principles and advantages DLP are compared with other while characteristics applicable fields each technique analyzed. applications tissue engineering, medical devices pharmaceutical field classified summarized. Besides, prospects challenges engineering discussed. With continuous advancement, will play an increasingly important role personalized medicine regenerative medicine.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 50, С. 396 - 413
Опубликована: Апрель 22, 2025
Язык: Английский
Процитировано
0