Recent Advances in Site Selective Transformations of β-Enaminones via C-H Functionalization/Annulation
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
β-Enaminone
transformation
strategies
are
widely
employed
in
the
synthesis
of
numerous
biologically
active
drugs
and
natural
products,
highlighting
their
significance
medicinal
chemistry.
Язык: Английский
Rh‐catalyzed three‐component synthesis of diverse N‐aryl pyrazoles via cascade pyrazole annulation and aryl C‐H addition to alkenes
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(9)
Опубликована: Июль 5, 2024
A
novel
Rh‐catalyzed
three‐component
synthesis
of
N
‐(
o
‐alkylaryl)
pyrazoles
via
cascade
pyrazole
annulation
and
aryl
C‐H
conjugate
addition
to
alkenes
has
been
developed
with
enaminones,
hydrazines,
functionalized
as
starting
materials.
The
raw
materials
used
in
this
reaction
are
simple,
cheap,
readily
available,
the
reactions
feature
excellent
step
economy
by
furnishing
products
formation
a
ring
key
activation
one‐step
operation.
Moreover,
proceeds
smoothly
under
air
atmosphere,
making
it
easy
operate.
Язык: Английский
Efficient Solvent-Free Synthesis of Indolizines Using CuBr Catalyst from Pyridine, Acetophenone, and Electron-Deficient Alkenes
Molecules,
Год журнала:
2024,
Номер
29(9), С. 2061 - 2061
Опубликована: Апрель 29, 2024
Herein,
we
have
developed
a
new
approach
for
the
synthesis
of
indolizine
via
Cu-catalyzed
reaction
pyridine,
acetophenone,
and
nitroolefin
under
mild
conditions
in
high
yields.
This
involved
formation
C–N
C–C
bonds
compounds
with
stereoselectivity
excellent
functional
group
tolerance.
Язык: Английский
Domino Approach to Heterocycles-Based Unsymmetrical Triarylmethanes through Heteroannulation of 2-(2-Enynyl)-pyridines with Enaminones
Feroz Ahmad,
Pavit K. Ranga,
Shaheen Fatma
и другие.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(17), С. 12104 - 12117
Опубликована: Авг. 13, 2024
Herein,
we
report
a
copper-catalyzed
protocol
to
access
unsymmetrical
triarylmethanes
containing
both
indolizine
and
the
chromone
scaffolds
in
same
molecule
via
5-endo-dig
cyclization
of
2-(2-enynyl)-pyridines
followed
by
reaction
with
2-hydroxyaryl
enaminones.
A
variety
enaminones
were
subjected
under
optimal
conditions,
respective
obtained
good
excellent
yields.
Язык: Английский
Base-mediated formal [4+1] annulation of ortho-hydroxyphenyl substituted para-quinone methides and CF3-imidoyl sulfoxonium ylides to access trifluoroacetimidoyl-substituted 2,3-dihydrobenzofurans
Journal of Fluorine Chemistry,
Год журнала:
2024,
Номер
277, С. 110308 - 110308
Опубликована: Июнь 7, 2024
Язык: Английский
One-Pot Formal [3+2] Annulation of 2-Pyridinyl-Substituted p-Quinone Methides and Arynes for the Synthesis of 3-Aryl Pyrido[1, 2-a]indoles
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(27), С. 5618 - 5628
Опубликована: Янв. 1, 2024
We
report
a
formal
[3
+
2]
cycloaddition
for
constructing
3-aryl
pyrido[1,2-
]indoles
from
aryne
intermediates
and
2-pyridinyl-substituted
p
-QMs
under
ambient
conditions.
Язык: Английский
HMPA-H2O mediated oxygenative carbocyclization of 2-alkynylphenyl-substituted p-quinone methides to indenones
Shaheen Fatma,
Feroz Ahmad,
Yogesh A. Pankhade
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(29), С. 5891 - 5896
Опубликована: Янв. 1, 2024
A
HMPA–water
mediated
protocol
to
access
substituted-indenones
through
an
oxygenative
carbocyclization
of
2-alkynylphenyl-substituted
p
-quinone
methides
has
been
developed
under
metal-
and
base-free
conditions.
