Direct C(sp3)-H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Recent
years
have
witnessed
the
emergence
of
direct
intermolecular
C(sp
Язык: Английский
Synthesis of Dithioester Derivatives by Base-Mediated Fragmentation of 1,3-Dithiolanes
Hasan Pelit,
Mehmet Aytug Sinmaz,
Oyku Acelya Ildem
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Dithioesters
are
important
agents
for
chain
transfer
in
polymer
chemistry
and
precursors
the
synthesis
of
heterocycles.
Straightforward
approaches
to
their
therefore
demand.
Outlined
herein
is
a
method
access
such
compounds
one-pot.
2-Aryl-1,3-dithiolanes
undergo
ring
fragmentation
with
LiHMDS
CPME
generate
aryl-dithiocarboxylates
5
min
at
100
°C.
These
anions
subsequently
captured
second
step
by
addition
various
alkyl
halides
diaryliodonium
salts
furnish
large
library
dithioesters
good
yields.
The
can
be
also
employed
one-pot,
one-step
manner
bromides
allows
gram
scale.
Язык: Английский
Direct Synthesis of Ethers from Alcohols & Aldehydes Enabled by an Oxocarbenium Ion Interception Strategy
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
While
a
combination
of
alcohol
and
aldehyde
under
acidic
conditions
typically
gives
an
acetal,
interception
the
intermediate
oxocarbenium
ion
by
phosphine
followed
hydrolysis
leads
to
ethers
without
need
for
hydride
donor.
Язык: Английский
Programmable Strategies for the Conversion of Aldehydes to Unsymmetrical (Deuterated) Diarylmethanes and Diarylketones
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
Herein,
we
present
a
versatile
method
for
synthesizing
unsymmetrical
diarylmethanes
and
diarylketones
from
aldehydes
arenes.
This
involves:
(1)
regioselective
Ar-H
alkylation
to
form
benzhydrylphosphonium
salts
via
one-pot,
four-component
reaction
with
simple
reagents
(2)
chemoselective
reductions
or
oxidations
of
the
benzylic
C-P
bond.
Notably,
D2O
yield
fully
deuterated
diarylmethanes.
high-yielding,
straightforward
approach
offers
valuable
building
blocks
enables
novel
transformations
academic
pharmaceutical
research.
Язык: Английский
Electroreductive Carboxylation of Benzylphosphonium salts with CO2 Through the Cleavage of the C(sp3)-P Bond
Fen Han,
Fenfen Xie,
Mengyun Yin
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(28), С. 5724 - 5728
Опубликована: Янв. 1, 2024
Herein,
a
novel
electroreductive
carboxylation
of
benzylphosphine
salts
with
CO
2
through
cleavage
the
C(sp
3
)-P
bond
was
reported
under
conditions
without
redox
reagents
and
noble
metal
catalysts.
Язык: Английский
1-Hydroxyalkylphosphonium Salts—Synthesis and Properties
Molecules,
Год журнала:
2023,
Номер
29(1), С. 18 - 18
Опубликована: Дек. 19, 2023
An
efficient
and
convenient
method
for
the
synthesis
of
1-hydroxyalkylphosphonium
salts
is
described.
Reactions
were
carried
out
at
room
temperature,
in
a
short
time,
without
chromatography
product
isolation.
The
properties
obtained
phosphonium
examined
discussed.
In
this
paper,
primary
attention
was
paid
to
stability
salts,
depending
on
structure
aldehydes
used
as
substrates
their
preparation.
Other
conditions
such
type
solvent,
molar
ratio
also
investigated.
Finally,
high
reactivity
demonstrated
reactions
with
amide-type
(hetero)aromatic
compounds.
developed
step-by-step
procedure
(with
isolation
1-hydroxyphosphonium
salts)
compared
one-pot
protocol
(in
situ
formation
salts).
Язык: Английский
Synthesis of Aryl Alkyl Thioethers via a Copper-Catalyzed Three-Component Reaction with DABSO, Aryldiazonium Salts, and Alkyl Bromides
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
We
developed
a
method
for
synthesizing
aryl
alkyl
thioether
compounds
via
three-component
reaction
involving
aryldiazonium
salts,
1,4-diazabicyclo[2.2.2]octane
bis(sulfur
dioxide),
and
bromides.
Optimal
yields
were
achieved
when
copper
catalyst
was
used
in
conjunction
with
zinc
tetrabutylammonium
bromide
an
acetonitrile
solvent
at
130
°C
10
h.
This
methodology
demonstrates
good
functional
group
tolerance
enables
the
successful
synthesis
of
various
thioethers
moderate
to
high
yields.
Язык: Английский