Deoxygenative Hetero- and Carbofunctionalizations of Diarylketones
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(11), С. 8157 - 8167
Опубликована: Май 10, 2024
Direct
transformations
of
diarylketones
to
hetero-
and
carbofunctionalized
diarylmethanes
have
been
developed.
The
reactions
involve
a
phospha-Brook
rearrangement
diphenylphosphine
oxide
with
diarylketones,
followed
by
substitutions
various
nucleophiles
such
as
amides,
amines,
phenols,
thiols,
diborylmethane
under
palladium
catalysis
afford
the
corresponding
functionalized
in
reductive
manner.
Язык: Английский
Programmable Strategies for the Conversion of Aldehydes to Unsymmetrical (Deuterated) Diarylmethanes and Diarylketones
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
Herein,
we
present
a
versatile
method
for
synthesizing
unsymmetrical
diarylmethanes
and
diarylketones
from
aldehydes
arenes.
This
involves:
(1)
regioselective
Ar-H
alkylation
to
form
benzhydrylphosphonium
salts
via
one-pot,
four-component
reaction
with
simple
reagents
(2)
chemoselective
reductions
or
oxidations
of
the
benzylic
C-P
bond.
Notably,
D2O
yield
fully
deuterated
diarylmethanes.
high-yielding,
straightforward
approach
offers
valuable
building
blocks
enables
novel
transformations
academic
pharmaceutical
research.
Язык: Английский
Synthesis and Functionalization of Thiophosphonium Salts: A Divergent Approach to Access Thioether, Thioester, and Dithioester Derivatives
Organic Letters,
Год журнала:
2023,
Номер
25(34), С. 6396 - 6400
Опубликована: Авг. 23, 2023
Herein,
we
report
a
straightforward
practical
method
for
efficiently
obtaining
diverse
range
of
thiophosphonium
salts.
This
involves
the
direct
coupling
commercially
available
thiols
and
aldehydes
with
Ph3P
TfOH.
The
setup
is
simple
carried
out
in
metal-free
manner.
synthetic
utility
these
salts
demonstrated
through
various
examples
C-P
bond
functionalizations,
enabling
synthesis
thioether,
deuterated
thioester,
dithioester
derivatives.
These
products,
which
serve
as
valuable
building
blocks,
are
obtained
high
yields.
Язык: Английский
Heteroarylation of Organophosphonium Salts with Indoles in Water: Synthesis of Symmetrical and Unsymmetrical 3,3'‐Bisindolylmethane Derivatives
Xin-Long Luo,
Wen-Jun Ji,
Zi-Lun Yu
и другие.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 16, 2024
Abstract
A
method
for
the
synthesis
of
symmetrical
and
unsymmetrical
3,3′‐bis(indolyl)methanes
(3,3′‐BIMs)
has
been
developed
through
direct
heteroarylation
indolyl‐containing
di(hetero)aryl
phosphonium
salts
with
indole
derivatives
in
aqueous
media.
This
metal‐free
reaction
proceeds
smoothly
under
mild
conditions,
eliminating
need
hazardous
solvents
expensive
additives/catalysts
typically
used
conventional
routes,
thereby
highlighting
synthetic
practicality
efficiency
process.
The
success
this
approach
is
largely
attributed
to
role
water
as
a
promoter,
facilitating
C−P
bond
functionalization
salts.
Furthermore,
demonstrates
broad
substrate
scope,
good
functional
group
tolerance,
excellent
scalability.
Moreover,
protocol
can
also
be
extended
triindolylmethane
compound
diarylmethylated
indole.
Язык: Английский
Practical Synthesis and Functionalization of Thiophosphonium Salts: A Divergent Approach to Access Thioether, Thioester, and Dithioe-ster Derivatives
Опубликована: Июль 13, 2023
Herein,
we
report
a
straightforward
method
for
efficiently
obtaining
diverse
range
of
thiophosphonium
salts.
This
involves
the
direct
coupling
commercially
available
thiols
and
aldehydes
with
Ph3P
TfOH.
The
setup
is
simple
carried
out
in
metal-free
manner.
synthetic
utility
these
salts
demonstrated
through
various
examples
C–+P
bond
functionalizations,
enabling
synthesis
thioether,
deuterated-thioether,
thioester,
dithioester
derivatives.
These
products,
which
serve
as
valuable
building
blocks,
are
obtained
high
yields.
Язык: Английский