Язык: Английский
Recent Advances in the Development of Indolizine Scaffolds: Synthetic Methodology and Mechanistic Insights
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Comprehensive
Summary
Indolizine
is
a
nitrogen‐containing
heterocycle
with
strong
aromaticity,
possessing
delocalized
10π‐electron
system.
Based
on
the
indolizine
scaffolds,
numerous
molecules
biological
activity
and
organic
functional
materials
have
been
synthesized.
Since
2016,
over
110
papers
published
synthesis
of
but
reviews
synthesizing
scaffolds
incomplete
not
up‐to‐date.
Herein,
from
perspective
structure
combination
pyrrole
pyridine
ring,
we
focus
construction
through
diversity
starting
substrates,
including
derivatives
(N1‐substituted
pyridinium
salt
derivatives,
C2‐substituted
N1‐
C2‐free
substituted
derivatives),
unoriginal
ring
substrates.
Furthermore,
corresponding
reaction
mechanisms
synthetic
methodologies
are
also
elaborated.
Therefore,
this
review
only
paves
way
for
provides
insight
into
exploring
new
modes
constructing
heterocycles.
Key
Scientists
was
discovered
by
Angeli
in
1890
first
prepared
Scholtz
1912
α‐picoline
acetic
anhydride.
A
general
approach
developed
Chichibabin
1927,
that
practical
value
preparation
2‐alkyl‐
or
2‐arylindolizines.
The
closure
quaternary
halides.
At
begining
21st
century,
Basavaiah
introduced
dimension
Baylis‐Hillman
chemistry
leading
to
novel
facile
convenient
methodology
one‐pot
operation.
In
2010,
Barluenga
reported
Cu(I)‐catalyzed
regioselective
[3+2]
cyclization
unsubstituted
pyridines
toward
alkenyldiazoacetates
functionalized
successful
example
metal‐catalyzed
π‐deficient
heterocyclic
system
alkenyldiazo
compounds.
2019
2022,
Xi
Liu
exploited
methods
non‐pyridine
as
synthesize
indolizines,
respectively.
Guo
an
environmentally
benign
electrooxidative
formyl‐
acyl‐substituted
indolizines.
Язык: Английский
One‐Pot Synthesis of 3‐Hydroxy‐1H‐Pyrrolo[3,4‐b]quinolin‐1‐one via Enaminamides
Xi Shen,
Zhi‐Cheng Yu,
You Zhou
и другие.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(21), С. 4399 - 4403
Опубликована: Июль 16, 2024
Abstract
A
multicomponent
cascade
cyclization
reaction
using
aryl
methyl
ketones,
amines,
and
enaminamide
reagents
to
construct
3‐hydroxy‐1
H
‐pyrrolo[3,4‐
b
]quinolin‐1‐one
skeleton
with
good
substrate
compatibility
(50
examples)
has
been
reported.
The
one‐pot,
metal‐free
process
formed
two
C−C
bonds,
C−N
a
tetrasubstituted
carbon
stereocenter
containing
hydroxyl
group.
enabled
modified
transformation
of
drug
molecules
derivatization
products.
Язык: Английский
Manganese‐ Mediated Cascade Radical Oxidative Cyclization/1,6‐Conjugate Addition of Unsaturated Oximes with p‐Quinone methides: Facile Access to β,β‐Diarylmethine Isoxazolines
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 9, 2024
A
simple
and
efficient
strategy
for
the
synthesis
of
structurally
diverse
β,β-diarylmethine
substituted
isoxazoline
derivatives
have
been
developed.
This
approach
employs
a
manganese-promoted
oxidative
cyclization
coupled
with
1,6-conjugate
addition
unsaturated
oximes
to
p-quinone
methides.
The
key
features
this
study
include
formation
C-O
C-C
bonds
through
intramolecular
intermolecular
interactions,
facilitated
by
in
situ
generated
iminoxyl
radicals.
isoxazolines,
bearing
wide
range
functional
groups,
were
isolated
high
yields.
Язык: Английский